OS9 Gene
protein-coding GIFtS: 55
GCID: GC12P058088
|
|
osteosarcoma amplified 9, endoplasmic reticulum lectin
| |
Aliases for OS9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin1 2 | | Endoplasmic Reticulum Lectin 22 | | ERLEC21 2 | | Erlectin 22 | | OS-91 2 | | Osteosarcoma Amplified 9, Endoplasmic Reticulum Associated Protein2 | | Amplified In Osteosarcoma 92 3 | | Protein OS-92 |
Export aliases for OS9 gene to outside databasesPrevious GC identifers: GC12P056375 GC12P055124 |
Summaries for OS9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for OS9: This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-induciblefactor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of itssubunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (providedby RefSeq, Jul 2008) UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438Function: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD).May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in theER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets includeTRPV4 Gene Wiki entry for OS9
|
Genomic Views for OS9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OS9 gene promoter: AML1a LCR-F1 CBF-C C/EBPalpha MZF-1 CBF-A CBF-B CP1A CP1C NF-Y Other transcription factors
Search SABiosciences Chromatin IP Primers for OS9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OS9 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13OS9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P058088: view genomic region
(about GC identifiers)
Start:
|
58,087,738 bp from pter |
End:
|
58,115,340 bp from pter |
Size:
|
27,603 bases |
Orientation:
|
plus strand |
|
Proteins for OS9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438 (See
protein sequence)Recommended Name: Protein OS-9 precursor Size: 667 amino acids; 75562 Da
Subunit: Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 and SEL1L with which itinteracts directly. Through this complex it may interact with ERLEC1 and HSPA5. Interacts with DERL2. Interacts withHSP90B1 and CREB3
Subcellular location: Endoplasmic reticulum lumen
1 PDB 3D structure from and Proteopedia for OS9:3AIH (3D)
 
Secondary accessions: A6NDD1 A6NFR7 A6NLB2 A8K5Q9 B4DPX1 B4E1I6 E7ENT8 F8VUH2 O00579 Q6IBL2 Q8IZ58Q9BW99Alternative splicing: 6 isoforms: Q13438-1 Q13438-2 Q13438-3 Q13438-4 Q13438-5 Q13438-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for OS9: NX_Q13438
Post-translational modifications:
Intramolecular disulfide bonds1
Isoform 1 and isoform 2 are N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13438 OS9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (8 alternative transcripts):
NP_001017956.1 NP_001017957.1 NP_001017958.1 NP_001248349.1 NP_001248350.1 NP_001248351.1 NP_001248352.1 NP_006803.1 ENSEMBL proteins: ENSP00000450010 ENSP00000318165 ENSP00000448478 ENSP00000447031 ENSP00000447451 ENSP00000449789 ENSP00000407360 ENSP00000373798 ENSP00000413112 ENSP00000447866 ENSP00000257966 ENSP00000389632 ENSP00000447719 ENSP00000373794 ENSP00000447163 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
OS9 for ontologies About GeneDecksing
OS9 Antibody Products: Assay Products for OS9: |
Protein
Domains / Families for OS9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OS9 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13438ProtoNet protein and cluster: Q13438 1 Blocks protein family: IPB012913 Glucosidase II beta subunit-like
UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438Similarity: Belongs to the OS-9 familySimilarity: Contains 1 PRKCSH domain |
Function for OS9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438Function: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD).May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in theER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets includeTRPV4Induction: Up-regulated in response to endoplasmic reticulum stress (at protein level) Genatlas biochemistry entry for OS9:homogeneously staining-region encoded sequence OS9,from an osteosarcoma-cell line,with three isoforms,coamplified withCDK4,PRIM1,SAS in osteosarcoma
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): OS9 (NM_006812) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OS9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OS9  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OS9 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
OS9 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for OS9:
|
Pathways & Interactions for OS9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein processing in endoplasmic reticulum | | | 2 | Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha | |
Pathway sources See GeneCards unified pathways Show all pathways
1 BioSystems Pathway for OS9 
1
Kegg Pathway (Kegg details for OS9):
OS9 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OS9
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/35 Interacting proteins for OS9 (Q134381, 2, 3 ENSP000003181654) via UniProtKB, MINT, STRING, and/or I2D (see all 35)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
OS9 for ontologies About GeneDecksing
|
Drugs & Compounds for OS9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for OS9 Search CenterWatch for drugs/clinical trials and news about OS9 
|
Transcripts for OS9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for OS9 gene (8 alternative transcripts): NM_001017956.2 NM_001017957.2 NM_001017958.2 NM_001261420.1 NM_001261421.1 NM_001261422.1 NM_001261423.1 NM_006812.3 Unigene Cluster for OS9: Osteosarcoma amplified 9, endoplasmic reticulum lectin Hs.527861 [show with all ESTs]Unigene Representative Sequence: NM_00681218/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23): ENST00000552285 ENST00000549897 ENST00000315970(uc001spj.3 uc010srx.2 uc001spk.3 uc001spl.3 uc001spm.3 uc001spn.3 uc010sry.2 uc010srz.2) ENST00000550848 ENST00000547079 ENST00000552787 ENST00000551285 ENST00000439210 ENST00000389146 ENST00000413095 ENST00000551035 ENST00000257966 ENST00000435406 ENST00000550372 ENST00000553208 ENST00000389142 ENST00000550793 ENST00000552423
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): OS9 (NM_006812) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OS9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OS9  |
Additional cDNA sequence: AB002806.1 AK130733.1 AK291374.1 AK293435.1 AK296770.1 AK298532.1 AK303858.1 AK304533.1 BC000532.2 BC006506.2 BC007254.1 BC023513.2 CR456791.1 EF036505.1 U09408.1 U41635.1 24/46 DOTS entries (see all 46): DT.455567 DT.100682332 DT.100682338 DT.100894740 DT.100846873 DT.95165428 DT.86846445 DT.100875178 DT.121176688 DT.121176686 DT.100682333 DT.100039316 DT.101965445 DT.121176647 DT.100682341 DT.95165476 DT.100682353 DT.121176622 DT.100682335 DT.121176593 DT.100682357 DT.121176695 DT.40313741 DT.95165517 24/962 AceView cDNA sequences (see all 962): AI378327 BX406876 BM707707 BE297464 BE796257 BQ890618 BM694089 BM995659 BQ219913 AA923719 AA447675 BM793039 BE465582 BU507753 CB153976 BQ923211 BQ059182 BM722067 BQ279025 BU619868 AW468445 CR616277 BU070132 BP431528 GeneLoc Exon Structure
5/26 Alternative Splicing Database (ASD) splice patterns (SP) for OS9 (see all 26) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   |
| ExUns: | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | · | 17c | · | 17d | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | · | 20c | |
| SP1: | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for OS9
|
Expression for OS9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OS9 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTCTTGAACA
About this image See OS9 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OS9
SOURCE GeneReport for Unigene cluster: Hs.527861 UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438Tissue specificity: Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas.Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detectedin all cell types examined SABiosciences Expression via Pathway-Focused PCR Arrays including OS9:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OS9 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OS9 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OS9 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OS9 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OS9 |
Orthologs for OS9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for OS9 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for OS9 (if available) TreeFam Gene Tree for OS9 (if available)  |
Paralogs for OS9 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for OS9 gene
- ERLEC12
1 SIMAP similar gene for OS9 using alignment to 10 protein entries: OS9_HUMAN (see all proteins):ERLEC1
OS9 for paralogs About GeneDecksing
|
Genomic Variants for OS9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for OS9 (58087738 - 58115340 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for OS9: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OS9 |
|
Disorders
/ Diseases for OS9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OS9 for disorders About GeneDecksing
OMIM gene information: 609677
OMIM disorders: --
5 diseases for OS9: About MalaCardsosteosarcoma hypoxia rhabdomyosarcoma sarcoma melanoma Human Genome Epidemiology (HuGE) Navigator: OS9 (1 document) Export disorders for OS9 gene to outside databases
|
Publications for OS9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OS9 gene, integrated from 9 sources (see all 39): (articles sorted by number of sources associating them with OS9) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Human OS-9, a lectin required for glycoprotein endoplasmic reticulum- associated degradation, recognizes mannose-trimmed N-glycans. (PubMed id 19346256)1, 2, 3 Hosokawa N.... Nagata K. (2009)
- OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. (PubMed id 18264092)1, 2, 3 Christianson J.C.... Kopito R.R. (2008)
- Genomic organization of the OS-9 gene amplified in human sarcomas. (PubMed id 9498564)1, 2, 3 Kimura Y....Yamada M. (1997)
- Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas. (PubMed id 8634085)1, 2, 3 Su Y.A.... Meltzer P.S. (1996)
- Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation. (PubMed id 21172656)1, 2 Satoh T.... Yamaguchi Y. (2010)
- Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins. (PubMed id 19084021)1, 2 Alcock F. and Swanton E. (2009)
- Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. (PubMed id 18502753)1, 2 Hosokawa N.... Nagata K. (2008)
- A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. (PubMed id 18417469)1, 2 Bernasconi R....Molinari M. (2008)
- OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. (PubMed id 17932042)1, 2 Wang Y....Wegierski T. (2007)
- Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. (PubMed id 9562620)1, 2 Kimura Y.... Yamada M. (1998)
|
External Searches for OS9 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OS9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OS9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OS9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for OS9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OS9 gene: Search GeneIP for patents involving OS9
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for OS9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | OriGene Antibodies for OS9 | | OriGene shRNA RFP for OS9 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OS9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OS9 | | OriGene Protein Over-expression Lysate for OS9 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for OS9 | | OriGene 3'-UTR Clone for OS9 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for OS9 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for OS9 | | OriGene Custom Protein Services for OS9 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OS9 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OS9 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OS9 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OS9 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OS9 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OS9 |
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| | | Search Tocris compounds for OS9 |
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 | | OS9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OS9 |
|  |  |  | | | ThermoFisher Antibody for OS9 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OS9 |
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