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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OS9 Gene

protein-coding GIFtS: 55
GCID: GC12P058088

osteosarcoma amplified 9, endoplasmic reticulum lectin

Explore 5 diseases affiliated with
OS9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin¹ ²		Endoplasmic Reticulum Lectin 2²
ERLEC2¹ ²		Erlectin 2²
OS-9¹ ²		Osteosarcoma Amplified 9, Endoplasmic Reticulum Associated Protein²
Amplified In Osteosarcoma 9² ³		Protein OS-9²

External Ids:	HGNC: 16994¹	Entrez Gene: 10956²	Ensembl: ENSG00000135506⁷	OMIM: 609677⁵	UniProtKB: Q13438³

Export aliases for OS9 gene to outside databases

Previous GC identifers: GC12P056375 GC12P055124

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OS9:

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible

factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its

subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438

Function: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD).

May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the

ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include

TRPV4

Gene Wiki entry for OS9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OS9 gene promoter:
AML1a LCR-F1 CBF-C C/EBPalpha MZF-1 CBF-A CBF-B CP1A CP1C NF-Y
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OS9 promoter sequence

Search SABiosciences Chromatin IP Primers for OS9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OS9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13

OS9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OS9 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P058088: view genomic region (about GC identifiers)

Start:	58,087,738 bp from pter	End:	58,115,340 bp from pter
Size:	27,603 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438 (See protein sequence)

Recommended Name: Protein OS-9 precursor

Size: 667 amino acids; 75562 Da

Subunit: Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 and SEL1L with which it

interacts directly. Through this complex it may interact with ERLEC1 and HSPA5. Interacts with DERL2. Interacts with

HSP90B1 and CREB3

Subcellular location: Endoplasmic reticulum lumen

1 PDB 3D structure from and Proteopedia for OS9:

3AIH (3D)

Secondary accessions: A6NDD1 A6NFR7 A6NLB2 A8K5Q9 B4DPX1 B4E1I6 E7ENT8 F8VUH2 O00579 Q6IBL2 Q8IZ58

Q9BW99

Alternative splicing: 6 isoforms: Q13438-1 Q13438-2 Q13438-3 Q13438-4 Q13438-5 Q13438-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OS9: NX_Q13438

Post-translational modifications:

Intramolecular disulfide bonds¹

Isoform 1 and isoform 2 are N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13438

OS9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (8 alternative transcripts):

NP_001017956.1 NP_001017957.1 NP_001017958.1 NP_001248349.1 NP_001248350.1 NP_001248351.1 NP_001248352.1 NP_006803.1

ENSEMBL proteins:

ENSP00000450010 ENSP00000318165 ENSP00000448478 ENSP00000447031 ENSP00000447451

ENSP00000449789 ENSP00000407360 ENSP00000373798 ENSP00000413112 ENSP00000447866

ENSP00000257966 ENSP00000389632 ENSP00000447719 ENSP00000373794 ENSP00000447163

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): OS9 OriGene Protein Over-expression Lysate (see all 2): OS9 OriGene Custom Protein Services for OS9
	GenScript Custom Purified and Recombinant Proteins Services for OS9
	Novus Biologicals OS9 Proteins Novus Biologicals OS9 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for OS9

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000836	Hrd1p ubiquitin ligase complex	NAS	18502753
GO:0005788	endoplasmic reticulum lumen	IDA	18417469

OS9 for ontologies About GeneDecksing

OS9 Antibody Products:

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	Abcam antibodies for OS9
	Uscn Antibodies for OS9
	ThermoFisher Antibody for OS9

Assay Products for OS9:

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	Uscn ELISAs and CLIAs for OS9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OS9 for domains About GeneDecksing

2 InterPro domains/families:

IPR009011 Man6P_isomerase_rcpt-bd_dom

IPR012913 PRKCSH

Graphical View of Domain Structure for InterPro Entry Q13438

ProtoNet protein and cluster: Q13438

1 Blocks protein family: IPB012913 Glucosidase II beta subunit-like

UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438

Similarity: Belongs to the OS-9 family

Similarity: Contains 1 PRKCSH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438

Function: Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD).

May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the

ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include

TRPV4

Induction: Up-regulated in response to endoplasmic reticulum stress (at protein level)

Genatlas biochemistry entry for OS9:

homogeneously staining-region encoded sequence OS9,from an osteosarcoma-cell line,with three isoforms,coamplified with

CDK4,PRIM1,SAS in osteosarcoma

miRNA Products:		OriGene 3'-UTR Clone (see all 4): OS9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OS9
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate OS9:
		hsa-miR-145 hsa-miR-219-5p hsa-miR-508-3p
		SwitchGear 3'UTR luciferase reporter plasmid: OS9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OS9 (see all 7) OriGene shRNA RFP: OS9 OriGene siRNA: OS9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OS9

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for OS9

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): OS9 (NM_006812)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OS9

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OS9
		Search LifeMap BioReagents cell lines for OS9

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OS9

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	IDA	19346256
GO:0002020	protease binding	IEA	--
GO:0005515	protein binding	IPI	15721254
GO:0030246	carbohydrate binding	--	--

OS9 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for OS9:

Decreased viability of wild-ty

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

1.00

Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

0.27

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for OS9

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

1 Kegg Pathway (Kegg details for OS9):

Protein processing in endoplasmic reticulum

OS9 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OS9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/35 Interacting proteins for OS9 (Q13438^{1, 2, 3} ENSP00000318165⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 35)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD2	Q15796²^,³	MINT-60916 I2D: score=3
ZNF512B	Q96KM6²^,³	MINT-60815 I2D: score=2
EGLN1	Q9GZT9¹^,³, ENSP00000355601⁴	EBI-1174342,EBI-1174818 I2D: score=4 STRING: ENSP00000355601
HIF1A	Q16665¹^,³, ENSP00000338018⁴	EBI-1174342,EBI-447269 I2D: score=5 STRING: ENSP00000338018
EGLN3	Q9H6Z9³, ENSP00000250457⁴	I2D: score=4 STRING: ENSP00000250457

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006605	protein targeting	IEA	--
GO:0006621	protein retention in ER lumen	IDA	18417469
GO:0016567	protein ubiquitination	IMP	19084021
GO:0030433	ER-associated protein catabolic process	IMP	18417469
GO:0034976	response to endoplasmic reticulum stress	IDA	19084021

OS9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OS9
Search CenterWatch for drugs/clinical trials and news about OS9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OS9 gene (8 alternative transcripts):

NM_001017956.2 NM_001017957.2 NM_001017958.2 NM_001261420.1 NM_001261421.1 NM_001261422.1 NM_001261423.1 NM_006812.3

Unigene Cluster for OS9:

Osteosarcoma amplified 9, endoplasmic reticulum lectin

Hs.527861 [show with all ESTs]

Unigene Representative Sequence: NM_006812

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000552285 ENST00000549897 ENST00000315970(uc001spj.3 uc010srx.2 uc001spk.3 uc001spl.3 uc001spm.3 uc001spn.3 uc010sry.2 uc010srz.2)

ENST00000550848 ENST00000547079 ENST00000552787 ENST00000551285 ENST00000439210

ENST00000389146 ENST00000413095 ENST00000551035 ENST00000257966 ENST00000435406

ENST00000550372 ENST00000553208 ENST00000389142 ENST00000550793 ENST00000552423

miRNA Products:		OriGene 3'-UTR Clone (see all 4): OS9 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OS9
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate OS9:
		hsa-miR-145 hsa-miR-219-5p hsa-miR-508-3p
		SwitchGear 3'UTR luciferase reporter plasmid: OS9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OS9 (see all 7) OriGene shRNA RFP: OS9 OriGene siRNA: OS9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OS9

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OS9 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): OS9 (NM_006812)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for OS9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OS9

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OS9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat OS9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OS9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OS9

Additional cDNA sequence:

AB002806.1 AK130733.1 AK291374.1 AK293435.1 AK296770.1 AK298532.1 AK303858.1 AK304533.1

BC000532.2 BC006506.2 BC007254.1 BC023513.2 CR456791.1 EF036505.1 U09408.1 U41635.1

24/46 DOTS entries (see all 46):

DT.455567 DT.100682332 DT.100682338 DT.100894740 DT.100846873 DT.95165428 DT.86846445 DT.100875178

DT.121176688 DT.121176686 DT.100682333 DT.100039316 DT.101965445 DT.121176647 DT.100682341 DT.95165476

DT.100682353 DT.121176622 DT.100682335 DT.121176593 DT.100682357 DT.121176695 DT.40313741 DT.95165517

24/962 AceView cDNA sequences (see all 962):

AI378327 BX406876 BM707707 BE297464 BE796257 BQ890618 BM694089 BM995659

BQ219913 AA923719 AA447675 BM793039 BE465582 BU507753 CB153976 BQ923211

BQ059182 BM722067 BQ279025 BU619868 AW468445 CR616277 BU070132 BP431528

GeneLoc Exon Structure

5/26 Alternative Splicing Database (ASD) splice patterns (SP) for OS9 (see all 26) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	^	10a	·	10b	·
SP1:									-														-										-		-								-
SP2:																							-										-		-								-
SP3:									-														-										-		-								-
SP4:																																											-
SP5:									-				-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	10c	^	11a	·	11b	·	11c	^	12	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	^	16a	·	16b	·	16c	^	17a	·	17b	·	17c	·	17d	^	18a	·	18b	^	19	^	20a	·	20b	·	20c
SP1:			-														-
SP2:			-
SP3:			-
SP4:			-														-
SP5:			-

ECgene alternative splicing isoforms for OS9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OS9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTGAACA

About this image
See OS9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OS9

SOURCE GeneReport for Unigene cluster: Hs.527861

UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438

Tissue specificity: Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas.

Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected

in all cell types examined

SABiosciences Expression via Pathway-Focused PCR Arrays including OS9:

Unfolded Protein Response in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OS9 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OS9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OS9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for OS9 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Os9^{1 , 5}	amplified in osteosarcoma^{1, 5}	83.68(n)¹ 82.38(a)¹		10 (74.50 cM)⁵ 216440¹ NM_001171026.1¹ NP_001164497.1¹ 127094259⁵
lizard (Anolis carolinensis)	Reptilia	OS9⁶	--	51(a)	1 ↔ 1	GL343847.1(116600-158913)
African clawed frog (Xenopus laevis)	Amphibia	Xl.19223²	Xenopus laevis transcribed sequence with weak similarity more	73.54(n)		BJ614758.1
zebrafish (Danio rerio)	Actinopterygii	os9¹	amplified in osteosarcoma	56.8(n) 51.27(a)		553455 NM_001075108.1 NP_001068576.1
worm (Caenorhabditis elegans)	Secernentea	F48E8.4⁶	Protein F48E8.4	10(a)	1 ↔ 1	III(5453567-5459629)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G35080⁶	protein OS-9	24(a)	1 → many	5(13354273-13356817)
rice (Oryza sativa)	Liliopsida	--	glucosidase II beta subunit-like domain containing...	23(a)	1 → many	6(26315045-26317959)

ENSEMBL Gene Tree for OS9 (if available)
TreeFam Gene Tree for OS9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OS9 gene

ERLEC1²

1 SIMAP similar gene for OS9 using alignment to 10 protein entries: OS9_HUMAN (see all proteins):

ERLEC1

OS9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80172693^1,2	C,F,	--	55122686(+)	`ATCCTA/CATGTT`	8	--	us2k¹		1		WA	118
rs77038249^1,2	C,F,	--	55122688(+)	`CCTAAT/CGTTAT`	8	--	us2k¹		1		WA	118
rs2619442^1,2	C,H	--	55122758(+)	`TTTTGT/ACTGTA`	8	--	us2k¹		4		NS EA	420
rs79326733^1,2	C,	--	55123088(+)	`CCCCAG/TCCTTT`	8	--	us2k¹		2		CSA WA	120
rs112824262^1,2	C,	--	55123115(+)	`TCTGTA/TACATG`	8	--	us2k¹		2		CSA WA	120
rs73334082^1,2	C,	--	55123621(+)	`TTCTTG/CTTTGT`	8	--	us2k¹		1		WA	2
rs75927612^1,2		--	55123797(+)	`GAGAAC/TTCTGA`	8	--	us2k¹		1		NA	120
rs113209851^1,2	C	--	55124049(+)	`GCATGG/TATGTA`	8	--	us2k¹		0	--	--	--	--
rs4760318^1,2		--	55124149(+)	`ctgggC/Ttcagg`	8	--	us2k¹		0	--	--	--	--
rs7132646^1,2	C,F,H,	--	55126111(+)	`TATGTT/GTCCCT`	8	--	int¹		8		NS EA NA	1088

HapMap Linkage Disequilibrium report for OS9 (58087738 - 58115340 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OS9: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OS9

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OS9 for disorders           About GeneDecksing

OMIM gene information: 609677    OMIM disorders: --

5 diseases for OS9:    About MalaCards

osteosarcoma hypoxia rhabdomyosarcoma sarcoma

melanoma

Human Genome Epidemiology (HuGE) Navigator: OS9 (1 document)

Export disorders for OS9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OS9 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with OS9)

Utopia: connect your pdf to the dynamic
world of online information

Human OS-9, a lectin required for glycoprotein endoplasmic reticulum- associated degradation, recognizes mannose-trimmed N-glycans. (PubMed id 19346256)^{1, 2, 3} Hosokawa N.... Nagata K. (2009)
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. (PubMed id 18264092)^{1, 2, 3} Christianson J.C.... Kopito R.R. (2008)
Genomic organization of the OS-9 gene amplified in human sarcomas. (PubMed id 9498564)^{1, 2, 3} Kimura Y....Yamada M. (1997)
Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas. (PubMed id 8634085)^{1, 2, 3} Su Y.A.... Meltzer P.S. (1996)
Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation. (PubMed id 21172656)^{1, 2} Satoh T.... Yamaguchi Y. (2010)
Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins. (PubMed id 19084021)^{1, 2} Alcock F. and Swanton E. (2009)
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. (PubMed id 18502753)^{1, 2} Hosokawa N.... Nagata K. (2008)
A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. (PubMed id 18417469)^{1, 2} Bernasconi R....Molinari M. (2008)
OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. (PubMed id 17932042)^{1, 2} Wang Y....Wegierski T. (2007)
Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. (PubMed id 9562620)^{1, 2} Kimura Y.... Yamada M. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10956	HGNC: 16994	AceView: OS-9	Ensembl:ENSG00000135506	euGenes: HUgn10956
ECgene: OS9	Kegg: 10956	H-InvDB: OS9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OS9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for OS9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OS9 gene:
Search GeneIP for patents involving OS9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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osteosarcoma amplified 9, endoplasmic reticulum lectin

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osteosarcoma amplified 9, endoplasmic reticulum lectin

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