Services
Jump to Section...
Aliases for OS9
Databases for OS9
Disorders for OS9
Domains/Families for OS9
Drugs/Compounds for OS9
Expression for OS9
Function for OS9
Location for OS9
Medical News for OS9
Orthologs for OS9
Paralogs for OS9
Pathways/Interactions for OS9
Proteins for OS9
Publications for OS9
SNPs for OS9
Search Box for OS9
Services for OS9
Summaries for OS9
Technologies for OS9
Transcripts for OS9
TOP
BOTTOM
Aliases & Descriptions for OS9
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Descriptions Amplified in osteosarcoma 9 3 amplified in osteosarcoma 2 osteosarcoma amplified 9 2 osteosarcoma amplified 9, endoplasmic reticulum associated protein 2
Search outside databases for aliases for OS9 gene
Summaries for OS9 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
EntrezGene summary for OS9 : This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to thehypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, andpromotes the degradation of one of its subunits. Alternate transcriptional splice variants,encoding different isoforms, have been characterized. [provided by RefSeq] UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438 Function : May play a role in the ER-associated degradation of misfolded glycoproteins
Gene Wiki entry for OS9
Genomic Location for OS9
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the OS9 gene Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q14.1 HGNC cytogenetic band: 12q13 OS9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P056375:
(about GC identifiers )
Start:
56,374,153 bp from pter
End:
56,401,607 bp from pter
Size:
27,455 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000012.10 NT_029419.11 Proteins for OS9
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438 (See
protein sequence )Recommended Name: Protein OS-9 precursor Size : 667 amino acids; 75562 Da
Secondary accessions : A6NDD1 O00579Alternative splicing : 3 isoforms : Q13438-1 Q13438-2 Q13438-3
REFSEQ proteins (4 alternative transcripts):
NP_001017956.1 NP_001017957.1 NP_001017958.1 NP_006803.1 ENSEMBL proteins: ENSP00000373798 ENSP00000257966 ENSP00000318165 ENSP00000373794 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for OS9: Assays for OS9:
Protein
Domains/ Families for OS9(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Graphical View of Domain Structure for InterPro Entry Q13438 ProtoNet protein and cluster: Q13438
1 Blocks protein family : IPB012913 Glucosidase II beta subunit-like UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438 Similarity : Belongs to the OS-9 familySimilarity : Contains 1 PRKCSH domain
Gene Function for OS9
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_001017956 Applied Biosystems Silencer ® siRNAs for OS9 Sigma-Aldrich siRNA for OS9 Sigma-Aldrich shRNA for OS9 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001017956                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001017956                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001017956  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006812 UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438 Function : May play a role in the ER-associated degradation of misfolded glycoproteins
Genatlas biochemistry entry for OS9 :homogeneously staining-region encoded sequence OS9,from an osteosarcoma-cell line,with threeisoforms,coamplified with CDK4,PRIM1,SAS in osteosarcoma 1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for OS9
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
5/16 Interacting proteins for OS9 (ENSP00000318165 3 Q13438 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 16
)About this table
Drugs & Compounds for OS9 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Browse Tocris compounds for OS9
Transcripts for OS9(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_001017956 Sigma-Aldrich siRNA for OS9 Sigma-Aldrich shRNA for OS9 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001017956 NM_001017957 NM_001017958 NM_006812
REFSEQ mRNAs for OS9 gene (4 alternative transcripts): NM_001017956.1 NM_001017957.1 NM_001017958.1 NM_006812.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001017956 NM_001017957 NM_001017958 NM_006812
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001017956                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001017956                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001017956  
Additional cDNA sequence: AB002806.1 AK129781.1 AK130733.1 AK291374.1 AK293435.1 AK294870.1 AK296770.1 AK298532.1 AK303858.1 AK304533.1 BC000532.2 BC006506.2 BC007254.1 BC023513.2 CR456791.1 CR593783.1 CR594965.1 CR600830.1 CR604702.1 CR610698.1 CR613922.1 CR616277.1 CR621694.1 EF036505.1 U09408.1 U41635.1
24/46 DOTS entries (see all 46
): DT.455567 DT.100682332 DT.100682338 DT.100894740 DT.100846873 DT.95165428 DT.86846445 DT.100875178 DT.121176688 DT.121176686 DT.100682333 DT.100039316 DT.101965445 DT.121176647 DT.100682341 DT.95165476 DT.100682353 DT.121176622 DT.100682335 DT.121176593 DT.100682357 DT.121176695 DT.40313741 DT.95165517
24/962 AceView cDNA sequences (see all 962
):AI307136 BE047727 CB217031 CB145494 CF132317 CR594965 AA311351 CA445865 AA364121 BM668805 AU132426 BQ707802 BQ181517 AA306439 AU133841 BE796257 AU130105 BM707707 BE300142 BQ937790 AA923719 AW068865 BE295383 AI683030
highest scoring ESTs for OS9 :U41635 AA013242 AA021448 AA025446 AA085848 AA130872 AA171903 AA196163 AA229456 AA229590
Unigene Cluster for OS9: Osteosarcoma amplified 9, endoplasmic reticulum associated protein Hs.527861 [show with all ESTs ] Unigene Representative Sequence: U41635 GeneLoc Exon Structure 5/26 Alternative Splicing Database (ASD) splice patterns (SP) for OS9 (see all 26
) ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · SP1 :         -               -           -   -         -           SP2 :                       -           -   -         -           SP3 :         -               -           -   -         -           SP4 :                                           -           SP5 :         -     -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -   -    
ExUns: 10c ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c SP1 :   -               -                                 SP2 :   -                                               SP3 :   -                                               SP4 :   -               -                                 SP5 :   -                                              
About this scheme ECgene alternative splicing isoforms for OS9 4 Ensembl transcripts including schematic representations : ENST00000389146
ENST00000257966
ENST00000315970
ENST00000389142
Expression for OS9
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
OS9 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for OS9 1 / 2 / 3
6 probe-sets matching OS9 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTCTTGAACASOURCE GeneReport for Unigene cluster: Hs.527861 UniProtKB/Swiss-Prot: OS9_HUMAN, Q13438 Tissue specificity : Ubiquitously expressed. Found as well in all tumor cell lines analyzed,amplified in sarcomas. Highly expressed in osteosarcoma OSA-CL and rhabdomyosarcoma RH30 celllines. OS-9-2 is the major isoform detected in all cell types examined
Orthologs for OS9
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Orthologs for OS9 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for OS9 ENSEMBL Gene Tree for OS9 Paralogs for OS9 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Paralogs for OS9 gene C2orf30 2
SNPs/Variants for OS9 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
HapMap Linkage Disequilibrium images for OS9 (up to first 250kb)
Disorders & Mutations for OS9
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
OMIM: 609677
Medical News for OS9 (Possibly Related Articles in
Doctor's Guide )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Publications for OS9 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
10/18 PubMed articles for OS9 gene (see all 18
):
Search for OS9
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Genome Databases showing OS9
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Other Databases showing OS9
(According to HUGE )
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
--
Specialized Databases showing OS9 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
-- Services for OS9 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
Jump to Section...
Aliases
Databases
Disorders
Domains/Families
Drugs/Compounds
Expression
Function
Location
Medical News
Orthologs
Paralogs
Pathways/Interactions
Proteins
Publications
SNPs
Search Box
Services
Summaries
Technologies
Transcripts
TOP
BOTTOM
Products for OS9:
Recombinant Proteins (OS9 ) Antibodies (OS9 )
Search Tocris compounds for OS9
Antibodies for OS9
Jump to Section...
Aliases for OS9
Databases for OS9
Disorders for OS9
Domains/Families for OS9
Drugs/Compounds for OS9
Expression for OS9
Function for OS9
Location for OS9
Medical News for OS9
Orthologs for OS9
Paralogs for OS9
Pathways/Interactions for OS9
Proteins for OS9
Publications for OS9
SNPs for OS9
Search Box for OS9
Services for OS9
Summaries for OS9
Technologies for OS9
Transcripts for OS9
TOP
BOTTOM
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009