Aliases for OS9 Gene
External Ids for OS9 Gene
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for OS9 Gene
OS9 (Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin) is a Protein Coding gene. Diseases associated with OS9 include hypoxia. Among its related pathways are Translational Control and Hypoxic and oxygen homeostasis regulation of HIF-1-alpha. GO annotations related to this gene include protease binding and glycoprotein binding. An important paralog of this gene is ERLEC1.
UniProtKB/Swiss-Prot for OS9 Gene
Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.