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Aliases for ORMDL2 Gene

Aliases for ORMDL2 Gene

  • ORMDL Sphingolipid Biosynthesis Regulator 2 2 3
  • Adoplin-2 3 4
  • ORM1 (S. Cerevisiae)-Like 2 2
  • ORM1-Like 2 (S. Cerevisiae) 2
  • Expressed In Normal Aorta 3
  • ORM1-Like Protein 2 3
  • HSPC160 3
  • MSTP095 3
  • MST095 3

External Ids for ORMDL2 Gene

Previous GeneCards Identifiers for ORMDL2 Gene

  • GC12P056308
  • GC12P056433
  • GC12P055928
  • GC12P054498
  • GC12P054499
  • GC12P056211
  • GC12P053250

Summaries for ORMDL2 Gene

GeneCards Summary for ORMDL2 Gene

ORMDL2 (ORMDL Sphingolipid Biosynthesis Regulator 2) is a Protein Coding gene. An important paralog of this gene is ORMDL3.

UniProtKB/Swiss-Prot for ORMDL2 Gene

  • Negative regulator of sphingolipid synthesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORMDL2 Gene

Genomics for ORMDL2 Gene

Genomic Location for ORMDL2 Gene

55,817,919 bp from pter
55,821,879 bp from pter
3,961 bases
Plus strand

Genomic View for ORMDL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORMDL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORMDL2 Gene

Proteins for ORMDL2 Gene

  • Protein details for ORMDL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ORM1-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RA58
    • Q7Z4E5
    • Q8NFX0
    • Q9P004

    Protein attributes for ORMDL2 Gene

    153 amino acids
    Molecular mass:
    17363 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ORMDL2 Gene

Proteomics data for ORMDL2 Gene at MOPED

Post-translational modifications for ORMDL2 Gene

  • Ubiquitination at Lys79
  • Modification sites at PhosphoSitePlus

Other Protein References for ORMDL2 Gene

Antibody Products

No data available for DME Specific Peptides for ORMDL2 Gene

Domains for ORMDL2 Gene

Protein Domains for ORMDL2 Gene


Suggested Antigen Peptide Sequences for ORMDL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q53FV1
  • Belongs to the ORM family.
genes like me logo Genes that share domains with ORMDL2: view

No data available for Gene Families for ORMDL2 Gene

Function for ORMDL2 Gene

Molecular function for ORMDL2 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of sphingolipid synthesis.

Animal Model Products

miRNA for ORMDL2 Gene

miRTarBase miRNAs that target ORMDL2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ORMDL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ORMDL2 Gene

Localization for ORMDL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORMDL2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ORMDL2 Gene COMPARTMENTS Subcellular localization image for ORMDL2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ORMDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12093374
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ORMDL2: view

Pathways for ORMDL2 Gene

SuperPathways for ORMDL2 Gene

No Data Available

Interacting Proteins for ORMDL2 Gene

Gene Ontology (GO) - Biological Process for ORMDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006672 ceramide metabolic process IMP 20182505
GO:0090155 negative regulation of sphingolipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with ORMDL2: view

No data available for Pathways by source for ORMDL2 Gene

Transcripts for ORMDL2 Gene

mRNA/cDNA for ORMDL2 Gene

Unigene Clusters for ORMDL2 Gene

ORM1-like 2 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ORMDL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORMDL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP2: -
SP3: - -

Relevant External Links for ORMDL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ORMDL2 Gene

mRNA expression in normal human tissues for ORMDL2 Gene

Protein differential expression in normal tissues for ORMDL2 Gene

This gene is overexpressed in Placenta (29.3), Fetal testis (15.5), and Lung (12.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORMDL2 Gene

SOURCE GeneReport for Unigene cluster for ORMDL2 Gene Hs.534450

mRNA Expression by UniProt/SwissProt for ORMDL2 Gene

Tissue specificity: Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.
genes like me logo Genes that share expressions with ORMDL2: view

Expression partners for ORMDL2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ORMDL2 Gene

Orthologs for ORMDL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORMDL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ORMDL2 35
  • 93.25 (n)
  • 97.39 (a)
  • 97 (a)
(Canis familiaris)
Mammalia ORMDL2 35
  • 93.46 (n)
  • 97.39 (a)
-- 36
  • 97 (a)
-- 36
  • 88 (a)
(Mus musculus)
Mammalia Ormdl2 35
  • 90.63 (n)
  • 97.39 (a)
Ormdl2 16
Ormdl2 36
  • 97 (a)
(Pan troglodytes)
Mammalia ORMDL2 35
  • 99.56 (n)
  • 99.35 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ormdl2 35
  • 90.2 (n)
  • 97.39 (a)
(Anolis carolinensis)
Reptilia ORMDL2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ormdl2 35
  • 79.52 (n)
  • 90.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24171 35
(Danio rerio)
Actinopterygii ormdl2 35
  • 76.47 (n)
  • 86.93 (a)
ormdl2 36
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta ORMDL 37
  • 50 (a)
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORM1 36
  • 24 (a)
ORM2 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01230 35
  • 51.02 (n)
  • 40.82 (a)
(Oryza sativa)
Liliopsida Os07g0452500 35
  • 52.45 (n)
  • 44.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4417 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
Species with no ortholog for ORMDL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORMDL2 Gene

Gene Tree for ORMDL2 (if available)
Gene Tree for ORMDL2 (if available)

Paralogs for ORMDL2 Gene

Paralogs for ORMDL2 Gene

Selected SIMAP similar genes for ORMDL2 Gene using alignment to 3 proteins: Pseudogenes for ORMDL2 Gene

genes like me logo Genes that share paralogs with ORMDL2: view

Variants for ORMDL2 Gene

Sequence variations from dbSNP and Humsavar for ORMDL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs35055573 -- 55,819,976(+) CTGGA(A/G)TAGTT intron-variant
rs76149424 -- 55,820,256(+) TCTCC(C/T)CAGCT intron-variant
rs145457304 -- 55,820,296(+) GATGC(A/T)GCGCA synonymous-codon, reference
rs145468768 -- 55,820,040(+) AAGAG(C/T)AGGGC intron-variant
rs145712498 -- 55,820,289(+) CAAGT(A/G)TGATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ORMDL2 Gene

Variant ID Type Subtype PubMed ID
nsv832423 CNV Gain 17160897
esv22731 CNV Loss 19812545

Relevant External Links for ORMDL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORMDL2 Gene

Disorders for ORMDL2 Gene

No disorders were found for ORMDL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ORMDL2 Gene

Publications for ORMDL2 Gene

  1. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. (PMID: 12093374) Hjelmqvist L. … Gonzalez-Duarte R. (Genome Biol. 2002) 2 3 4
  2. A family of membrane proteins associated with presenilin expression and gamma-secretase function. (PMID: 17928364) Araki W. … Tabira T. (FASEB J. 2008) 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Orm family proteins mediate sphingolipid homeostasis. (PMID: 20182505) Breslow D.K. … Weissman J.S. (Nature 2010) 3 4
  5. Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis. (PMID: 23066021) Siow D.L. … Wattenberg B.W. (J. Biol. Chem. 2012) 2 3

Products for ORMDL2 Gene

Sources for ORMDL2 Gene

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