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Aliases for ORMDL2 Gene

Aliases for ORMDL2 Gene

  • ORMDL Sphingolipid Biosynthesis Regulator 2 2 3
  • Adoplin-2 3 4
  • ORM1 (S. Cerevisiae)-Like 2 2
  • ORM1-Like 2 (S. Cerevisiae) 2
  • Expressed In Normal Aorta 3
  • ORM1-Like Protein 2 3
  • HSPC160 3
  • MSTP095 3
  • MST095 3

External Ids for ORMDL2 Gene

Summaries for ORMDL2 Gene

GeneCards Summary for ORMDL2 Gene

ORMDL2 (ORMDL Sphingolipid Biosynthesis Regulator 2) is a Protein Coding gene. An important paralog of this gene is ORMDL3.

UniProtKB/Swiss-Prot for ORMDL2 Gene

  • Negative regulator of sphingolipid synthesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORMDL2 Gene

Genomics for ORMDL2 Gene

Genomic Location for ORMDL2 Gene

Start:
55,817,919 bp from pter
End:
55,821,879 bp from pter
Size:
3,961 bases
Orientation:
Plus strand

Genomic View for ORMDL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORMDL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORMDL2 Gene

Proteins for ORMDL2 Gene

  • Protein details for ORMDL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FV1-ORML2_HUMAN
    Recommended name:
    ORM1-like protein 2
    Protein Accession:
    Q53FV1
    Secondary Accessions:
    • B2RA58
    • Q7Z4E5
    • Q8NFX0
    • Q9P004

    Protein attributes for ORMDL2 Gene

    Size:
    153 amino acids
    Molecular mass:
    17363 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ORMDL2 Gene

Proteomics data for ORMDL2 Gene at MOPED

Post-translational modifications for ORMDL2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys79

Other Protein References for ORMDL2 Gene

No data available for DME Specific Peptides for ORMDL2 Gene

Domains for ORMDL2 Gene

Protein Domains for ORMDL2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ORML2_HUMAN
Family:
  • Belongs to the ORM family.:
    • Q53FV1
genes like me logo Genes that share domains with ORMDL2: view

No data available for Gene Families for ORMDL2 Gene

Function for ORMDL2 Gene

Molecular function for ORMDL2 Gene

UniProtKB/Swiss-Prot Function: Negative regulator of sphingolipid synthesis.

miRNA for ORMDL2 Gene

miRTarBase miRNAs that target ORMDL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ORMDL2 Gene

Localization for ORMDL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORMDL2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORMDL2 Gene COMPARTMENTS Subcellular localization image for ORMDL2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ORMDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12093374
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ORMDL2: view

Pathways for ORMDL2 Gene

SuperPathways for ORMDL2 Gene

No Data Available

Interacting Proteins for ORMDL2 Gene

Gene Ontology (GO) - Biological Process for ORMDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006672 ceramide metabolic process IMP 20182505
GO:0090155 negative regulation of sphingolipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with ORMDL2: view

No data available for Pathways by source for ORMDL2 Gene

Transcripts for ORMDL2 Gene

Unigene Clusters for ORMDL2 Gene

ORM1-like 2 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORMDL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1:
SP2: -
SP3: - -

Relevant External Links for ORMDL2 Gene

GeneLoc Exon Structure for
ORMDL2
ECgene alternative splicing isoforms for
ORMDL2

Expression for ORMDL2 Gene

mRNA expression in normal human tissues for ORMDL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORMDL2 Gene

SOURCE GeneReport for Unigene cluster for ORMDL2 Gene Hs.534450

mRNA Expression by UniProt/SwissProt for ORMDL2 Gene

Q53FV1-ORML2_HUMAN
Tissue specificity: Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.
genes like me logo Genes that share expressions with ORMDL2: view

Orthologs for ORMDL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORMDL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORMDL2 36
  • 99.56 (n)
  • 99.35 (a)
ORMDL2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ORMDL2 36
  • 93.25 (n)
  • 97.39 (a)
ORMDL2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 97 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
ORMDL2 36
  • 93.46 (n)
  • 97.39 (a)
mouse
(Mus musculus)
Mammalia Ormdl2 36
  • 90.63 (n)
  • 97.39 (a)
Ormdl2 16
Ormdl2 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ormdl2 36
  • 90.2 (n)
  • 97.39 (a)
lizard
(Anolis carolinensis)
Reptilia ORMDL2 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24171 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ormdl2 36
  • 79.52 (n)
  • 90.2 (a)
zebrafish
(Danio rerio)
Actinopterygii ormdl2 36
  • 76.47 (n)
  • 86.93 (a)
ormdl2 37
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ORMDL 37
  • 49 (a)
OneToMany
ORMDL 38
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORM1 37
  • 24 (a)
ManyToMany
ORM2 37
  • 27 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01230 36
  • 51.02 (n)
  • 40.82 (a)
rice
(Oryza sativa)
Liliopsida Os07g0452500 36
  • 52.45 (n)
  • 44.06 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4417 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 63 (a)
OneToMany
Species with no ortholog for ORMDL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORMDL2 Gene

ENSEMBL:
Gene Tree for ORMDL2 (if available)
TreeFam:
Gene Tree for ORMDL2 (if available)

Paralogs for ORMDL2 Gene

Paralogs for ORMDL2 Gene

Selected SIMAP similar genes for ORMDL2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ORMDL2 Gene

genes like me logo Genes that share paralogs with ORMDL2: view

Variants for ORMDL2 Gene

Sequence variations from dbSNP and Humsavar for ORMDL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs35055573 -- 55,819,976(+) CTGGA(A/G)TAGTT intron-variant
rs76149424 -- 55,820,256(+) TCTCC(C/T)CAGCT intron-variant
rs145457304 -- 55,820,296(+) GATGC(A/T)GCGCA synonymous-codon, reference
rs145468768 -- 55,820,040(+) AAGAG(C/T)AGGGC intron-variant
rs145712498 -- 55,820,289(+) CAAGT(A/G)TGATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ORMDL2 Gene

Variant ID Type Subtype PubMed ID
nsv832423 CNV Gain 17160897
esv22731 CNV Loss 19812545

Relevant External Links for ORMDL2 Gene

HapMap Linkage Disequilibrium report
ORMDL2

Disorders for ORMDL2 Gene

No disorders were found for ORMDL2 Gene.

No data available for UniProtKB/Swiss-Prot for ORMDL2 Gene

Publications for ORMDL2 Gene

  1. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. (PMID: 12093374) Hjelmqvist L. … Gonzalez-Duarte R. (Genome Biol. 2002) 2 3 4
  2. A family of membrane proteins associated with presenilin expression and gamma-secretase function. (PMID: 17928364) Araki W. … Tabira T. (FASEB J. 2008) 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Orm family proteins mediate sphingolipid homeostasis. (PMID: 20182505) Breslow D.K. … Weissman J.S. (Nature 2010) 3 4
  5. Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis. (PMID: 23066021) Siow D.L. … Wattenberg B.W. (J. Biol. Chem. 2012) 2 3

Products for ORMDL2 Gene

Sources for ORMDL2 Gene

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