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Aliases for ORMDL1 Gene

Aliases for ORMDL1 Gene

  • ORMDL Sphingolipid Biosynthesis Regulator 1 2 3 5
  • Adoplin-1 3 4
  • ORM1 (S. Cerevisiae)-Like 1 2
  • ORM1-Like 1 (S. Cerevisiae) 2

External Ids for ORMDL1 Gene

Previous GeneCards Identifiers for ORMDL1 Gene

  • GC00U991061
  • GC02U900735
  • GC02M190460
  • GC02M190343
  • GC02M190634
  • GC02M182494

Summaries for ORMDL1 Gene

GeneCards Summary for ORMDL1 Gene

ORMDL1 (ORMDL Sphingolipid Biosynthesis Regulator 1) is a Protein Coding gene. An important paralog of this gene is ORMDL2.

UniProtKB/Swiss-Prot for ORMDL1 Gene

  • Negative regulator of sphingolipid synthesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORMDL1 Gene

Genomics for ORMDL1 Gene

Regulatory Elements for ORMDL1 Gene

Enhancers for ORMDL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ORMDL1 on UCSC Golden Path with GeneCards custom track

Promoters for ORMDL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ORMDL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ORMDL1 Gene

189,767,220 bp from pter
189,784,371 bp from pter
17,152 bases
Minus strand

Genomic View for ORMDL1 Gene

Genes around ORMDL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORMDL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORMDL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORMDL1 Gene

Proteins for ORMDL1 Gene

  • Protein details for ORMDL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ORM1-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R8W3
    • D3DPH9

    Protein attributes for ORMDL1 Gene

    153 amino acids
    Molecular mass:
    17371 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ORMDL1 Gene

Proteomics data for ORMDL1 Gene at MOPED

Post-translational modifications for ORMDL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ORMDL1 Gene

Antibody Products

No data available for DME Specific Peptides for ORMDL1 Gene

Domains & Families for ORMDL1 Gene

Protein Domains for ORMDL1 Gene


Suggested Antigen Peptide Sequences for ORMDL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ORM family.
  • Belongs to the ORM family.
genes like me logo Genes that share domains with ORMDL1: view

No data available for Gene Families for ORMDL1 Gene

Function for ORMDL1 Gene

Molecular function for ORMDL1 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of sphingolipid synthesis.
genes like me logo Genes that share phenotypes with ORMDL1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORMDL1 Gene

Localization for ORMDL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORMDL1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ORMDL1 Gene COMPARTMENTS Subcellular localization image for ORMDL1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ORMDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ORMDL1: view

Pathways & Interactions for ORMDL1 Gene

SuperPathways for ORMDL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ORMDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006672 ceramide metabolic process IEA,IMP 20182505
genes like me logo Genes that share ontologies with ORMDL1: view

No data available for Pathways by source and SIGNOR curated interactions for ORMDL1 Gene

Drugs & Compounds for ORMDL1 Gene

No Compound Related Data Available

Transcripts for ORMDL1 Gene

Unigene Clusters for ORMDL1 Gene

ORM1-like 1 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORMDL1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP11: - - - - - - - - - - -

ExUns: 6f

Relevant External Links for ORMDL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ORMDL1 Gene

mRNA expression in normal human tissues for ORMDL1 Gene

Protein differential expression in normal tissues from HIPED for ORMDL1 Gene

This gene is overexpressed in Nasal epithelium (50.2) and Bone (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORMDL1 Gene

SOURCE GeneReport for Unigene cluster for ORMDL1 Gene Hs.700632

mRNA Expression by UniProt/SwissProt for ORMDL1 Gene

Tissue specificity: Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. Expressed at intermediate level in pancreas, placenta and brain but low in skeletal muscle and lung.
genes like me logo Genes that share expression patterns with ORMDL1: view

Protein tissue co-expression partners for ORMDL1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ORMDL1 Gene

Orthologs for ORMDL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ORMDL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ORMDL1 35
  • 96.3 (n)
  • 98.69 (a)
  • 99 (a)
(Canis familiaris)
Mammalia ORMDL1 35
  • 94.12 (n)
  • 98.69 (a)
  • 99 (a)
(Mus musculus)
Mammalia Ormdl1 35
  • 91.29 (n)
  • 98.69 (a)
Ormdl1 16
Ormdl1 36
  • 99 (a)
(Pan troglodytes)
Mammalia ORMDL1 35
  • 99.78 (n)
  • 100 (a)
  • 100 (a)
(Gallus gallus)
Aves ORMDL1 35
  • 81.26 (n)
  • 96.08 (a)
-- 36
  • 96 (a)
-- 36
  • 57 (a)
(Anolis carolinensis)
Reptilia ORMDL1 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ormdl1 35
  • 78.65 (n)
  • 95.42 (a)
(Danio rerio)
Actinopterygii ormdl1 35
  • 78.43 (n)
  • 92.81 (a)
ormdl1 36
  • 93 (a)
fruit fly
(Drosophila melanogaster)
Insecta ORMDL 36
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORM1 36
  • 23 (a)
ORM2 36
  • 25 (a)
ORM2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
Species with no ortholog for ORMDL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORMDL1 Gene

Gene Tree for ORMDL1 (if available)
Gene Tree for ORMDL1 (if available)

Paralogs for ORMDL1 Gene

Paralogs for ORMDL1 Gene

(2) SIMAP similar genes for ORMDL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ORMDL1: view

Variants for ORMDL1 Gene

Sequence variations from dbSNP and Humsavar for ORMDL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1866643 -- 189,772,310(+) AACCT(C/G)TACTG intron-variant
rs1866644 -- 189,780,323(+) GTTTC(C/T)GATTA intron-variant
rs1055091 -- 189,770,417(-) CAGTT(A/G)TATGA intron-variant, utr-variant-3-prime
rs6746951 -- 189,779,787(+) GGGAT(A/C)AAGTT intron-variant
rs3791767 -- 189,775,189(-) TTCAC(G/T)GGCCA intron-variant

Variation tolerance for ORMDL1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ORMDL1 Gene

Disorders for ORMDL1 Gene

Relevant External Links for ORMDL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ORMDL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORMDL1 Gene

Publications for ORMDL1 Gene

  1. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. (PMID: 12093374) Hjelmqvist L. … Gonzalez-Duarte R. (Genome Biol. 2002) 2 3 4 67
  2. Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis. (PMID: 23066021) Siow D.L. … Wattenberg B.W. (J. Biol. Chem. 2012) 2 3
  3. A family of membrane proteins associated with presenilin expression and gamma-secretase function. (PMID: 17928364) Araki W. … Tabira T. (FASEB J. 2008) 3 23
  4. Expression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cells. (PMID: 25395622) Gupta S.D. … Harmon J.M. (J. Biol. Chem. 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for ORMDL1 Gene

Sources for ORMDL1 Gene