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Aliases for ORMDL1 Gene

Aliases for ORMDL1 Gene

  • ORMDL Sphingolipid Biosynthesis Regulator 1 2 3
  • Adoplin-1 3 4
  • ORM1 (S. Cerevisiae)-Like 1 2
  • ORM1-Like 1 (S. Cerevisiae) 2
  • ORM1-Like Protein 1 3

External Ids for ORMDL1 Gene

Summaries for ORMDL1 Gene

GeneCards Summary for ORMDL1 Gene

ORMDL1 (ORMDL Sphingolipid Biosynthesis Regulator 1) is a Protein Coding gene. An important paralog of this gene is ORMDL2.

UniProtKB/Swiss-Prot for ORMDL1 Gene

  • Negative regulator of sphingolipid synthesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORMDL1 Gene

Genomics for ORMDL1 Gene

Genomic Location for ORMDL1 Gene

Start:
189,770,267 bp from pter
End:
189,784,371 bp from pter
Size:
14,105 bases
Orientation:
Minus strand

Genomic View for ORMDL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORMDL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORMDL1 Gene

Regulatory Elements for ORMDL1 Gene

Proteins for ORMDL1 Gene

  • Protein details for ORMDL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0S3-ORML1_HUMAN
    Recommended name:
    ORM1-like protein 1
    Protein Accession:
    Q9P0S3
    Secondary Accessions:
    • B2R8W3
    • D3DPH9

    Protein attributes for ORMDL1 Gene

    Size:
    153 amino acids
    Molecular mass:
    17371 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ORMDL1 Gene

Proteomics data for ORMDL1 Gene at MOPED

Post-translational modifications for ORMDL1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys79 and Lys152

Other Protein References for ORMDL1 Gene

No data available for DME Specific Peptides for ORMDL1 Gene

Domains for ORMDL1 Gene

Protein Domains for ORMDL1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ORML1_HUMAN
Family:
  • Belongs to the ORM family.:
    • Q9P0S3
genes like me logo Genes that share domains with ORMDL1: view

No data available for Gene Families for ORMDL1 Gene

Function for ORMDL1 Gene

Molecular function for ORMDL1 Gene

UniProtKB/Swiss-Prot Function: Negative regulator of sphingolipid synthesis.

Phenotypes for ORMDL1 Gene

GenomeRNAi human phenotypes for ORMDL1:
genes like me logo Genes that share phenotypes with ORMDL1: view

miRNA for ORMDL1 Gene

miRTarBase miRNAs that target ORMDL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for ORMDL1 Gene

Localization for ORMDL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORMDL1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORMDL1 Gene COMPARTMENTS Subcellular localization image for ORMDL1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ORMDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 12093374
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ORMDL1: view

Pathways for ORMDL1 Gene

SuperPathways for ORMDL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ORMDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006672 ceramide metabolic process IMP 20182505
GO:0090155 negative regulation of sphingolipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with ORMDL1: view

No data available for Pathways by source for ORMDL1 Gene

Transcripts for ORMDL1 Gene

Unigene Clusters for ORMDL1 Gene

ORM1-like 1 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORMDL1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - - -
SP10:
SP11: - - - - - - - - - - -
SP12:

ExUns: 6f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ORMDL1 Gene

GeneLoc Exon Structure for
ORMDL1
ECgene alternative splicing isoforms for
ORMDL1

Expression for ORMDL1 Gene

mRNA expression in normal human tissues for ORMDL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORMDL1 Gene

SOURCE GeneReport for Unigene cluster for ORMDL1 Gene Hs.700632

mRNA Expression by UniProt/SwissProt for ORMDL1 Gene

Q9P0S3-ORML1_HUMAN
Tissue specificity: Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. Expressed at intermediate level in pancreas, placenta and brain but low in skeletal muscle and lung.
genes like me logo Genes that share expressions with ORMDL1: view

Orthologs for ORMDL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ORMDL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORMDL1 36
  • 99.78 (n)
  • 100 (a)
ORMDL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ORMDL1 36
  • 96.3 (n)
  • 98.69 (a)
ORMDL1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ORMDL1 36
  • 94.12 (n)
  • 98.69 (a)
ORMDL1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ormdl1 36
  • 91.29 (n)
  • 98.69 (a)
Ormdl1 16
Ormdl1 37
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 37
  • 96 (a)
OneToMany
-- 37
  • 57 (a)
OneToMany
ORMDL1 36
  • 81.26 (n)
  • 96.08 (a)
lizard
(Anolis carolinensis)
Reptilia ORMDL1 37
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ormdl1 36
  • 78.65 (n)
  • 95.42 (a)
zebrafish
(Danio rerio)
Actinopterygii ormdl1 36
  • 78.43 (n)
  • 92.81 (a)
ormdl1 37
  • 93 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ORMDL 37
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORM1 37
  • 23 (a)
ManyToMany
ORM2 37
  • 25 (a)
ManyToMany
ORM2 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 63 (a)
OneToMany
Species with no ortholog for ORMDL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORMDL1 Gene

ENSEMBL:
Gene Tree for ORMDL1 (if available)
TreeFam:
Gene Tree for ORMDL1 (if available)

Paralogs for ORMDL1 Gene

Paralogs for ORMDL1 Gene

Selected SIMAP similar genes for ORMDL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ORMDL1: view

Variants for ORMDL1 Gene

Sequence variations from dbSNP and Humsavar for ORMDL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6942 -- 189,771,685(+) TATCA(C/G)AGAAA utr-variant-3-prime
rs1055091 -- 189,770,417(-) CAGTT(A/G)TATGA utr-variant-3-prime
rs1225106 -- 189,769,823(-) cttgc(A/G)gcaat downstream-variant-500B
rs1225107 -- 189,769,812(-) tacta(C/T)tgtgg downstream-variant-500B
rs1866643 -- 189,772,310(+) AACCT(C/G)TACTG intron-variant

Relevant External Links for ORMDL1 Gene

HapMap Linkage Disequilibrium report
ORMDL1

No data available for Structural Variations from Database of Genomic Variants (DGV) for ORMDL1 Gene

Disorders for ORMDL1 Gene

(1) University of Copenhagen DISEASES for ORMDL1 Gene

genes like me logo Genes that share disorders with ORMDL1: view

No data available for UniProtKB/Swiss-Prot for ORMDL1 Gene

Publications for ORMDL1 Gene

  1. A family of membrane proteins associated with presenilin expression and gamma-secretase function. (PMID: 17928364) Araki W. … Tabira T. (FASEB J. 2008) 3 4 23
  2. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. (PMID: 12093374) Hjelmqvist L. … Gonzalez-Duarte R. (Genome Biol. 2002) 2 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Orm family proteins mediate sphingolipid homeostasis. (PMID: 20182505) Breslow D.K. … Weissman J.S. (Nature 2010) 3 4
  5. Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis. (PMID: 23066021) Siow D.L. … Wattenberg B.W. (J. Biol. Chem. 2012) 2 3

Products for ORMDL1 Gene

Sources for ORMDL1 Gene

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