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Aliases for ORM2 Gene

Aliases for ORM2 Gene

  • Orosomucoid 2 2 3 5
  • Orosomucoid-2 3 4
  • AGP 2 3 4
  • OMD 2 3 4
  • AGP2 3 4
  • Alpha-1-Acid Glycoprotein, Type 2 3
  • Alpha-1-Acid Glycoprotein 2
  • Type 2 2
  • AGP-B 3

External Ids for ORM2 Gene

Previous GeneCards Identifiers for ORM2 Gene

  • GC09U990059
  • GC09P108818
  • GC09P022004
  • GC09P112462
  • GC09P112468
  • GC09P114165
  • GC09P114171
  • GC09P116131
  • GC09P117092
  • GC09P086697

Summaries for ORM2 Gene

Entrez Gene Summary for ORM2 Gene

  • This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

GeneCards Summary for ORM2 Gene

ORM2 (Orosomucoid 2) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation. An important paralog of this gene is ORM1.

UniProtKB/Swiss-Prot for ORM2 Gene

  • Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORM2 Gene

Genomics for ORM2 Gene

Regulatory Elements for ORM2 Gene

Promoters for ORM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ORM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ORM2 Gene

Chromosome:
9
Start:
114,329,789 bp from pter
End:
114,333,256 bp from pter
Size:
3,468 bases
Orientation:
Plus strand

Genomic View for ORM2 Gene

Genes around ORM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORM2 Gene

Proteins for ORM2 Gene

  • Protein details for ORM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19652-A1AG2_HUMAN
    Recommended name:
    Alpha-1-acid glycoprotein 2
    Protein Accession:
    P19652
    Secondary Accessions:
    • B2R5L2
    • Q16571
    • Q5T538
    • Q6IB74

    Protein attributes for ORM2 Gene

    Size:
    201 amino acids
    Molecular mass:
    23603 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29873.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA29874.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ORM2 Gene

neXtProt entry for ORM2 Gene

Proteomics data for ORM2 Gene at MOPED

Post-translational modifications for ORM2 Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn 33, Asn 56, Asn 72, Asn 93, and Asn 103
  • Modification sites at PhosphoSitePlus

Other Protein References for ORM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ORM2 Gene

Domains & Families for ORM2 Gene

Gene Families for ORM2 Gene

Suggested Antigen Peptide Sequences for ORM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19652

UniProtKB/Swiss-Prot:

A1AG2_HUMAN :
  • Contains a beta-barrel that binds various ligands in its interior.
  • Belongs to the calycin superfamily. Lipocalin family.
Domain:
  • Contains a beta-barrel that binds various ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with ORM2: view

Function for ORM2 Gene

Molecular function for ORM2 Gene

GENATLAS Biochemistry:
orosomucoid 2 (lipocalin family,outlier group),abundant in plasma
UniProtKB/Swiss-Prot Function:
Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
UniProtKB/Swiss-Prot Induction:
Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.
genes like me logo Genes that share phenotypes with ORM2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ORM2 Gene

Localization for ORM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORM2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORM2 Gene COMPARTMENTS Subcellular localization image for ORM2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ORM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with ORM2: view

Pathways & Interactions for ORM2 Gene

genes like me logo Genes that share pathways with ORM2: view

Interacting Proteins for ORM2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000394936%0d%0a9606.ENSP00000342026%0d%0a9606.ENSP00000326018%0d%0a9606.ENSP00000275016%0d%0a9606.ENSP00000390500%0d%0a
Selected Interacting proteins: ENSP00000394936 for ORM2 Gene via STRING

Gene Ontology (GO) - Biological Process for ORM2 Gene

None

No data available for SIGNOR curated interactions for ORM2 Gene

Drugs & Compounds for ORM2 Gene

(4) Drugs for ORM2 Gene - From: DrugBank and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorpromazine Approved Pharma Antagonist, Target, binder 13
Oxycodone Approved, Illicit, Investigational Pharma Target, binder 333
Thalidomide Approved, Investigational, Withdrawn Pharma Target, binder Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 808
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1844
genes like me logo Genes that share compounds with ORM2: view

Transcripts for ORM2 Gene

mRNA/cDNA for ORM2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(657) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ORM2 Gene

Orosomucoid 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORM2 Gene

No ASD Table

Relevant External Links for ORM2 Gene

GeneLoc Exon Structure for
ORM2
ECgene alternative splicing isoforms for
ORM2

Expression for ORM2 Gene

mRNA expression in normal human tissues for ORM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORM2 Gene

This gene is overexpressed in Liver (x52.3).

Protein differential expression in normal tissues from HIPED for ORM2 Gene

This gene is overexpressed in Serum (10.9), Monocytes (9.3), Synovial fluid (8.6), and Plasma (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORM2 Gene



SOURCE GeneReport for Unigene cluster for ORM2 Gene Hs.719954

mRNA Expression by UniProt/SwissProt for ORM2 Gene

P19652-A1AG2_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expression patterns with ORM2: view

Protein tissue co-expression partners for ORM2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ORM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC464682 35
  • 97.31 (n)
  • 96.89 (a)
cow
(Bos Taurus)
Mammalia AGP 36
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Orm1 36
  • 47 (a)
ManyToMany
Orm2 36
  • 43 (a)
ManyToMany
Orm3 36
  • 44 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves OGCHI 36
  • 25 (a)
OneToMany
Species with no ortholog for ORM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ORM2 Gene

ENSEMBL:
Gene Tree for ORM2 (if available)
TreeFam:
Gene Tree for ORM2 (if available)

Paralogs for ORM2 Gene

Paralogs for ORM2 Gene

(1) SIMAP similar genes for ORM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ORM2: view

Variants for ORM2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ORM2 Gene

P19652-A1AG2_HUMAN
Many different variants of ORM2 are known.

Sequence variations from dbSNP and Humsavar for ORM2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs147969317 - 114,330,017(+) GGACC(A/G)GGTGA reference, missense
rs2636889 - 114,330,830(+) GAATG(C/T)CCAGC reference, missense
rs12685968 - 114,331,659(+) ACTGG(A/C/G)GGCTG reference, missense
rs1126777 - 114,331,888(+) GCTTG(C/T)GCATT reference, missense
rs2636890 - 114,331,909(+) ATGTC(A/G)TGTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ORM2 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
dgv33e196 CNV Duplication 17116639
dgv948n27 CNV Gain 19166990
nsv893754 CNV Loss 21882294
nsv893757 CNV Gain 21882294
dgv949n27 CNV Gain 19166990
nsv471320 CNV Gain 18288195
nsv528823 CNV Gain 19592680
nsv509319 CNV Insertion 20534489
nsv893759 CNV Loss 21882294
nsv893760 CNV Gain 21882294
esv22321 CNV Gain 19812545
dgv8275n71 CNV Gain 21882294
nsv893763 CNV Gain+Loss 21882294
nsv893764 CNV Gain 21882294
dgv1233n67 CNV Gain 20364138
esv2752277 CNV Gain 17911159
esv2664309 CNV Deletion 23128226
esv2462819 CNV Deletion 19546169

Variation tolerance for ORM2 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORM2 Gene

HapMap Linkage Disequilibrium report
ORM2

Disorders for ORM2 Gene

Relevant External Links for ORM2

Genetic Association Database (GAD)
ORM2
Human Genome Epidemiology (HuGE) Navigator
ORM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORM2

No disorders were found for ORM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORM2 Gene

Publications for ORM2 Gene

  1. Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene. (PMID: 2970990) Merritt C.M. … Board P.G. (Gene 1988) 2 3 4 67
  2. Investigation of genetic variants of alpha-1 acid glycoprotein by ultra-performance liquid chromatography-mass spectrometry. (PMID: 19018521) Budai L. … VAckey K. (Anal Bioanal Chem 2009) 3 23
  3. Genetic determinants of warfarin dosing in the Han-Chinese population. (PMID: 19958090) Lee M.T. … Chen Y.T. (Pharmacogenomics 2009) 3 23
  4. Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte-associated antigen 4, and programmed cell death 1 in primary SjAPgren's syndrome. (PMID: 12528117) Bolstad A.I. … Jonsson R. (Arthritis Rheum. 2003) 3 23
  5. Characterization of genomic rearrangements of the alpha1-acid glycoprotein/orosomucoid gene in Ghanaians. (PMID: 11587070) Yuasa I. … Umetsu K. (J. Hum. Genet. 2001) 3 23

Products for ORM2 Gene

Sources for ORM2 Gene

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