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Aliases for ORM2 Gene

Aliases for ORM2 Gene

  • Orosomucoid 2 2 3 5
  • Alpha-1-Acid Glycoprotein, Type 2 2 3
  • AGP 2 3 4
  • OMD 2 3 4
  • AGP2 3 4
  • Alpha-1-Acid Glycoprotein 2 3
  • Orosomucoid-2 4
  • AGP-B 3

External Ids for ORM2 Gene

Previous GeneCards Identifiers for ORM2 Gene

  • GC09U990059
  • GC09P108818
  • GC09P022004
  • GC09P112462
  • GC09P112468
  • GC09P114165
  • GC09P114171
  • GC09P116131
  • GC09P117092
  • GC09P086697

Summaries for ORM2 Gene

Entrez Gene Summary for ORM2 Gene

  • This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

GeneCards Summary for ORM2 Gene

ORM2 (Orosomucoid 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is ORM1.

UniProtKB/Swiss-Prot for ORM2 Gene

  • Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORM2 Gene

Genomics for ORM2 Gene

Regulatory Elements for ORM2 Gene

Enhancers for ORM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G113992 1.2 FANTOM5 Ensembl ENCODE 16.3 -336.9 -336940 1.1 MAX REST RAD21 FOXA1 NR2F2 GABPA YY1 JUND ATF3 HNF4G ORM2 AMBP ORM1 COL27A1 GC09P114396 ZNF618
GH09G114317 1.4 FANTOM5 Ensembl ENCODE 10.5 -11.6 -11615 1.2 YY1 GATA2 ZNF366 SCRT2 THAP11 CEBPB REST ZNF518A ZFP69B ATF4 ORM2 ATP6V1G1 ORM1 TNFSF15 LOC105376224 MIR455
GH09G114314 1 FANTOM5 ENCODE 8.4 -14.6 -14563 0.5 TAF1 HLF CEBPB MAX RAD21 NR2F2 GABPA YY1 FOXA1 JUND ORM1 AMBP ORM2 LOC105376224 MIR455
GH09G114329 0.8 Ensembl 7.4 -0.1 -143 1.0 SOX13 FOXA2 SAP130 CEBPG RARA YY1 TEAD3 NR2F6 GATAD2A NFIA ORM2 ORM1
GH09G114331 0.6 dbSUPER 6.2 +3.9 3938 4.0 ZNF664 PKNOX1 POLR2A CEBPB NFE2 CEBPG NFE2L2 ORM2 ORM1 WHRN ENSG00000235119
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ORM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ORM2 Gene

Chromosome:
9
Start:
114,329,789 bp from pter
End:
114,333,256 bp from pter
Size:
3,468 bases
Orientation:
Plus strand

Genomic View for ORM2 Gene

Genes around ORM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORM2 Gene

Proteins for ORM2 Gene

  • Protein details for ORM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19652-A1AG2_HUMAN
    Recommended name:
    Alpha-1-acid glycoprotein 2
    Protein Accession:
    P19652
    Secondary Accessions:
    • B2R5L2
    • Q16571
    • Q5T538
    • Q6IB74

    Protein attributes for ORM2 Gene

    Size:
    201 amino acids
    Molecular mass:
    23603 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29873.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA29874.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ORM2 Gene

neXtProt entry for ORM2 Gene

Post-translational modifications for ORM2 Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn33, Asn56, Asn72, Asn93, and Asn103
  • Modification sites at PhosphoSitePlus

Other Protein References for ORM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ORM2 Gene

Domains & Families for ORM2 Gene

Gene Families for ORM2 Gene

Suggested Antigen Peptide Sequences for ORM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19652

UniProtKB/Swiss-Prot:

A1AG2_HUMAN :
  • Contains a beta-barrel that binds various ligands in its interior.
  • Belongs to the calycin superfamily. Lipocalin family.
Domain:
  • Contains a beta-barrel that binds various ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with ORM2: view

Function for ORM2 Gene

Molecular function for ORM2 Gene

GENATLAS Biochemistry:
orosomucoid 2 (lipocalin family,outlier group),abundant in plasma
UniProtKB/Swiss-Prot Function:
Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
UniProtKB/Swiss-Prot Induction:
Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.
genes like me logo Genes that share phenotypes with ORM2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ORM2 Gene

Localization for ORM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORM2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORM2 gene
Compartment Confidence
extracellular 5
lysosome 4

Gene Ontology (GO) - Cellular Components for ORM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IDA 16502470
GO:0031093 platelet alpha granule lumen TAS --
GO:0035578 azurophil granule lumen TAS --
GO:0035580 specific granule lumen TAS --
genes like me logo Genes that share ontologies with ORM2: view

Pathways & Interactions for ORM2 Gene

genes like me logo Genes that share pathways with ORM2: view

Gene Ontology (GO) - Biological Process for ORM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0002682 regulation of immune system process IEA --
GO:0006810 transport IEA --
GO:0006953 acute-phase response TAS,IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with ORM2: view

No data available for SIGNOR curated interactions for ORM2 Gene

Drugs & Compounds for ORM2 Gene

(4) Drugs for ORM2 Gene - From: DrugBank and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorpromazine Approved, Vet_approved Pharma Antagonist, Target, binder 18
Oxycodone Approved, Illicit, Investigational Pharma Target, binder 379
Thalidomide Approved, Investigational, Withdrawn Pharma Target, binder Immunomodulatory agent,sedative drug,angiogenesis inhibitor, Immunomodulatory agents, TNF-alpha synthesis inhibitor 1142
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1967
genes like me logo Genes that share compounds with ORM2: view

Transcripts for ORM2 Gene

mRNA/cDNA for ORM2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(657) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ORM2 Gene

Orosomucoid 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORM2 Gene

No ASD Table

Relevant External Links for ORM2 Gene

GeneLoc Exon Structure for
ORM2
ECgene alternative splicing isoforms for
ORM2

Expression for ORM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORM2 Gene

This gene is overexpressed in Liver (x52.3).

Protein differential expression in normal tissues from HIPED for ORM2 Gene

This gene is overexpressed in Serum (10.9), Monocytes (9.3), Synovial fluid (8.6), and Plasma (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ORM2 Gene



Protein tissue co-expression partners for ORM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ORM2 Gene:

ORM2

SOURCE GeneReport for Unigene cluster for ORM2 Gene:

Hs.719954

mRNA Expression by UniProt/SwissProt for ORM2 Gene:

P19652-A1AG2_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for ORM2 Gene

  • Liver(4.8)
  • Bone marrow(4.2)
  • Muscle(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ORM2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ORM2 Gene

Orthologs for ORM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC464682 34
  • 97.31 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 57 (a)
OneToMany
cow
(Bos Taurus)
Mammalia AGP 35
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Orm1 35
  • 47 (a)
ManyToMany
Orm3 35
  • 44 (a)
ManyToMany
Orm2 35
  • 43 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves OGCHI 35
  • 25 (a)
OneToMany
Species where no ortholog for ORM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ORM2 Gene

ENSEMBL:
Gene Tree for ORM2 (if available)
TreeFam:
Gene Tree for ORM2 (if available)

Paralogs for ORM2 Gene

Paralogs for ORM2 Gene

(1) SIMAP similar genes for ORM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ORM2: view

Variants for ORM2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ORM2 Gene

A1AG2_HUMAN-P19652
Many different variants of ORM2 are known.

Sequence variations from dbSNP and Humsavar for ORM2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001439416 -- 114,327,835(+) AGCCA(C/T)GAAGG upstream-variant-2KB
rs1001633471 -- 114,333,351(+) AAGAG(-/C)CCCCA downstream-variant-500B
rs1002905971 -- 114,332,357(+) GCCAC(A/C)GTCAC intron-variant
rs1004687526 -- 114,333,312(+) ACCCT(C/G)GCTGG downstream-variant-500B
rs1005038826 -- 114,333,003(+) CCCCG(C/G)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ORM2 Gene

Variant ID Type Subtype PubMed ID
dgv1233n67 CNV gain 20364138
dgv12859n54 CNV gain 21841781
dgv12860n54 CNV gain 21841781
dgv1503e214 CNV gain 21293372
dgv2181e212 CNV gain 25503493
dgv2182e212 CNV gain 25503493
dgv33e196 CNV duplication 17116639
dgv7706n100 CNV gain 25217958
dgv948n27 CNV gain 19166990
dgv949n27 CNV gain 19166990
esv22321 CNV gain 19812545
esv2462819 CNV deletion 19546169
esv2664309 CNV deletion 23128226
esv2752277 CNV gain 17911159
esv2761285 CNV gain 21179565
esv3442507 CNV duplication 20981092
esv3449600 CNV duplication 20981092
esv3576696 CNV gain 25503493
esv3576701 CNV gain 25503493
esv3621549 CNV gain 21293372
esv3621554 CNV loss 21293372
nsv1110578 CNV duplication 24896259
nsv471320 CNV gain 18288195
nsv509319 CNV insertion 20534489
nsv528823 CNV gain 19592680
nsv615233 CNV gain 21841781
nsv615247 CNV loss 21841781
nsv968749 CNV duplication 23825009

Variation tolerance for ORM2 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORM2

Disorders for ORM2 Gene

Relevant External Links for ORM2

Genetic Association Database (GAD)
ORM2
Human Genome Epidemiology (HuGE) Navigator
ORM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORM2

No disorders were found for ORM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORM2 Gene

Publications for ORM2 Gene

  1. Genetic determinants of warfarin dosing in the Han-Chinese population. (PMID: 19958090) Lee M.T. … Chen Y.T. (Pharmacogenomics 2009) 3 22 46 64
  2. Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene. (PMID: 2970990) Merritt C.M. … Board P.G. (Gene 1988) 2 3 4 64
  3. Investigation of genetic variants of alpha-1 acid glycoprotein by ultra-performance liquid chromatography-mass spectrometry. (PMID: 19018521) Budai L. … VAckey K. (Anal Bioanal Chem 2009) 3 22 64
  4. Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia. (PMID: 19584153) Kim D.H. … Lipton J.H. (Clin. Cancer Res. 2009) 3 46 64
  5. Association of warfarin dose with genes involved in its action and metabolism. (PMID: 17048007) Wadelius M. … Deloukas P. (Hum. Genet. 2007) 3 46 64

Products for ORM2 Gene

Sources for ORM2 Gene

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