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Aliases for ORM2 Gene

Aliases for ORM2 Gene

  • Orosomucoid 2 2 3
  • Orosomucoid-2 3 4
  • AGP 2 3 4
  • OMD 2 3 4
  • AGP2 3 4
  • Alpha-1-Acid Glycoprotein, Type 2 3
  • Alpha-1-Acid Glycoprotein 2 3
  • Alpha-1-Acid Glycoprotein 2
  • Type 2 2
  • AGP-B 3

External Ids for ORM2 Gene

Previous GeneCards Identifiers for ORM2 Gene

  • GC09U990059
  • GC09P108818
  • GC09P022004
  • GC09P112462
  • GC09P112468
  • GC09P114165
  • GC09P114171
  • GC09P116131
  • GC09P117092
  • GC09P086697

Summaries for ORM2 Gene

Entrez Gene Summary for ORM2 Gene

  • This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

GeneCards Summary for ORM2 Gene

ORM2 (Orosomucoid 2) is a Protein Coding gene. An important paralog of this gene is ORM1.

UniProtKB/Swiss-Prot for ORM2 Gene

  • Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORM2 Gene

Genomics for ORM2 Gene

Regulatory Elements for ORM2 Gene

Genomic Location for ORM2 Gene

Start:
114,329,789 bp from pter
End:
114,333,256 bp from pter
Size:
3,468 bases
Orientation:
Plus strand

Genomic View for ORM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORM2 Gene

Proteins for ORM2 Gene

  • Protein details for ORM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19652-A1AG2_HUMAN
    Recommended name:
    Alpha-1-acid glycoprotein 2
    Protein Accession:
    P19652
    Secondary Accessions:
    • B2R5L2
    • Q16571
    • Q5T538
    • Q6IB74

    Protein attributes for ORM2 Gene

    Size:
    201 amino acids
    Molecular mass:
    23603 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29873.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA29874.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ORM2 Gene

neXtProt entry for ORM2 Gene

Proteomics data for ORM2 Gene at MOPED

Post-translational modifications for ORM2 Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn33, Asn56, Asn72, Asn93, and Asn103
  • Modification sites at PhosphoSitePlus

Other Protein References for ORM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ORM2 Gene

Domains for ORM2 Gene

Gene Families for ORM2 Gene

HGNC:
  • LCN :Lipocalins

Suggested Antigen Peptide Sequences for ORM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P19652

UniProtKB/Swiss-Prot:

A1AG2_HUMAN :
  • P19652
Domain:
  • Contains a beta-barrel that binds various ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with ORM2: view

Function for ORM2 Gene

Molecular function for ORM2 Gene

GENATLAS Biochemistry:
orosomucoid 2 (lipocalin family,outlier group),abundant in plasma
UniProtKB/Swiss-Prot Function:
Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
UniProtKB/Swiss-Prot Induction:
Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation

Phenotypes for ORM2 Gene

genes like me logo Genes that share phenotypes with ORM2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ORM2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ORM2 Gene

Localization for ORM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORM2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORM2 Gene COMPARTMENTS Subcellular localization image for ORM2 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for ORM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with ORM2: view

Pathways for ORM2 Gene

SuperPathways for ORM2 Gene

No Data Available

Interacting Proteins for ORM2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000394936%0d%0a9606.ENSP00000342026%0d%0a9606.ENSP00000326018%0d%0a9606.ENSP00000275016%0d%0a9606.ENSP00000390500%0d%0a
Selected Interacting proteins: ENSP00000394936 for ORM2 Gene via STRING

Gene Ontology (GO) - Biological Process for ORM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002682 regulation of immune system process IEA --
GO:0006810 transport IEA --
GO:0006953 acute-phase response IEA --
genes like me logo Genes that share ontologies with ORM2: view

No data available for Pathways by source for ORM2 Gene

Transcripts for ORM2 Gene

mRNA/cDNA for ORM2 Gene

(657) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ORM2 Gene

Orosomucoid 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ORM2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORM2 Gene

No ASD Table

Relevant External Links for ORM2 Gene

GeneLoc Exon Structure for
ORM2
ECgene alternative splicing isoforms for
ORM2

Expression for ORM2 Gene

mRNA expression in normal human tissues for ORM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORM2 Gene

This gene is overexpressed in Liver (52.3).

Protein differential expression in normal tissues for ORM2 Gene

This gene is overexpressed in Serum (10.9), Monocytes (9.3), Synovial fluid (8.6), and Plasma (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORM2 Gene

SOURCE GeneReport for Unigene cluster for ORM2 Gene Hs.719954

mRNA Expression by UniProt/SwissProt for ORM2 Gene

P19652-A1AG2_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with ORM2: view

Expression partners for ORM2 Gene

In Situ Assay Products

Orthologs for ORM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC464682 35
  • 97.31 (n)
  • 96.89 (a)
mouse
(Mus musculus)
Mammalia Orm2 16
Orm1 36
  • 47 (a)
ManyToMany
Orm2 36
  • 43 (a)
ManyToMany
Orm3 36
  • 44 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia AGP 36
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves OGCHI 36
  • 25 (a)
OneToMany
Species with no ortholog for ORM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ORM2 Gene

ENSEMBL:
Gene Tree for ORM2 (if available)
TreeFam:
Gene Tree for ORM2 (if available)

Paralogs for ORM2 Gene

Paralogs for ORM2 Gene

Selected SIMAP similar genes for ORM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ORM2: view

Variants for ORM2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ORM2 Gene

P19652-A1AG2_HUMAN
Many different variants of ORM2 are known

Sequence variations from dbSNP and Humsavar for ORM2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1126777 - 114,331,888(+) GCTTG(C/T)GCATT missense, reference
rs1126780 -- 114,331,898(+) TCCCA(A/G)GTCAG missense, reference
rs1687383 -- 114,332,446(+) ACTTG(C/T)GTTGG intron-variant
rs1687416 -- 114,330,686(+) GAGGG(C/T)TGGCT intron-variant
rs1687417 -- 114,332,866(+) CCCAT(G/T)GTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ORM2 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
dgv33e196 CNV Duplication 17116639
dgv948n27 CNV Gain 19166990
nsv893754 CNV Loss 21882294
nsv893757 CNV Gain 21882294
dgv949n27 CNV Gain 19166990
nsv471320 CNV Gain 18288195
nsv528823 CNV Gain 19592680
nsv509319 CNV Insertion 20534489
nsv893759 CNV Loss 21882294
nsv893760 CNV Gain 21882294
esv22321 CNV Gain 19812545
dgv8275n71 CNV Gain 21882294
nsv893763 CNV Gain+Loss 21882294
nsv893764 CNV Gain 21882294
dgv1233n67 CNV Gain 20364138
esv2752277 CNV Gain 17911159
esv2664309 CNV Deletion 23128226
esv2462819 CNV Deletion 19546169

Relevant External Links for ORM2 Gene

HapMap Linkage Disequilibrium report
ORM2

Disorders for ORM2 Gene

(1) Novoseek inferred disease relationships for ORM2 Gene

Disease -log(P) Hits PubMed IDs
inflammation 0 1

Relevant External Links for ORM2

Genetic Association Database (GAD)
ORM2
Human Genome Epidemiology (HuGE) Navigator
ORM2
genes like me logo Genes that share disorders with ORM2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ORM2 Gene

Publications for ORM2 Gene

  1. Genetic determinants of warfarin dosing in the Han-Chinese population. (PMID: 19958090) Lee M.T. … Chen Y.T. (Pharmacogenomics 2009) 3 23 48
  2. Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene. (PMID: 2970990) Merritt C.M. … Board P.G. (Gene 1988) 2 3 4
  3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  4. Association of warfarin dose with genes involved in its action and metabolism. (PMID: 17048007) Wadelius M. … Deloukas P. (Hum. Genet. 2007) 3 48
  5. Investigation of genetic variants of alpha-1 acid glycoprotein by ultra-performance liquid chromatography-mass spectrometry. (PMID: 19018521) Budai L. … VAckey K. (Anal Bioanal Chem 2009) 3 23

Products for ORM2 Gene

Sources for ORM2 Gene

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