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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ORM1 Gene

protein-coding   GIFtS: 53
GCID: GC09P117085

orosomucoid 1

 Explore 26 diseases affiliated with
ORM1 via our new
 Human Malady Compendium 
Biological research products
for ORM1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Orosomucoid 11 2     ORM2
AGP12 3 5     Alpha-1-Acid Glycoprotein 12
AGP 12 3     Orosomucoid-13
OMD 12 3     Orosomucoid-13
AGP-A2     

External Ids:    HGNC: 84981   Entrez Gene: 50042   Ensembl: ENSG000002293147   OMIM: 1386005   UniProtKB: P027633   

Export aliases for ORM1 gene to outside databases

Previous GC identifers: GC09P107883 GC09P108817 GC09P022002 GC09P112461 GC09P114164 GC09P116125 GC09P086691


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ORM1:
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is
classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it
may be involved in aspects of immunosuppression. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763
Function: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel
domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function
in modulating the activity of the immune system during the acute-phase reaction

Gene Wiki entry for ORM1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ORM1 gene promoter:
         STAT1   AML1a   NCX/Ncx   Brachyury   NF-E2 p45   C/EBPalpha   Pax-4a   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidORM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ORM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31-q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q31-qter

ORM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORM1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P117085:  view genomic region     (about GC identifiers)

Start:
117,085,303 bp from pter      End:
117,088,759 bp from pter
Size:
3,457 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763 (See protein sequence)
Recommended Name: Alpha-1-acid glycoprotein 1 precursor  
Size: 201 amino acids; 23512 Da
Subcellular location: Secreted
Sequence caution: Sequence=CAA29229.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for ORM1:
3KQ0 (3D)    
Secondary accessions: B7ZKQ5 Q5T539 Q5U067 Q8TC16

Explore the universe of human proteins at neXtProt for ORM1: NX_P02763

Post-translational modifications:

  • N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P02763

  • ORM1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000598.2  
    ENSEMBL proteins: 
     ENSP00000259396   ENSP00000442679  

    Human Recombinant Protein Products: 
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    Novus Biologicals ORM1 Proteins
    Novus Biologicals ORM1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ORM1
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--


    ORM1 for ontologies           About GeneDecksing



    ORM1 Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ORM1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR001500 A1A_glycop
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P02763

    ProtoNet protein and cluster: P02763

    2 Blocks protein families:
    IPB001500 Alpha-1-acid glycoprotein signature
    IPB002345 Lipocalin signature


    UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763
    Domain: Contains a beta-barrel that binds various ligands in its interior
    Similarity: Belongs to the calycin superfamily. Lipocalin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763
    Function: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel
    domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function
    in modulating the activity of the immune system during the acute-phase reaction
    Induction: Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon
    inflammation

         Genatlas biochemistry entry for ORM1:
    orosomucoid 1 (lipocalin family,outlier group),abundant in plasma

    miRNA
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ORM1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16272158


    ORM1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ORM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for ORM1 (P027631, 3 ENSP000002593964) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINE1P051211, 3, ENSP000002230954EBI-976767,EBI-953978 I2D: score=3 STRING: ENSP00000223095
    PIK3R3Q925693, ENSP000002627414I2D: score=2 STRING: ENSP00000262741
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    CCR5P516813, ENSP000002923034I2D: score=1 STRING: ENSP00000292303
    LGALS3P179313I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002682regulation of immune system process IEA--
    GO:0006810transport IEA--
    GO:0006953acute-phase response IEA--
    GO:0006954inflammatory response TAS3360326


    ORM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ORM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ORM1

    10/27 DrugBank Compounds for ORM1 (see all 27)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DisopyramideDisopiramida [INN-Spanish] (see all 4)3737-09-5carrierother/unknown2860235 10322928 10824133 2862237 14616427
    Penbutolol-- 36507-48-9carrierother/unknown8733828 8174208 8444514 1974610
    AcenocoumarolAcenocoumarin (see all 7)152-72-7carrier--2751692 16290938 8398591
    MaprotilineMaprotilina [INN-Spanish] (see all 4)10262-69-8carrier--7461027 3368020 2870173
    Tamsulosin-- 106133-20-4carrier--17666829 10737910 8973992
    AlfentanilAlfentanilum [INN-Latin] (see all 2)71195-58-9carrier--2071261 3146505
    AmitriptylineAmitriprolidine (see all 7)50-48-6carrier--6108517 2870173
    Nortriptyline-- 72-69-5carrier--6108517 2870173
    PhenprocoumonFenprocumone [DCIT] (see all 5)435-97-2carrier--16290938 11002825
    Quinidine-- 56-54-2carrier--11814462 9620113

    1 Novoseek chemical compound relationship for ORM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 25.9 4 7504986 (2), 14650355 (1)

    Search CenterWatch for drugs/clinical trials and news about ORM1 / A1AG1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ORM1 gene: 
    NM_000607.2  

    Unigene Cluster for ORM1:

    Orosomucoid 1
    Hs.522356  [show with all ESTs]
    Unigene Representative Sequence: AK316207
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259396(uc004bik.4 uc011lxo.2) ENST00000477456 ENST00000538816


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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORM1

    Additional cDNA sequence: 

    AK312035.1 AK316207.1 BC007032.1 BC026238.1 BC104818.1 BC104820.1 BC143313.1 BC143314.1 
    BT019790.1 M13692.1 X02544.1 

    20 DOTS entries:

    DT.92463996  DT.450404  DT.75156719  DT.100670840  DT.92464010  DT.121186697  DT.95175806  DT.100670839 
    DT.121186696  DT.95175870  DT.100883934  DT.92464011  DT.95175892  DT.95175894  DT.86840646  DT.92463997 
    DT.92464002  DT.92464007  DT.92464008  DT.95175888 

    24/657 AceView cDNA sequences (see all 657):

    AV682753 CB124856 AV645952 T64422 AA344117 CR607356 AA344049 T69622 
    AV656930 BC056239 AA313164 AA345342 BQ446130 AA345746 BG562529 AA345520 
    CB148255 AA344271 AA344010 AA343509 BG562428 BC026238 T28642 AW963039 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ORM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTACCTCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ORM1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ORM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ORM1

    SOURCE GeneReport for Unigene cluster: Hs.522356

    UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763
    Tissue specificity: Expressed by the liver and secreted in plasma

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ORM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for ORM1 (if available)
    TreeFam Gene Tree for ORM1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ORM1 gene
    ORM22  
    1 SIMAP similar gene for ORM1 using alignment to 2 protein entries:     A1AG1_HUMAN (see all proteins):
    ORM2

    ORM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763
    Polymorphism: Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S
    has Arg-38/Val-174. The sequence shown is that of allele ORM1*F1


    10/187 NCBI SNPs in ORM1 are shown (see all 187    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465225151,2
    C,--117083305(+) TGAGA-/CCCCCC 1 -- us2k10--------
    rs1401899691,2
    --117083493(+) AAAACA/GAAAAC 1 -- us2k10--------
    rs2003898641,2
    --117083498(+) AAAAC-/AAAAAA 1 -- us2k10--------
    rs109821481,2
    F,H,--117083513(+) ATAGAG/CTAAGT 1 -- us2k15Minor allele frequency- C:0.01NS EA 538
    rs2017367401,2
    --117083545(+) TACAC-/TTTT  
            
    TTTTA
    1 -- us2k10--------
    rs1841931021,2
    --117083550(+) CTTTTA/TTTTAT 1 -- us2k10--------
    rs1874518801,2
    --117083618(+) GTAGTA/GGCAAA 1 -- us2k10--------
    rs70324491,2
    C,--117083651(+) AACTCC/TTGGGC 1 -- us2k14Minor allele frequency- T:0.22NA WA EA 360
    rs1176602771,2
    F,--117083664(+) AAGCAA/GTCTTC 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1152910481,2
    F,--117083705(+) CAGGTA/GCATGG 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for ORM1 (117085303 - 117088759 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for ORM1
         9 CNVs: 53071 8632 7718 70782 53884 5263 29804 96277 5264

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ORM1 for disorders           About GeneDecksing

    OMIM gene information: 138600    OMIM disorders: --

    20/26 diseases for ORM1 (see all 26):    About MalaCards
    focal dermal hypoplasia    familial adenomatous polyposis    major depressive disorder    pediatric multiple sclerosis
    atopic dermatitis    gestational diabetes    multiple sclerosis    chronic myeloid leukemia
    myeloid leukemia    appendicitis    polyposis    rheumatoid arthritis
    polyneuropathy    dermatitis    hyperlipidemia    hepatitis b
    vaginitis    vaccinia    arthritis    leukemia

    Human Genome Epidemiology (HuGE) Navigator: ORM1 (11 documents)

    Export disorders for ORM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ORM1 gene, integrated from 9 sources (see all 139):
    (articles sorted by number of sources associating them with ORM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. (PubMed id 9050929)1, 2, 9 Yuasa I....Irizawa Y. (1997)
    2. Selective binding of coumarin enantiomers to human alpha1-acid glycoprotein genetic variants. (PubMed id 16290938)1, 7, 9 Hazai E....Simonyi M. (2006)
    3. The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin. (PubMed id 18823996)1, 2 Schonfeld D.L....Skerra A. (2008)
    4. The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra. (PubMed id 17321687)1, 2 Zsila F. and Iwao Y. (2007)
    5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    7. A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation. (PubMed id 15253437)1, 2 Hagglund P.... Roepstorff P. (2004)
    8. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (2004)
    9. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5004 HGNC: 8498 AceView: ORM1andORM2 Ensembl:ENSG00000229314 euGenes: HUgn5004
    ECgene: ORM1 H-InvDB: ORM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ORM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ORM1 gene:
    Search GeneIP for patents involving ORM1

    GeneCards and IP:
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