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Aliases for ORM1 Gene

Aliases for ORM1 Gene

  • Orosomucoid 1 2 3 5
  • Orosomucoid-1 3 4
  • AGP 1 3 4
  • OMD 1 3 4
  • AGP1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 153w 3
  • HEL-S-153w 3
  • AGP-A 3
  • ORM 3

External Ids for ORM1 Gene

Previous GeneCards Identifiers for ORM1 Gene

  • GC09P107883
  • GC09P108817
  • GC09P022002
  • GC09P112461
  • GC09P114164
  • GC09P116125
  • GC09P117085
  • GC09P086691

Summaries for ORM1 Gene

Entrez Gene Summary for ORM1 Gene

  • This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

GeneCards Summary for ORM1 Gene

ORM1 (Orosomucoid 1) is a Protein Coding gene. Diseases associated with ORM1 include Mitochondrial Complex Deficiency, Nuclear Type 4 and Combined Oxidative Phosphorylation Deficiency 22. Among its related pathways are Platelet activation, signaling and aggregation. An important paralog of this gene is ORM2.

UniProtKB/Swiss-Prot for ORM1 Gene

  • Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

Gene Wiki entry for ORM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORM1 Gene

Genomics for ORM1 Gene

Regulatory Elements for ORM1 Gene

Enhancers for ORM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ORM1 on UCSC Golden Path with GeneCards custom track

Promoters for ORM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ORM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ORM1 Gene

Chromosome:
9
Start:
114,323,023 bp from pter
End:
114,326,479 bp from pter
Size:
3,457 bases
Orientation:
Plus strand

Genomic View for ORM1 Gene

Genes around ORM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORM1 Gene

Proteins for ORM1 Gene

  • Protein details for ORM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02763-A1AG1_HUMAN
    Recommended name:
    Alpha-1-acid glycoprotein 1
    Protein Accession:
    P02763
    Secondary Accessions:
    • B7ZKQ5
    • Q5T539
    • Q5U067
    • Q8TC16

    Protein attributes for ORM1 Gene

    Size:
    201 amino acids
    Molecular mass:
    23512 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29229.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ORM1 Gene

neXtProt entry for ORM1 Gene

Proteomics data for ORM1 Gene at MOPED

Post-translational modifications for ORM1 Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
  • Glycosylation at Asn 33, Asn 56, Asn 72, Asn 93, and Asn 103
  • Modification sites at PhosphoSitePlus

Other Protein References for ORM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ORM1 (alpha 1-Acid Glycoprotein)

No data available for DME Specific Peptides for ORM1 Gene

Domains & Families for ORM1 Gene

Gene Families for ORM1 Gene

Suggested Antigen Peptide Sequences for ORM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02763

UniProtKB/Swiss-Prot:

A1AG1_HUMAN :
  • Contains a beta-barrel that binds various ligands in its interior.
  • Belongs to the calycin superfamily. Lipocalin family.
Domain:
  • Contains a beta-barrel that binds various ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with ORM1: view

Function for ORM1 Gene

Molecular function for ORM1 Gene

GENATLAS Biochemistry:
orosomucoid 1 (lipocalin family,outlier group),abundant in plasma
UniProtKB/Swiss-Prot Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
UniProtKB/Swiss-Prot Induction:
Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation.
genes like me logo Genes that share phenotypes with ORM1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ORM1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ORM1 Gene

Localization for ORM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORM1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORM1 Gene COMPARTMENTS Subcellular localization image for ORM1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ORM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
genes like me logo Genes that share ontologies with ORM1: view

Pathways & Interactions for ORM1 Gene

genes like me logo Genes that share pathways with ORM1: view

Gene Ontology (GO) - Biological Process for ORM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0032715 negative regulation of interleukin-6 production IDA 23973664
GO:0032720 negative regulation of tumor necrosis factor production IDA 23973664
genes like me logo Genes that share ontologies with ORM1: view

No data available for SIGNOR curated interactions for ORM1 Gene

Drugs & Compounds for ORM1 Gene

(51) Drugs for ORM1 Gene - From: DrugBank and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vandetanib Approved April 2011 Pharma Carrier, binder VEGFR, EGFR, and RET inhibitor, EGFR Inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Abiraterone Approved Pharma Carrier, substrate Potent CYP17 inhibitor 0
Acenocoumarol Approved Pharma Carrier 27
Alfentanil Approved, Illicit Pharma Carrier 36
Amitriptyline Approved Pharma Antagonist, Carrier 103

(1) Additional Compounds for ORM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ORM1: view

Transcripts for ORM1 Gene

mRNA/cDNA for ORM1 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(657) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ORM1 Gene

Orosomucoid 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORM1 Gene

No ASD Table

Relevant External Links for ORM1 Gene

GeneLoc Exon Structure for
ORM1
ECgene alternative splicing isoforms for
ORM1

Expression for ORM1 Gene

mRNA expression in normal human tissues for ORM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORM1 Gene

This gene is overexpressed in Liver (x52.3).

Protein differential expression in normal tissues from HIPED for ORM1 Gene

This gene is overexpressed in Synovial fluid (9.4), Plasma (9.3), and Serum (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ORM1 Gene



SOURCE GeneReport for Unigene cluster for ORM1 Gene Hs.522356

mRNA Expression by UniProt/SwissProt for ORM1 Gene

P02763-A1AG1_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expression patterns with ORM1: view

Protein tissue co-expression partners for ORM1 Gene

- Elite partner

Primer Products

Orthologs for ORM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ORM1 35
  • 70.56 (n)
  • 56.85 (a)
AGP 36
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ORM1 35
  • 70.74 (n)
  • 55 (a)
-- 36
  • 55 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ORM1 35
  • 98.18 (n)
  • 98 (a)
rat
(Rattus norvegicus)
Mammalia Orm1 35
  • 65.14 (n)
  • 52.55 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Orm1 36
  • 49 (a)
ManyToMany
Orm2 36
  • 45 (a)
ManyToMany
Orm3 36
  • 44 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
OneToMany
chicken
(Gallus gallus)
Aves OGCHI 36
  • 25 (a)
OneToMany
Species with no ortholog for ORM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ORM1 Gene

ENSEMBL:
Gene Tree for ORM1 (if available)
TreeFam:
Gene Tree for ORM1 (if available)

Paralogs for ORM1 Gene

Paralogs for ORM1 Gene

(1) SIMAP similar genes for ORM1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ORM1: view

Variants for ORM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ORM1 Gene

A1AG1_HUMAN-P02763
Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S has Arg-38/Val-174. The sequence shown is that of allele ORM1*F1.

Sequence variations from dbSNP and Humsavar for ORM1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_013840 -
rs1126801 - 114,325,132(+) ATGTC(A/G/T)TGTAC reference, missense
rs3182034 - 114,325,111(+) GCTTG(C/T)GCATT reference, missense
rs700126 -- 114,323,755(+) TACTT(C/T)ACCCC reference, synonymous-codon
rs1017989 -- 114,321,995(+) GAGAC(A/G)GGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ORM1 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
dgv33e196 CNV Duplication 17116639
dgv948n27 CNV Gain 19166990
nsv893754 CNV Loss 21882294
nsv893757 CNV Gain 21882294
dgv949n27 CNV Gain 19166990
nsv471320 CNV Gain 18288195
nsv528823 CNV Gain 19592680
nsv509319 CNV Insertion 20534489
nsv893759 CNV Loss 21882294
esv33804 CNV Gain+Loss 17666407
nsv893760 CNV Gain 21882294
esv22321 CNV Gain 19812545
dgv8275n71 CNV Gain 21882294
nsv893762 CNV Loss 21882294
nsv893763 CNV Gain+Loss 21882294
nsv893764 CNV Gain 21882294
dgv1233n67 CNV Gain 20364138
esv2752277 CNV Gain 17911159
esv2664309 CNV Deletion 23128226

Variation tolerance for ORM1 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for ORM1 Gene

Disorders for ORM1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ORM1 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
mitochondrial complex deficiency, nuclear type 4
  • mitochondrial complex v deficiency nuclear type 4
combined oxidative phosphorylation deficiency 22
  • coxpd22
pediatric multiple sclerosis
  • ms pediatric
odontogenic myxoma
- elite association - COSMIC cancer census association via MalaCards
Search ORM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ORM1

Genetic Association Database (GAD)
ORM1
Human Genome Epidemiology (HuGE) Navigator
ORM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORM1
genes like me logo Genes that share disorders with ORM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ORM1 Gene

Publications for ORM1 Gene

  1. Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. (PMID: 9050929) Yuasa I. … Irizawa Y. (Hum. Genet. 1997) 3 4 23 67
  2. Selective binding of coumarin enantiomers to human alpha1-acid glycoprotein genetic variants. (PMID: 16290938) Hazai E. … Simonyi M. (Bioorg. Med. Chem. 2006) 3 23 25
  3. Orosomucoid influences the response to antidepressants in major depressive disorder. (PMID: 19395425) Harley J. … Kennedy M. (J. Psychopharmacol. (Oxford) 2010) 3 23
  4. Investigation of genetic variants of alpha-1 acid glycoprotein by ultra-performance liquid chromatography-mass spectrometry. (PMID: 19018521) Budai L. … VAckey K. (Anal Bioanal Chem 2009) 3 23
  5. A/G Gln20Arg (exon 1) and G/A Val156Met (exon 5) polymorphisms of the human orosomucoid 1 gene in Mexico. (PMID: 18273814) GarcA-a-Ortiz L. … MartA-nez-Cordero E. (Genet. Mol. Res. 2008) 3 23

Products for ORM1 Gene

Sources for ORM1 Gene

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