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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ORM1 Gene

protein-coding   GIFtS: 54
GCID: GC09P117085

Orosomucoid 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Orosomucoid 11 2     ORM2
AGP12 3 5     Alpha-1-Acid Glycoprotein 12
AGP 12 3     orosomucoid-12
OMD 12 3     Orosomucoid-13
AGP-A2     

External Ids:    HGNC: 84981   Entrez Gene: 50042   Ensembl: ENSG000002293147   OMIM: 1386005   UniProtKB: P027633   

Export aliases for ORM1 gene to outside databases

Previous GC identifers: GC09P107883 GC09P108817 GC09P022002 GC09P112461 GC09P114164 GC09P116125 GC09P086691


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ORM1 Gene:
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this
protein is classified as an acute-phase reactant. The specific function of this protein has not yet been
determined; however, it may be involved in aspects of immunosuppression. (provided by RefSeq, Jul 2008)

GeneCards Summary for ORM1 Gene: 
ORM1 (orosomucoid 1) is a protein-coding gene. Diseases associated with ORM1 include pediatric multiple sclerosis, and focal dermal hypoplasia. GO annotations related to this gene include protein binding. An important paralog of this gene is ORM2.

UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763
Function: Functions as transport protein in the blood stream. Binds various ligands in the interior of its
beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body.
Appears to function in modulating the activity of the immune system during the acute-phase reaction

Gene Wiki entry for ORM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ORM1 gene promoter:
         STAT1   AML1a   NCX/Ncx   Brachyury   NF-E2 p45   C/EBPalpha   Pax-4a   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidORM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ORM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

ORM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORM1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P117085:  view genomic region     (about GC identifiers)

Start:
117,085,303 bp from pter      End:
117,088,759 bp from pter
Size:
3,457 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763 (See protein sequence)
Recommended Name: Alpha-1-acid glycoprotein 1 precursor  
Size: 201 amino acids; 23512 Da
Subcellular location: Secreted
Sequence caution: Sequence=CAA29229.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for ORM1:
3KQ0 (3D)    
Secondary accessions: B7ZKQ5 Q5T539 Q5U067 Q8TC16

Explore the universe of human proteins at neXtProt for ORM1: NX_P02763

Explore proteomics data for ORM1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5
    (minor)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02763

  • ORM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ORM1 Protein Expression
    REFSEQ proteins: NP_000598.2  
    ENSEMBL proteins: 
     ENSP00000259396   ENSP00000442679  

    Human Recombinant Protein Products for ORM1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ORM1
    OriGene Protein Over-expression Lysate for ORM1
    OriGene MassSpec for ORM1 
    OriGene Custom Protein Services for ORM1
    GenScript Custom Purified and Recombinant Proteins Services for ORM1
    Novus Biologicals ORM1 Proteins
    Novus Biologicals ORM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ORM1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IEA--

    ORM1 for ontologies           About GeneDecksing



    ORM1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ORM1 Antibodies
    Abcam antibodies for ORM1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for ORM1
    LSBio Antibodies in human, mouse, rat for ORM1 

    Assay Products for ORM1: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for ORM1 (alpha 1-Acid Glycoprotein)
    GenScript Custom Assay Services for ORM1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LCN: Lipocalins

    4 InterPro protein domains:
     IPR012674 Calycin
     IPR011038 Calycin-like
     IPR001500 A1A_glycop
     IPR000566 Lipocln_cytosolic_FA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P02763

    ProtoNet protein and cluster: P02763

    2 Blocks protein domains:
    IPB001500 Alpha-1-acid glycoprotein signature
    IPB002345 Lipocalin signature


    UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763
    Domain: Contains a beta-barrel that binds various ligands in its interior
    Similarity: Belongs to the calycin superfamily. Lipocalin family


    ORM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: A1AG1_HUMAN, P02763
    Function: Functions as transport protein in the blood stream. Binds various ligands in the interior of its
    beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body.
    Appears to function in modulating the activity of the immune system during the acute-phase reaction
    Induction: Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold
    upon inflammation

         Genatlas biochemistry entry for ORM1:
    orosomucoid 1 (lipocalin family,outlier group),abundant in plasma

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16272158
         
    ORM1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ORM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ORM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ORM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ORM1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORM1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ORM1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ORM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ORM1
    Sirion Biotech Customized adenovirus for overexpression of ORM1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ORM1 (see all 7)
    OriGene ORF clones in mouse, rat for ORM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ORM1 (NM_000607)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORM1
    Sirion Biotech Customized lentivirus for stable overexpression of ORM1 
                         Customized lentivirus expression plasmids for stable overexpression of ORM1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ORM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for ORM1 (P027631, 3 ENSP000002593964) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINE1P051211, 3, ENSP000002230954EBI-976767,EBI-953978 I2D: score=3 STRING: ENSP00000223095
    PIK3R3Q925693, ENSP000002627414I2D: score=2 STRING: ENSP00000262741
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    CCR5P516813, ENSP000002923034I2D: score=1 STRING: ENSP00000292303
    LGALS3P179313I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002682regulation of immune system process IEA--
    GO:0006810transport IEA--
    GO:0006953acute-phase response IEA--
    GO:0006954inflammatory response TAS3360326

    ORM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ORM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ORM1 (A1AG1)

    10/42 DrugBank Compounds for ORM1 (see all 42)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DisopyramideDisopiramida [INN-Spanish] (see all 4)3737-09-5carrierother/unknown2860235 10322928 10824133 2862237 14616427
    Penbutolol(2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol (see all 6)36507-48-9carrierother/unknown8733828 8174208 8444514 1974610
    AcenocoumarolAcenocoumarin (see all 7)152-72-7carrier--2751692 16290938 8398591
    MaprotilineMaprotilina [INN-Spanish] (see all 4)10262-69-8carrier--7461027 3368020 2870173
    Tamsulosin-- 106133-20-4carrier--17666829 10737910 8973992
    AlfentanilAlfentanilum [INN-Latin] (see all 2)71195-58-9carrier--2071261 3146505
    AmitriptylineAmitriprolidine (see all 5)50-48-6carrier--6108517 2870173
    Nortriptyline-- 72-69-5carrier--6108517 2870173
    PhenprocoumonFenprocumone [DCIT] (see all 5)435-97-2carrier--16290938 11002825
    Quinidine-- 56-54-2carrier--11814462 9620113

    1 Novoseek inferred chemical compound relationship for ORM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 25.9 4 7504986 (2), 14650355 (1)

    Search CenterWatch for drugs/clinical trials and news about ORM1 / A1AG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ORM1 gene: 
    NM_000607.2  

    Unigene Cluster for ORM1:

    Orosomucoid 1
    Hs.522356  [show with all ESTs]
    Unigene Representative Sequence: AK316207
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259396(uc004bik.4 uc011lxo.2) ENST00000477456 ENST00000538816

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORM1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ORM1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ORM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORM1
    Clone
    Products:
         
    OriGene clones in human, mouse for ORM1 (see all 7)
    OriGene ORF clones in mouse, rat for ORM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ORM1 (NM_000607)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORM1
    Sirion Biotech Customized lentivirus for stable overexpression of ORM1 
                         Customized lentivirus expression plasmids for stable overexpression of ORM1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ORM1
    OriGene qSTAR qPCR primer pairs in human, mouse for ORM1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ORM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORM1

    Additional mRNA sequence: 

    AK312035.1 AK316207.1 BC007032.1 BC026238.1 BC104818.1 BC104820.1 BC143313.1 BC143314.1 
    BT019790.1 M13692.1 X02544.1 

    20 DOTS entries:

    DT.92463996  DT.450404  DT.75156719  DT.100670840  DT.92464010  DT.100670839  DT.121186697  DT.95175806 
    DT.121186696  DT.92464008  DT.95175870  DT.100883934  DT.92464011  DT.95175892  DT.95175894  DT.86840646 
    DT.92463997  DT.92464002  DT.92464007  DT.95175888 

    24/657 AceView cDNA sequences (see all 657):

    AA344049 BG562428 AA344010 BQ446130 CR607356 CB124856 NM_000608 AA345342 
    AV645952 BC056239 AV656930 D17069 AA345746 AW963039 AA344271 T64422 
    T40117 AA313164 AA343509 CB148255 BG562529 AA345541 BC026238 D16954 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ORM1 expression in normal human tissues (normalized intensities)      ORM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTACCTCAG
    ORM1 Expression
    About this image


    ORM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
             leukocytes   
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Liver (Hepatobiliary System)
             Human Hepatocyte (HH)   
     
     Gall Bladder (Hepatobiliary System)
             gallbladder   
     
     Uterus (Reproductive System)
             cervix   

    See ORM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ORM1

    SOURCE GeneReport for Unigene cluster: Hs.522356

    UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763
    Tissue specificity: Expressed by the liver and secreted in plasma

        SABiosciences Custom PCR Arrays for ORM1
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORM1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ORM1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Orm15 orosomucoid 1   --   4 (33.96 cM) 63344560 
    chicken
    (Gallus gallus)
    Aves OGCHI6
    ovoglycoprotein precursor
    25(a)
    1 → many
    17(4788861-4790491)


    ENSEMBL Gene Tree for ORM1 (if available)
    TreeFam Gene Tree for ORM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ORM1 gene
    ORM22  
    1 SIMAP similar gene for ORM1 using alignment to 2 protein entries:     A1AG1_HUMAN (see all proteins):
    ORM2

    ORM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: A1AG1_HUMAN, P02763
    Polymorphism: Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and
    ORM1*S has Arg-38/Val-174. The sequence shown is that of allele ORM1*F1


    10/237 SNPs in ORM1 are shown (see all 237)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0138404
    ----see VAR_0138402 Q R mis40--------
    rs727467071,2
    C--117083725(+) TGGCTA/GATTTT 1 -- us2k10--------
    rs1118665451,2
    F--117084412(+) AGGAGG/CCTGAG 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs59000821,2
    C--117084514(+) AAAAA-/ATGAAT 1 -- us2k10--------
    rs17660761,2
    C,F,O,A,H--117084905(-) AACATA/GGATTC 1 -- us2k119Minor allele frequency- G:0.11EA NA NS WA CSA 1027
    rs342727081,2
    C--117084913(+) GTTTGC/TCTTCC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1465225151,2
    C--117095304(+) TGAGA-/CCCCCC 1 -- us2k10--------
    rs1401899691,2
    C--117095492(+) AAAACA/GAAAAC 1 -- us2k10--------
    rs2003898641,2
    C--117095497(+) AAAAC-/AAAAAA 1 -- us2k10--------
    rs109821481,2
    F,H--117095512(+) ATAGAG/CTAAGT 1 -- us2k15Minor allele frequency- C:0.01NS EA 538

    HapMap Linkage Disequilibrium report for ORM1 (117085303 - 117088759 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for ORM1 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664309CNV Deletion23128226
    dgv33e196CNV Duplication17116639
    nsv509319CNV Insertion20534489
    nsv893754CNV Loss21882294
    nsv893759CNV Loss21882294
    nsv893762CNV Loss21882294
    nsv893750CNV Loss21882294
    dgv1233n67CNV Gain20364138
    nsv893760CNV Gain21882294
    dgv949n27CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138600    OMIM disorders: --

    20/25 diseases for ORM1 (see all 25):    About MalaCards
    pediatric multiple sclerosis    focal dermal hypoplasia    appendicitis    chronic myeloid leukemia
    gestational diabetes    vaccinia    major depressive disorder    vaginitis
    polyneuropathy    familial adenomatous polyposis    multiple sclerosis    atopic dermatitis
    dermatitis    hepatitis b    myeloid leukemia    rheumatoid arthritis
    arthritis    anemia    lupus erythematosus    cervicitis


    ORM1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ORM1
    Human Genome Epidemiology (HuGE) Navigator: ORM1 (11 documents)

    Export disorders for ORM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ORM1 gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with ORM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. (PubMed id 9050929)1, 2, 9 Yuasa I....Irizawa Y. (1997)
    2. Orosomucoid influences the response to antidepressants in major depressive disorder. (PubMed id 19395425)1, 4, 9 Harley J....Kennedy M. (2009)
    3. Selective binding of coumarin enantiomers to human alpha1-acid glycoprotein genetic variants. (PubMed id 16290938)1, 7, 9 Hazai E....Simonyi M. (2006)
    4. The IFNG (IFN-gamma) genotype predicts cytogenetic an d molecular response to imatinib therapy in chronic myeloid leukemia. (PubMed id 20959405)1, 4 Kim D.H....Lipton J.H. (2010)
    5. Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) a re predictor variables for warfarin response in very elderly, frail inpatients. (PubMed id 19794411)1, 4 Pautas E....Siguret V. (2010)
    6. Genetic determinants of warfarin dosing in the Han-Ch inese population. (PubMed id 19958090)1, 4 Lee M.T....Chen Y.T. (2009)
    7. Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia. (PubMed id 19141860)1, 4 Kim D.H....Lipton J.H. (2009)
    8. The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin. (PubMed id 18823996)1, 2 Schonfeld D.L....Skerra A. (2008)
    9. Population pharmacokinetics and pharmacogenetics of imatinib in children and adults. (PubMed id 18981009)1, 4 Petain A....Vassal G. (2008)
    10. Genetic factors contribute to patient-specific warfarin dose for Han Chinese. (PubMed id 18680736)1, 4 Wang T.L....Tai S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5004 HGNC: 8498 AceView: ORM1andORM2 Ensembl:ENSG00000229314 euGenes: HUgn5004
    ECgene: ORM1 H-InvDB: ORM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ORM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ORM1 gene:
    Search GeneIP for patents involving ORM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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