Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ORM1 Gene

Aliases for ORM1 Gene

  • Orosomucoid 1 2 3
  • AGP1 3 4 6
  • Orosomucoid-1 3 4
  • AGP 1 3 4
  • OMD 1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 153w 3
  • Alpha-1-Acid Glycoprotein 1 3
  • HEL-S-153w 3
  • AGP-A 3
  • ORM 3

External Ids for ORM1 Gene

Summaries for ORM1 Gene

Entrez Gene Summary for ORM1 Gene

  • This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

GeneCards Summary for ORM1 Gene

ORM1 (Orosomucoid 1) is a Protein Coding gene. Diseases associated with ORM1 include pediatric multiple sclerosis. An important paralog of this gene is ORM2.

UniProtKB/Swiss-Prot for ORM1 Gene

  • Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

Gene Wiki entry for ORM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORM1 Gene

Genomics for ORM1 Gene

Genomic Location for ORM1 Gene

Start:
114,323,023 bp from pter
End:
114,326,479 bp from pter
Size:
3,457 bases
Orientation:
Plus strand

Genomic View for ORM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORM1 Gene

Regulatory Elements for ORM1 Gene

Proteins for ORM1 Gene

  • Protein details for ORM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02763-A1AG1_HUMAN
    Recommended name:
    Alpha-1-acid glycoprotein 1
    Protein Accession:
    P02763
    Secondary Accessions:
    • B7ZKQ5
    • Q5T539
    • Q5U067
    • Q8TC16

    Protein attributes for ORM1 Gene

    Size:
    201 amino acids
    Molecular mass:
    23512 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA29229.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ORM1 Gene

neXtProt entry for ORM1 Gene

Proteomics data for ORM1 Gene at MOPED

Post-translational modifications for ORM1 Gene

  • N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn33, Asn56, Asn72, Asn93, and Asn103

Other Protein References for ORM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ORM1 Gene

Domains for ORM1 Gene

Gene Families for ORM1 Gene

HGNC:
  • LCN :Lipocalins

UniProtKB/Swiss-Prot:

A1AG1_HUMAN
Domain:
  • Contains a beta-barrel that binds various ligands in its interior.:
    • P02763
Family:
  • Belongs to the calycin superfamily. Lipocalin family.:
    • P02763
genes like me logo Genes that share domains with ORM1: view

Function for ORM1 Gene

Molecular function for ORM1 Gene

GENATLAS Biochemistry: orosomucoid 1 (lipocalin family,outlier group),abundant in plasma
UniProtKB/Swiss-Prot Function: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
UniProtKB/Swiss-Prot Induction: Synthesis is controlled by glucocorticoids, interleukin-1 and interleukin-6, It increases 5- to 50-fold upon inflammation

Gene Ontology (GO) - Molecular Function for ORM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16272158
genes like me logo Genes that share ontologies with ORM1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ORM1 Gene

Localization for ORM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORM1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORM1 Gene COMPARTMENTS Subcellular localization image for ORM1 gene
Compartment Confidence
extracellular 5
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ORM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with ORM1: view

Pathways for ORM1 Gene

SuperPathways for ORM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ORM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002682 regulation of immune system process IEA --
GO:0006810 transport IEA --
GO:0006953 acute-phase response IEA --
GO:0006954 inflammatory response TAS 3360326
GO:0032715 negative regulation of interleukin-6 production IDA 23973664
genes like me logo Genes that share ontologies with ORM1: view

No data available for Pathways by source for ORM1 Gene

Compounds for ORM1 Gene

(42) Drugbank Compounds for ORM1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abiraterone
154229-19-3 carrier substrate
Acenocoumarol
  • Acenocoumarin
152-72-7 carrier
Ajmaline
4360-12-7 carrier
Alfentanil
  • Alfentanilum [INN-Latin]
71195-58-9 carrier
Amitriptyline
  • Amitriprolidine
50-48-6 carrier

(1) Novoseek inferred chemical compound relationships for ORM1 Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 25.9 3
genes like me logo Genes that share compounds with ORM1: view

Transcripts for ORM1 Gene

mRNA/cDNA for ORM1 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(657) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ORM1 Gene

Orosomucoid 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORM1 Gene

No ASD Table

Relevant External Links for ORM1 Gene

GeneLoc Exon Structure for
ORM1
ECgene alternative splicing isoforms for
ORM1

Expression for ORM1 Gene

mRNA expression in normal human tissues for ORM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORM1 Gene

This gene is overexpressed in Liver (52.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ORM1 Gene

SOURCE GeneReport for Unigene cluster for ORM1 Gene Hs.522356

mRNA Expression by UniProt/SwissProt for ORM1 Gene

P02763-A1AG1_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with ORM1: view

Orthologs for ORM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORM1 36
  • 98.18 (n)
  • 98 (a)
cow
(Bos Taurus)
Mammalia AGP 37
  • 56 (a)
OneToMany
ORM1 36
  • 70.56 (n)
  • 56.85 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 55 (a)
OneToMany
ORM1 36
  • 70.74 (n)
  • 55 (a)
mouse
(Mus musculus)
Mammalia Orm1 16
Orm1 37
  • 49 (a)
ManyToMany
Orm2 37
  • 45 (a)
ManyToMany
Orm3 37
  • 44 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 35 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 41 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Orm1 36
  • 65.14 (n)
  • 52.55 (a)
chicken
(Gallus gallus)
Aves OGCHI 37
  • 25 (a)
OneToMany
Species with no ortholog for ORM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ORM1 Gene

ENSEMBL:
Gene Tree for ORM1 (if available)
TreeFam:
Gene Tree for ORM1 (if available)

Paralogs for ORM1 Gene

Paralogs for ORM1 Gene

Selected SIMAP similar genes for ORM1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ORM1: view

Variants for ORM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ORM1 Gene

P02763-A1AG1_HUMAN
Three common alleles of ORM1 are known. ORM1*F1 has Gln-38/Val-174; ORM1*F2 has Gln-38/Met-174 and ORM1*S has Arg-38/Val-174. The sequence shown is that of allele ORM1*F1

Sequence variations from dbSNP and Humsavar for ORM1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs17650 -- 114,323,246(+) GGACC(A/G)GGTGA missense, reference
rs1017989 -- 114,321,995(+) GAGAC(A/G)GGTGA upstream-variant-2KB
rs1017990 -- 114,322,025(+) TCCAG(A/G)CCAGC upstream-variant-2KB
rs1111796 -- 114,323,946(+) GCCCC(A/G/T)GGACT intron-variant
rs1126708 -- 114,324,844(+) GACCT(A/T)CATGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ORM1 Gene

Variant ID Type Subtype PubMed ID
nsv893750 CNV Loss 21882294
dgv33e196 CNV Duplication 17116639
dgv948n27 CNV Gain 19166990
nsv893754 CNV Loss 21882294
nsv893757 CNV Gain 21882294
dgv949n27 CNV Gain 19166990
nsv471320 CNV Gain 18288195
nsv528823 CNV Gain 19592680
nsv509319 CNV Insertion 20534489
nsv893759 CNV Loss 21882294
esv33804 CNV Gain+Loss 17666407
nsv893760 CNV Gain 21882294
esv22321 CNV Gain 19812545
dgv8275n71 CNV Gain 21882294
nsv893762 CNV Loss 21882294
nsv893763 CNV Gain+Loss 21882294
nsv893764 CNV Gain 21882294
dgv1233n67 CNV Gain 20364138
esv2752277 CNV Gain 17911159
esv2664309 CNV Deletion 23128226

Relevant External Links for ORM1 Gene

HapMap Linkage Disequilibrium report
ORM1

Disorders for ORM1 Gene

Relevant External Links for ORM1

Genetic Association Database (GAD)
ORM1
Human Genome Epidemiology (HuGE) Navigator
ORM1
genes like me logo Genes that share disorders with ORM1: view

No data available for UniProtKB/Swiss-Prot for ORM1 Gene

Publications for ORM1 Gene

  1. Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S. (PMID: 9050929) Yuasa I. … Irizawa Y. (Hum. Genet. 1997) 3 4 23
  2. Orosomucoid influences the response to antidepressants in major depressive disorder. (PMID: 19395425) Harley J. … Kennedy M. (J. Psychopharmacol. (Oxford) 2010) 3 23 49
  3. Selective binding of coumarin enantiomers to human alpha1-acid glycoprotein genetic variants. (PMID: 16290938) Hazai E. … Simonyi M. (Bioorg. Med. Chem. 2006) 3 23 25
  4. A/G Gln20Arg (exon 1) and G/A Val156Met (exon 5) polymorphisms of the human orosomucoid 1 gene in Mexico. (PMID: 18273814) GarcA-a-Ortiz L. … MartA-nez-Cordero E. (Genet. Mol. Res. 2008) 3 23
  5. The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2. (PMID: 11027547) Nakamura H. … Kimura K. (Biochem. Biophys. Res. Commun. 2000) 3 23

Products for ORM1 Gene

Sources for ORM1 Gene

Back to Top

Content