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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ORC6 Gene

protein-coding   GIFtS: 59
GCID: GC16P046724

Origin Recognition Complex, Subunit 6

(Previous names: origin recognition complex, subunit 6 homolog-like (yeast),...)
(Previous symbol: ORC6L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Origin Recognition Complex, Subunit 61 2
ORC6L1 2 3 5
Origin Recognition Complex, Subunit 6 Homolog-Like (Yeast)1
Origin Recognition Complex, Subunit 6 Like (Yeast)1
Origin Recognition Complex Subunit 62

External Ids:    HGNC: 171511   Entrez Gene: 235942   Ensembl: ENSG000000916517   OMIM: 6072135   UniProtKB: Q9Y5N63   
ORGUL members:         
NONCODE14:n410474      

Export aliases for ORC6 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ORC6 Gene:
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the
initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically
to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6
and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with
small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome
replication and segregation with cytokinesis. (provided by RefSeq, Oct 2010)

GeneCards Summary for ORC6 Gene: 
ORC6 (origin recognition complex, subunit 6) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with ORC6 include meier-gorlin syndrome 3, and meier-gorlin syndrome, and among its related super-pathways are Activation of the pre-replicative complex and Mitotic G1-G1/S phases. GO annotations related to this gene include protein binding and DNA binding.

UniProtKB/Swiss-Prot: ORC6_HUMAN, Q9Y5N6
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far.
ORC is required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Wiki entry for ORC6 (ORC6L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ORC6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidORC6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ORC6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12   Ensembl cytogenetic band:  16q11.2   HGNC cytogenetic band: 16q12

ORC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORC6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P046724:  view genomic region     (about GC identifiers)

Start:
46,723,555 bp from pter      End:
46,732,306 bp from pter
Size:
8,752 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ORC6_HUMAN, Q9Y5N6 (See protein sequence)
Recommended Name: Origin recognition complex subunit 6  
Size: 252 amino acids; 28107 Da
Subunit: ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially
assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By
similarity)
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for ORC6:
3M03 (3D)    
Secondary accessions: B3KN89

Explore the universe of human proteins at neXtProt for ORC6: NX_Q9Y5N6

Explore proteomics data for ORC6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5N6

  • ORC6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ORC6 Protein Expression
    REFSEQ proteins: NP_055136.1  
    ENSEMBL proteins: 
     ENSP00000454299   ENSP00000219097   ENSP00000457282   ENSP00000456981  
    Reactome Protein details: Q9Y5N6
    Human Recombinant Protein Products for ORC6: 
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    Novus Biologicals ORC6 Proteins
    Novus Biologicals ORC6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000808origin recognition complex IDA17716973
    GO:0005654nucleoplasm TAS--
    GO:0005664nuclear origin of replication recognition complex IEA--

    ORC6 for ontologies           About GeneDecksing



    ORC6 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR020529 ORC6_met/pln
     IPR008721 ORC6

    Graphical View of Domain Structure for InterPro Entry Q9Y5N6

    ProtoNet protein and cluster: Q9Y5N6

    1 Blocks protein domain: IPB008721 Origin recognition complex subunit 6

    UniProtKB/Swiss-Prot: ORC6_HUMAN, Q9Y5N6
    Similarity: Belongs to the ORC6 family


    ORC6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORC6_HUMAN, Q9Y5N6
    Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
    ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far.
    ORC is required to assemble the pre-replication complex necessary to initiate DNA replication

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI15232106
         
    ORC6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ORC6:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ORC6 
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    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ORC6:
    hsa-miR-548p hsa-miR-4318 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidORC6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ORC6 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.67
    Cell cycle Start of DNA replication in early S phase0.54
    DNA Replication0.67
    2Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4CDK-mediated phosphorylation and removal of Cdc6
    CDT1 association with the CDC6:ORC:origin complex0.91
    M/G1 Transition0.81
    Assembly of the pre-replicative complex0.91
    DNA Replication Pre-Initiation0.81
    Removal of licensing factors from origins0.89
    Synthesis of DNA0.79
    Regulation of DNA replication0.89
    S Phase0.79
    5CDC6 association with the ORC:origin complex
    CDC6 association with the ORC:origin complex0.75
    E2F-enabled inhibition of pre-replication complex formation0.64
    Assembly of the ORC complex at the origin of replication0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ORC6
        Meiosis
    Cell cycle Start of DNA replication in early S phase


    1 Cell Signaling Technology (CST) Pathway for ORC6
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for ORC6
        Cell cycle Start of DNA replication in early S phase

    3 BioSystems Pathways for ORC6
        Cell cycle
    G1 to S cell cycle control
    DNA Replication

    5/24        Reactome Pathways for ORC6 (see all 24)
        Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    DNA Replication
    E2F-enabled inhibition of pre-replication complex formation
    Removal of licensing factors from origins


    1         Kegg Pathway  (Kegg details for ORC6):
        Cell cycle


    ORC6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ORC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for ORC6 (Q9Y5N61, 2, 3 ENSP000002190974) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC7O003112, 3, ENSP000002346264MINT-50410 I2D: score=6 STRING: ENSP00000234626
    ORC3Q9UBD51, 3, ENSP000002577894EBI-374840,EBI-374916 I2D: score=5 STRING: ENSP00000257789
    ORC4O439293, ENSP000002641694I2D: score=5 STRING: ENSP00000264169
    MCM4P339913, ENSP000002621054I2D: score=4 STRING: ENSP00000262105
    CDC6Q997413, ENSP000002097284I2D: score=3 STRING: ENSP00000209728
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0006261DNA-dependent DNA replication IEA--

    ORC6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ORC6

    Search CenterWatch for drugs/clinical trials and news about ORC6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ORC6 gene: 
    NM_014321.3  

    Unigene Cluster for ORC6:

    Origin recognition complex, subunit 6
    Hs.49760  [show with all ESTs]
    Unigene Representative Sequence: NR_037620
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563599 ENST00000219097(uc002eeh.3 uc021thp.1) ENST00000569239(uc002eeg.1)
    ENST00000563306(uc010cbe.2) ENST00000568364 ENST00000570260 ENST00000566860
    ENST00000575571 ENST00000567000
    miRNA
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    hsa-miR-548p hsa-miR-4318 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidORC6 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF139658.1 AK021946.1 AK024019.1 BC039032.1 BC050725.1 BC063565.1 NR_037620.1 

    13 DOTS entries:

    DT.91755690  DT.102836317  DT.456058  DT.95284323  DT.120665379  DT.100023075  DT.100796529  DT.120665407 
    DT.97855458  DT.100689297  DT.100881303  DT.120665429  DT.91755686 

    24/122 AceView cDNA sequences (see all 122):

    BU509667 NM_014321 BC050725 BM787326 BM764335 AL514678 T83154 BU857227 
    BG112807 AU118020 BE793867 BM843660 BQ054869 AI203373 BQ954972 BE549396 
    BQ065829 AU142989 BM914889 BM479936 CR604421 CR619046 H83116 BQ064129 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ORC6 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                -                       -     -     -                           
    SP2:                                -                       -                                       
    SP3:                                -                       -     -     -     -                     
    SP4:                                                        -     -     -                           
    SP5:                                -                                                               


    ECgene alternative splicing isoforms for ORC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ORC6 expression in normal human tissues (normalized intensities)      ORC6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ORC6 Expression
    About this image


    ORC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Human fetal bone marrow-derived mesenchymal stromal cells
     
     Blood (Hematopoietic System)
             bone marrow cd34+   

    See ORC6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ORC6

    SOURCE GeneReport for Unigene cluster: Hs.49760
        SABiosciences Custom PCR Arrays for ORC6
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ORC6 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Orc61 , 5 origin recognition complex, subunit 61, 5 82.07(n)1
    77.69(a)1
      8 (41.61 cM)5
    564521  NM_019716.21  NP_062690.21 
     852996325 
    chicken
    (Gallus gallus)
    Aves ORC61 origin recognition complex, subunit 6 64.08(n)
    56.73(a)
      415749  XM_414114.2  XP_414114.2 
    lizard
    (Anolis carolinensis)
    Reptilia ORC66
    origin recognition complex, subunit 6
    58(a)
    1 ↔ 1
    LGc(3588848-3598438)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80172 Xenopus laevis transcribed sequence with weak similarity to protein refNP_055136.1 (H.sapiens) origin recognition complex, subunit 6 (yeast homolog)-like; origin recognition complex subunit 6 [Homo sapiens] less 74.99(n)    CA983315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc22h102 Danio rerio cDNA clone MGC65798 IMAGE6791676, complete cds less 76.69(n)    BC056528.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Orc61 Origin recognition complex subunit 6 43.79(n)
    29.24(a)
      36017  NM_057971.5  NP_477319.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ORC61 origin recognition complex subunit 6 47.49(n)
    33.33(a)
      839227  NM_102448.3  NP_174006.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g06286001 hypothetical protein 47.21(n)
    30.47(a)
      4343985  NM_001066886.1  NP_001060351.1 


    ENSEMBL Gene Tree for ORC6 (if available)
    TreeFam Gene Tree for ORC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/197 SNPs in ORC6 are shown (see all 197)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0654874
    Meier-Gorlin syndrome 3 (MGORS3)4--see VAR_0654872 Y S mis40--------
    VAR_0292834
    ----see VAR_0292832 R W mis40--------
    rs3750622811,2
    C--32617328(+) TGGCC-/GGGGCG 2 -- int10--------
    rs3726843571,2
    C--46725185(+) TTTTGC/TATTGG 2 -- int10--------
    rs1483694941,2
    C--46725231(+) CTGTTC/TTCCCT 2 -- int10--------
    rs1849713761,2
    --46725422(+) TCTGTG/TAGCCT 2 -- int10--------
    rs1902189561,2
    --46725542(+) ACTCAA/TTAAAT 2 -- int10--------
    rs1406328451,2
    --46725684(+) CCTTGG/TTTTTT 2 -- int10--------
    rs1504520861,2
    --46725722(+) TATTTA/GTCTTA 2 -- int10--------
    rs1832190401,2
    --46725744(+) CTTATC/TGTTAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for ORC6 (46723555 - 46732306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ORC6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526656CNV Gain19592680


    Human Gene Mutation Database (HGMD): ORC6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ORC6
    DNA2.0 Custom Variant and Variant Library Synthesis for ORC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607213    OMIM disorders: --

    UniProtKB/Swiss-Prot: ORC6_HUMAN, Q9Y5N6
  • Meier-Gorlin syndrome 3 (MGORS3) [MIM:613803]: A syndrome characterized by bilateral microtia,
    aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature
    and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently
    low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract
    anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial
    prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic
    patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 8 diseases for ORC6:    About MalaCards
    meier-gorlin syndrome 3    meier-gorlin syndrome    microtia    dwarfism
    microcephaly    short stature    cleft palate    colon cancer


    ORC6 for disorders           About GeneDecksing


    Export disorders for ORC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ORC6 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with ORC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of the human ORC6 homolog. (PubMed id 10945994)1, 3, 9 Dhar S.K. and Dutta A. (2000)
    2. ATP-dependent assembly of the human origin recognition complex. (PubMed id 17716973)1, 2, 9 Siddiqui K. and Stillman B. (2007)
    3. Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PubMed id 21358632)1, 2 Bicknell L.S....Jackson A.P. (2011)
    4. Structural analysis of human Orc6 protein reveals a h omology with transcription factor TFIIB. (PubMed id 21502537)1, 2 Liu S....Liu Y. (2011)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Functional analysis of an Orc6 mutant in Drosophila. (PubMed id 19541634)1, 9 Balasov M....Chesnokov I. (2009)
    9. Orc6 involved in DNA replication, chromosome segregation, and cytokinesis. (PubMed id 12169736)1, 9 Prasanth S.G....Stillman B. (2002)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23594 HGNC: 17151 AceView: ORC6L Ensembl:ENSG00000091651 euGenes: HUgn23594
    ECgene: ORC6 Kegg: 23594 H-InvDB: ORC6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ORC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ORC6 gene:
    Search GeneIP for patents involving ORC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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