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Aliases for ORC6 Gene

Aliases for ORC6 Gene

  • Origin Recognition Complex Subunit 6 2 3 5
  • ORC6L 3 4
  • Origin Recognition Complex, Subunit 6 Homolog-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 6 Like (Yeast) 2
  • Origin Recognition Complex, Subunit 6 2

External Ids for ORC6 Gene

Previous HGNC Symbols for ORC6 Gene

  • ORC6L

Previous GeneCards Identifiers for ORC6 Gene

  • GC16P046724

Summaries for ORC6 Gene

Entrez Gene Summary for ORC6 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

GeneCards Summary for ORC6 Gene

ORC6 (Origin Recognition Complex Subunit 6) is a Protein Coding gene. Diseases associated with ORC6 include meier-gorlin syndrome 3 and alazami syndrome. Among its related pathways are Cell Cycle, Mitotic and Cell cycle.

UniProtKB/Swiss-Prot for ORC6 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene Wiki entry for ORC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORC6 Gene

Genomics for ORC6 Gene

Regulatory Elements for ORC6 Gene

Promoters for ORC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ORC6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ORC6 Gene

Chromosome:
16
Start:
46,689,643 bp from pter
End:
46,698,394 bp from pter
Size:
8,752 bases
Orientation:
Plus strand

Genomic View for ORC6 Gene

Genes around ORC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC6 Gene

Proteins for ORC6 Gene

  • Protein details for ORC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5N6-ORC6_HUMAN
    Recommended name:
    Origin recognition complex subunit 6
    Protein Accession:
    Q9Y5N6
    Secondary Accessions:
    • B3KN89

    Protein attributes for ORC6 Gene

    Size:
    252 amino acids
    Molecular mass:
    28107 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity).

    Three dimensional structures from OCA and Proteopedia for ORC6 Gene

neXtProt entry for ORC6 Gene

Proteomics data for ORC6 Gene at MOPED

Post-translational modifications for ORC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ORC6 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ORC6 (ORC6L)

No data available for DME Specific Peptides for ORC6 Gene

Domains & Families for ORC6 Gene

Gene Families for ORC6 Gene

Protein Domains for ORC6 Gene

Suggested Antigen Peptide Sequences for ORC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5N6

UniProtKB/Swiss-Prot:

ORC6_HUMAN :
  • Belongs to the ORC6 family.
Family:
  • Belongs to the ORC6 family.
genes like me logo Genes that share domains with ORC6: view

Function for ORC6 Gene

Molecular function for ORC6 Gene

UniProtKB/Swiss-Prot Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Phenotypes for ORC6 Gene

genes like me logo Genes that share phenotypes with ORC6: view

Human Phenotype Ontology for ORC6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ORC6 Gene

Localization for ORC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORC6 Gene COMPARTMENTS Subcellular localization image for ORC6 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ORC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005664 nuclear origin of replication recognition complex IEA --
GO:0015629 actin cytoskeleton IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ORC6: view

Pathways & Interactions for ORC6 Gene

genes like me logo Genes that share pathways with ORC6: view

Pathways by source for ORC6 Gene

1 GeneGo (Thomson Reuters) pathway for ORC6 Gene
1 Qiagen pathway for ORC6 Gene

Gene Ontology (GO) - Biological Process for ORC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with ORC6: view

No data available for SIGNOR curated interactions for ORC6 Gene

Drugs & Compounds for ORC6 Gene

No Compound Related Data Available

Transcripts for ORC6 Gene

Unigene Clusters for ORC6 Gene

Origin recognition complex, subunit 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORC6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ORC6 Gene

GeneLoc Exon Structure for
ORC6
ECgene alternative splicing isoforms for
ORC6

Expression for ORC6 Gene

mRNA expression in normal human tissues for ORC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORC6 Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for ORC6 Gene

This gene is overexpressed in Testis (29.5), Fetal ovary (27.3), and Ovary (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORC6 Gene



SOURCE GeneReport for Unigene cluster for ORC6 Gene Hs.49760

genes like me logo Genes that share expression patterns with ORC6: view

Protein tissue co-expression partners for ORC6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ORC6 Gene

Orthologs for ORC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORC6 36
  • 99 (a)
OneToOne
ORC6 35
  • 99.74 (n)
  • 99.21 (a)
cow
(Bos Taurus)
Mammalia ORC6 36
  • 85 (a)
OneToOne
ORC6 35
  • 87.57 (n)
  • 84.92 (a)
dog
(Canis familiaris)
Mammalia ORC6 35
  • 86.24 (n)
  • 84.13 (a)
ORC6 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Orc6 36
  • 75 (a)
OneToOne
Orc6 16
Orc6 35
  • 82.07 (n)
  • 77.69 (a)
oppossum
(Monodelphis domestica)
Mammalia ORC6 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORC6 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Orc6 35
  • 79.55 (n)
  • 74.1 (a)
chicken
(Gallus gallus)
Aves ORC6 35
  • 64.08 (n)
  • 57.14 (a)
ORC6 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ORC6 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8017 35
tropical clawed frog
(Silurana tropicalis)
Amphibia orc6 35
  • 62.92 (n)
  • 60.24 (a)
Str.6097 35
zebrafish
(Danio rerio)
Actinopterygii orc6 36
  • 52 (a)
OneToOne
orc6 35
  • 60.63 (n)
  • 54.73 (a)
wufc22h10 35
fruit fly
(Drosophila melanogaster)
Insecta Orc6 36
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ORC6 35
  • 47.49 (n)
  • 33.33 (a)
rice
(Oryza sativa)
Liliopsida Os07g0628600 35
  • 48.05 (n)
  • 31.6 (a)
Species with no ortholog for ORC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORC6 Gene

ENSEMBL:
Gene Tree for ORC6 (if available)
TreeFam:
Gene Tree for ORC6 (if available)

Paralogs for ORC6 Gene

No data available for Paralogs for ORC6 Gene

Variants for ORC6 Gene

Sequence variations from dbSNP and Humsavar for ORC6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_029283 -
rs3218745 - 46,693,146(+) CAGGC(A/C)ACTTT nc-transcript-variant, reference, missense
VAR_065487 Meier-Gorlin syndrome 3 (MGORS3)
rs39710 -- 46,694,004(-) aggcc(A/G)caggg intron-variant
rs41187 -- 46,695,040(-) CACTG(G/T)TTTCT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ORC6 Gene

Variant ID Type Subtype PubMed ID
nsv526656 CNV Gain 19592680

Variation tolerance for ORC6 Gene

Residual Variation Intolerance Score: 37.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORC6 Gene

HapMap Linkage Disequilibrium report
ORC6
Human Gene Mutation Database (HGMD)
ORC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC6 Gene

Disorders for ORC6 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ORC6 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
meier-gorlin syndrome 3
  • mgors3
alazami syndrome
  • alazs
microcephaly, short stature, and impaired glucose metabolism
  • microcephaly, short stature, and impaired glucose metabolism 1
meier-gorlin syndrome 1
  • meier-gorlin syndrome
acid-labile subunit, deficiency of
  • acid-labile subunit deficiency
- elite association - COSMIC cancer census association via MalaCards
Search ORC6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ORC6_HUMAN
  • Meier-Gorlin syndrome 3 (MGORS3) [MIM:613803]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269 PubMed:21358632}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ORC6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORC6
genes like me logo Genes that share disorders with ORC6: view

No data available for Genatlas for ORC6 Gene

Publications for ORC6 Gene

  1. Identification and characterization of the human ORC6 homolog. (PMID: 10945994) Dhar S.K. … Dutta A. (J. Biol. Chem. 2000) 2 3 23 67
  2. Functional analysis of an Orc6 mutant in Drosophila. (PMID: 19541634) Balasov M. … Chesnokov I. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. ATP-dependent assembly of the human origin recognition complex. (PMID: 17716973) Siddiqui K. … Stillman B. (J. Biol. Chem. 2007) 3 23
  4. Orc6 involved in DNA replication, chromosome segregation, and cytokinesis. (PMID: 12169736) Prasanth S.G. … Stillman B. (Science 2002) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ORC6 Gene

Sources for ORC6 Gene

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