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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ORC6 Gene

protein-coding GIFtS: 57
GCID: GC16P046724

origin recognition complex, subunit 6

(Previous names: origin recognition complex, subunit 6 homolog-like (yeast),...)
(Previous symbol: ORC6L)

Explore 7 diseases affiliated with
ORC6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Origin Recognition Complex, Subunit 6¹ ²
ORC6L¹ ² ³ ⁵
Origin Recognition Complex, Subunit 6 Homolog-Like (Yeast)¹
Origin Recognition Complex, Subunit 6 Like (Yeast)¹
Origin Recognition Complex Subunit 6²

External Ids:	HGNC: 17151¹	Entrez Gene: 23594²	Ensembl: ENSG00000091651⁷	OMIM: 607213⁵	UniProtKB: Q9Y5N6³

ORGUL members:
	NONCODE:n410474

Export aliases for ORC6 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ORC6:

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of

the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of

replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.

The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA

demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with

cytokinesis. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: ORC6_HUMAN, Q9Y5N6

Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is

ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC

is required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Wiki entry for ORC6 (ORC6L)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ORC6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ORC6 promoter sequence

Search SABiosciences Chromatin IP Primers for ORC6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORC6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12 Ensembl cytogenetic band: 16q11.2 HGNC cytogenetic band: 16q12

ORC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORC6 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P046724: view genomic region (about GC identifiers)

Start:	46,723,555 bp from pter	End:	46,732,306 bp from pter
Size:	8,752 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ORC6_HUMAN, Q9Y5N6 (See protein sequence)

Recommended Name: Origin recognition complex subunit 6

Size: 252 amino acids; 28107 Da

Subunit: ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled

at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity)

Subcellular location: Nucleus

1 PDB 3D structure from and Proteopedia for ORC6:

3M03 (3D)

Secondary accessions: B3KN89

Explore the universe of human proteins at neXtProt for ORC6: NX_Q9Y5N6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y5N6

ORC6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055136.1

ENSEMBL proteins:

ENSP00000454299 ENSP00000219097 ENSP00000457282 ENSP00000456981

Reactome Protein details: Q9Y5N6
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals ORC6 Protein Novus Biologicals ORC6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ORC6

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000808	origin recognition complex	IDA	17716973
GO:0005654	nucleoplasm	TAS	--
GO:0005664	nuclear origin of replication recognition complex	IEA	--

ORC6 for ontologies About GeneDecksing

ORC6 Antibody Products:

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	GenScript Custom Superior Antibodies Services for ORC6
	Novus Biologicals ORC6 Antibodies
	Search for Antibodies for ORC6 at Abcam
	Uscn Antibodies for ORC6
	ThermoFisher Antibody for ORC6

Assay Products for ORC6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ORC6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ORC6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ORC6 for domains About GeneDecksing

2 InterPro domains/families:

IPR020529 ORC6_met/pln

IPR008721 ORC6

Graphical View of Domain Structure for InterPro Entry Q9Y5N6

ProtoNet protein and cluster: Q9Y5N6

1 Blocks protein family: IPB008721 Origin recognition complex subunit 6

UniProtKB/Swiss-Prot: ORC6_HUMAN, Q9Y5N6

Similarity: Belongs to the ORC6 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ORC6_HUMAN, Q9Y5N6

Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is

ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC

is required to assemble the pre-replication complex necessary to initiate DNA replication

miRNA Products:		OriGene 3'-UTR Clone: ORC6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORC6
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ORC6:
		hsa-miR-548p hsa-miR-4318 hsa-miR-3143
		SwitchGear 3'UTR luciferase reporter plasmid: ORC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ORC6 (see all 4) OriGene shRNA RFP: ORC6 OriGene siRNA: ORC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORC6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ORC6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ORC6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ORC6 (NM_014321)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ORC6
		Search LifeMap BioReagents cell lines for ORC6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC6

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	17716973

ORC6 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ORC6:

Upregulation of Wnt/beta-caten

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/12 pathways (see all 12)
CDT1 association with the CDC6:ORC:origin complex	0.84	DNA Replication Pre-Initiation	0.62
Assembly of the pre-replicative complex	0.77	M/G1 Transition	0.62
Switching of origins to a post-replicative state	0.70	Synthesis of DNA	0.51
Orc1 removal from chromatin	0.70	DNA Replication	0.49

CDC6 association with the ORC:origin complex

	CDC6 association with the ORC:origin complex	1.00			E2F-enabled inhibition of pre-replication complex formation	0.64
	Assembly of the ORC complex at the origin of replication	0.75

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ORC6

	Meiosis
	Cell cycle Start of DNA replication in early S phase

1 Cell Signaling Technology (CST) Pathway for ORC6

Cell Cycle / Checkpoint Control

1 GeneGo (Thomson Reuters) Pathway for ORC6

Cell cycle Start of DNA replication in early S phase

3 BioSystems Pathways for ORC6

	G1 to S cell cycle control
	Cell cycle
	DNA Replication

5/24 Reactome Pathways for ORC6 (see all 24)

	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	DNA Replication
	E2F-enabled inhibition of pre-replication complex formation
	Removal of licensing factors from origins

1 Kegg Pathway (Kegg details for ORC6):

Cell cycle

ORC6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ORC6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/51 Interacting proteins for ORC6 (Q9Y5N6^{1, 2, 3} ENSP00000219097⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC7	O00311²^,³, ENSP00000234626⁴	MINT-50410 I2D: score=6 STRING: ENSP00000234626
ORC3	Q9UBD5¹^,³, ENSP00000257789⁴	EBI-374840,EBI-374916 I2D: score=5 STRING: ENSP00000257789
ORC4	O43929³, ENSP00000264169⁴	I2D: score=5 STRING: ENSP00000264169
MCM4	P33991³, ENSP00000262105⁴	I2D: score=4 STRING: ENSP00000262105
CDC6	Q99741³, ENSP00000209728⁴	I2D: score=3 STRING: ENSP00000209728

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

ORC6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ORC6
Search CenterWatch for drugs/clinical trials and news about ORC6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ORC6 gene:

NM_014321.3

Unigene Cluster for ORC6:

Origin recognition complex, subunit 6

Hs.49760 [show with all ESTs]

Unigene Representative Sequence: NR_037620

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000563599 ENST00000219097(uc002eeh.3 uc021thp.1) ENST00000569239(uc002eeg.1)

ENST00000563306(uc010cbe.2) ENST00000568364 ENST00000570260 ENST00000566860

ENST00000575571 ENST00000567000

miRNA Products:		OriGene 3'-UTR Clone: ORC6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORC6
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ORC6:
		hsa-miR-548p hsa-miR-4318 hsa-miR-3143
		SwitchGear 3'UTR luciferase reporter plasmid: ORC6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ORC6 (see all 4) OriGene shRNA RFP: ORC6 OriGene siRNA: ORC6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORC6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ORC6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ORC6 (NM_014321)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORC6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ORC6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ORC6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORC6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORC6

Additional cDNA sequence:

AF139658.1 AK021946.1 AK024019.1 BC039032.1 BC050725.1 BC063565.1 NR_037620.1

13 DOTS entries:

DT.91755690 DT.102836317 DT.456058 DT.95284323 DT.120665379 DT.100023075 DT.100796529 DT.120665407

DT.97855458 DT.100689297 DT.100881303 DT.120665429 DT.91755686

24/122 AceView cDNA sequences (see all 122):

BM764335 BE793867 BC050725 BU509667 AI203373 BF223498 BF305653 BM912280

BQ954972 BM787326 BU147234 T83154 AL514678 BQ064129 BQ065829 NM_014321

CR604421 BM479936 BE549396 BM914889 BG112807 CR619046 H83116 BC063565

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ORC6 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b
SP1:											-								-		-		-
SP2:											-								-
SP3:											-								-		-		-		-
SP4:																			-		-		-
SP5:											-

ECgene alternative splicing isoforms for ORC6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ORC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ORC6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ORC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ORC6

SOURCE GeneReport for Unigene cluster: Hs.49760

SABiosciences Custom PCR Arrays for ORC6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ORC6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORC6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC6 gene from 8/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Orc6^{1 , 5}	origin recognition complex, subunit 6^{1, 5}	82.07(n)¹ 77.69(a)¹		8 (41.61 cM)⁵ 56452¹ NM_019716.2¹ NP_062690.2¹ 85299632⁵
chicken (Gallus gallus)	Aves	ORC6¹	origin recognition complex, subunit 6	64.08(n) 56.73(a)		415749 XM_414114.2 XP_414114.2
lizard (Anolis carolinensis)	Reptilia	ORC6⁶	--	57(a)	1 ↔ 1	LGc(3588470-3598042)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8017²	Xenopus laevis transcribed sequence with weak similarity more	74.99(n)		CA983315.1
zebrafish (Danio rerio)	Actinopterygii	wufc22h10²	Danio rerio cDNA clone MGC65798 IMAGE6791676, complete more	76.69(n)		BC056528.1
fruit fly (Drosophila melanogaster)	Insecta	Orc6¹	Origin recognition complex subunit 6	43.79(n) 29.24(a)		36017 NM_057971.5 NP_477319.1
thale cress (Arabidopsis thaliana)	eudicotyledons	ORC6¹	origin recognition complex subunit 6	47.49(n) 33.33(a)		839227 NM_102448.3 NP_174006.2
rice (Oryza sativa)	Liliopsida	Os07g0628600¹	hypothetical protein	47.21(n) 30.47(a)		4343985 NM_001066886.1 NP_001060351.1

ENSEMBL Gene Tree for ORC6 (if available)
TreeFam Gene Tree for ORC6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74320950^1,2	C,	--	32610945(+)	`ACACAG/ATGCAG`	1	--	int¹		2		NA	122
rs182309233^1,2	F	--	32611838(+)	`AAGCAG/ACACCC`	1	--	ut5¹		2		EU	3754
rs72816873^1,2	C,F,	--	32612134(+)	`TGTCAA/CGAAGG`	1	--	us2k¹		1		NA	120
rs9933097^1,2	C,H	--	32612232(+)	`CCTGAT/ATGGTT`	1	--	us2k¹ tfbs³		4		NS EA	418
rs79904644^1,2		--	32612286(+)	`CCGGGC/GGTGGG`	1	--	us2k¹		0	--	--	--	--
rs67506574^1,2	C,	--	32612758(+)	`ATAGCG/TGGGAA`	1	--	us2k¹		3		WA NA	240
rs3218744^1,2	C,F,H	--	32613695(+)	`TGTCCC/TGGGTG`	1	--	us2k¹ ese³		10		NA NS EA	1010
rs77925976^1,2	C,	--	32618957(+)	`AAAAAA/CAAAAT`	3	K N	mis¹		0	--	--	--	--
rs75541543^1,2		--	32621828(+)	`TACAGC/GAAAAA`	2	--	ds500¹		0	--	--	--	--
rs114341620^1,2	F,	--	46721635(+)	`TGGAAT/ATTTAG`	3	--	us2k¹ int¹		1		WA	118

HapMap Linkage Disequilibrium report for ORC6 (46723555 - 46732306 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ORC6: --
Human Gene Mutation Database (HGMD): ORC6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ORC6

DNA2.0 Custom Variant and Variant Library Synthesis for ORC6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ORC6 for disorders About GeneDecksing

OMIM gene information: 607213 OMIM disorders: --

UniProtKB/Swiss-Prot: ORC6_HUMAN, Q9Y5N6

Defects in ORC6 are the cause of Meier-Gorlin syndrome type 3 (MGORS3) [MIM:613803]. MGORS3 is a syndrome

characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth

retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial

sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate,

micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial

dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and

absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal

7 diseases for ORC6: About MalaCards

meier-gorlin syndrome intrauterine and postnatal growth retardation short stature microtia

dwarfism microcephaly colon cancer

Export disorders for ORC6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ORC6 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with ORC6)

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Identification and characterization of the human ORC6 homolog. (PubMed id 10945994)^{1, 3, 9} Dhar S.K. and Dutta A. (2000)
ATP-dependent assembly of the human origin recognition complex. (PubMed id 17716973)^{1, 2, 9} Siddiqui K. and Stillman B. (2007)
Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PubMed id 21358632)^{1, 2} Bicknell L.S....Jackson A.P. (2011)
Structural analysis of human Orc6 protein reveals a h omology with transcription factor TFIIB. (PubMed id 21502537)^{1, 2} Liu S....Liu Y. (2011)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Functional analysis of an Orc6 mutant in Drosophila. (PubMed id 19541634)^{1, 9} Balasov M....Chesnokov I. (2009)
Orc6 involved in DNA replication, chromosome segregation, and cytokinesis. (PubMed id 12169736)^{1, 9} Prasanth S.G....Stillman B. (2002)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23594	HGNC: 17151	AceView: ORC6L	Ensembl:ENSG00000091651	euGenes: HUgn23594
ECgene: ORC6	Kegg: 23594	H-InvDB: ORC6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ORC6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ORC6 gene
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Patent Information for ORC6 gene:
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origin recognition complex, subunit 6

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origin recognition complex, subunit 6

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