Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ORC5 Gene

Aliases for ORC5 Gene

  • Origin Recognition Complex Subunit 5 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 117 2 3
  • ORC5L 3 4
  • Origin Recognition Complex, Subunit 5 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 5 Homolog (Yeast) 2
  • Origin Recognition Complex, Subunit 5-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 5 2
  • PPP1R117 3
  • ORC5P 3
  • ORC5T 3

External Ids for ORC5 Gene

Previous HGNC Symbols for ORC5 Gene

  • ORC5L

Previous GeneCards Identifiers for ORC5 Gene

  • GC07M103767

Summaries for ORC5 Gene

Entrez Gene Summary for ORC5 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]

GeneCards Summary for ORC5 Gene

ORC5 (Origin Recognition Complex Subunit 5) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and E2F mediated regulation of DNA replication. GO annotations related to this gene include nucleotide binding and DNA replication origin binding.

UniProtKB/Swiss-Prot for ORC5 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Gene Wiki entry for ORC5 Gene

Additional gene information for ORC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORC5 Gene

Genomics for ORC5 Gene

Regulatory Elements for ORC5 Gene

Enhancers for ORC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H104940 1.8 FANTOM5 ENCODE dbSUPER 37.1 -735.6 -735600 6.5 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 SLC30A9 ZNF766 ORC5 RINT1 LINC01004 ATXN7L1 KMT2E RNU6-1322P KMT2E-AS1 LOC101927902 SRPK2 GC07P104968
GH07H105005 1.7 Ensembl ENCODE dbSUPER 32.6 -804.3 -804257 12.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 MEF2D KMT2E ATXN7L1 RINT1 ORC5 EIF4BP6 PUS7 KMT2E-AS1 RPL36P12 YBX1P2 LINC01004
GH07H104882 1.4 Ensembl ENCODE 30.6 -676.2 -676162 2.7 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ORC5 KMT2E LINC01004 ATXN7L1 RINT1 PUS7 KMT2E-AS1 ENSG00000272604 RN7SL8P GC07M104825
GH07H104931 1.4 Ensembl ENCODE dbSUPER 19.6 -725.0 -725048 4.1 HDGF NFRKB ZSCAN4 KLF17 ZNF195 YBX1 FEZF1 ZNF121 SCRT2 ZNF207 KMT2E EIF4BP6 LINC01004 ORC5 ENSG00000272604 RINT1 ENSG00000272918 KMT2E-AS1 ATXN7L1 LHFPL3-AS2
GH07H103809 1 ENCODE 20.7 +397.7 397656 1.2 HDGF PKNOX1 FOXA2 ATF1 MLX ARNT YY1 TCF12 ZNF766 GATA2 CRYZP1 DNAJC2 ORC5 PMPCB GC07P103723 RELN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ORC5 on UCSC Golden Path with GeneCards custom track

Promoters for ORC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216233 247 2001 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CBX5 ZNF143

Genomic Locations for ORC5 Gene

Genomic Locations for ORC5 Gene
chr7:104,126,341-104,208,047
(GRCh38/hg38)
Size:
81,707 bases
Orientation:
Minus strand
chr7:103,766,788-103,848,495
(GRCh37/hg19)

Genomic View for ORC5 Gene

Genes around ORC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC5 Gene

Proteins for ORC5 Gene

  • Protein details for ORC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43913-ORC5_HUMAN
    Recommended name:
    Origin recognition complex subunit 5
    Protein Accession:
    O43913
    Secondary Accessions:
    • A4D0P8
    • O60590
    • O95268

    Protein attributes for ORC5 Gene

    Size:
    435 amino acids
    Molecular mass:
    50283 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.

    Three dimensional structures from OCA and Proteopedia for ORC5 Gene

    Alternative splice isoforms for ORC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ORC5 Gene

Post-translational modifications for ORC5 Gene

  • Ubiquitination at posLast=107107 and posLast=263263
  • Modification sites at PhosphoSitePlus

Other Protein References for ORC5 Gene

No data available for DME Specific Peptides for ORC5 Gene

Domains & Families for ORC5 Gene

Gene Families for ORC5 Gene

Protein Domains for ORC5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43913

UniProtKB/Swiss-Prot:

ORC5_HUMAN :
  • Belongs to the ORC5 family.
Family:
  • Belongs to the ORC5 family.
genes like me logo Genes that share domains with ORC5: view

Function for ORC5 Gene

Molecular function for ORC5 Gene

UniProtKB/Swiss-Prot Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Phenotypes From GWAS Catalog for ORC5 Gene

Gene Ontology (GO) - Molecular Function for ORC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 9765232
GO:0003674 molecular_function ND --
GO:0003688 DNA replication origin binding TAS 9765232
GO:0005515 protein binding IPI 15232106
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ORC5: view
genes like me logo Genes that share phenotypes with ORC5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORC5 Gene

Localization for ORC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORC5 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ORC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000808 origin recognition complex IEA,IDA 17716973
GO:0005634 nucleus IEA,NAS 9765232
GO:0005654 nucleoplasm TAS --
GO:0005664 nuclear origin of replication recognition complex NAS 9765232
genes like me logo Genes that share ontologies with ORC5: view

Pathways & Interactions for ORC5 Gene

genes like me logo Genes that share pathways with ORC5: view

Gene Ontology (GO) - Biological Process for ORC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS,IEA --
GO:0006270 DNA replication initiation TAS 9765232
genes like me logo Genes that share ontologies with ORC5: view

No data available for SIGNOR curated interactions for ORC5 Gene

Drugs & Compounds for ORC5 Gene

No Compound Related Data Available

Transcripts for ORC5 Gene

Unigene Clusters for ORC5 Gene

Origin recognition complex, subunit 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORC5 Gene

No ASD Table

Relevant External Links for ORC5 Gene

GeneLoc Exon Structure for
ORC5
ECgene alternative splicing isoforms for
ORC5

Expression for ORC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ORC5 Gene

This gene is overexpressed in Bone (37.4) and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ORC5 Gene



NURSA nuclear receptor signaling pathways regulating expression of ORC5 Gene:

ORC5

SOURCE GeneReport for Unigene cluster for ORC5 Gene:

Hs.432948

mRNA Expression by UniProt/SwissProt for ORC5 Gene:

O43913-ORC5_HUMAN
Tissue specificity: Abundant in spleen, ovary, prostate, testis, and colon mucosa.
genes like me logo Genes that share expression patterns with ORC5: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORC5 Gene

Orthologs for ORC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORC5 33 34
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia ORC5L 34
  • 96 (a)
OneToOne
ORC5 33
  • 92.95 (n)
dog
(Canis familiaris)
Mammalia ORC5 34 33
  • 94.18 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORC5 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Orc5 33 16 34
  • 88.97 (n)
oppossum
(Monodelphis domestica)
Mammalia ORC5 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Orc5 33
  • 87.59 (n)
chicken
(Gallus gallus)
Aves ORC5 33 34
  • 79.07 (n)
lizard
(Anolis carolinensis)
Reptilia ORC5 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia orc5 33
  • 71.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19639 33
zebrafish
(Danio rerio)
Actinopterygii orc5 33 34
  • 64.37 (n)
wufb62d08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3282 33
fruit fly
(Drosophila melanogaster)
Insecta Orc5 33 34
  • 47.05 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000978 33
  • 43.57 (n)
worm
(Caenorhabditis elegans)
Secernentea orc-5 34
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORC5 34 36
  • 20 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ORC5 33
  • 44.88 (n)
rice
(Oryza sativa)
Liliopsida Os03g0759500 33
  • 41.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes orc5 33
  • 43.97 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05433 33
  • 40.13 (n)
Species where no ortholog for ORC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ORC5 Gene

ENSEMBL:
Gene Tree for ORC5 (if available)
TreeFam:
Gene Tree for ORC5 (if available)

Paralogs for ORC5 Gene

(1) SIMAP similar genes for ORC5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ORC5: view

No data available for Paralogs for ORC5 Gene

Variants for ORC5 Gene

Sequence variations from dbSNP and Humsavar for ORC5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000006848 -- 104,169,205(+) AATCC(C/T)TCAAA intron-variant
rs1000064003 -- 104,186,487(+) AGTAT(C/T)ATAAG intron-variant, utr-variant-3-prime
rs1000065192 -- 104,205,614(+) AAGCA(C/G)CTCAA intron-variant
rs1000075161 -- 104,163,573(+) GCTAC(A/G)CCTCC intron-variant
rs1000113277 -- 104,163,588(+) TTCAC(A/G)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ORC5 Gene

Variant ID Type Subtype PubMed ID
nsv608065 CNV gain 21841781
nsv527105 CNV loss 19592680
nsv526062 CNV gain 19592680
nsv507406 OTHER sequence alteration 20534489
esv3891172 CNV gain 25118596
esv3614387 CNV loss 21293372
esv3614386 CNV gain 21293372
esv3542206 CNV deletion 23714750
esv3429813 CNV insertion 20981092
esv3385126 CNV insertion 20981092
esv3304800 CNV mobile element insertion 20981092
esv28909 CNV loss 19812545
esv2762692 CNV gain 21179565
dgv6544n100 CNV gain 25217958
dgv1231e199 CNV deletion 23128226

Variation tolerance for ORC5 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC5 Gene

Disorders for ORC5 Gene

Relevant External Links for ORC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORC5

No disorders were found for ORC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORC5 Gene

Publications for ORC5 Gene

  1. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. (PMID: 9829972) Tugal T … Stillman B (The Journal of biological chemistry 1998) 2 3 4 22 60
  2. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. (PMID: 9417919) Ishiai M … Eki T (Genomics 1997) 2 3 4 22 60
  3. ATP-dependent assembly of the human origin recognition complex. (PMID: 17716973) Siddiqui K … Stillman B (The Journal of biological chemistry 2007) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60

Products for ORC5 Gene

Sources for ORC5 Gene

Content
Loading form....