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Aliases for ORC5 Gene

Aliases for ORC5 Gene

  • Origin Recognition Complex, Subunit 5 2 3
  • ORC5L 3 4 6
  • Origin Recognition Complex, Subunit 5 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 5 Homolog (Yeast) 2
  • Origin Recognition Complex, Subunit 5-Like (Yeast) 2
  • Protein Phosphatase 1, Regulatory Subunit 117 3
  • Origin Recognition Complex Subunit 5 3
  • Regulatory Subunit 117 2
  • Protein Phosphatase 1 2
  • PPP1R117 3
  • ORC5P 3
  • ORC5T 3

External Ids for ORC5 Gene

Previous HGNC Symbols for ORC5 Gene

  • ORC5L

Previous GeneCards Identifiers for ORC5 Gene

  • GC07M103767

Summaries for ORC5 Gene

Entrez Gene Summary for ORC5 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]

GeneCards Summary for ORC5 Gene

ORC5 (Origin Recognition Complex, Subunit 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include nucleotide binding and DNA replication origin binding.

UniProtKB/Swiss-Prot for ORC5 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Wiki entry for ORC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORC5 Gene

Genomics for ORC5 Gene

Genomic Location for ORC5 Gene

Start:
104,126,341 bp from pter
End:
104,208,047 bp from pter
Size:
81,707 bases
Orientation:
Minus strand

Genomic View for ORC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC5 Gene

No data available for Regulatory Elements for ORC5 Gene

Proteins for ORC5 Gene

  • Protein details for ORC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43913-ORC5_HUMAN
    Recommended name:
    Origin recognition complex subunit 5
    Protein Accession:
    O43913
    Secondary Accessions:
    • A4D0P8
    • O60590
    • O95268

    Protein attributes for ORC5 Gene

    Size:
    435 amino acids
    Molecular mass:
    50283 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.

    Alternative splice isoforms for ORC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ORC5 Gene

Proteomics data for ORC5 Gene at MOPED

Post-translational modifications for ORC5 Gene

  • Ubiquitination at Lys107 and Lys263
  • Modification sites at PhosphoSitePlus

Other Protein References for ORC5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ORC5 Gene

Domains for ORC5 Gene

Protein Domains for ORC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ORC5 Gene

Graphical View of Domain Structure for InterPro Entry

O43913

UniProtKB/Swiss-Prot:

ORC5_HUMAN :
  • O43913
Family:
  • Belongs to the ORC5 family.
genes like me logo Genes that share domains with ORC5: view

No data available for Gene Families for ORC5 Gene

Function for ORC5 Gene

Molecular function for ORC5 Gene

UniProtKB/Swiss-Prot Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Ontology (GO) - Molecular Function for ORC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 9765232
GO:0003674 molecular_function ND --
GO:0003688 DNA replication origin binding TAS 9765232
GO:0005515 protein binding IPI 15232106
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ORC5: view

Phenotypes for ORC5 Gene

genes like me logo Genes that share phenotypes with ORC5: view

Animal Model Products

CRISPR Products

miRNA for ORC5 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ORC5 Gene

Localization for ORC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC5 Gene

Gene Ontology (GO) - Cellular Components for ORC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000808 origin recognition complex IDA 17716973
GO:0005634 nucleus NAS 9765232
GO:0005654 nucleoplasm TAS --
GO:0005664 nuclear origin of replication recognition complex NAS 9765232
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with ORC5: view

No data available for Subcellular locations from COMPARTMENTS for ORC5 Gene

Pathways for ORC5 Gene

genes like me logo Genes that share pathways with ORC5: view

Pathways by source for ORC5 Gene

1 KEGG pathway for ORC5 Gene
1 GeneGo (Thomson Reuters) pathway for ORC5 Gene

Gene Ontology (GO) - Biological Process for ORC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006270 DNA replication initiation TAS 9765232
genes like me logo Genes that share ontologies with ORC5: view

Transcripts for ORC5 Gene

Unigene Clusters for ORC5 Gene

Origin recognition complex, subunit 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ORC5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORC5 Gene

No ASD Table

Relevant External Links for ORC5 Gene

GeneLoc Exon Structure for
ORC5
ECgene alternative splicing isoforms for
ORC5

Expression for ORC5 Gene

mRNA expression in normal human tissues for ORC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORC5 Gene

SOURCE GeneReport for Unigene cluster for ORC5 Gene Hs.432948

mRNA Expression by UniProt/SwissProt for ORC5 Gene

O43913-ORC5_HUMAN
Tissue specificity: Abundant in spleen, ovary, prostate, testis, and colon mucosa.
genes like me logo Genes that share expressions with ORC5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ORC5 Gene

Orthologs for ORC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORC5 35
  • 99.85 (n)
  • 100 (a)
ORC5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ORC5 35
  • 92.95 (n)
  • 95.86 (a)
ORC5L 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ORC5 35
  • 94.18 (n)
  • 96.32 (a)
ORC5 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Orc5 35
  • 88.97 (n)
  • 93.79 (a)
Orc5 16
Orc5 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ORC5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORC5 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Orc5 35
  • 87.59 (n)
  • 92.64 (a)
chicken
(Gallus gallus)
Aves ORC5 35
  • 79.07 (n)
  • 82.79 (a)
ORC5 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ORC5 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19639 35
tropical clawed frog
(Silurana tropicalis)
Amphibia orc5 35
  • 71.89 (n)
  • 77.42 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3282 35
zebrafish
(Danio rerio)
Actinopterygii orc5 35
  • 64.37 (n)
  • 68.41 (a)
orc5 36
  • 65 (a)
OneToOne
wufb62d08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000978 35
  • 43.57 (n)
  • 37.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Orc5 35
  • 47.05 (n)
  • 39.23 (a)
Orc5 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea orc-5 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORC5 36
  • 20 (a)
OneToOne
ORC5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ORC5 35
  • 44.88 (n)
  • 32.19 (a)
rice
(Oryza sativa)
Liliopsida Os03g0759500 35
  • 41.46 (n)
  • 28.93 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05433 35
  • 40.13 (n)
  • 29.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes orc5 35
  • 43.97 (n)
  • 30.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for ORC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ORC5 Gene

ENSEMBL:
Gene Tree for ORC5 (if available)
TreeFam:
Gene Tree for ORC5 (if available)

Paralogs for ORC5 Gene

Selected SIMAP similar genes for ORC5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ORC5: view

No data available for Paralogs for ORC5 Gene

Variants for ORC5 Gene

Sequence variations from dbSNP and Humsavar for ORC5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs55848 -- 104,133,088(+) gatca(C/T)ttggg intron-variant
rs113877 -- 104,143,587(-) GATCA(A/G)TCATC intron-variant
rs194838 -- 104,126,071(+) CAAAG(C/T)TCACA downstream-variant-500B
rs194839 -- 104,128,603(+) TGTGC(C/T)ATGCT intron-variant
rs194840 -- 104,128,775(+) ACCAC(A/G)GACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ORC5 Gene

Variant ID Type Subtype PubMed ID
dgv1231e199 CNV Deletion 23128226
esv28909 CNV Loss 19812545
nsv507406 CNV Insertion 20534489
nsv526062 CNV Gain 19592680
nsv527105 CNV Loss 19592680
esv269078 CNV Insertion 20981092

Relevant External Links for ORC5 Gene

HapMap Linkage Disequilibrium report
ORC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC5 Gene

Disorders for ORC5 Gene

No disorders were found for ORC5 Gene.

No data available for UniProtKB/Swiss-Prot for ORC5 Gene

Publications for ORC5 Gene

  1. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. (PMID: 9417919) Ishiai M. … Eki T. (Genomics 1997) 2 3 4 23
  2. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. (PMID: 9829972) Tugal T. … Stillman B. (J. Biol. Chem. 1998) 2 3 4 23
  3. Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22. (PMID: 11379876) FrAPhling S. … DAPhner K. (Hum. Genet. 2001) 3 23
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for ORC5 Gene

Sources for ORC5 Gene

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