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ORC5 Gene

protein-coding   GIFtS: 56
GCID: GC07M103767

Origin Recognition Complex, Subunit 5

(Previous names: origin recognition complex, subunit 5 (yeast homolog)-like,...)
(Previous symbol: ORC5L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Origin Recognition Complex, Subunit 51 2     Origin Recognition Complex, Subunit 5-Like (Yeast)1
ORC5L1 2 3 5     ORC5P2
Origin Recognition Complex, Subunit 5 (Yeast Homolog)-Like1     ORC5T2
Origin Recognition Complex, Subunit 5 Homolog (Yeast)1     Origin Recognition Complex Subunit 52

External Ids:    HGNC: 84911   Entrez Gene: 50012   Ensembl: ENSG000001648157   OMIM: 6023315   UniProtKB: O439133   

Export aliases for ORC5 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ORC5 Gene:
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the
initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically
to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6
and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced
transcript variants encoding distinct isoforms have been described. (provided by RefSeq, Oct 2010)

GeneCards Summary for ORC5 Gene:
ORC5 (origin recognition complex, subunit 5) is a protein-coding gene. Diseases associated with ORC5 include narcolepsy, and leiomyoma. GO annotations related to this gene include DNA replication origin binding and nucleotide binding.

UniProtKB/Swiss-Prot: ORC5_HUMAN, O43913
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is
required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Wiki entry for ORC5 (ORC5L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ORC5
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidORC5 promoter sequence
   Search Chromatin IP Primers for ORC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ORC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.2   HGNC cytogenetic band: 7q22.1

ORC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORC5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M103767:  view genomic region     (about GC identifiers)

Start:
103,766,788 bp from pter      End:
103,848,495 bp from pter
Size:
81,708 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 103,127,226-103,208,947     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ORC5_HUMAN, O43913 (See protein sequence)
Recommended Name: Origin recognition complex subunit 5  
Size: 435 amino acids; 50283 Da
Subunit: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC
is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis
and disassembled as cells enter S phase
Secondary accessions: A4D0P8 O60590 O95268
Alternative splicing: 2 isoforms:  O43913-1   O43913-2   (Does not interact with ORC2)

Explore the universe of human proteins at neXtProt for ORC5: NX_O43913

Explore proteomics data for ORC5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys107, Lys263
  • Modification sites at PhosphoSitePlus

  • See ORC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002544.1  NP_859531.1  

    ENSEMBL proteins: 
     ENSP00000297431   ENSP00000393208   ENSP00000395747   ENSP00000387465   ENSP00000438018  
    Reactome Protein details: O43913

    ORC5 Human Recombinant Protein Products:

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    Novus Biologicals ORC5 Protein
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    Browse Sino Biological Cell Lysates
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR020796 ORC5

    Graphical View of Domain Structure for InterPro Entry O43913

    ProtoNet protein and cluster: O43913

    UniProtKB/Swiss-Prot: ORC5_HUMAN, O43913
    Similarity: Belongs to the ORC5 family


    ORC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORC5_HUMAN, O43913
    Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
    ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is
    required to assemble the pre-replication complex necessary to initiate DNA replication

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS9765232
    GO:0003674molecular_function ND--
    GO:0003688DNA replication origin binding TAS9765232
    GO:0005515protein binding IPI15232106
    GO:0005524ATP binding IEA--
         
    ORC5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ORC5:
     Increased homologous recombina  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ORC5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ORC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ORC5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ORC5:
    hsa-mir-100-5p (MIRT048551), hsa-mir-186-5p (MIRT021090), hsa-mir-92a-3p (MIRT049358), hsa-mir-99a-5p (MIRT048630)

    Block miRNA regulation of human, mouse, rat ORC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ORC5 (see all 19):
    hsa-miR-100* hsa-miR-128 hsa-miR-374a hsa-miR-371-5p hsa-miR-10b* hsa-miR-2115 hsa-miR-508-5p hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidORC5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ORC5
    Predesigned siRNA for gene silencing in human, mouse, rat ORC5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): ORC5 (NM_002553)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC5

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ORC5_HUMAN, O43913: Nucleus

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000808origin recognition complex IDA17716973
    GO:0005634nucleus NAS9765232
    GO:0005654nucleoplasm TAS--
    GO:0005664nuclear origin of replication recognition complex NAS9765232
    GO:0005737cytoplasm IDA--

    ORC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ORC5 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    E2F-enabled inhibition of pre-replication complex formation0.00
    G1 to S cell cycle control0.35
    Assembly of the ORC complex at the origin of replication0.00
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4CDK-mediated phosphorylation and removal of Cdc6
    Switching of origins to a post-replicative state0.93
    Removal of licensing factors from origins0.86
    Orc1 removal from chromatin0.93
    M/G1 Transition0.81
    Regulation of DNA replication0.93
    DNA Replication Pre-Initiation0.81
    Synthesis of DNA0.92
    S Phase0.78
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ORC5
        Cell Cycle Control of Chromosomal Replication

    1 GeneGo (Thomson Reuters) Pathway for ORC5
        Cell cycle Start of DNA replication in early S phase

    3 BioSystems Pathways for ORC5
        Cell cycle
    G1 to S cell cycle control
    DNA Replication

    Selected Reactome Pathways for ORC5 (see all 10)
        Activation of ATR in response to replication stress
    Removal of licensing factors from origins
    E2F-enabled inhibition of pre-replication complex formation
    Orc1 removal from chromatin
    Assembly of the pre-replicative complex


    1 Kegg Pathway  (Kegg details for ORC5):
        Cell cycle


    ORC5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ORC5
    Interactions:

        Search GeneGlobe Interaction Network for ORC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ORC5 (O439131, 2, 3 ENSP000002974314) via UniProtKB, MINT, STRING, and/or I2D (see all 137)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORC1Q134151, 3, ENSP000003606214EBI-374928,EBI-374847 I2D: score=6 STRING: ENSP00000360621
    ORC2Q134161, 3, ENSP000002342964EBI-374928,EBI-374957 I2D: score=6 STRING: ENSP00000234296
    ORC3Q9UBD51, 3, ENSP000002577894EBI-374928,EBI-374916 I2D: score=6 STRING: ENSP00000257789
    CDC45O754192, 3, ENSP000002632014MINT-50390 I2D: score=5 STRING: ENSP00000263201
    ORC4O439291, 3, ENSP000002641694EBI-374928,EBI-374889 I2D: score=5 STRING: ENSP00000264169
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0006270DNA replication initiation TAS9765232

    ORC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ORC5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ORC5 gene (3 alternative transcripts): 
    NM_002553.3  NM_181747.3  NM_001197292.1  

    Unigene Cluster for ORC5:

    Origin recognition complex, subunit 5
    Hs.432948  [show with all ESTs]
    Unigene Representative Sequence: NM_002553
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297431(uc003vcb.3) ENST00000422497 ENST00000477223 ENST00000447452(uc003vcc.3)
    ENST00000463152 ENST00000485726 ENST00000448563 ENST00000545943(uc011klp.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat ORC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ORC5 (see all 19):
    hsa-miR-100* hsa-miR-128 hsa-miR-374a hsa-miR-371-5p hsa-miR-10b* hsa-miR-2115 hsa-miR-508-5p hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidORC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ORC5
    Predesigned siRNA for gene silencing in human, mouse, rat ORC5
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ORC5 (NM_002553)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC5
    Primer
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    OriGene qPCR primer pairs and template standards for ORC5
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ORC5
      QuantiTect SYBR Green Assays in human, mouse, rat ORC5
      QuantiFast Probe-based Assays in human, mouse, rat ORC5

    Additional mRNA sequence: 

    AF047599.1 AF049127.1 AF081459.1 AK223361.1 AK292285.1 AK313596.1 BC023652.2 U92538.1 

    5 DOTS entries:

    DT.410278  DT.100706216  DT.100781814  DT.100768692  DT.91736566 

    Selected AceView cDNA sequences (see all 86):

    AL039751 CR614443 AI659276 BC023652 NM_181747 U92538 AI952721 BI518836 
    BG575350 NM_002553 AF047599 BU633857 CD108943 AA382652 BU735163 BM456678 
    BU681914 BG107849 BM696647 CR608840 AA976714 AF081459 CD697135 BX419143 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ORC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCTGATG
    ORC5 Expression
    About this image


    ORC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Liver (Hepatobiliary System)
    ORC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ORC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432948

    UniProtKB/Swiss-Prot: ORC5_HUMAN, O43913
    Tissue specificity: Abundant in spleen, ovary, prostate, testis, and colon mucosa

        Custom PCR Arrays for ORC5
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    QuantiFast Probe-based Assays in human, mouse, rat ORC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ORC5 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Orc51 , 5 origin recognition complex, subunit 51, 5 88.97(n)1
    93.79(a)1
      5 (10.07 cM)5
    264291  NM_011959.21  NP_036089.11 
     224864855 
    chicken
    (Gallus gallus)
    Aves ORC51 origin recognition complex, subunit 5 79.07(n)
    82.79(a)
      417714  NM_001030729.1  NP_001025900.1 
    lizard
    (Anolis carolinensis)
    Reptilia ORC56
    origin recognition complex, subunit 5
    74(a)
    1 ↔ 1
    5(95896666-95992984)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.196392 Xenopus laevis transcribed sequence with moderate similarity more 77.51(n)    BJ055210.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb62d082 Transcribed sequence with moderate similarity to protein more 71.63(n)    AL726600.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Orc51 Origin recognition complex subunit 5 47.05(n)
    39.23(a)
      34794  NM_057784.7  NP_477132.1 
    worm
    (Caenorhabditis elegans)
    Secernentea orc-56
    Protein ORC-5, isoform a
    23(a)
    1 ↔ 1
    IV(10732831-10734632) WBGene00013857
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ORC5(YNL261W)4 Subunit of the origin recognition complex, which directs more   --   14(155100-156539) 855460  NP_014138.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ORC51 ORC5 44.88(n)
    32.19(a)
      829114  NM_119137.4  NP_194720.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g07595001 Os03g0759500 41.46(n)
    28.93(a)
      4334180  NM_001057874.1  NP_001051339.1 


    ENSEMBL Gene Tree for ORC5 (if available)
    TreeFam Gene Tree for ORC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ORC5 gene
    1 SIMAP similar gene for ORC5 using alignment to 3 protein entries:     ORC5_HUMAN (see all proteins):
    ORC5L

    ORC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ORC5 (see all 1946)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344989701,2
    C--98127861(+) GACTT-/A/G   
      
    /GGA/T
    GGTTT
    2 -- int1 cds10--------
    rs356197421,2
    C--98149341(+) GTCTC-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs743135091,2
    C--98156497(+) ACCCA-/GAATAA 1 -- int10--------
    rs347694761,2
    C--98179425(+) TTTTT-/TAAGAG 2 -- int11Minor allele frequency- T:0.00NA 2
    rs588376831,2
    C--103138170(+) AAAAA-/A/AAA 
            
    CAATT
    2 -- int1 cds11NA 2
    rs1476598301,2
    C--103142318(+) AAGAG-/AAAAAA 1 -- int10--------
    rs341380781,2
    C--103147303(+) TGTCC-/TTCAAC 1 -- int10--------
    rs343459941,2
    C--103148113(+) GATTT-/TGTAGC 1 -- int10--------
    rs50029931,2
    C--103210047(+) TAAGAC/TGGTTA 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs43704651,2
    C,A--103210048(+) AAGATG/TGTTAT 2 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for ORC5 (103766788 - 103848495 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ORC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1231e199CNV Deletion23128226
    nsv507406CNV Insertion20534489
    esv269078CNV Insertion20981092
    esv28909CNV Loss19812545
    nsv527105CNV Loss19592680
    nsv526062CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ORC5
    DNA2.0 Custom Variant and Variant Library Synthesis for ORC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602331    OMIM disorders: --

    8 diseases for ORC5:    
    About MalaCards
    narcolepsy    leiomyoma    myeloid leukemia    hiv-1
    leukemia    prostatitis    malaria    neuronitis


    ORC5 for disorders           About GeneDecksing


    Export disorders for ORC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ORC5 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with ORC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. (PubMed id 9417919)1, 2, 3, 9 Ishiai M.... Eki T. (Genomics 1997)
    2. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. (PubMed id 9829972)1, 2, 3, 9 Tugal T.... Stillman B. (J. Biol. Chem. 1998)
    3. ATP-dependent assembly of the human origin recognition complex. (PubMed id 17716973)1, 2 Siddiqui K. and Stillman B. (J. Biol. Chem. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases. (PubMed id 9765232)1, 2 Quintana D.G....Dutta A. (J. Biol. Chem. 1998)
    8. Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22. (PubMed id 11379876)1, 9 FrAPhling S....DAPhner K. (Hum. Genet. 2001)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5001 HGNC: 8491 AceView: ORC5L Ensembl:ENSG00000164815 euGenes: HUgn5001
    ECgene: ORC5 Kegg: 5001 H-InvDB: ORC5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ORC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ORC5 gene:
    Search GeneIP for patents involving ORC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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