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Aliases for ORC4 Gene

Aliases for ORC4 Gene

  • Origin Recognition Complex Subunit 4 2 3 5
  • ORC4L 3 4
  • Origin Recognition Complex, Subunit 4 Homolog (S. Cerevisiae) 2
  • Origin Recognition Complex, Subunit 4 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 4-Like (S. Cerevisiae) 2
  • Origin Recognition Complex, Subunit 4-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 4 Homolog 3
  • Origin Recognition Complex, Subunit 4 2
  • ORC4P 3

External Ids for ORC4 Gene

Previous HGNC Symbols for ORC4 Gene

  • ORC4L

Previous GeneCards Identifiers for ORC4 Gene

  • GC02M148691

Summaries for ORC4 Gene

Entrez Gene Summary for ORC4 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for ORC4 Gene

ORC4 (Origin Recognition Complex Subunit 4) is a Protein Coding gene. Diseases associated with ORC4 include meier-gorlin syndrome 2 and meier-gorlin syndrome 1. Among its related pathways are Cell cycle and Cell Cycle Control of Chromosomal Replication. GO annotations related to this gene include nucleotide binding and DNA replication origin binding.

UniProtKB/Swiss-Prot for ORC4 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene Wiki entry for ORC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORC4 Gene

Genomics for ORC4 Gene

Regulatory Elements for ORC4 Gene

Enhancers for ORC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ORC4 on UCSC Golden Path with GeneCards custom track

Promoters for ORC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ORC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ORC4 Gene

Chromosome:
2
Start:
147,930,397 bp from pter
End:
148,021,604 bp from pter
Size:
91,208 bases
Orientation:
Minus strand

Genomic View for ORC4 Gene

Genes around ORC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC4 Gene

Proteins for ORC4 Gene

  • Protein details for ORC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43929-ORC4_HUMAN
    Recommended name:
    Origin recognition complex subunit 4
    Protein Accession:
    O43929
    Secondary Accessions:
    • B7Z3D0
    • B7Z5F1
    • D3DP86
    • F5H069
    • Q96C42

    Protein attributes for ORC4 Gene

    Size:
    436 amino acids
    Molecular mass:
    50377 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (PubMed:12909626, PubMed:17716973). Interacts with DBF4 (By similarity). Interacts with POLQ (PubMed:24989122).

    Alternative splice isoforms for ORC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ORC4 Gene

Proteomics data for ORC4 Gene at MOPED

Post-translational modifications for ORC4 Gene

  • Ubiquitination at Lys 204, Lys 243, and Lys 417
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ORC4 Gene

Domains & Families for ORC4 Gene

Gene Families for ORC4 Gene

Protein Domains for ORC4 Gene

Graphical View of Domain Structure for InterPro Entry

O43929

UniProtKB/Swiss-Prot:

ORC4_HUMAN :
  • Belongs to the ORC4 family.
Family:
  • Belongs to the ORC4 family.
genes like me logo Genes that share domains with ORC4: view

Function for ORC4 Gene

Molecular function for ORC4 Gene

UniProtKB/Swiss-Prot Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene Ontology (GO) - Molecular Function for ORC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003688 DNA replication origin binding IMP 9353276
GO:0005515 protein binding IPI 15232106
genes like me logo Genes that share ontologies with ORC4: view

Phenotypes for ORC4 Gene

genes like me logo Genes that share phenotypes with ORC4: view

Human Phenotype Ontology for ORC4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ORC4 Gene

MGI Knock Outs for ORC4:
  • Orc4 tm1a(EUCOMM)Wtsi

Animal Model Products

miRNA for ORC4 Gene

miRTarBase miRNAs that target ORC4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ORC4 Gene

Localization for ORC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORC4 Gene COMPARTMENTS Subcellular localization image for ORC4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
mitochondrion 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ORC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IEA,IDA 9353276
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ORC4: view

Pathways & Interactions for ORC4 Gene

genes like me logo Genes that share pathways with ORC4: view

Gene Ontology (GO) - Biological Process for ORC4 Gene

None

No data available for SIGNOR curated interactions for ORC4 Gene

Drugs & Compounds for ORC4 Gene

No Compound Related Data Available

Transcripts for ORC4 Gene

Unigene Clusters for ORC4 Gene

Origin recognition complex, subunit 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORC4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2:
SP3: -
SP4: -

Relevant External Links for ORC4 Gene

GeneLoc Exon Structure for
ORC4
ECgene alternative splicing isoforms for
ORC4

Expression for ORC4 Gene

mRNA expression in normal human tissues for ORC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ORC4 Gene

This gene is overexpressed in Testis (24.3) and Bone (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORC4 Gene



SOURCE GeneReport for Unigene cluster for ORC4 Gene Hs.558364

genes like me logo Genes that share expression patterns with ORC4: view

Protein tissue co-expression partners for ORC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ORC4 Gene

Orthologs for ORC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ORC4 35
  • 91.44 (n)
  • 91.74 (a)
ORC4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ORC4 35
  • 92.66 (n)
  • 94.27 (a)
ORC4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Orc4 35
  • 88.53 (n)
  • 89.61 (a)
Orc4 16
Orc4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ORC4 35
  • 99.85 (n)
  • 99.54 (a)
ORC4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Orc4 35
  • 87.25 (n)
  • 89.4 (a)
oppossum
(Monodelphis domestica)
Mammalia ORC4 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORC4 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves ORC4 35
  • 72.71 (n)
  • 75.69 (a)
ORC4 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ORC4 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia orc4 35
  • 68.9 (n)
  • 72.92 (a)
Str.7089 35
African clawed frog
(Xenopus laevis)
Amphibia Orc4 35
zebrafish
(Danio rerio)
Actinopterygii Dr.20190 35
orc4 35
  • 62.56 (n)
  • 66.05 (a)
orc4 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007063 35
  • 46.93 (n)
  • 48.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Orc4 35
  • 48.5 (n)
  • 47.69 (a)
Orc4 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORC4 36
  • 22 (a)
OneToOne
ORC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ORC4 35
  • 46.2 (n)
  • 31.17 (a)
rice
(Oryza sativa)
Liliopsida Os01g0683400 35
  • 44.97 (n)
  • 31.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes orc4 35
  • 47.47 (n)
  • 36.63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1951 36
  • 50 (a)
OneToOne
Species with no ortholog for ORC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORC4 Gene

ENSEMBL:
Gene Tree for ORC4 (if available)
TreeFam:
Gene Tree for ORC4 (if available)

Paralogs for ORC4 Gene

(1) SIMAP similar genes for ORC4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ORC4: view

No data available for Paralogs for ORC4 Gene

Variants for ORC4 Gene

Sequence variations from dbSNP and Humsavar for ORC4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2307397 - 147,972,798(-) CTGCT(C/G)TCCAT intron-variant, reference, missense, utr-variant-5-prime
rs2307394 - 147,958,859(-) AATAA(A/C/G)TCATG reference, missense, utr-variant-5-prime
VAR_065486 Meier-Gorlin syndrome 2 (MGORS2)
rs1598207 -- 148,000,301(+) caaca(A/G)agaga intron-variant
rs1020653 -- 147,974,841(+) CCTCA(C/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ORC4 Gene

Variant ID Type Subtype PubMed ID
nsv875275 CNV Gain 21882294
esv271545 CNV Insertion 20981092

Variation tolerance for ORC4 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.48; 91.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORC4 Gene

HapMap Linkage Disequilibrium report
ORC4
Human Gene Mutation Database (HGMD)
ORC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC4 Gene

Disorders for ORC4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ORC4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
meier-gorlin syndrome 2
  • mgors2
meier-gorlin syndrome 1
  • meier-gorlin syndrome
microtia
- elite association - COSMIC cancer census association via MalaCards
Search ORC4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ORC4_HUMAN
  • Meier-Gorlin syndrome 2 (MGORS2) [MIM:613800]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269 PubMed:21358631, ECO:0000269 PubMed:21358632}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ORC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORC4
genes like me logo Genes that share disorders with ORC4: view

No data available for Genatlas for ORC4 Gene

Publications for ORC4 Gene

  1. Identification of HsORC4, a member of the human origin of replication recognition complex. (PMID: 9353276) Quintana D.G. … Dutta A. (J. Biol. Chem. 1997) 2 3 4 67
  2. Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22-->q23 by in situ hybridization and somatic cell hybrid analysis. (PMID: 9691185) Eki T. … Hanaoka F. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Novel ORC4L gene mutation in B-cell lymphoproliferative disorders. (PMID: 20010161) Radojkovic M. … Radojkovic D. (Am. J. Med. Sci. 2009) 3 23
  4. Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex. (PMID: 10460412) Springer J. … Grummt F. (Chromosoma 1999) 3 23
  5. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. (PMID: 9829972) Tugal T. … Stillman B. (J. Biol. Chem. 1998) 3 23

Products for ORC4 Gene

Sources for ORC4 Gene

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