ORC4 Gene
protein-coding GIFtS: 55
GCID: GC02M148691
|
|
origin recognition complex, subunit 4(Previous names: origin recognition complex, subunit 4 (yeast homolog)-like,...)
(Previous symbol: ORC4L)
| |
Aliases
for ORC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Origin Recognition Complex, Subunit 41 2 | | Origin Recognition Complex, Subunit 4-Like (S. Cerevisiae)1 | | ORC4L1 2 3 5 | | Origin Recognition Complex, Subunit 4-Like (Yeast)1 | | HsORC41 | | ORC4P2 | | Orc4p1 | | Origin Recognition Complex Subunit 42 | | Origin Recognition Complex, Subunit 4 (Yeast Homolog)-Like1 | | Origin Recognition Complex, Subunit 4 Homolog2 | | Origin Recognition Complex, Subunit 4 Homolog (S. Cerevisiae)1 | | |
Export aliases for ORC4 gene to outside databases |
Summaries
for ORC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ORC4:
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation ofthe DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins ofreplication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of whichencode the same protein, have been reported for this gene. (provided by RefSeq, Oct 2010)
UniProtKB/Swiss-Prot: ORC4_HUMAN, O43929Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding isATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORCis required to assemble the pre-replication complex necessary to initiate DNA replication
Gene Wiki entry for ORC4 (ORC4L)
|
Genomic Views
for ORC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ORC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ORC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q22-q23 Ensembl cytogenetic band: 2q23.1 HGNC cytogenetic band: 2q22-q23ORC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M148691: view genomic region
(about GC identifiers)
Start:
|
148,691,732 bp from pter |
End:
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148,779,147 bp from pter |
Size:
|
87,416 bases |
Orientation:
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minus strand |
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Proteins
for ORC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ORC4_HUMAN, O43929 (See
protein sequence)Recommended Name: Origin recognition complex subunit 4 Size: 436 amino acids; 50377 Da
Subunit: ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembledat the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity)
Subcellular location: Nucleus
Secondary accessions: B7Z3D0 D3DP86 Q96C42Alternative splicing: 2 isoforms: O43929-1 O43929-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ORC4: NX_O43929
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43929
ORC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001177808.1 NP_001177810.1 NP_001177811.1 NP_002543.2 NP_859525.1 NP_859526.1
ENSEMBL proteins: ENSP00000376597 ENSP00000413939 ENSP00000391484 ENSP00000403105 ENSP00000264169 ENSP00000441953 ENSP00000376598 ENSP00000438326 ENSP00000441502 ENSP00000437440 Reactome Protein details: O43929
Human Recombinant Protein Products for ORC4:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ORC4 for ontologies About GeneDecksing
ORC4 Antibody Products:
Assay Products for ORC4: |
Protein
Domains /
Families
for ORC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ORC4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43929ProtoNet protein and cluster: O43929 UniProtKB/Swiss-Prot: ORC4_HUMAN, O43929Similarity: Belongs to the ORC4 family |
Function
for ORC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ORC4_HUMAN, O43929Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding isATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORCis required to assemble the pre-replication complex necessary to initiate DNA replication Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
ORC4 for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Orc4):
ORC4 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC4 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ORC4 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): ORC4 (NM_181742) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ORC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC4 |
|
Pathways & Interactions
for ORC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitinated Orc1 is degraded by the proteasome | | | 2 | CDC6 association with the ORC:origin complex | | | 3 | Cell cycle | | | 4 | Cell cycle_Start of DNA replication in early S phase | | | 5 | Activation of ATR in response to replication stress | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for ORC4
1  GeneGo (Thomson Reuters) Pathway for ORC4
3  BioSystems Pathways for ORC4
5/25 
Reactome Pathways for ORC4 (see all 25)
1 
Kegg Pathway (Kegg details for ORC4):
ORC4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ORC4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/98 Interacting proteins for ORC4 (O439291, 2, 3 ENSP000002641694) via UniProtKB, MINT, STRING, and/or I2D (see all 98)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000075 | cell cycle checkpoint |
TAS | -- | | GO:0000082 | G1/S transition of mitotic cell cycle |
TAS | -- | | GO:0000084 | S phase of mitotic cell cycle |
TAS | -- | | GO:0000216 | M/G1 transition of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- |
ORC4 for ontologies About GeneDecksing
|
Drugs & Compounds
for ORC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ORC4
Search CenterWatch for drugs/clinical trials and news about ORC4
|
Transcripts
for ORC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ORC4 gene (6 alternative transcripts): NM_001190879.2 NM_001190881.2 NM_001190882.2 NM_002552.4 NM_181741.3 NM_181742.3 Unigene Cluster for ORC4: Origin recognition complex, subunit 4 Hs.558364 [show with all ESTs]Unigene Representative Sequence: NM_00119087918 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392857 ENST00000488761 ENST00000481488 ENST00000483608 ENST00000478904
ENST00000461711 ENST00000496670 ENST00000490200 ENST00000416719 ENST00000457954
ENST00000440042 ENST00000495601 ENST00000264169(uc002twk.3) ENST00000535373(uc021vqr.1 uc002twi.3 uc010zbp.2 uc010zbr.2)
ENST00000392858(uc002twj.3) ENST00000540442(uc010zbo.2) ENST00000536575(uc010zbq.2)
ENST00000542387
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC4 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ORC4 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): ORC4 (NM_181742) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ORC4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC4 |
Additional cDNA sequence: AF022108.1 AF047598.1 AF132596.1 AK128860.1 AK225092.1 AK291989.1 AK295721.1 AK298862.1 BC005388.1 BC014847.1 BC016177.1 22 DOTS entries: DT.100645984 DT.213973 DT.91752473 DT.91752469 DT.86845579 DT.40260274 DT.100816443 DT.100816449 DT.100816448 DT.121032338 DT.100816444 DT.91752462 DT.95276183 DT.99951864 DT.99998627 DT.100816450 DT.40263590 DT.91752464 DT.95276188 DT.97776689 DT.100766759 DT.40126586 24/229 AceView cDNA sequences (see all 229): BX505237 CB145852 BP345092 BP354324 NM_181742 AI167500 BM675130 BM977028 AA831302 BC014847 BX118071 BM459157 CA431036 NM_002552 NM_181741 BQ006399 BI496505 BX109988 BQ232753 CR599779 BU165452 AI342875 Z41817 AU133109
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ORC4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for ORC4
|
Expression
for ORC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ORC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ORC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ORC4
SOURCE GeneReport for Unigene cluster: Hs.558364
SABiosciences Custom PCR Arrays for ORC4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ORC4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ORC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC4 |
Orthologs
for ORC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ORC4 gene from 9/32 species (see all 32) About this table
ENSEMBL Gene Tree for ORC4 (if available)
TreeFam Gene Tree for ORC4 (if available) |
Paralogs
for ORC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ORC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ORC4 (148691732 - 148779147 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ORC4: --
Human Gene Mutation Database (HGMD): ORC4
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ORC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ORC4 for disorders About GeneDecksing
OMIM gene information: 603056
OMIM disorders: --
UniProtKB/Swiss-Prot: ORC4_HUMAN, O43929
Defects in ORC4 are the cause of Meier-Gorlin syndrome type 2 (MGORS2) [MIM:613800]. MGORS2 is a syndromecharacterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growthretardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranialsutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate,micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordialdwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia andabsent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal
11  diseases for ORC4: About MalaCardsmeier-gorlin syndrome intrauterine and postnatal growth retardation short stature microtia
chronic lymphocytic leukemia lymphocytic leukemia dwarfism microcephaly
leiomyoma leukemia neuronitis
Export disorders for ORC4 gene to outside databases
|
Publications
for ORC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ORC4 gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with ORC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of HsORC4, a member of the human origin of replication recognition complex. (PubMed id 9353276)1, 2, 3 Quintana D.G.... Dutta A. (1997)
- Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22-->q23 by in situ hybridization and somatic cell hybrid analysis. (PubMed id 9691185)1, 3, 9 Eki T....Hanaoka F. (1998)
- Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PubMed id 21358632)1, 2 Bicknell L.S....Jackson A.P. (2011)
- Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. (PubMed id 21358631)1, 2 Guernsey D.L.... Samuels M.E. (2011)
- ATP-dependent assembly of the human origin recognition complex. (PubMed id 17716973)1, 2 Siddiqui K. and Stillman B. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. (PubMed id 9829972)1, 9 Tugal T.... Stillman B. (1998)
- Novel ORC4L gene mutation in B-cell lymphoproliferati ve disorders. (PubMed id 20010161)1, 9 Radojkovic M....Radojkovic D. (2009)
- Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex. (PubMed id 10460412)1, 9 Springer J....Grummt F. (1999)
|
External Searches for ORC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ORC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ORC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ORC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ORC4 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/orc4l/ |
|
| | |
About This Section
| Patent Information for ORC4 gene:
Search GeneIP for patents involving ORC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ORC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ORC4 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ORC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ORC4 | | | OriGene Protein Over-expression Lysate for ORC4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ORC4 | | OriGene 3'-UTR Clone for ORC4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ORC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ORC4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ORC4 | | OriGene Custom Protein Services for ORC4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ORC4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ORC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORC4 |
| |
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| | | | Search Tocris compounds for ORC4 |
| |  |  |  |  | | | | |
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 |
 |
 | | | ORC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC4 |
|  |  |  |  | | | | ThermoFisher Antibodies for ORC4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC4 |
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