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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ORC3 Gene

protein-coding GIFtS: 54
GCID: GC06P088299

origin recognition complex, subunit 3

(Previous names: origin recognition complex, subunit 3 (yeast homolog)-like,...)
(Previous symbol: ORC3L)

Explore 5 diseases affiliated with
ORC3 via

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Origin Recognition Complex, Subunit 3¹ ²		Origin Recognition Complex, Subunit 3 (Yeast Homolog)-Like¹
ORC3L¹ ² ³ ⁵		Origin Recognition Complex, Subunit 3 Honolog (Yeast)¹
LATHEO¹ ² ³		Origin Recognition Complex, Subunit 3-Like (Yeast)¹
Origin Recognition Complex Subunit Latheo² ³		Homolog Of Latheo, Drosophila²
LAT² ⁵		Origin Recognition Complex Subunit 3²
IMAGE50150¹		Origin Recognition Complex, Subunit 3 Honolog²

External Ids:	HGNC: 8489¹	Entrez Gene: 23595²	Ensembl: ENSG00000135336⁷	OMIM: 604972⁵	UniProtKB: Q9UBD5³

Export aliases for ORC3 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ORC3:

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of

the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of

replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.

The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a

possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript

variants encoding distinct isoforms have been reported for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ORC3_HUMAN, Q9UBD5

Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is

ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC

is required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Wiki entry for ORC3 (ORC3L)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ORC3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ORC3 promoter sequence

Search SABiosciences Chromatin IP Primers for ORC3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.3-q16.1 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q

ORC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORC3 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P088299: view genomic region (about GC identifiers)

Start:	88,299,839 bp from pter	End:	88,377,169 bp from pter
Size:	77,331 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ORC3_HUMAN, Q9UBD5 (See protein sequence)

Recommended Name: Origin recognition complex subunit 3

Size: 711 amino acids; 82254 Da

Subunit: ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled

at the exit from anaphase of mitosis and disassembled as cells enter S phase

Subcellular location: Nucleus

Secondary accessions: A2A2T5 B4E025 Q13565 Q53GY6 Q5T159 Q6IUY7 Q86TN5 Q9UG44 Q9UNT6

Alternative splicing: 3 isoforms: Q9UBD5-1 Q9UBD5-2 Q9UBD5-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ORC3: NX_Q9UBD5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBD5

ORC3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001184188.1 NP_036513.2 NP_862820.1

ENSEMBL proteins:

ENSP00000376586 ENSP00000257789 ENSP00000390176 ENSP00000444695

Reactome Protein details: Q9UBD5
Human Recombinant Protein Products:

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	Novus Biologicals ORC3 Proteins Novus Biologicals ORC3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ORC3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000808	origin recognition complex	IDA	17716973
GO:0005654	nucleoplasm	TAS	--
GO:0005664	nuclear origin of replication recognition complex	IDA	--

ORC3 for ontologies About GeneDecksing

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	Uscn Antibodies for ORC3
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	Uscn ELISAs and CLIAs for ORC3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ORC3 for domains About GeneDecksing

1 InterPro domain/family:

IPR020795 ORC3

Graphical View of Domain Structure for InterPro Entry Q9UBD5

ProtoNet protein and cluster: Q9UBD5

UniProtKB/Swiss-Prot: ORC3_HUMAN, Q9UBD5

Similarity: Belongs to the ORC3 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ORC3_HUMAN, Q9UBD5

Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is

ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC

is required to assemble the pre-replication complex necessary to initiate DNA replication

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ORC3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORC3
		1 QIAGEN miScript miRNA Assays for microRNA that regulate ORC3:
		hsa-miR-466
		SwitchGear 3'UTR luciferase reporter plasmid: ORC3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ORC3 (see all 4) OriGene shRNA RFP: ORC3 OriGene siRNA: ORC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORC3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ORC3

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		GenScript: all cDNA clones in your preferred vector: ORC3 (NM_015358)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ORC3
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003688	DNA replication origin binding	TAS	9829972
GO:0005515	protein binding	IPI	17716973

ORC3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ORC3:

Increased cell number in G2M,

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Orc3):

cellular

nervous system

ORC3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/12 pathways (see all 12)
CDT1 association with the CDC6:ORC:origin complex	0.84	DNA Replication Pre-Initiation	0.62
Assembly of the pre-replicative complex	0.77	M/G1 Transition	0.62
Switching of origins to a post-replicative state	0.70	Synthesis of DNA	0.51
Orc1 removal from chromatin	0.70	DNA Replication	0.49

CDC6 association with the ORC:origin complex

	CDC6 association with the ORC:origin complex	1.00			E2F-enabled inhibition of pre-replication complex formation	0.64
	Assembly of the ORC complex at the origin of replication	0.75			Association of licensing factors with the pre-replicative complex	0.43

Cell cycle

	Cell cycle	1.00			G1 to S cell cycle control	0.38
	Cell cycle	0.57

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Activation of ATR in response to replication stress

Activation of ATR in response to replication stress

1.00

G2/M Checkpoints

0.86

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ORC3

	Meiosis
	Cell cycle Start of DNA replication in early S phase

1 GeneGo (Thomson Reuters) Pathway for ORC3

Cell cycle Start of DNA replication in early S phase

3 BioSystems Pathways for ORC3

	Cell cycle
	G1 to S cell cycle control
	DNA Replication

5/25 Reactome Pathways for ORC3 (see all 25)

	Activation of ATR in response to replication stress
	Mitotic G1-G1/S phases
	DNA Replication
	E2F-enabled inhibition of pre-replication complex formation
	Removal of licensing factors from origins

1 Kegg Pathway (Kegg details for ORC3):

Cell cycle

ORC3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ORC3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/792 Interacting proteins for ORC3 (Q9UBD5^{1, 2, 3} ENSP00000257789⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 792)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ORC2	Q13416²^,³, ENSP00000234296⁴	MINT-7945693 MINT-7947479 MINT-8076236 I2D: score=4 STRING: ENSP00000234296
ORC5	O43913¹^,³, ENSP00000297431⁴	EBI-374916,EBI-374928 I2D: score=6 STRING: ENSP00000297431
CDC45	O75419²^,³, ENSP00000263201⁴	MINT-50389 I2D: score=5 STRING: ENSP00000263201
CDC6	Q99741²^,³, ENSP00000209728⁴	MINT-50405 I2D: score=5 STRING: ENSP00000209728
ORC6	Q9Y5N6¹^,³, ENSP00000219097⁴	EBI-374916,EBI-374840 I2D: score=5 STRING: ENSP00000219097

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000075	cell cycle checkpoint	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--

ORC3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ORC3
Search CenterWatch for drugs/clinical trials and news about ORC3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ORC3 gene (3 alternative transcripts):

NM_001197259.1 NM_012381.3 NM_181837.2

Unigene Cluster for ORC3:

Origin recognition complex, subunit 3

Hs.410228 [show with all ESTs]

Unigene Representative Sequence: NM_181837

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392844(uc011dzl.2 uc011dzm.2 uc003pmg.3 uc003pmh.3 uc011dzp.2 uc011dzo.2)

ENST00000257789(uc003pmj.1) ENST00000468486 ENST00000478028 ENST00000417380(uc011dzn.2)

ENST00000546266

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate ORC3:
		hsa-miR-466
		SwitchGear 3'UTR luciferase reporter plasmid: ORC3 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC3 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ORC3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORC3

Additional cDNA sequence:

AF093535.1 AF125507.1 AF135044.1 AK222795.1 AK303056.1 AK303182.1 AK303195.1 AK316298.1

AL080116.1 BC035494.2 BC047689.1 CR456814.1 U50950.1

18 DOTS entries:

DT.97854848 DT.100666302 DT.100888519 DT.95169046 DT.70103783 DT.411911 DT.100031274 DT.121392143

DT.99930366 DT.92454804 DT.100712401 DT.75118545 DT.75153526 DT.95169041 DT.100775641 DT.91973750

DT.95169026 DT.95169053

24/220 AceView cDNA sequences (see all 220):

AL600904 AA830005 BC047689 AW778738 BQ009113 CA417086 BM973415 AI361049

BC035494 BQ718539 BM478060 BU632641 NM_012381 AW167807 CB152486 AA262375

AK094135 BU153003 AV708200 CD655888 CR618350 AL709158 BF059711 CR619723

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ORC3 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^
SP1:							-		-		-		-		-																								-
SP2:											-
SP3:							-				-
SP4:
SP5:

ExUns:	22	^	23
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ORC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ORC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See ORC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ORC3

SOURCE GeneReport for Unigene cluster: Hs.410228

SABiosciences Custom PCR Arrays for ORC3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC3 gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Orc3^{1 , 5}	origin recognition complex, subunit 3^{1, 5}	84.09(n)¹ 80.37(a)¹		4 (16.81 cM)⁵ 50793¹ NM_015824.4¹ NP_056639.3¹ 34570796⁵
chicken (Gallus gallus)	Aves	ORC3¹	origin recognition complex, subunit 3	69.6(n) 67.6(a)		421822 NM_001031082.1 NP_001026253.1
lizard (Anolis carolinensis)	Reptilia	ORC3⁶	--	65(a)	1 ↔ 1	1(176277188-176325900)
African clawed frog (Xenopus laevis)	Amphibia	MGC53625²	similar to origin recognition complex, subunit 3-like more	73.28(n)		AF045607.1
zebrafish (Danio rerio)	Actinopterygii	Dr.2362²	Danio rerio mRNA similar to origin recognition complex, more	74.98(n)		BC045352.1
fruit fly (Drosophila melanogaster)	Insecta	CG34315¹	CG34315	45.56(n) 35.2(a)		5740282 NM_057556.4 NP_476904.1
thale cress (Arabidopsis thaliana)	eudicotyledons	ORC3¹	origin recognition complex subunit 3	42.33(n) 25.85(a)		831530 NM_121674.3 NP_197171.2
rice (Oryza sativa)	Liliopsida	Os10g0402200¹	hypothetical protein	44.26(n) 28.12(a)		4348571 NM_001071085.1 NP_001064550.1

ENSEMBL Gene Tree for ORC3 (if available)
TreeFam Gene Tree for ORC3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ORC3 gene

1 SIMAP similar gene for ORC3 using alignment to 2 protein entries: ORC3_HUMAN (see all proteins):

ORC3L

ORC3 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for ORC3
PGOHUM00000242813 PGOHUM00000249119 PGOHUM00000249299

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78832253^1,2	F,	--	88297838(+)	`AAACAC/AAATTT`	4	--	int¹ us2k¹		3		WA NA EA	358
rs17563943^1,2	C,F,H,	--	88297911(+)	`ACAGCT/ATAGAT`	4	--	int¹ us2k¹		7		NA NS EA	558
rs76420101^1,2	C,F,	--	88297939(+)	`CCTTCC/TCTGAT`	4	--	us2k¹ int¹		1		WA	118
rs190861832^1,2		--	88298019(+)	`GAAGAC/TTTCTG`	4	--	us2k¹ int¹		0	--	--	--	--
rs56821299^1,2	C,	--	88298063(+)	`CATGAG/AAAATC`	4	--	int¹ us2k¹		1		WA	2
rs112669106^1,2	C,F,	--	88298236(+)	`AGAGGT/GGCACC`	4	--	int¹ us2k¹		3		NA	124
rs72922586^1,2		--	88298270(+)	`AAAAAA/TTTTGT`	4	--	us2k¹ int¹		0	--	--	--	--
rs28381451^1,2	C,F,	--	88298304(+)	`TCCACG/ACTGGT`	4	--	us2k¹ int¹		3		NS NA EA	396
rs116161182^1,2	F,	--	88298321(+)	`CTCCTG/AGGCTC`	4	--	int¹ us2k¹		1		WA	118
rs185195876^1,2		--	88298322(+)	`TCCTGC/GGCTCA`	4	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ORC3 (88299839 - 88377169 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ORC3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ORC3 for disorders           About GeneDecksing

OMIM gene information: 604972    OMIM disorders: --

5 diseases for ORC3:    About MalaCards

chronic lymphocytic leukemia lymphocytic leukemia neuronitis leukemia

schizophrenia

Export disorders for ORC3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ORC3 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with ORC3)

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Latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. (PubMed id 10402192)^{1, 2, 3} Pinto S.... Tully T. (1999)
ATP-dependent assembly of the human origin recognition complex. (PubMed id 17716973)^{1, 2} Siddiqui K. and Stillman B. (2007)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)^{1, 2} Matsuoka S.... Elledge S.J. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. (PubMed id 9829972)^{1, 3} Tugal T.... Stillman B. (1998)
The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. (PubMed id 18628273)^{1, 9} DeRosse P....Malhotra A.K. (2008)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)¹ Li S....Dorf M.E. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23595	HGNC: 8489	AceView: ORC3L	Ensembl:ENSG00000135336	euGenes: HUgn23595
ECgene: ORC3	Kegg: 23595	H-InvDB: ORC3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ORC3	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/orc3l/

Intellectual Property for ORC3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ORC3 gene:
Search GeneIP for patents involving ORC3

GeneCards and IP:
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origin recognition complex, subunit 3

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origin recognition complex, subunit 3

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