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ORC3 Gene

protein-coding   GIFtS: 57
GCID: GC06P088299

Origin Recognition Complex, Subunit 3

(Previous names: origin recognition complex, subunit 3 (yeast homolog)-like,...)
(Previous symbol: ORC3L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Origin Recognition Complex, Subunit 31 2     Origin Recognition Complex, Subunit 3 Honolog (Yeast)1
ORC3L1 2 3 5     Origin Recognition Complex, Subunit 3-Like (Yeast)1
Origin Recognition Complex Subunit Latheo2 3     Homolog Of Latheo, Drosophila2
LATHEO2 3     Origin Recognition Complex Subunit 32
LAT2 5     Origin Recognition Complex, Subunit 3 Honolog2
Origin Recognition Complex, Subunit 3 (Yeast Homolog)-Like1     

External Ids:    HGNC: 84891   Entrez Gene: 235952   Ensembl: ENSG000001353367   OMIM: 6049725   UniProtKB: Q9UBD53   

Export aliases for ORC3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ORC3 Gene:
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the
initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically
to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6
and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in
Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory.
Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for ORC3 Gene:
ORC3 (origin recognition complex, subunit 3) is a protein-coding gene. Diseases associated with ORC3 include chronic lymphocytic leukemia, and tonsillitis. GO annotations related to this gene include DNA replication origin binding.

UniProtKB/Swiss-Prot: ORC3_HUMAN, Q9UBD5
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is
required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4
trimethylation marks H3K9me3, H3K27me3 and H4K20me3

Gene Wiki entry for ORC3 (ORC3L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ORC3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidORC3 promoter sequence
   Search Chromatin IP Primers for ORC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ORC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.3-q16.1   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q

ORC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORC3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P088299:  view genomic region     (about GC identifiers)

Start:
88,299,785 bp from pter      End:
88,377,172 bp from pter
Size:
77,388 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ORC3_HUMAN, Q9UBD5 (See protein sequence)
Recommended Name: Origin recognition complex subunit 3  
Size: 711 amino acids; 82254 Da
Subunit: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC
is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis
and disassembled as cells enter S phase
Secondary accessions: A2A2T5 B4E025 Q13565 Q53GY6 Q5T159 Q6IUY7 Q86TN5 Q9UG44 Q9UNT6
Alternative splicing: 3 isoforms:  Q9UBD5-1   Q9UBD5-2   Q9UBD5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ORC3: NX_Q9UBD5

Explore proteomics data for ORC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys428, Lys523
  • Modification sites at PhosphoSitePlus

  • See ORC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001184188.1  NP_036513.2  NP_862820.1  

    ENSEMBL proteins: 
     ENSP00000376586   ENSP00000257789   ENSP00000475988   ENSP00000390176   ENSP00000444695  
    Reactome Protein details: Q9UBD5

    ORC3 Human Recombinant Protein Products:

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    Novus Biologicals ORC3 Proteins
    Novus Biologicals ORC3 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR020795 ORC3

    Graphical View of Domain Structure for InterPro Entry Q9UBD5

    ProtoNet protein and cluster: Q9UBD5

    UniProtKB/Swiss-Prot: ORC3_HUMAN, Q9UBD5
    Similarity: Belongs to the ORC3 family


    ORC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORC3_HUMAN, Q9UBD5
    Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
    ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is
    required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4
    trimethylation marks H3K9me3, H3K27me3 and H4K20me3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003688DNA replication origin binding TAS9829972
    GO:0005515protein binding IPI15232106
         
    ORC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ORC3:
     Increased cell number in G2M,  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Orc3):
     cellular  nervous system 

    ORC3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ORC3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ORC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ORC3

    miRNA
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    miRTarBase miRNAs that target ORC3:
    hsa-mir-1 (MIRT023644)

    Block miRNA regulation of human, mouse, rat ORC3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ORC3:
    hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidORC3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ORC3
    Predesigned siRNA for gene silencing in human, mouse, rat ORC3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ORC3 (NM_015358)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ORC3_HUMAN, Q9UBD5: Nucleus

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000808origin recognition complex IDA17716973
    GO:0005654nucleoplasm TAS--
    GO:0005664nuclear origin of replication recognition complex IDA--

    ORC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ORC3 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    E2F-enabled inhibition of pre-replication complex formation0.00
    G1 to S cell cycle control0.35
    Assembly of the ORC complex at the origin of replication0.00
    3Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    4CDK-mediated phosphorylation and removal of Cdc6
    Switching of origins to a post-replicative state0.93
    Removal of licensing factors from origins0.86
    Orc1 removal from chromatin0.93
    M/G1 Transition0.81
    Regulation of DNA replication0.93
    DNA Replication Pre-Initiation0.81
    Synthesis of DNA0.92
    S Phase0.78
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ORC3
        Cell Cycle Control of Chromosomal Replication

    1 GeneGo (Thomson Reuters) Pathway for ORC3
        Cell cycle Start of DNA replication in early S phase

    3 BioSystems Pathways for ORC3
        G1 to S cell cycle control
    Cell cycle
    DNA Replication

    Selected Reactome Pathways for ORC3 (see all 10)
        Activation of ATR in response to replication stress
    Removal of licensing factors from origins
    E2F-enabled inhibition of pre-replication complex formation
    Orc1 removal from chromatin
    Assembly of the pre-replicative complex


    1 Kegg Pathway  (Kegg details for ORC3):
        Cell cycle


    ORC3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ORC3
    Interactions:

        Search GeneGlobe Interaction Network for ORC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ORC3 (Q9UBD51, 2, 3 ENSP000002577894) via UniProtKB, MINT, STRING, and/or I2D (see all 887)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORC2Q134162, 3, ENSP000002342964MINT-7945693 MINT-7947479 MINT-8076236 I2D: score=4 STRING: ENSP00000234296
    ORC5O439131, 3, ENSP000002974314EBI-374916,EBI-374928 I2D: score=6 STRING: ENSP00000297431
    CDC45O754192, 3, ENSP000002632014MINT-50389 I2D: score=5 STRING: ENSP00000263201
    CDC6Q997412, 3, ENSP000002097284MINT-50405 I2D: score=5 STRING: ENSP00000209728
    ORC6Q9Y5N61, 3, ENSP000002190974EBI-374916,EBI-374840 I2D: score=5 STRING: ENSP00000219097
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0061351neural precursor cell proliferation IEA--

    ORC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ORC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ORC3 gene (3 alternative transcripts): 
    NM_001197259.1  NM_012381.3  NM_181837.2  

    Unigene Cluster for ORC3:

    Origin recognition complex, subunit 3
    Hs.410228  [show with all ESTs]
    Unigene Representative Sequence: NM_181837
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392844(uc011dzl.2 uc011dzm.2 uc003pmg.3 uc003pmh.3 uc011dzp.2 uc011dzo.2)
    ENST00000468486 ENST00000257789(uc003pmj.1) ENST00000478028 ENST00000508875
    ENST00000417380(uc011dzn.2) ENST00000546266
    miRNA
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    Block miRNA regulation of human, mouse, rat ORC3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ORC3:
    hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidORC3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ORC3
    Predesigned siRNA for gene silencing in human, mouse, rat ORC3
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    GenScript: all cDNA clones in your preferred vector: ORC3 (NM_015358)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC3
    Primer
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    OriGene qPCR primer pairs and template standards for ORC3
    OriGene qSTAR qPCR primer pairs in human, mouse for ORC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ORC3
      QuantiTect SYBR Green Assays in human, mouse, rat ORC3
      QuantiFast Probe-based Assays in human, mouse, rat ORC3

    Additional mRNA sequence: 

    AF093535.1 AF125507.1 AF135044.1 AK222795.1 AK303056.1 AK303182.1 AK303195.1 AK316298.1 
    AL080116.1 BC035494.2 BC047689.1 CR456814.1 U50950.1 

    18 DOTS entries:

    DT.97854848  DT.100666302  DT.100888519  DT.95169046  DT.70103783  DT.411911  DT.100031274  DT.121392143 
    DT.92454804  DT.99930366  DT.100712401  DT.75118545  DT.75153526  DT.95169041  DT.100775641  DT.91973750 
    DT.95169026  DT.95169053 

    Selected AceView cDNA sequences (see all 220):

    BI520392 AL709158 NM_181837 AU117920 BI091781 CD655888 AK094135 CR619723 
    CA391505 AA194876 CA422811 AA262375 BQ102522 AL710982 AA788676 AF135044 
    AW474417 BM971022 CR608982 AA262314 BM802602 CR618350 BU509511 AW500090 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ORC3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                    -     -     -     -     -                                                                       -                                       
    SP2:                                -                                                                                                                           
    SP3:                    -           -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for ORC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ORC3 expression in normal human tissues (normalized intensities)      ORC3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ORC3 Expression
    About this image


    ORC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ORC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ORC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410228
        Custom PCR Arrays for ORC3
    Primer
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    OriGene qPCR primer pairs and template standards for ORC3
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    QuantiTect SYBR Green Assays in human, mouse, rat ORC3
    QuantiFast Probe-based Assays in human, mouse, rat ORC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ORC3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Orc31 , 5 origin recognition complex, subunit 31, 5 84.06(n)1
    80.34(a)1
      4 (16.81 cM)5
    507931  NM_015824.41  NP_056639.31 
     345707965 
    chicken
    (Gallus gallus)
    Aves ORC31 origin recognition complex, subunit 3 69.6(n)
    67.6(a)
      421822  NM_001031082.1  NP_001026253.1 
    lizard
    (Anolis carolinensis)
    Reptilia ORC36
    origin recognition complex, subunit 3
    66(a)
    1 ↔ 1
    1(176274850-176325900)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC536252 similar to origin recognition complex, subunit 3-like more 73.28(n)    AF045607.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.23622 Danio rerio mRNA similar to origin recognition complex, more 74.98(n)    BC045352.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lat1 latheo 46(n)
    36.21(a)
      36454  NM_165971.2  NP_725260.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ORC31 ORC3 43.4(n)
    27.56(a)
      831530  NM_121674.3  NP_197171.2 
    rice
    (Oryza sativa)
    Liliopsida Os10g04022001 Os10g0402200 44.37(n)
    28.26(a)
      4348571  NM_001071085.1  NP_001064550.1 


    ENSEMBL Gene Tree for ORC3 (if available)
    TreeFam Gene Tree for ORC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ORC3 gene
    1 SIMAP similar gene for ORC3 using alignment to 3 protein entries:     ORC3_HUMAN (see all proteins):
    ORC3L

    ORC3 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ORC3
    PGOHUM00000242813 PGOHUM00000249119 PGOHUM00000249299


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ORC3 (see all 1489)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1130796031,2
    C,F--88301961(+) ATTTGG/AAAAGG 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1895425061,2
    --88302274(+) CCCGGC/GAGGTA 3 -- int10--------
    rs1820013341,2
    --88302352(+) AACAAC/TAGCAG 3 -- int10--------
    rs1871269611,2
    --88302434(+) GGTCTG/TTAACA 3 -- int10--------
    rs69020691,2
    C,F,H--88302447(+) ATCCTG/AAGACA 3 -- int19Minor allele frequency- A:0.07NS EA NA CSA WA 664
    rs1911854811,2
    --88302481(+) CATTCC/TGTCTT 3 -- int10--------
    rs1416142181,2
    --88302519(+) AAGAAA/GTTATC 3 -- int10--------
    rs1462243841,2
    --88302533(+) CAGGCC/TGGGTG 3 -- int10--------
    rs1808435091,2
    --88302534(+) AGGCCA/GGGTGC 3 -- int10--------
    rs1865668611,2
    --88302569(+) CACTTG/TGGGAG 3 -- int10--------

    HapMap Linkage Disequilibrium report for ORC3 (88299785 - 88377172 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ORC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732392CNV Deletion23290073
    dgv1992e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ORC3
    DNA2.0 Custom Variant and Variant Library Synthesis for ORC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604972    OMIM disorders: --

    11 diseases for ORC3:    About MalaCards
    chronic lymphocytic leukemia    tonsillitis    schizophrenia    neuronitis
    obesity    leukemia    thyroiditis    cerebritis
    malaria    prostatitis    endotheliitis


    ORC3 for disorders           About GeneDecksing


    Export disorders for ORC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ORC3 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with ORC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. (PubMed id 10402192)1, 2, 3 Pinto S.... Tully T. (Neuron 1999)
    2. ATP-dependent assembly of the human origin recognition complex. (PubMed id 17716973)1, 2 Siddiqui K. and Stillman B. (J. Biol. Chem. 2007)
    3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)1, 2 Matsuoka S.... Elledge S.J. (Science 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. (PubMed id 9829972)1, 3 Tugal T.... Stillman B. (J. Biol. Chem. 1998)
    8. The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. (PubMed id 18628273)1, 9 DeRosse P....Malhotra A.K. (Schizophr Bull 2008)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23595 HGNC: 8489 AceView: ORC3L Ensembl:ENSG00000135336 euGenes: HUgn23595
    ECgene: ORC3 Kegg: 23595 H-InvDB: ORC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ORC3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/orc3l/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ORC3 gene:
    Search GeneIP for patents involving ORC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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