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Aliases for ORC3 Gene

Aliases for ORC3 Gene

  • Origin Recognition Complex Subunit 3 2 3 5
  • Origin Recognition Complex Subunit Latheo 3 4
  • LATHEO 3 4
  • ORC3L 3 4
  • Origin Recognition Complex, Subunit 3 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 3 Honolog (Yeast) 2
  • Origin Recognition Complex, Subunit 3-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 3 Honolog 3
  • Origin Recognition Complex, Subunit 3 2
  • Homolog Of Latheo, Drosophila 3
  • LAT 3

External Ids for ORC3 Gene

Previous HGNC Symbols for ORC3 Gene

  • ORC3L

Previous GeneCards Identifiers for ORC3 Gene

  • GC06P088299

Summaries for ORC3 Gene

Entrez Gene Summary for ORC3 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ORC3 Gene

ORC3 (Origin Recognition Complex Subunit 3) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include DNA replication origin binding.

UniProtKB/Swiss-Prot for ORC3 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene Wiki entry for ORC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORC3 Gene

Genomics for ORC3 Gene

Regulatory Elements for ORC3 Gene

Enhancers for ORC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G087755 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +166.8 166750 2.2 ZFP64 FEZF1 YY1 TCF12 GATA2 CBX5 ZNF143 FOS ZNF202 JUNB AKIRIN2 RARS2 LINC01590 ENSG00000272008 ENSG00000238628 ORC3 GC06P087742 LOC101928911
GH06G087716 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 +128.4 128369 3.0 PKNOX1 MAX CEBPG ZNF664 CTBP1 GATA3 FOS RFX1 ZBED1 ZNF10 AKIRIN2 ORC3 RARS2 SLC35A1 ENSG00000238628
GH06G087824 1.3 FANTOM5 Ensembl ENCODE 9.6 +235.8 235817 2.2 FOXA2 CEBPB JUNB CEBPG BMI1 EED CREB1 TCF7 RELB SPI1 AKIRIN2 SLC35A1 RARS2 ORC3 GC06P087824 GC06M087828 ENSG00000207131
GH06G087659 1.1 Ensembl ENCODE dbSUPER 11 +70.0 70049 1.5 BACH1 MAFG ZNF316 MAFF IRF1 FOS NFE2 MAFK EMSY SLC35A1 RARS2 AKIRIN2 ORC3 GC06P087659 GC06M087700
GH06G087747 0.9 Ensembl dbSUPER 10.4 +157.9 157934 0.8 PKNOX1 MTA2 BHLHE40 TBX21 FOSL1 IKZF1 TARDBP NBN RELB MLLT1 ENSG00000238628 AKIRIN2 ORC3 RARS2 GC06P087742 LOC101928911
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ORC3 on UCSC Golden Path with GeneCards custom track

Promoters for ORC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199759 33 2601 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for ORC3 Gene

Chromosome:
6
Start:
87,590,067 bp from pter
End:
87,667,454 bp from pter
Size:
77,388 bases
Orientation:
Plus strand

Genomic View for ORC3 Gene

Genes around ORC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC3 Gene

Proteins for ORC3 Gene

  • Protein details for ORC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBD5-ORC3_HUMAN
    Recommended name:
    Origin recognition complex subunit 3
    Protein Accession:
    Q9UBD5
    Secondary Accessions:
    • A2A2T5
    • B4E025
    • Q13565
    • Q53GY6
    • Q5T159
    • Q6IUY7
    • Q86TN5
    • Q9UG44
    • Q9UNT6

    Protein attributes for ORC3 Gene

    Size:
    711 amino acids
    Molecular mass:
    82254 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.

    Three dimensional structures from OCA and Proteopedia for ORC3 Gene

    Alternative splice isoforms for ORC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ORC3 Gene

Post-translational modifications for ORC3 Gene

  • Ubiquitination at posLast=428428 and posLast=523523
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ORC3 Gene

Domains & Families for ORC3 Gene

Gene Families for ORC3 Gene

Protein Domains for ORC3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UBD5

UniProtKB/Swiss-Prot:

ORC3_HUMAN :
  • Belongs to the ORC3 family.
Family:
  • Belongs to the ORC3 family.
genes like me logo Genes that share domains with ORC3: view

Function for ORC3 Gene

Molecular function for ORC3 Gene

UniProtKB/Swiss-Prot Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene Ontology (GO) - Molecular Function for ORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003688 DNA replication origin binding TAS 9829972
GO:0005515 protein binding IPI 15232106
genes like me logo Genes that share ontologies with ORC3: view
genes like me logo Genes that share phenotypes with ORC3: view

Animal Models for ORC3 Gene

MGI Knock Outs for ORC3:
  • Orc3 tm1a(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

miRNA for ORC3 Gene

miRTarBase miRNAs that target ORC3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ORC3 Gene

Localization for ORC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORC3 gene
Compartment Confidence
nucleus 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000808 origin recognition complex IDA 17716973
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005656 nuclear pre-replicative complex IBA --
genes like me logo Genes that share ontologies with ORC3: view

Pathways & Interactions for ORC3 Gene

genes like me logo Genes that share pathways with ORC3: view

Gene Ontology (GO) - Biological Process for ORC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication IBA --
GO:0006270 DNA replication initiation IBA --
GO:0061351 neural precursor cell proliferation IEA --
genes like me logo Genes that share ontologies with ORC3: view

No data available for SIGNOR curated interactions for ORC3 Gene

Drugs & Compounds for ORC3 Gene

No Compound Related Data Available

Transcripts for ORC3 Gene

Unigene Clusters for ORC3 Gene

Origin recognition complex, subunit 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - - -
SP2: -
SP3: - -
SP4:
SP5:

ExUns: 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ORC3 Gene

GeneLoc Exon Structure for
ORC3
ECgene alternative splicing isoforms for
ORC3

Expression for ORC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORC3 Gene

Protein differential expression in normal tissues from HIPED for ORC3 Gene

This gene is overexpressed in Breast (27.7), Testis (6.8), and Lymph node (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ORC3 Gene



Protein tissue co-expression partners for ORC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ORC3 Gene:

ORC3

SOURCE GeneReport for Unigene cluster for ORC3 Gene:

Hs.410228

Evidence on tissue expression from TISSUES for ORC3 Gene

  • Nervous system(4.9)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ORC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORC3 Gene

Orthologs for ORC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORC3 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia ORC3 34 35
  • 90.85 (n)
cow
(Bos Taurus)
Mammalia ORC3 34 35
  • 89.12 (n)
rat
(Rattus norvegicus)
Mammalia Orc3 34
  • 84.41 (n)
mouse
(Mus musculus)
Mammalia Orc3 34 16 35
  • 84.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ORC3 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ORC3 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ORC3 34 35
  • 69.6 (n)
lizard
(Anolis carolinensis)
Reptilia ORC3 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia orc3 34
  • 68.46 (n)
Str.19920 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53625 34
zebrafish
(Danio rerio)
Actinopterygii orc3 34 35
  • 58.69 (n)
Dr.2362 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.410 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010406 34
  • 46.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta lat 34 35
  • 46 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ORC3 34
  • 43.4 (n)
rice
(Oryza sativa)
Liliopsida Os10g0402200 34
  • 44.37 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02683 34
  • 38.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for ORC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORC3 Gene

ENSEMBL:
Gene Tree for ORC3 (if available)
TreeFam:
Gene Tree for ORC3 (if available)

Paralogs for ORC3 Gene

(1) SIMAP similar genes for ORC3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ORC3 Gene

genes like me logo Genes that share paralogs with ORC3: view

No data available for Paralogs for ORC3 Gene

Variants for ORC3 Gene

Sequence variations from dbSNP and Humsavar for ORC3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs147391618 Pathogenic 87,589,923(+) ATACC(C/T)GGCAA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs774923951 Pathogenic 87,589,957(+) CGCCA(A/C/G/T)GTCCA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs200228607 Uncertain significance 87,589,970(+) TCTAC(A/G)GAAGT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs201693843 Uncertain significance 87,589,939(+) AGCGC(A/G/T)GCGAA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs371367255 Uncertain significance 87,589,932(+) AAGCA(A/G)TAGCG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ORC3 Gene

Variant ID Type Subtype PubMed ID
dgv6085n100 CNV gain 25217958
esv2732392 CNV deletion 23290073
esv2759454 CNV loss 17122850
esv3540112 CNV deletion 23714750
nsv1117652 CNV deletion 24896259
nsv1137123 CNV deletion 24896259

Variation tolerance for ORC3 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.00; 80.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC3 Gene

Disorders for ORC3 Gene

Relevant External Links for ORC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORC3

No disorders were found for ORC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORC3 Gene

Publications for ORC3 Gene

  1. Latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. (PMID: 10402192) Pinto S. … Tully T. (Neuron 1999) 2 3 4 64
  2. The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. (PMID: 18628273) DeRosse P. … Malhotra A.K. (Schizophr Bull 2008) 3 22 64
  3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S. … Elledge S.J. (Science 2007) 3 4 64
  4. ATP-dependent assembly of the human origin recognition complex. (PMID: 17716973) Siddiqui K. … Stillman B. (J. Biol. Chem. 2007) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ORC3 Gene

Sources for ORC3 Gene

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