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Aliases for ORC2 Gene

Aliases for ORC2 Gene

  • Origin Recognition Complex Subunit 2 2 3 5
  • ORC2L 3 4
  • Origin Recognition Complex, Subunit 2 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 2 Homolog (Yeast) 2
  • Origin Recognition Complex, Subunit 2-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 2 Homolog 3
  • Origin Recognition Complex Protein 2 Homolog 3
  • Origin Recognition Complex, Subunit 2 2

External Ids for ORC2 Gene

Previous HGNC Symbols for ORC2 Gene

  • ORC2L

Previous GeneCards Identifiers for ORC2 Gene

  • GC02M201774

Summaries for ORC2 Gene

Entrez Gene Summary for ORC2 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]

GeneCards Summary for ORC2 Gene

ORC2 (Origin Recognition Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Mitotic G1-G1/S phases. GO annotations related to this gene include DNA replication origin binding.

UniProtKB/Swiss-Prot for ORC2 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.

Gene Wiki entry for ORC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORC2 Gene

Genomics for ORC2 Gene

Regulatory Elements for ORC2 Gene

Enhancers for ORC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F201147 1.4 Ensembl ENCODE 34 -187.1 -187124 5.8 HDGF MLX ZNF133 ZFP64 SIN3A ARID4B DMAP1 ZNF121 ELK1 FOS PPIL3 ORC2 RNU6-312P CASP10 LOC100420110 LOC105373835 GC02P201142 CFLAR-AS1
GH02F200866 0.6 ENCODE 33.4 +96.5 96481 1.1 TBP INSM2 FEZF1 GTF3C2 ZNF366 ZNF548 ZNF362 CEBPB ZEB2 ZNF843 PPIL3 ORC2 RNU6-762P TYW5 LOC100420110 CLK1 RNU6-312P
GH02F200867 0.6 ENCODE 33.4 +95.7 95746 0.1 ZBTB8A ZIC2 GTF3C2 HIC1 KLF9 ZNF600 ZNF548 SP7 ORC2 RNU6-762P TYW5 LOC100420110 CLK1 RNU6-312P
GH02F201805 1.2 Ensembl ENCODE 22.8 -843.4 -843442 2.4 PKNOX1 FEZF1 ZIC2 ZNF2 CTBP1 POLR2A PRDM10 ZNF600 MAFK ZNF680 ORC2 NOP58 LOC100420110 ALS2 FZD7 RNU6-440P LOC729224 ENSG00000212309 SNORD70 GC02P201809
GH02F200176 0.5 Ensembl ENCODE 22 +785.1 785132 3.2 SOX13 ZNF202 ZNF274 POLR2A SMARCA4 BCL6 ZBTB33 ZNF652 LOC101927687 ORC2 TYW5 RNU6-762P SPATS2L LOC105373834 GC02P200203
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ORC2 on UCSC Golden Path with GeneCards custom track

Promoters for ORC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000605455 103 2801 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for ORC2 Gene

Chromosome:
2
Start:
200,908,973 bp from pter
End:
200,963,703 bp from pter
Size:
54,731 bases
Orientation:
Minus strand

Genomic View for ORC2 Gene

Genes around ORC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC2 Gene

Proteins for ORC2 Gene

  • Protein details for ORC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13416-ORC2_HUMAN
    Recommended name:
    Origin recognition complex subunit 2
    Protein Accession:
    Q13416
    Secondary Accessions:
    • Q13204
    • Q53TX5

    Protein attributes for ORC2 Gene

    Size:
    577 amino acids
    Molecular mass:
    65972 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (PubMed:12909626, PubMed:17716973). Interacts with DBF4 (By similarity). Interacts with MCM10 (PubMed:11095689). Interacts with LRWD1 throughout the cell cycle; this interaction, wich occurs only with non-ubiquitinated form of LRWD1, prevents LRWD1 ubiquitination and hence stabilizes the protein (PubMed:22645314). Interacts with POLQ (PubMed:24989122).

    Three dimensional structures from OCA and Proteopedia for ORC2 Gene

neXtProt entry for ORC2 Gene

Post-translational modifications for ORC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ORC2 Gene

No data available for DME Specific Peptides for ORC2 Gene

Domains & Families for ORC2 Gene

Gene Families for ORC2 Gene

Protein Domains for ORC2 Gene

Suggested Antigen Peptide Sequences for ORC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13416

UniProtKB/Swiss-Prot:

ORC2_HUMAN :
  • Belongs to the ORC2 family.
Family:
  • Belongs to the ORC2 family.
genes like me logo Genes that share domains with ORC2: view

Function for ORC2 Gene

Molecular function for ORC2 Gene

UniProtKB/Swiss-Prot Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.

Gene Ontology (GO) - Molecular Function for ORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003688 DNA replication origin binding IEA,TAS --
GO:0005515 protein binding IPI 11095689
genes like me logo Genes that share ontologies with ORC2: view
genes like me logo Genes that share phenotypes with ORC2: view

Animal Model Products

miRNA for ORC2 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ORC2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORC2 Gene

Localization for ORC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORC2 Gene COMPARTMENTS Subcellular localization image for ORC2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0000785 chromatin IEA --
GO:0000792 heterochromatin IDA 15215892
GO:0000808 origin recognition complex IEA,IDA 17716973
GO:0000939 condensed chromosome inner kinetochore IEA --
genes like me logo Genes that share ontologies with ORC2: view

Pathways & Interactions for ORC2 Gene

genes like me logo Genes that share pathways with ORC2: view

SIGNOR curated interactions for ORC2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ORC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 8808289
GO:0006260 DNA replication IEA,TAS --
GO:0006270 DNA replication initiation TAS 8808289
genes like me logo Genes that share ontologies with ORC2: view

Drugs & Compounds for ORC2 Gene

(1) Drugs for ORC2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ORC2: view

Transcripts for ORC2 Gene

Unigene Clusters for ORC2 Gene

Origin recognition complex, subunit 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ORC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORC2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - -
SP2:
SP3: - -
SP4:

Relevant External Links for ORC2 Gene

GeneLoc Exon Structure for
ORC2
ECgene alternative splicing isoforms for
ORC2

Expression for ORC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ORC2 Gene

Protein differential expression in normal tissues from HIPED for ORC2 Gene

This gene is overexpressed in Plasma (20.3), Urinary Bladder (11.3), Testis (11.2), and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ORC2 Gene



Protein tissue co-expression partners for ORC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ORC2 Gene:

ORC2

SOURCE GeneReport for Unigene cluster for ORC2 Gene:

Hs.444870
genes like me logo Genes that share expression patterns with ORC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ORC2 Gene

Orthologs for ORC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORC2 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia ORC2 34 35
  • 91.9 (n)
cow
(Bos Taurus)
Mammalia ORC2 34 35
  • 91.15 (n)
mouse
(Mus musculus)
Mammalia Orc2 34 16 35
  • 84.55 (n)
rat
(Rattus norvegicus)
Mammalia Orc2 34
  • 84.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ORC2 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ORC2 34 35
  • 68.84 (n)
lizard
(Anolis carolinensis)
Reptilia ORC2 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia orc2 34
  • 64.53 (n)
Str.20373 34
African clawed frog
(Xenopus laevis)
Amphibia orc2-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii ORC2 35
  • 61 (a)
OneToOne
zgc:153041 34
  • 59.8 (n)
Dr.12649 34
fruit fly
(Drosophila melanogaster)
Insecta Orc2 34 35
  • 47 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000474 34
  • 45.49 (n)
worm
(Caenorhabditis elegans)
Secernentea orc-2 35
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ORC2 35 37
  • 19 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ORC2 34
  • 47.03 (n)
rice
(Oryza sativa)
Liliopsida Os03g0184700 34
  • 47.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToOne
Species where no ortholog for ORC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ORC2 Gene

ENSEMBL:
Gene Tree for ORC2 (if available)
TreeFam:
Gene Tree for ORC2 (if available)

Paralogs for ORC2 Gene

No data available for Paralogs for ORC2 Gene

Variants for ORC2 Gene

Sequence variations from dbSNP and Humsavar for ORC2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10167387 -- 200,943,895(+) TTATT(C/T)CATCT intron-variant
rs10172647 -- 200,914,227(+) gtggc(A/G)tgatc intron-variant
rs10183261 -- 200,932,953(+) TTTAC(A/G)CCCAA intron-variant
rs10185727 -- 200,938,988(+) gagcc(A/G)agatc intron-variant
rs10189671 -- 200,961,591(+) GTTCA(C/T)TGGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ORC2 Gene

Variant ID Type Subtype PubMed ID
nsv3109 CNV deletion 18451855

Variation tolerance for ORC2 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORC2 Gene

Disorders for ORC2 Gene

Relevant External Links for ORC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORC2

No disorders were found for ORC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORC2 Gene

Publications for ORC2 Gene

  1. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. (PMID: 8808289) Takahara K. … Greenspan D.S. (Genomics 1996) 2 3 4 22 64
  2. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PMID: 11095689) Izumi M. … Hanaoka F. (Nucleic Acids Res. 2000) 3 4 22 64
  3. Orc2 protects ORCA from ubiquitin-mediated degradation. (PMID: 22935713) Shen Z. … Prasanth S.G. (Cell Cycle 2012) 3 4 64
  4. ATP-dependent assembly of the human origin recognition complex. (PMID: 17716973) Siddiqui K. … Stillman B. (J. Biol. Chem. 2007) 3 4 64
  5. Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation. (PMID: 16407251) Teer J.K. … Dutta A. (J. Biol. Chem. 2006) 3 22 64

Products for ORC2 Gene

Sources for ORC2 Gene

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