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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ORC2 Gene

protein-coding   GIFtS: 56
GCID: GC02M201774

origin recognition complex, subunit 2

(Previous names: origin recognition complex, subunit 2 (yeast homolog)-like,...)
(Previous symbol: ORC2L)
 Explore 3 diseases affiliated with
ORC2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ORC2    

Aliases
for ORC2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Origin Recognition Complex, Subunit 21 2     Origin Recognition Complex, Subunit 2-Like (Yeast)1
ORC2L1 2 3 5     Origin Recognition Complex Protein 2 Homolog2
Origin Recognition Complex, Subunit 2 (Yeast Homolog)-Like1     Origin Recognition Complex Subunit 22
Origin Recognition Complex, Subunit 2 Homolog (Yeast)1     Origin Recognition Complex, Subunit 2 Homolog2

External Ids:    HGNC: 84881   Entrez Gene: 49992   Ensembl: ENSG000001159427   OMIM: 6011825   UniProtKB: Q134163   
ORGUL members:         
NONCODE:n409529    

Export aliases for ORC2 gene to outside databases


Summaries
for ORC2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ORC2:
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of
the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of
replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.
The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and
-5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA
replication. This protein has been demonstrated to specifically associate with the origin of replication of
Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.
Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.
(provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: ORC2_HUMAN, Q13416
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC
is required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Wiki entry for ORC2 (ORC2L)


Genomic Views
for ORC2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ORC2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ORC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ORC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33

ORC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORC2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M201774:  view genomic region     (about GC identifiers)

Start:
 201,773,696 bp from pter      End:
 201,828,424 bp from pter
Size:
 54,729 bases      Orientation:
 minus strand

Proteins
for ORC2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ORC2_HUMAN, Q13416 (See protein sequence)
Recommended Name: Origin recognition complex subunit 2  
Size: 577 amino acids; 65972 Da
Subunit: ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled
at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity).
Interacts with MCM10
Subcellular location: Nucleus
Secondary accessions: Q13204 Q53TX5

Explore the universe of human proteins at neXtProt for ORC2: NX_Q13416

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13416

    • ORC2 Protein expression data from MOPED and PaxDb:    About this image 
    ORC2 Protein Expression
    REFSEQ proteins: NP_006181.1  
    ENSEMBL proteins: 
     ENSP00000234296   ENSP00000386390   ENSP00000396641  
    Reactome Protein details: Q13416
    Human Recombinant Protein Products for ORC2: 
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    Novus Biologicals ORC2 Protein
    Novus Biologicals ORC2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ORC2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin ----
    GO:0000792heterochromatin IEA--
    GO:0000808origin recognition complex IDA17716973
    GO:0000939condensed chromosome inner kinetochore IEA--
    GO:0005634nucleus TAS8808289

    ORC2 for ontologies           About GeneDecksing



    ORC2 Antibody Products: 
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    ThermoFisher Antibodies for ORC2

    Assay Products for ORC2: 
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    Uscn ELISAs and CLIAs for ORC2

    Protein Domains /
    Families
    for ORC2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ORC2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007220 ORC2

    Graphical View of Domain Structure for InterPro Entry Q13416

    ProtoNet protein and cluster: Q13416

    1 Blocks protein family: IPB007220 Origin recognition complex subunit 2

    UniProtKB/Swiss-Prot: ORC2_HUMAN, Q13416
    Similarity: Belongs to the ORC2 family


    Function
    for ORC2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORC2_HUMAN, Q13416
    Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
    ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC
    is required to assemble the pre-replication complex necessary to initiate DNA replication

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003688DNA replication origin binding IEA--
    GO:0005515protein binding IPI17716973
         
    ORC2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ORC2:
     Increased 8N DNA content  Increased cell death in breast  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ORC2 

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORC2
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate ORC2 (see all 38):
    hsa-miR-596 hsa-miR-4307 hsa-miR-136 hsa-miR-300 hsa-miR-488 hsa-miR-30d hsa-miR-218 hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmid: ORC2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ORC2 (see all 4)
    OriGene shRNA RFP: ORC2
    OriGene siRNA: ORC2
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    Sirion Biotech Custom design and validation of potent shRNA sequences against ORC2 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ORC2 
    Sirion Biotech Customized adenovirus for potent knockdown of ORC2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC2 (see all 4)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ORC2 (NM_006190)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC2 

    Cell Line
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    Sirion Biotech Customized inducible overexpressing cell line services for ORC2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC2


    Pathways & Interactions
    for ORC2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/12 pathways (see all 12)
    		CDT1 association with the CDC6:ORC:origin complex0.84
    		DNA Replication Pre-Initiation0.62
    		Assembly of the pre-replicative complex0.77
    		M/G1 Transition0.62
    		Switching of origins to a post-replicative state0.70
    		Synthesis of DNA0.51
    		Orc1 removal from chromatin0.70
    		DNA Replication0.49
    2CDC6 association with the ORC:origin complex
    		CDC6 association with the ORC:origin complex1.00
    		E2F-enabled inhibition of pre-replication complex formation0.64
    		Assembly of the ORC complex at the origin of replication0.75
    		Association of licensing factors with the pre-replicative complex0.43
    3Cell cycle
    		Cell cycle1.00
    		G1 to S cell cycle control0.38
    		Cell cycle0.57
    4Cell cycle_Start of DNA replication in early S phase
    		Cell cycle_Start of DNA replication in early S phase1.00
    		Cell cycle Start of DNA replication in early S phase0.98
    5Activation of ATR in response to replication stress
    		Activation of ATR in response to replication stress1.00
    		G2/M Checkpoints0.86

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for ORC2
        Meiosis
    Cell cycle Start of DNA replication in early S phase


    1 Cell Signaling Technology (CST) Pathway for ORC2
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for ORC2
        Cell cycle Start of DNA replication in early S phase

    3 BioSystems Pathways for ORC2 
        G1 to S cell cycle control
    Cell cycle
    DNA Replication

    5/25        Reactome Pathways for ORC2 (see all 25)
        Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    DNA Replication
    E2F-enabled inhibition of pre-replication complex formation
    Removal of licensing factors from origins


    1         Kegg Pathway  (Kegg details for ORC2):
        Cell cycle


    ORC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ORC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/809 Interacting proteins for ORC2 (Q134161, 2, 3 ENSP000002342964) via UniProtKB, MINT, STRING, and/or I2D (see all 809)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCM3P252051, 2, 3, ENSP000002298544EBI-374957,EBI-355153 MINT-8076071 MINT-8076347 MINT-8076236 I2D: score=4 STRING: ENSP00000229854
    MCM4P339912, 3, ENSP000002621054MINT-8076071 MINT-8076347 MINT-8076236 I2D: score=5 STRING: ENSP00000262105
    ORC3Q9UBD52, 3, ENSP000002577894MINT-7945693 MINT-7947479 MINT-8076236 I2D: score=4 STRING: ENSP00000257789
    MCM5P339922, 3, ENSP000002161224MINT-8076071 MINT-8076347 MINT-8076236 I2D: score=3 STRING: ENSP00000216122
    MCM6Q145662, 3, ENSP000002641564MINT-8076071 MINT-8076236 I2D: score=4 STRING: ENSP00000264156
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS8808289
    GO:0000216M/G1 transition of mitotic cell cycle TAS--

    ORC2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ORC2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ORC2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ORC2
    1 Novoseek chemical compound relationship for ORC2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 18.5 1 12807890 (1)

    Search CenterWatch for drugs/clinical trials and news about ORC2 

    Transcripts
    for ORC2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ORC2 gene: 
    NM_006190.4  

    Unigene Cluster for ORC2:

    Origin recognition complex, subunit 2
    Hs.444870  [show with all ESTs]
    Unigene Representative Sequence: NR_033915
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234296(uc002uwr.3) ENST00000464147 ENST00000487853 ENST00000474877
    ENST00000467605 ENST00000410039 ENST00000457595

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORC2
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate ORC2 (see all 38):
    hsa-miR-596 hsa-miR-4307 hsa-miR-136 hsa-miR-300 hsa-miR-488 hsa-miR-30d hsa-miR-218 hsa-miR-766
    SwitchGear 3'UTR luciferase reporter plasmid: ORC2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ORC2 (see all 4)
    OriGene shRNA RFP: ORC2
    OriGene siRNA: ORC2
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    Clone
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    Additional cDNA sequence: 

    AK302614.1 AK316433.1 BC014834.1 NR_033915.1 U27459.1 U40268.2 

    13 DOTS entries:

    DT.311834  DT.100730274  DT.100780158  DT.91819810  DT.311835  DT.100780159  DT.120963437  DT.306161 
    DT.40122280  DT.75122760  DT.95269944  DT.120963364  DT.95225732 

    24/125 AceView cDNA sequences (see all 125):

    AI814392 AW473208 NM_006190 BM470184 CF552296 AW472983 BQ775398 U40268 
    AW085682 CR596826 BU685377 AU130158 BC014834 BM834055 BF445652 AI805763 
    AI890085 AW004830 BU182508 BQ003777 AI087962 BF475416 BP367458 AV705856 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ORC2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
    SP1:                                      -                                                                       -                     
    SP2:                                                                                                                                    
    SP3:                    -                 -                                                                                             
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for ORC2

    Expression
    for ORC2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ORC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    ORC2 Expression
    About this image
    See ORC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ORC2

    SOURCE GeneReport for Unigene cluster: Hs.444870
        SABiosciences Custom PCR Arrays for ORC2

    Primer
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    In Situ
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    Orthologs
    for ORC2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ORC2 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Orc21 , 5 origin recognition complex, subunit 21, 5 84.55(n)1
    78.99(a)1    		   1 (29.10 cM)5
    183931  NM_008765.21  NP_032791.11 
     584627715 
    chicken
    (Gallus gallus)    		 Aves ORC21 origin recognition complex, subunit 2 68.84(n)
    67.78(a)    		   424077  NM_001006517.1  NP_001006517.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ORC26
    		 --
    		 60(a)
    		 1 ↔ 1
    		 GL343478.1(525269-549739)
    African clawed frog
    (Xenopus laevis)    		 Amphibia orc2-A-prov2 origin recognition complex subunit 2 homolog 73.8(n)    U31984.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.126492 Transcribed sequence with moderate similarity to protein more 71.63(n)    BI877690.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Orc21 Origin recognition complex subunit 2 46.81(n)
    41(a)    		   41703  NM_169563.1  NP_731873.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea orc-21 Protein ORC-2 41.93(n)
    28.12(a)    		   174676  NM_063938.3  NP_496339.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ORC21 origin recognition complex subunit 2 47.18(n)
    38.02(a)    		   818332  NM_129311.2  NP_181292.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g01847001 hypothetical protein 47.41(n)
    36.96(a)    		   4331860  NM_001055727.2  NP_001049192.1 


    ENSEMBL Gene Tree for ORC2 (if available)
    TreeFam Gene Tree for ORC2 (if available) 

    Paralogs
    for ORC2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ORC2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/787 NCBI SNPs in ORC2 are shown (see all 787)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1512346281,2
    		Cother201814290(+) GCCATA/C/TTTTTC 5 K N syn1 mis11NA 4478
    rs1851575541,2
    		--201774493(+) GATTTA/TAAAAA 2 -- ds50010--------
    rs1907902691,2
    		--201774610(+) CTCCAC/TAGCAG 2 -- ds50010--------
    rs168355181,2
    		C,F--201774693(-) GCCTGG/AGCAAC 2 -- ds50011Minor allele frequency- A:0.04NS 168
    rs1820845471,2
    		--201774897(+) GCTGAC/TGTAGT 2 -- nc-transcript-variantut310--------
    rs1160877071,2
    		--201774974(+) TATGTG/AATGAC 2 -- nc-transcript-variantut311Minor allele frequency- A:0.01NA 120
    rs1446709291,2
    		--201774981(+) TGACTA/GTAAGC 2 -- ut31 nc-transcript-variant0--------
    rs1479014011,2
    		--201775039(+) TCTCGC/TGCAAA 2 -- nc-transcript-variantut310--------
    rs1870733141,2
    		--201775205(+) ATATAC/TAAGAA 2 -- nc-transcript-variantut310--------
    rs1399230411,2
    		--201775298(+) CACTGG/TTATCA 2 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for ORC2 (201773696 - 201828424 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ORC2: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ORC2
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    Disorders / Diseases
    for ORC2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ORC2 for disorders           About GeneDecksing

    OMIM gene information: 601182    OMIM disorders: --

    3 diseases for ORC2:    About MalaCards
    leiomyoma    retinoblastoma    neuronitis

    1 Novoseek disease relationship for ORC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 2 11509178 (1)


    Export disorders for ORC2 gene to outside databases

    Publications
    for ORC2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ORC2 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with ORC2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. (PubMed id 8808289)1, 2, 3, 9 Takahara K.... Greenspan D.S. (1996)
    2. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. (PubMed id 11095689)1, 2, 9 Izumi M.... Hanaoka F. (2000)
    3. ATP-dependent assembly of the human origin recognition complex. (PubMed id 17716973)1, 2 Siddiqui K. and Stillman B. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Conserved initiator proteins in eukaryotes. (PubMed id 7502077)1, 2 Gavin K.A.... Stillman B.D. (1995)
    6. Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin. (PubMed id 11509178)1, 9 Dhar S.K....Dutta A. (2001)
    7. Localization of proteins bound to a replication origin of human DNA along the cell cycle. (PubMed id 12912926)1, 9 Abdurashidova G....Falaschi A. (2003)
    8. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals. (PubMed id 10835370)1, 9 Natale D.A....DePamphilis M.L. (2000)
    9. Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin. (PubMed id 9733749)1, 9 Ritzi M....Knippers R. (1998)
    10. Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation. (PubMed id 16407251)1, 9 Teer J.K....Dutta A. (2006)

    External Searches for ORC2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ORC2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4999 HGNC: 8488 AceView: ORC2L Ensembl:ENSG00000115942 euGenes: HUgn4999
    ECgene: ORC2 Kegg: 4999 H-InvDB: ORC2

    Other Databases showing ORC2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ORC2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ORC2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/orc2l/

    Intellectual Property
    for ORC2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ORC2 gene:
    Search GeneIP for patents involving ORC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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