Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ORC1 Gene

protein-coding   GIFtS: 59
GCID: GC01M052839

origin recognition complex, subunit 1

(Previous names: origin recognition complex, subunit 1 (yeast homolog)-like,...)
(Previous symbol: ORC1L)
 Explore 9 diseases affiliated with
ORC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ORC1    

Aliases
for ORC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Origin Recognition Complex, Subunit 11 2     Origin Recognition Complex, Subunit 1 Homolog (S. Cerevisiae)1
ORC1L1 2 3 5     Origin Recognition Complex, Subunit 1-Like (Yeast)1
PARC11 2 3     Origin Recognition Complex Subunit 12
HSORC11 2     Origin Recognition Complex, Subunit 1 Homolog2
Replication Control Protein 12 3     HS5
Origin Recognition Complex, Subunit 1 (Yeast Homolog)-Like1     

External Ids:    HGNC: 84871   Entrez Gene: 49982   Ensembl: ENSG000000858407   OMIM: 6019025   UniProtKB: Q134153   

Export aliases for ORC1 gene to outside databases


Summaries
for ORC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ORC1:
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of
the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of
replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.
The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable
throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be
controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be
selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2
(MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: ORC1_HUMAN, Q13415
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC
is required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Wiki entry for ORC1


Genomic Views
for ORC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ORC1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ORC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ORC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32

ORC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORC1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M052839:  view genomic region     (about GC identifiers)

Start:
 52,838,501 bp from pter      End:
 52,870,143 bp from pter
Size:
 31,643 bases      Orientation:
 minus strand

Proteins
for ORC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ORC1_HUMAN, Q13415 (See protein sequence)
Recommended Name: Origin recognition complex subunit 1  
Size: 861 amino acids; 97350 Da
Subunit: ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled
at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1
Subcellular location: Nucleus
Developmental stage: Expression is cell-cycle regulated, it starts to accumulate in mid-G1 phase, reaches a peak at the
G1/S boundary, and decreases to a basal level in S phase (at protein level)
Secondary accessions: D3DQ34 Q13471 Q5T0F5

Explore the universe of human proteins at neXtProt for ORC1: NX_Q13415

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13415

    • ORC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001177747.1  NP_001177748.1  NP_004144.2  

    ENSEMBL proteins: 
     ENSP00000360623   ENSP00000360621  
    Reactome Protein details: Q13415
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ORC1
    OriGene Custom Protein Services for ORC1 
    GenScript Custom Purified and Recombinant Proteins Services for ORC1
    Novus Biologicals ORC1 Protein
    Novus Biologicals ORC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ORC1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000808origin recognition complex IDA17716973
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005664nuclear origin of replication recognition complex IDA--
    GO:0005730nucleolus IDA--


    ORC1 for ontologies           About GeneDecksing



    ORC1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ORC1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ORC1  (ORC1L)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ORC1 
    GenScript Custom Superior Antibodies Services for ORC1
    Novus Biologicals ORC1 Antibodies
    Search for Antibodies for ORC1 at Abcam  
    Uscn Antibodies for ORC1
    ThermoFisher Antibodies for ORC1

    Assay Products for ORC1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ORC1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ORC1

    Protein Domains /
    Families
    for ORC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ORC1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003959 ATPase_AAA_core
     IPR001025 BAH_dom
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR020793 ORC1
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q13415

    ProtoNet protein and cluster: Q13415

    1 Blocks protein family: IPB001025 Bromo adjacent region

    UniProtKB/Swiss-Prot: ORC1_HUMAN, Q13415
    Domain: The BAH domain mediates binding to dimethylated histone H4 'Lys-20' (H4K20me2), which is enriched at
    replication origins (By similarity)
    Similarity: Belongs to the ORC1 family
    Similarity: Contains 1 BAH domain


    Function
    for ORC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ORC1_HUMAN, Q13415
    Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is
    ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC
    is required to assemble the pre-replication complex necessary to initiate DNA replication

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORC1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ORC1:
    hsa-miR-587 hsa-miR-3611 hsa-miR-3148 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmid: ORC1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ORC1 (see all 4)
    OriGene shRNA RFP: ORC1
    OriGene siRNA: ORC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORC1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ORC1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ORC1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): ORC1 (NM_004153)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ORC1
    Search LifeMap BioReagents cell lines for ORC1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI17716973
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--


    ORC1 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ORC1:
     Cell division defect  Decreased viability of wild-ty  Increased G2M DNA content, inc  Increased number of mitotic ce 


    Pathways & Interactions
    for ORC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/13 pathways (see all 13)
    		Ubiquitinated Orc1 is degraded by the proteasome1.00
    		DNA Replication Pre-Initiation0.62
    		CDT1 association with the CDC6:ORC:origin complex0.84
    		M/G1 Transition0.62
    		Assembly of the pre-replicative complex0.77
    		Synthesis of DNA0.51
    		Switching of origins to a post-replicative state0.70
    		DNA Replication0.49
    2CDC6 association with the ORC:origin complex
    		CDC6 association with the ORC:origin complex1.00
    		E2F-enabled inhibition of pre-replication complex formation0.64
    		Assembly of the ORC complex at the origin of replication0.75
    		Association of licensing factors with the pre-replicative complex0.43
    3G1/S-Specific Transcription
    		G1/S-Specific Transcription1.00
    		E2F mediated regulation of DNA replication0.45
    		Activation of E2F target genes at G1/S1.00
    4Cell cycle
    		Cell cycle1.00
    		G1 to S cell cycle control0.38
    		Cell cycle0.57
    5Cell cycle_Start of DNA replication in early S phase
    		Cell cycle_Start of DNA replication in early S phase1.00
    		Cell cycle Start of DNA replication in early S phase0.98

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for ORC1
        Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Start of DNA replication in early S phase


    1 Cell Signaling Technology (CST) Pathway for ORC1
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for ORC1
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle Start of DNA replication in early S phase

    4 BioSystems Pathways for ORC1 
        Cell cycle
    G1 to S cell cycle control
    DNA Replication
    E2F transcription factor network

    5/28        Reactome Pathways for ORC1 (see all 28)
        Activation of ATR in response to replication stress
    Mitotic G1-G1/S phases
    DNA Replication
    E2F-enabled inhibition of pre-replication complex formation
    Removal of licensing factors from origins


    1         Kegg Pathway  (Kegg details for ORC1):
        Cell cycle


    ORC1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ORC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for ORC1 (Q134151, 2, 3 ENSP000003606214) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORC3Q9UBD51, 3, ENSP000002577894EBI-374847,EBI-374916 I2D: score=4 STRING: ENSP00000257789
    SKP2Q133091, 3, ENSP000002742554EBI-374847,EBI-456291 I2D: score=4 STRING: ENSP00000274255
    ABL1P005192, 3, ENSP000003614234MINT-8110599 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111427 I2D: score=3 STRING: ENSP00000357656
    TERF2Q155542, 3, ENSP000002549424MINT-2831781 MINT-2831892 I2D: score=2 STRING: ENSP00000254942
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S phase of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--


    ORC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ORC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ORC1
    Search CenterWatch for drugs/clinical trials and news about ORC1 

    Transcripts
    for ORC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ORC1 gene (3 alternative transcripts): 
    NM_001190818.1  NM_001190819.1  NM_004153.3  

    Unigene Cluster for ORC1:

    Origin recognition complex, subunit 1
    Hs.17908  [show with all ESTs]
    Unigene Representative Sequence: NM_004153
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371568(uc001ctt.3 uc010oni.2 uc001ctu.3) ENST00000371566
    ENST00000476332

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORC1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ORC1:
    hsa-miR-587 hsa-miR-3611 hsa-miR-3148 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmid: ORC1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ORC1 (see all 4)
    OriGene shRNA RFP: ORC1
    OriGene siRNA: ORC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORC1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ORC1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): ORC1 (NM_004153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ORC1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ORC1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORC1

    Additional cDNA sequence: 

    AK291909.1 AK303420.1 BC011539.1 U40152.1 U43416.1 

    3 DOTS entries:

    DT.209714  DT.100742042  DT.75184465 

    24/93 AceView cDNA sequences (see all 93):

    BX281133 AL558857 BX110476 BQ423782 BU854819 BM476715 BE937466 BQ433201 
    BM556110 CR594568 BP364182 BU198520 BQ229865 BQ055912 NM_004153 BM852299 
    AU125429 BU854876 BM743410 BU552785 CR619175 BX474463 BG822626 AI636405 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ORC1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                          -                                                               
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          


    ECgene alternative splicing isoforms for ORC1

    Expression
    for ORC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ORC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTTTGGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ORC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ORC1

    SOURCE GeneReport for Unigene cluster: Hs.17908
        SABiosciences Custom PCR Arrays for ORC1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ORC1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ORC1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORC1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORC1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC1

    Orthologs
    for ORC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ORC1 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Orc11 , 5 origin recognition complex, subunit 11, 5 76.19(n)1
    68.55(a)1    		   4 (50.64 cM)5
    183921  NM_011015.21  NP_035145.21 
     1085794235 
    chicken
    (Gallus gallus)    		 Aves ORC11 origin recognition complex, subunit 1 60.92(n)
    56.28(a)    		   424640  NM_001031286.1  NP_001026457.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ORC16
    		 --
    		 47(a)
    		 1 ↔ 1
    		 4(114550694-114572314)
    African clawed frog
    (Xenopus laevis)    		 Amphibia XORC12 origin recognition complex protein 1 75.43(n)    U67190.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa11h082 wufa11h08 74.45(n)   335020  BC047200.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Orc11 Origin recognition complex subunit 1 52.19(n)
    46.46(a)    		   35686  NM_057955.3  NP_477303.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea orc-16
    		 Protein ORC-1
    		 21(a)
    		 1 ↔ 1
    		 III(10642966-10646008)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATORC1B6
    ATORC1A6
    		 origin recognition complex subunit 1
    		 22(a)
    22(a)
    		 many → 1
    many → 1
    		 4(7459646-7462253)
    4(8422231-8424760)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 ORC1 - Putative origin recognition complex subunit...
    		 21(a)
    		 1 ↔ 1
    		 6(4392377-4400130)


    ENSEMBL Gene Tree for ORC1 (if available)
    TreeFam Gene Tree for ORC1 (if available) 

    Paralogs
    for ORC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ORC1 gene
    CDC62  
    1 SIMAP similar gene for ORC1 using alignment to 1 protein entry:     ORC1_HUMAN:
    ORC1L

    ORC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ORC1
    PGOHUM00000241222


    Genomic Variants
    for ORC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/563 NCBI SNPs in ORC1 are shown (see all 563)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs30874711,2
    		C,F,H,--50954625(-) GTTGCC/TAAGCT 3 -- ut3114Minor allele frequency- T:0.07NA NS EA WA 1806
    rs127383051,2
    		C--50955607(+) CTACCC/TTAACG 3 -- int11Minor allele frequency- T:0.00NA 2
    rs746532811,2
    		F,--50955835(+) AGAGCT/CATCTC 3 -- int11Minor allele frequency- C:0.07WA 118
    rs793837821,2
    		--50958656(+) CCTTGG/ATGCTA 3 -- int11Minor allele frequency- A:0.01WA 118
    rs1137799061,2
    		C,--50959037(+) CTCCAA/CCTCCT 3 -- int12Minor allele frequency- C:0.33WA CSA 3
    rs2000536961,2
    		C--50959400(-) AATTTG/TTNNNN 3 -- int10--------
    rs112059521,2
    		C,H--50960830(+) CAAATC/TTAAGT 3 -- int14Minor allele frequency- T:0.00NS EA 404
    rs747826051,2
    		F,--50962022(+) ACCAAA/GATCAA 3 -- int11Minor allele frequency- G:0.07WA 118
    rs759861331,2
    		F,--50962061(+) GAAAGG/AACAAT 3 -- int11Minor allele frequency- A:0.04NA 120
    rs1115153281,2
    		C,--50962863(+) CTGGAG/AAGTGT 3 -- int12Minor allele frequency- A:0.03NA 122

    HapMap Linkage Disequilibrium report for ORC1 (52838501 - 52870143 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ORC1: --
    Human Gene Mutation Database (HGMD): ORC1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ORC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ORC1

    Disorders / Diseases
    for ORC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ORC1 for disorders           About GeneDecksing

    OMIM gene information: 601902    OMIM disorders: --

    UniProtKB/Swiss-Prot: ORC1_HUMAN, Q13415
  • Defects in ORC1 are the cause of Meier-Gorlin syndrome type 1 (MGORS1) [MIM:224690]; also called ear patella
    • short stature syndrome (EPS) or microtia absent patellae micrognathia syndrome. MGORS1 is a syndrome characterized by
    bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with
    short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly,
    apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary
    tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial
    prenatal and postnatal growth retardation, not all MGORS1 cases have microcephaly, and microtia and absent/hypoplastic
    patella are absent in some. Despite the presence of microcephaly, intellect is usually normal

    9 diseases for ORC1:    About MalaCards
    meier-gorlin syndrome    intrauterine and postnatal growth retardation    absent patella    short stature
    microtia    dwarfism    microcephaly    retinoblastoma
    malaria

    1 Novoseek disease relationship for ORC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malaria 18.8 4 19633266 (2), 12543146 (1), 16216221 (1)


    Export disorders for ORC1 gene to outside databases

    Publications
    for ORC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ORC1 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with ORC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1. (PubMed id 12909627)1, 2, 9 Tatsumi Y....Obuse C. (2003)
    2. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. (PubMed id 9566895)1, 2, 9 Saha P.... Dutta A. (1998)
    3. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. (PubMed id 21358633)1, 2 Bicknell L.S.... Jeggo P.A. (2011)
    4. Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PubMed id 21358632)1, 2 Bicknell L.S....Jackson A.P. (2011)
    5. Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. (PubMed id 21358631)1, 2 Guernsey D.L.... Samuels M.E. (2011)
    6. ATP-dependent assembly of the human origin recognition complex. (PubMed id 17716973)1, 2 Siddiqui K. and Stillman B. (2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle. (PubMed id 12909626)1, 2 Ohta S....Obuse C. (2003)
    9. Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein. (PubMed id 10438470)1, 2 Iizuka M. and Stillman B. (1999)
    10. Mapping of the human homologue (ORC1L) of the yeast origin recognition complex subunit 1 gene to chromosome band 1p32. (PubMed id 8884289)1, 3 Eki T....Hanaoka F. (1996)

    External Searches for ORC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ORC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4998 HGNC: 8487 AceView: ORC1L Ensembl:ENSG00000085840 euGenes: HUgn4998
    ECgene: ORC1 Kegg: 4998 H-InvDB: ORC1

    Other Databases showing ORC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ORC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ORC1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ORC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ORC1 gene:
    Search GeneIP for patents involving ORC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ORC1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ORC1
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ORC1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ORC1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ORC1  
     OriGene Protein Over-expression Lysate for ORC1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ORC1   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ORC1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ORC1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ORC1   OriGene Custom Protein Services for ORC1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ORC1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ORC1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORC1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORC1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORC1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORC1
     GenScript Custom Purified and Recombinant Proteins Services for ORC1 GenScript cDNA clones with any tag delivered in your preferred vector for ORC1
     GenScript Custom Assay Services for ORC1 GenScript Custom Superior Antibodies Services for ORC1
     GenScript Custom overexpressing Cell Line Services for ORC1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for ORC1  (ORC1L)

     Search Regulatory tfbs for ORC1
     Search Chromatin IP Primers for ORC1
     RT2 qPCR Primer Assay in human, mouse, rat ORC1
     Search GNC Networks for ORC1
     SABiosciences Custom PCR Arrays for ORC1
     Search Tocris compounds for ORC1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ORC1 antibodies
     ORC1 proteins
     ORC1 lysates
     Search for Antibodies for ORC1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ORC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ORC1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ORC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORC1
     SwitchGear 3'UTR luciferase reporter plasmids for ORC1
     SwitchGear Promoter luciferase reporter plasmids for ORC1
     ThermoFisher Antibodies for ORC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORC1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ORC1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4