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Aliases for ORC1 Gene

Aliases for ORC1 Gene

  • Origin Recognition Complex, Subunit 1 2 3
  • Replication Control Protein 1 2 3 4
  • ORC1L 3 4 6
  • PARC1 3 4
  • Origin Recognition Complex, Subunit 1 Homolog (S. Cerevisiae) 2
  • Origin Recognition Complex, Subunit 1 (Yeast Homolog)-Like 2
  • Origin Recognition Complex, Subunit 1-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 1 Homolog 3
  • Origin Recognition Complex Subunit 1 3
  • Origin Recognition Complex 1 2
  • Origin Recognition Complex 2
  • S. Cerevisiae 2
  • Homolog-Like 2
  • Subunit 1 2
  • HSORC1 3

External Ids for ORC1 Gene

Previous Symbols for ORC1 Gene

  • ORC1L

Summaries for ORC1 Gene

Entrez Gene Summary for ORC1 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for ORC1 Gene

ORC1 (Origin Recognition Complex, Subunit 1) is a Protein Coding gene. Diseases associated with ORC1 include meier-gorlin syndrome 1 and malaria. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include nucleoside-triphosphatase activity. An important paralog of this gene is CDC6.

UniProtKB/Swiss-Prot for ORC1 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Wiki entry for ORC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORC1 Gene

Genomics for ORC1 Gene

Genomic Location for ORC1 Gene

Start:
52,372,829 bp from pter
End:
52,404,471 bp from pter
Size:
31,643 bases
Orientation:
Minus strand

Genomic View for ORC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC1 Gene

No data available for Regulatory Elements for ORC1 Gene

Proteins for ORC1 Gene

  • Protein details for ORC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13415-ORC1_HUMAN
    Recommended name:
    Origin recognition complex subunit 1
    Protein Accession:
    Q13415
    Secondary Accessions:
    • D3DQ34
    • Q13471
    • Q5T0F5

    Protein attributes for ORC1 Gene

    Size:
    861 amino acids
    Molecular mass:
    97350 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.

neXtProt entry for ORC1 Gene

Proteomics data for ORC1 Gene at MOPED

Post-translational modifications for ORC1 Gene

Other Protein References for ORC1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ORC1 Gene

Domains for ORC1 Gene

Gene Families for ORC1 Gene

HGNC:
  • AATP :ATPases / AAA-type

Protein Domains for ORC1 Gene

UniProtKB/Swiss-Prot:

ORC1_HUMAN
Domain:
  • The BAH domain mediates binding to dimethylated histone H4 Lys-20 (H4K20me2), which is enriched at replication origins.:
    • Q13415
  • Contains 1 BAH domain.:
    • Q13415
Family:
  • Belongs to the ORC1 family.:
    • Q13415
genes like me logo Genes that share domains with ORC1: view

Function for ORC1 Gene

Molecular function for ORC1 Gene

UniProtKB/Swiss-Prot Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication

Gene Ontology (GO) - Molecular Function for ORC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 11931757
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ORC1: view
genes like me logo Genes that share phenotypes with ORC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ORC1 Gene

Localization for ORC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC1 Gene

Gene Ontology (GO) - Cellular Components for ORC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000808 origin recognition complex IDA 17716973
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005664 nuclear origin of replication recognition complex IDA 20932478
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ORC1: view

Pathways for ORC1 Gene

genes like me logo Genes that share pathways with ORC1: view

Pathways by source for ORC1 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for ORC1 Gene
1 Qiagen pathway for ORC1 Gene
1 Cell Signaling Technology pathway for ORC1 Gene

Gene Ontology (GO) - Biological Process for ORC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006270 DNA replication initiation TAS 7502077
genes like me logo Genes that share ontologies with ORC1: view

Transcripts for ORC1 Gene

Unigene Clusters for ORC1 Gene

Origin recognition complex, subunit 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for ORC1 Gene

GeneLoc Exon Structure for
ORC1
ECgene alternative splicing isoforms for
ORC1

Expression for ORC1 Gene

mRNA expression in normal human tissues for ORC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORC1 Gene

This gene is overexpressed in Testis (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORC1 Gene

SOURCE GeneReport for Unigene cluster for ORC1 Gene Hs.17908

genes like me logo Genes that share expressions with ORC1: view

Orthologs for ORC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ORC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORC1 36
  • 99.26 (n)
  • 98.72 (a)
ORC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ORC1 36
  • 84.58 (n)
  • 80.19 (a)
ORC1 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ORC1 36
  • 85.66 (n)
  • 81.28 (a)
ORC1 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Orc1 36
  • 76.07 (n)
  • 68.67 (a)
Orc1 16
Orc1 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ORC1 37
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORC1 37
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Orc1 36
  • 76.96 (n)
  • 70.65 (a)
chicken
(Gallus gallus)
Aves ORC1 36
  • 60.88 (n)
  • 56.28 (a)
ORC1 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ORC1 37
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XORC1 36
tropical clawed frog
(Silurana tropicalis)
Amphibia orc1 36
  • 58.58 (n)
  • 56.45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6145 36
zebrafish
(Danio rerio)
Actinopterygii orc1 36
  • 55.29 (n)
  • 52.79 (a)
orc1 37
  • 46 (a)
OneToOne
wufa11h08 36
fruit fly
(Drosophila melanogaster)
Insecta Orc1 37
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea orc-1 37
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC6 37
  • 16 (a)
OneToMany
ORC1 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14864 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.987 37
  • 60 (a)
OneToOne
Species with no ortholog for ORC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ORC1 Gene

ENSEMBL:
Gene Tree for ORC1 (if available)
TreeFam:
Gene Tree for ORC1 (if available)

Paralogs for ORC1 Gene

Paralogs for ORC1 Gene

Selected SIMAP similar genes for ORC1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ORC1 Gene

genes like me logo Genes that share paralogs with ORC1: view

Variants for ORC1 Gene

Sequence variations from dbSNP and Humsavar for ORC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1983833 -- 52,376,598(-) GGACA(C/T)CCTTA intron-variant
rs2274126 -- 52,389,500(-) CTTCA(A/G)TTATA intron-variant
rs3049207 -- 52,382,595(+) ttttt(-/TT)gagac intron-variant
rs3087470 - 52,388,459(-) TCACG(A/G)AGGTG reference, missense
rs3087471 -- 52,372,950(-) GTTGC(C/T)AAGCT utr-variant-3-prime

Relevant External Links for ORC1 Gene

HapMap Linkage Disequilibrium report
ORC1
Human Gene Mutation Database (HGMD)
ORC1

No data available for Structural Variations from Database of Genomic Variants (DGV) for ORC1 Gene

Disorders for ORC1 Gene

(1) OMIM Diseases for ORC1 Gene (601902)

UniProtKB/Swiss-Prot

ORC1_HUMAN
  • Meier-Gorlin syndrome 1 (MGORS1) [MIM:224690]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269 PubMed:21358631, ECO:0000269 PubMed:21358632, ECO:0000269 PubMed:21358633}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for ORC1 Gene

Disease -log(P) Hits PubMed IDs
malaria 18.8 4
genes like me logo Genes that share disorders with ORC1: view

Publications for ORC1 Gene

  1. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. (PMID: 9566895) Saha P. … Dutta A. (Mol. Cell. Biol. 1998) 3 4 23
  2. The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1. (PMID: 12909627) Tatsumi Y. … Obuse C. (J. Biol. Chem. 2003) 3 4 23
  3. Localization of proteins bound to a replication origin of human DNA along the cell cycle. (PMID: 12912926) Abdurashidova G. … Falaschi A. (EMBO J. 2003) 3 23
  4. Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. (PMID: 16226712) Niture S.K. … Srivenugopal K.S. (Biochem. Biophys. Res. Commun. 2005) 3 23
  5. Cyclin-mediated export of human Orc1. (PMID: 11716535) Laman H. … Jones N. (Exp. Cell Res. 2001) 3 23

Products for ORC1 Gene

Sources for ORC1 Gene

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