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Aliases for ORAOV1 Gene

Aliases for ORAOV1 Gene

  • Oral Cancer Overexpressed 1 2 3 5
  • Tumor-Amplified And Overexpressed Sequence 1 3 4
  • Oral Cancer Overexpressed Protein 1-A 2 3
  • TAOS1 3 4
  • Oral Cancer-Overexpressed Protein 1 3

External Ids for ORAOV1 Gene

Previous GeneCards Identifiers for ORAOV1 Gene

  • GC11M071975
  • GC11M071166
  • GC11M069727
  • GC11M069253
  • GC11M069189
  • GC11M069468
  • GC11M065772

Summaries for ORAOV1 Gene

GeneCards Summary for ORAOV1 Gene

ORAOV1 (Oral Cancer Overexpressed 1) is a Protein Coding gene. Diseases associated with ORAOV1 include Oral Cancer and Oral Squamous Cell Carcinoma.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAOV1 Gene

Genomics for ORAOV1 Gene

Regulatory Elements for ORAOV1 Gene

Enhancers for ORAOV1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G069292 2 FANTOM5 Ensembl ENCODE dbSUPER 43.9 +376.8 376810 11.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 FEZF1 ZBTB7B ZNF766 ZNF143 ORAOV1 ENSG00000260808 TPCN2 FADD ENSG00000260877 LOC338694 LOC105369370 MYEOV
GH11G069477 1.2 ENCODE dbSUPER 54.5 +198.0 197969 1.5 HDGF PKNOX1 ATF1 ARNT YBX1 ZBTB7B TCF12 GATA2 ZNF143 ZNF207 ORAOV1 MRGPRF-AS1 ENSG00000261625 MRGPRF ENSG00000260808 IGHMBP2 ENSG00000246889 LOC105379407 GC11P069470
GH11G069121 1.5 Ensembl ENCODE dbSUPER 22.8 +552.3 552310 2.9 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A ZBTB7B YY1 FOS ZNF263 ORAOV1 LOC338694 MRGPRF-AS1 PIR51352 ENSG00000260895
GH11G069635 1.7 FANTOM5 ENCODE dbSUPER 18.8 +33.0 32951 13.5 HDGF PKNOX1 FOXA2 AGO1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ORAOV1 CCND1
GH11G069442 2 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +231.5 231477 3.6 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YBX1 ENSG00000246889 ORAOV1 CCND1 ENSG00000255606 LOC102724265
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ORAOV1 on UCSC Golden Path with GeneCards custom track

Promoters for ORAOV1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041413 116 1400 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143

Genomic Location for ORAOV1 Gene

Chromosome:
11
Start:
69,653,076 bp from pter
End:
69,675,416 bp from pter
Size:
22,341 bases
Orientation:
Minus strand

Genomic View for ORAOV1 Gene

Genes around ORAOV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAOV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAOV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAOV1 Gene

Proteins for ORAOV1 Gene

  • Protein details for ORAOV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV07-ORAV1_HUMAN
    Recommended name:
    Oral cancer-overexpressed protein 1
    Protein Accession:
    Q8WV07
    Secondary Accessions:
    • B2R4R2
    • Q8NFK0

    Protein attributes for ORAOV1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15354 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Amplified and overexpressed in oral cancer cells.

neXtProt entry for ORAOV1 Gene

Post-translational modifications for ORAOV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ORAOV1 Gene

Domains & Families for ORAOV1 Gene

Protein Domains for ORAOV1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ORAOV1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV07

UniProtKB/Swiss-Prot:

ORAV1_HUMAN :
  • Belongs to the ORAOV1 family.
Family:
  • Belongs to the ORAOV1 family.
genes like me logo Genes that share domains with ORAOV1: view

No data available for Gene Families for ORAOV1 Gene

Function for ORAOV1 Gene

Gene Ontology (GO) - Molecular Function for ORAOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with ORAOV1: view
genes like me logo Genes that share phenotypes with ORAOV1: view

Animal Model Products

CRISPR Products

miRNA for ORAOV1 Gene

miRTarBase miRNAs that target ORAOV1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAOV1 Gene

Localization for ORAOV1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORAOV1 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ORAOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0030896 checkpoint clamp complex IBA --
GO:0035861 site of double-strand break IBA --
genes like me logo Genes that share ontologies with ORAOV1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ORAOV1 Gene

Pathways & Interactions for ORAOV1 Gene

SuperPathways for ORAOV1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ORAOV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IBA --
GO:0006289 nucleotide-excision repair IBA --
GO:0008150 biological_process ND --
GO:0031573 intra-S DNA damage checkpoint IBA --
GO:0033314 mitotic DNA replication checkpoint IBA --
genes like me logo Genes that share ontologies with ORAOV1: view

No data available for Pathways by source and SIGNOR curated interactions for ORAOV1 Gene

Transcripts for ORAOV1 Gene

Unigene Clusters for ORAOV1 Gene

Oral cancer overexpressed 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORAOV1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8
SP1: - - - - - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - -
SP12: - -
SP13:

Relevant External Links for ORAOV1 Gene

GeneLoc Exon Structure for
ORAOV1
ECgene alternative splicing isoforms for
ORAOV1

Expression for ORAOV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORAOV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ORAOV1 Gene

This gene is overexpressed in Pancreatic juice (57.7) and Testis (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ORAOV1 Gene



Protein tissue co-expression partners for ORAOV1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ORAOV1 Gene:

ORAOV1

SOURCE GeneReport for Unigene cluster for ORAOV1 Gene:

Hs.667996

mRNA Expression by UniProt/SwissProt for ORAOV1 Gene:

Q8WV07-ORAV1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.

Evidence on tissue expression from TISSUES for ORAOV1 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ORAOV1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORAOV1 Gene

Orthologs for ORAOV1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORAOV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORAOV1 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia ORAOV1 34 35
  • 86.62 (n)
cow
(Bos Taurus)
Mammalia ORAOV1 34 35
  • 85.64 (n)
mouse
(Mus musculus)
Mammalia Oraov1 34 16 35
  • 77.13 (n)
rat
(Rattus norvegicus)
Mammalia Oraov1 34
  • 76.31 (n)
oppossum
(Monodelphis domestica)
Mammalia ORAOV1 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORAOV1 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ORAOV1 34 35
  • 69.38 (n)
lizard
(Anolis carolinensis)
Reptilia ORAOV1 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oraov1 34
  • 63.26 (n)
zebrafish
(Danio rerio)
Actinopterygii oraov1 34 35
  • 64.44 (n)
Species where no ortholog for ORAOV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORAOV1 Gene

ENSEMBL:
Gene Tree for ORAOV1 (if available)
TreeFam:
Gene Tree for ORAOV1 (if available)

Paralogs for ORAOV1 Gene

Pseudogenes.org Pseudogenes for ORAOV1 Gene

genes like me logo Genes that share paralogs with ORAOV1: view

No data available for Paralogs for ORAOV1 Gene

Variants for ORAOV1 Gene

Sequence variations from dbSNP and Humsavar for ORAOV1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000343924 -- 69,674,364(+) GAGTA(A/G)CACTG intron-variant
rs1000375301 -- 69,674,632(+) TCAGC(A/G)CCTGA intron-variant
rs1000493325 -- 69,668,129(+) TCGTT(C/T)AAAAG intron-variant
rs1000858545 -- 69,669,745(+) GCCCC(A/G)GTGCG intron-variant
rs1000941105 -- 69,664,964(+) GATGG(C/T)GTTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ORAOV1 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV loss 17160897
esv3626752 CNV loss 21293372
nsv825973 CNV gain 20364138
nsv825974 CNV gain 20364138

Variation tolerance for ORAOV1 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORAOV1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ORAOV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAOV1 Gene

Disorders for ORAOV1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ORAOV1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oral cancer
  • malignant neoplasm of mouth
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ORAOV1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORAOV1
genes like me logo Genes that share disorders with ORAOV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ORAOV1 Gene

Publications for ORAOV1 Gene

  1. High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. (PMID: 12172009) Huang X. … Godfrey T.E. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3 64
  4. ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma. (PMID: 25732110) Li M. … Li F. (Hum. Pathol. 2015) 3 64
  5. Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production. (PMID: 24930674) Togashi Y. … Nishio K. (Oncotarget 2014) 3 64

Products for ORAOV1 Gene

Sources for ORAOV1 Gene

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