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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ORAOV1 Gene

protein-coding   GIFtS: 50
GCID: GC11M069468

Oral Cancer Overexpressed 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Oral Cancer Overexpressed 11 2
TAOS12 3 5
Oral Cancer Overexpressed Protein 1-A1 2
Tumor-Amplified And Overexpressed Sequence 12 3
Oral Cancer-Overexpressed Protein 12

External Ids:    HGNC: 175891   Entrez Gene: 2200642   Ensembl: ENSG000001497167   OMIM: 6072245   UniProtKB: Q8WV073   

Export aliases for ORAOV1 gene to outside databases

Previous GC identifers: GC11M071975 GC11M071166 GC11M069727 GC11M069253 GC11M069189 GC11M065772


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ORAOV1 Gene: 
ORAOV1 (oral cancer overexpressed 1) is a protein-coding gene. Diseases associated with ORAOV1 include oral cancer, and oral squamous cell carcinoma. GO annotations related to this gene include molecular_function.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ORAOV1 gene promoter:
         Sp1   Tal-1   Olf-1   IRF-1   GATA-1   HNF-1A   C/EBPalpha   E47   GATA-2   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidORAOV1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ORAOV1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORAOV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13.2

ORAOV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORAOV1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M069468:  view genomic region     (about GC identifiers)

Start:
69,467,844 bp from pter      End:
69,490,184 bp from pter
Size:
22,341 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ORAV1_HUMAN, Q8WV07 (See protein sequence)
Recommended Name: Oral cancer-overexpressed protein 1  
Size: 137 amino acids; 15354 Da
Miscellaneous: Amplified and overexpressed in oral cancer cells
Secondary accessions: B2R4R2 Q8NFK0

Explore the universe of human proteins at neXtProt for ORAOV1: NX_Q8WV07

Explore proteomics data for ORAOV1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WV07

  • ORAOV1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ORAOV1 Protein Expression
    REFSEQ proteins: NP_703152.1  
    ENSEMBL proteins: 
     ENSP00000446428   ENSP00000279147   ENSP00000441984   ENSP00000455359   ENSP00000446129  
     ENSP00000443669   ENSP00000443936   ENSP00000444112   ENSP00000409643   ENSP00000437367  

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    Novus Biologicals ORAOV1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ORAOV1
    Cloud-Clone Corp. Proteins for ORAOV1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    ORAOV1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ORAOV1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019191 Essential_protein_Yae1_N

    Graphical View of Domain Structure for InterPro Entry Q8WV07

    ProtoNet protein and cluster: Q8WV07

    UniProtKB/Swiss-Prot: ORAV1_HUMAN, Q8WV07
    Similarity: Belongs to the ORAOV1 family


    ORAOV1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    ORAOV1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ORAOV1:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ORAOV1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ORAOV1 
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ORAOV1:
    hsa-miR-1206 hsa-miR-26b*
    SwitchGear 3'UTR luciferase reporter plasmidORAOV1 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of ORAOV1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORAOV1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ORAOV1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for ORAOV1 (Q8WV073 ENSP000002791474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL2P605203I2D: score=1 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    ORAOV1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ORAOV1 (ORAV1)

    Search CenterWatch for drugs/clinical trials and news about ORAOV1 / ORAV1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ORAOV1 gene: 
    NM_153451.2  

    Unigene Cluster for ORAOV1:

    Oral cancer overexpressed 1
    Hs.667996  [show with all ESTs]
    Unigene Representative Sequence: AK126490
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542515(uc010rqh.1) ENST00000569105 ENST00000538554(uc010rqi.1)
    ENST00000279147(uc001opc.3 uc009ysm.3 uc001opd.3) ENST00000544096
    ENST00000536870 ENST00000537272 ENST00000535657 ENST00000542470 ENST00000535542
    ENST00000543863 ENST00000543562 ENST00000539414 ENST00000441922 ENST00000537324
    ENST00000542341(uc001ope.1) ENST00000355486 ENST00000543023
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORAOV1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ORAOV1:
    hsa-miR-1206 hsa-miR-26b*
    SwitchGear 3'UTR luciferase reporter plasmidORAOV1 3' UTR sequence
    Inhib. RNA
    Products:
         
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                         Customized lentivirus expression plasmids for stable overexpression of ORAOV1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORAOV1
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    Additional mRNA sequence: 

    AF503940.1 AK026600.1 AK125280.1 AK126490.1 AK294004.1 AK311918.1 BC006448.2 BC019024.1 
    BC065542.1 EF639695.1 JX460858.1 

    19 DOTS entries:

    DT.97869862  DT.437026  DT.97812341  DT.120734297  DT.91923745  DT.100771800  DT.97802642  DT.91738695 
    DT.100735643  DT.100755144  DT.70105440  DT.91638611  DT.100755143  DT.91752669  DT.95287813  DT.120734273 
    DT.455928  DT.92046346  DT.99980797 

    24/194 AceView cDNA sequences (see all 194):

    BC065542 BU181761 BX440862 NM_001004327 BM770125 NM_153451 AF503940 CF593377 
    CB242407 BQ050679 CA443325 BP871305 BM126256 AK126490 BM770094 AI571105 
    BM909743 BM770735 BC006448 BM756560 BM756466 BX404647 BM771361 BM771921 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ORAOV1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8
    SP1:                                            -     -                 -     -           -           -           -     -     -     -     -               
    SP2:                                            -     -                 -     -           -           -                                                   
    SP3:                                                                    -     -           -                                                               
    SP4:                                            -     -                 -     -     -     -           -                                                   
    SP5:                                            -     -                 -     -           -                                                               


    ECgene alternative splicing isoforms for ORAOV1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ORAOV1 expression in normal human tissues (normalized intensities)      ORAOV1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTGCTGG
    ORAOV1 Expression
    About this image


    ORAOV1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Larynx (Respiratory System)
     
     Stomach (Gastrointestinal Tract)

    See ORAOV1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ORAOV1

    SOURCE GeneReport for Unigene cluster: Hs.667996

    UniProtKB/Swiss-Prot: ORAV1_HUMAN, Q8WV07
    Tissue specificity: Widely expressed. Highly expressed in placenta, kidney and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ORAOV1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oraov11 , 5 oral cancer overexpressed 11, 5 77.13(n)1
    77.37(a)1
      7 (88.92 cM)5
    722841  NM_028184.31  NP_082460.21 
     1449151005 
    chicken
    (Gallus gallus)
    Aves ORAOV11 oral cancer overexpressed 1 69.38(n)
    69.63(a)
      423142  NM_001031186.1  NP_001026357.1 
    lizard
    (Anolis carolinensis)
    Reptilia ORAOV16
    Uncharacterized protein
    58(a)
    1 ↔ 1
    1(55265649-55270953)
    zebrafish
    (Danio rerio)
    Actinopterygii oraov11 oral cancer overexpressed 1 65.38(n)
    56.92(a)
      563810  NM_001083552.1  NP_001077021.1 


    ENSEMBL Gene Tree for ORAOV1 (if available)
    TreeFam Gene Tree for ORAOV1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ORAOV1 gene

    ORAOV1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ORAOV1
    PGOHUM00000245789


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/311 SNPs in ORAOV1 are shown (see all 311)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495048721,2
    C--69479850(+) GCAGGC/TGTAGG 1 -- int10--------
    rs767455141,2
    F--69479984(+) AGGGAG/CAGAGA 1 -- int12Minor allele frequency- C:0.15CSA WA 120
    rs1441831561,2
    C--69480157(+) ACTCTC/TGCAGT 1 -- int10--------
    rs112635271,2
    C,F,A,H--69480191(+) GAGACA/GAGCTG 1 -- int118Minor allele frequency- G:0.18NS EA NA WA CSA 2222
    rs1867473241,2
    --69480194(+) ACAAGA/CTGGCA 1 -- int10--------
    rs735227511,2
    C,F--69480287(+) TAAATG/AATGCC 1 -- int14Minor allele frequency- A:0.35WA CSA 124
    rs769149321,2
    C,F--69480293(+) ATGCCG/ATGTTA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1115678161,2
    F--69480321(+) TAAATG/CGTCCC 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs10558251,2
    C,F--69480363(-) AACTGT/GAAAAA 1 -- ut317Minor allele frequency- G:0.36WA NA CSA 246
    rs760711911,2
    C,F--69480379(+) AATAAT/CACATT 1 -- ut312Minor allele frequency- C:0.13CSA WA 119

    HapMap Linkage Disequilibrium report for ORAOV1 (69467844 - 69490184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ORAOV1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv16n68CNV Loss17160897
    nsv825973CNV Gain20364138
    nsv825974CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ORAOV1
    DNA2.0 Custom Variant and Variant Library Synthesis for ORAOV1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607224    OMIM disorders: --

    7 diseases for ORAOV1:    About MalaCards
    oral cancer    oral squamous cell carcinoma    gastric adenocarcinoma    cervical cancer
    squamous cell carcinoma    cervicitis    adenocarcinoma


    ORAOV1 for disorders           About GeneDecksing


    Export disorders for ORAOV1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ORAOV1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ORAOV1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. (PubMed id 12172009)1, 2, 3, 9 Huang X.... Godfrey T.E. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The function of ORAOV1/LTO1, a gene that is overexpres sed frequently in cancer: essential roles in the function and biogenesis of the ribosome. (PubMed id 23318452)1 Zhai C....Panaretou B. (2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O....Lill R. (2012)
    6. ORAOV1 is a probable target within the 11q13.3 amplico n in lymph node metastases from gastric adenocarcinoma. (PubMed id 21993861)1 Kang J.U. and Koo S.H. (2012)
    7. ORAOV1 is amplified in oral squamous cell carcinoma. (PubMed id 21623924)1 Xavier F.C....Nunes F.D. (2012)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Oral cancer overexpressed 1 (ORAOV1) regulates cell c ycle and apoptosis in cervical cancer HeLa cells. (PubMed id 20105337)1 Jiang L....Chen Q. (2010)
    10. Genome-wide association study identifies five new bre ast cancer susceptibility loci. (PubMed id 20453838)1 Turnbull C....Easton D.F. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 220064 HGNC: 17589 AceView: ORAOV1andFLJ42258 Ensembl:ENSG00000149716 euGenes: HUgn220064
    ECgene: ORAOV1 H-InvDB: ORAOV1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ORAOV1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ORAOV1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for ORAOV1 gene:
    Search GeneIP for patents involving ORAOV1

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