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Aliases for ORAOV1 Gene

Aliases for ORAOV1 Gene

  • Oral Cancer Overexpressed 1 2 3 5
  • Tumor-Amplified And Overexpressed Sequence 1 3 4
  • Oral Cancer Overexpressed Protein 1-A 2 3
  • TAOS1 3 4

External Ids for ORAOV1 Gene

Previous GeneCards Identifiers for ORAOV1 Gene

  • GC11M071975
  • GC11M071166
  • GC11M069727
  • GC11M069253
  • GC11M069189
  • GC11M069468
  • GC11M065772

Summaries for ORAOV1 Gene

GeneCards Summary for ORAOV1 Gene

ORAOV1 (Oral Cancer Overexpressed 1) is a Protein Coding gene. Diseases associated with ORAOV1 include oral cancer and oral squamous cell carcinoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAOV1 Gene

Genomics for ORAOV1 Gene

Regulatory Elements for ORAOV1 Gene

Promoters for ORAOV1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ORAOV1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ORAOV1 Gene

Chromosome:
11
Start:
69,653,076 bp from pter
End:
69,675,416 bp from pter
Size:
22,341 bases
Orientation:
Minus strand

Genomic View for ORAOV1 Gene

Genes around ORAOV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAOV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAOV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAOV1 Gene

Proteins for ORAOV1 Gene

  • Protein details for ORAOV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV07-ORAV1_HUMAN
    Recommended name:
    Oral cancer-overexpressed protein 1
    Protein Accession:
    Q8WV07
    Secondary Accessions:
    • B2R4R2
    • Q8NFK0

    Protein attributes for ORAOV1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15354 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Amplified and overexpressed in oral cancer cells.

neXtProt entry for ORAOV1 Gene

Proteomics data for ORAOV1 Gene at MOPED

Post-translational modifications for ORAOV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ORAOV1 Gene

Domains & Families for ORAOV1 Gene

Protein Domains for ORAOV1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ORAOV1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV07

UniProtKB/Swiss-Prot:

ORAV1_HUMAN :
  • Belongs to the ORAOV1 family.
Family:
  • Belongs to the ORAOV1 family.
genes like me logo Genes that share domains with ORAOV1: view

No data available for Gene Families for ORAOV1 Gene

Function for ORAOV1 Gene

genes like me logo Genes that share phenotypes with ORAOV1: view

Animal Model Products

miRNA for ORAOV1 Gene

miRTarBase miRNAs that target ORAOV1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAOV1 Gene

Localization for ORAOV1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ORAOV1 Gene COMPARTMENTS Subcellular localization image for ORAOV1 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ORAOV1 Gene

Pathways & Interactions for ORAOV1 Gene

SuperPathways for ORAOV1 Gene

No Data Available

Interacting Proteins for ORAOV1 Gene

Gene Ontology (GO) - Biological Process for ORAOV1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ORAOV1 Gene

Drugs & Compounds for ORAOV1 Gene

No Compound Related Data Available

Transcripts for ORAOV1 Gene

Unigene Clusters for ORAOV1 Gene

Oral cancer overexpressed 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORAOV1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8
SP1: - - - - - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - -
SP12: - -
SP13:

Relevant External Links for ORAOV1 Gene

GeneLoc Exon Structure for
ORAOV1
ECgene alternative splicing isoforms for
ORAOV1

Expression for ORAOV1 Gene

mRNA expression in normal human tissues for ORAOV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ORAOV1 Gene

This gene is overexpressed in Pancreatic juice (57.7) and Testis (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORAOV1 Gene



SOURCE GeneReport for Unigene cluster for ORAOV1 Gene Hs.667996

mRNA Expression by UniProt/SwissProt for ORAOV1 Gene

Q8WV07-ORAV1_HUMAN
Tissue specificity: Widely expressed. Highly expressed in placenta, kidney and skeletal muscle.
genes like me logo Genes that share expression patterns with ORAOV1: view

Protein tissue co-expression partners for ORAOV1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ORAOV1 Gene

Orthologs for ORAOV1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ORAOV1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ORAOV1 35
  • 85.64 (n)
  • 89.78 (a)
ORAOV1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ORAOV1 35
  • 86.62 (n)
  • 91.24 (a)
ORAOV1 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oraov1 35
  • 77.13 (n)
  • 77.37 (a)
Oraov1 16
Oraov1 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ORAOV1 35
  • 99.51 (n)
  • 100 (a)
ORAOV1 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oraov1 35
  • 76.31 (n)
  • 77.69 (a)
oppossum
(Monodelphis domestica)
Mammalia ORAOV1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORAOV1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ORAOV1 35
  • 69.38 (n)
  • 69.63 (a)
ORAOV1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ORAOV1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oraov1 35
  • 63.26 (n)
  • 52.55 (a)
zebrafish
(Danio rerio)
Actinopterygii oraov1 35
  • 64.44 (n)
  • 56.3 (a)
oraov1 36
  • 51 (a)
OneToOne
Species with no ortholog for ORAOV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORAOV1 Gene

ENSEMBL:
Gene Tree for ORAOV1 (if available)
TreeFam:
Gene Tree for ORAOV1 (if available)

Paralogs for ORAOV1 Gene

Pseudogenes.org Pseudogenes for ORAOV1 Gene

genes like me logo Genes that share paralogs with ORAOV1: view

No data available for Paralogs for ORAOV1 Gene

Variants for ORAOV1 Gene

Sequence variations from dbSNP and Humsavar for ORAOV1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs56107468 - 69,675,233(+) ACTGC(C/T)AGCCA reference, missense, utr-variant-5-prime
rs1055825 -- 69,665,595(-) AACTG(G/T)AAAAA intron-variant, utr-variant-3-prime, utr-variant-5-prime
rs948886 -- 69,664,366(+) AAGGA(A/G)GGAGC intron-variant, utr-variant-3-prime, utr-variant-5-prime
rs948887 -- 69,664,367(+) AGGAA(C/G)GAGCA intron-variant, utr-variant-3-prime, utr-variant-5-prime
rs1192925 -- 69,661,511(+) ccatg(C/T)gcagc intron-variant, utr-variant-3-prime, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ORAOV1 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV Loss 17160897
nsv825973 CNV Gain 20364138
nsv825974 CNV Gain 20364138

Variation tolerance for ORAOV1 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORAOV1 Gene

HapMap Linkage Disequilibrium report
ORAOV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAOV1 Gene

Disorders for ORAOV1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ORAOV1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oral cancer
  • malignant neoplasm of mouth
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ORAOV1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ORAOV1
genes like me logo Genes that share disorders with ORAOV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ORAOV1 Gene

Publications for ORAOV1 Gene

  1. High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. (PMID: 12172009) Huang X. … Godfrey T.E. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23 67
  2. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  3. ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma. (PMID: 25732110) Li M. … Li F. (Hum. Pathol. 2015) 3
  4. Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production. (PMID: 24930674) Togashi Y. … Nishio K. (Oncotarget 2014) 3
  5. The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. (PMID: 23318452) Zhai C. … Panaretou B. (Oncogene 2013) 3

Products for ORAOV1 Gene

Sources for ORAOV1 Gene

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