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ORAI3 Gene

protein-coding   GIFtS: 48
GCID: GC16P030960

ORAI Calcium Release-Activated Calcium Modulator 3

(Previous name: transmembrane protein 142C)
(Previous symbol: TMEM142C)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ORAI Calcium Release-Activated Calcium Modulator 31 2
TMEM142C1 2 3 5
Transmembrane Protein 142C1 2 3
Protein Orai-32

External Ids:    HGNC: 281851   Entrez Gene: 931292   Ensembl: ENSG000001759387   OMIM: 6109305   UniProtKB: Q9BRQ53   

Export aliases for ORAI3 gene to outside databases

Previous GC identifers: GC16P030869 GC16P030870 GC16P028524


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ORAI3 Gene:
ORAI3 (ORAI calcium release-activated calcium modulator 3) is a protein-coding gene. An important paralog of this gene is ORAI2.

UniProtKB/Swiss-Prot: ORAI3_HUMAN, Q9BRQ5
Function: Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import
(By similarity)

summary for ORAI3 Gene:
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated
calcium entry (SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the
emptying of intracellular Ca2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and
STIM2, serve as ER Ca2+ sensors. They contain N'-terminal Ca2+-sensing EF-hand domains and are localized to
the tubular ER. Following Ca2+ store depletion, STIMs rapidly cluster and relocalize to the plasma
membrane-adjacent ER regions, where they oligomerize and form 'puncta'. Orai proteins, Orai1, Orai2 and
Orai3, are STIM binding partners that form the pore of the channel. Orai proteins are uniformly distributed
in the plasma membrane and exist as dimers in the resting state. STIM activation induces tetramerization of
Orai proteins and subsequent STIM-Orai colocalization, which forms the active store-operated calcium
channel.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ORAI3 gene promoter:
         NF-1/L   NF-1   HTF   LCR-F1   NF-AT   Arnt   MZF-1   AREB6   CREB   c-Rel   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidORAI3 promoter sequence
   Search Chromatin IP Primers for ORAI3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ORAI3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ORAI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORAI3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P030960:  view genomic region     (about GC identifiers)

Start:
30,960,387 bp from pter      End:
30,967,782 bp from pter
Size:
7,396 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ORAI3_HUMAN, Q9BRQ5 (See protein sequence)
Recommended Name: Protein orai-3  
Size: 295 amino acids; 31499 Da
Subunit: Interacts with EFCAB4B/CRACR2A
Secondary accessions: Q96BI8

Explore the universe of human proteins at neXtProt for ORAI3: NX_Q9BRQ5

Explore proteomics data for ORAI3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser213, Ser214, Ser216, Ser220
  • Modification sites at PhosphoSitePlus

  • See ORAI3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689501.1  
    ENSEMBL proteins: 
     ENSP00000322249   ENSP00000457221   ENSP00000457388   ENSP00000457025  

    ORAI3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals ORAI3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ORAI3

     
    Search eBioscience for Proteins for ORAI3 

    ORAI3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies for ORAI3
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    Novus Biologicals ORAI3 Antibody
    Abcam antibodies for ORAI3
    Cloud-Clone Corp. Antibodies for ORAI3
    ThermoFisher Antibodies for ORAI3
    LSBio Antibodies in human, mouse, rat for ORAI3

    ORAI3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ORAI3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ORAI3
    Cloud-Clone Corp. CLIAs for ORAI3
    Search eBioscience for ELISAs for ORAI3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ORAI: ORAI calcium release-activated calcium modulators

    1 InterPro protein domain:
     IPR012446 CRAC_channel

    Graphical View of Domain Structure for InterPro Entry Q9BRQ5

    ProtoNet protein and cluster: Q9BRQ5

    1 Blocks protein domain: IPB012446 Protein of unknown function DUF1650

    UniProtKB/Swiss-Prot: ORAI3_HUMAN, Q9BRQ5
    Similarity: Belongs to the Orai family


    Find genes that share domains with ORAI3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORAI3_HUMAN, Q9BRQ5
    Function: Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import
    (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with ORAI3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ORAI3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ORAI3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ORAI3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ORAI3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ORAI3:
    hsa-mir-335-5p (MIRT016774), hsa-mir-18a-5p (MIRT050737)

    Block miRNA regulation of human, mouse, rat ORAI3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ORAI3 (see all 24):
    hsa-miR-34b* hsa-miR-1321 hsa-miR-624 hsa-miR-650 hsa-miR-449a hsa-miR-629* hsa-miR-613 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidORAI3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ORAI3
    Predesigned siRNA for gene silencing in human, mouse, rat ORAI3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ORAI3

    Clone
    Products:
         
    OriGene clones in human, mouse for ORAI3 (see all 7)
    OriGene ORF clones in mouse, rat for ORAI3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ORAI3 (NM_152288)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORAI3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORAI3
    Addgene plasmids for ORAI3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ORAI3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ORAI3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORAI3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ORAI3_HUMAN, Q9BRQ5: Membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2
    peroxisome2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ORAI3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ORAI3 About    
    See pathways by source

    SuperPathContained pathways About
    1Calcium signaling pathway
    Calcium signaling pathway


    Find genes that share SuperPaths with ORAI3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for ORAI3):
        Calcium signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ORAI3
    Interactions:

        Search GeneGlobe Interaction Network for ORAI3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for ORAI3 (Q9BRQ53 ENSP000003222494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX6P261963I2D: score=3 
    ORAI1ENSP000003282164STRING: ENSP00000328216
    STIM1ENSP000003007374STRING: ENSP00000300737
    EFCAB4BENSP000004093824STRING: ENSP00000409382
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ORAI3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SKF 96365 hydrochlorideTRPC channel blocker; also inhibits store-operated Ca2+ entry[130495-35-1]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ORAI3 gene: 
    NM_152288.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318663(uc002eac.3) ENST00000563161 ENST00000566237 ENST00000562699

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ORAI3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ORAI3 (see all 24):
    hsa-miR-34b* hsa-miR-1321 hsa-miR-624 hsa-miR-650 hsa-miR-449a hsa-miR-629* hsa-miR-613 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidORAI3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ORAI3
    Predesigned siRNA for gene silencing in human, mouse, rat ORAI3
    Clone
    Products:
         
    OriGene clones in human, mouse for ORAI3 (see all 7)
    OriGene ORF clones in mouse, rat for ORAI3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ORAI3 (NM_152288)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORAI3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORAI3
    Addgene plasmids for ORAI3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ORAI3
    OriGene qSTAR qPCR primer pairs in human, mouse for ORAI3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ORAI3
      QuantiTect SYBR Green Assays in human, mouse, rat ORAI3
      QuantiFast Probe-based Assays in human, mouse, rat ORAI3

    Selected AceView cDNA sequences (see all 186):

    BC059173 BQ648716 BM726312 BM904282 BM556657 AW027088 BF002009 BM680919 
    AK098777 CK819710 AI280701 BQ574949 BM129511 C01878 AI216337 AL137589 
    AA862341 AI289104 BC048811 BX111140 BI196649 AW444819 BU185173 AA515878 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ORAI3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTAGATAG
    ORAI3 Expression
    About this image

    ORAI3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ORAI3 Protein Expression
        Custom PCR Arrays for ORAI3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ORAI3
    OriGene qSTAR qPCR primer pairs in human, mouse for ORAI3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ORAI3
    QuantiTect SYBR Green Assays in human, mouse, rat ORAI3
    QuantiFast Probe-based Assays in human, mouse, rat ORAI3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORAI3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ORAI3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Orai31 , 5 ORAI calcium release-activated calcium modulator 31, 5 86.04(n)1
    89.27(a)1
      7 (69.73 cM)5
    2699991  NM_198424.31  NP_940816.11 
     1277698155 
    lizard
    (Anolis carolinensis)
    Reptilia ORAI36
    ORAI calcium release-activated calcium modulator 3...
    61(a)
    1 ↔ 1
    GL343220.1(1845020-1858078)
    zebrafish
    (Danio rerio)
    Actinopterygii orai1b6
    ORAI calcium release-activated calcium modulator 1...
    68(a)
    many ↔ many
    10(43279209-43286542) ENSDARG00000004154
    fruit fly
    (Drosophila melanogaster)
    Insecta olf186-F6
    olf186-F
    23(a)
    1 → many
    2R(13730950-13748075)
    worm
    (Caenorhabditis elegans)
    Secernentea orai-16
    Protein ORAI-1, isoform b (orai-1) mRNA, complete ...
    28(a)
    1 → many
    III(647126-654463) WBGene00015648


    ENSEMBL Gene Tree for ORAI3 (if available)
    TreeFam Gene Tree for ORAI3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ORAI3 gene
    ORAI22  ORAI12  
    2 SIMAP similar genes for ORAI3 using alignment to 4 protein entries:     ORAI3_HUMAN (see all proteins):
    ORAI2    ORAI1

    Find genes that share paralogs with ORAI3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ORAI3 (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs596732291,2
    C--30963464(+) TTTTT-/TTGAGAC 1 -- int11Minor allele frequency- TT:0.00NA 2
    rs617384911,2
    C,F--31959349(+) TGCCCG/AGCTGG 1 -- us2k12Minor allele frequency- A:0.01NS EU 411
    rs2008759081,2
    --31959364(+) TGCCGC/GGCCCC 1 -- us2k10--------
    rs1999499971,2
    C--31959468(+) CCTCCA/GGCTTC 1 -- us2k10--------
    rs1164233891,2
    C,F--31959548(+) GATTCC/GCACCC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs796486081,2
    F--31959697(+) GAGCCG/AAAGGG 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs727993541,2
    C--31959734(+) GTGTTA/GGGGGG 1 -- us2k10--------
    rs1854342261,2
    --31959999(+) AATACC/TCCCTT 1 -- us2k10--------
    rs1425159371,2
    C--31960254(+) GGAGCC/TGGGGT 1 -- us2k10--------
    rs1442870331,2
    --31960373(+) GGCACC/TCGCCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ORAI3 (30960387 - 30967782 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ORAI3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv35n68CNV Loss17160897
    nsv833189CNV Loss17160897
    nsv905738CNV Loss21882294
    nsv457483CNV Loss19166990
    dgv2671n71CNV Loss21882294
    nsv905729CNV Loss21882294
    nsv905733CNV Loss21882294
    dgv2670n71CNV Loss21882294
    nsv482192CNV Gain20164927
    nsv833193CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ORAI3
    DNA2.0 Custom Variant and Variant Library Synthesis for ORAI3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610930    OMIM disorders: --


    Find genes that share disorders with ORAI3           About GenesLikeMe


    Export disorders for ORAI3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ORAI3 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ORAI3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PubMed id 16582901)1, 2, 3 Feske S.... Rao A. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Are Orai1 and Orai3 channels more important than calcium influx for cell proliferation? (PubMed id 24321771)1 Borowiec A.S....Capiod T. (Biochim. Biophys. Acta 2014)
    4. ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells. (PubMed id 23266555)1 Faouzi M....Ouadid-Ahidouch H. (Biochim. Biophys. Acta 2013)
    5. Orai3 is an estrogen receptor I+-regulated CaA^a8_ channel that promotes tumorigenesis. (PubMed id 22993197)1 Motiani R.K....Trebak M. (FASEB J. 2013)
    6. Expression of Orai genes and I(CRAC) activation in the human retinal pigment epithelium. (PubMed id 20607548)1 Cordeiro S. and Strauss O. (Graefes Arch. Clin. Exp. Ophthalmol. 2011)
    7. Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells. (PubMed id 20683915)1 Faouzi M....Ouadid-Ahidouch H. (J. Cell. Physiol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Molecular determinants within N terminus of Orai3 protein that control channel activation and gating. (PubMed id 21724845)1 Bergsmann J....Romanin C. (J. Biol. Chem. 2011)
    10. Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. (PubMed id 20354224)1 Bogeski I....Niemeyer B.A. (Sci Signal 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93129 HGNC: 28185 AceView: FBXL19andMGC13024 Ensembl:ENSG00000175938 euGenes: HUgn93129
    ECgene: ORAI3 Kegg: 93129 H-InvDB: ORAI3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ORAI3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ORAI3 gene:
    Search GeneIP for patents involving ORAI3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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