Aliases for ORAI3 Gene
Aliases for ORAI3 Gene
External Ids for ORAI3 Gene
- HGNC: 28185
- NCBI Gene: 93129
- Ensembl: ENSG00000175938
- OMIM®: 610930
- UniProtKB/Swiss-Prot: Q9BRQ5
Previous HGNC Symbols for ORAI3 Gene
- TMEM142C
Previous GeneCards Identifiers for ORAI3 Gene
- GC16P030869
- GC16P030870
- GC16P030960
- GC16P028524
Summaries for ORAI3 Gene
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Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
GeneCards Summary for ORAI3 Gene
ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3) is a Protein Coding gene. Diseases associated with ORAI3 include Immunodeficiency 10 and T Cell And Nk Cell Immunodeficiency. Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI1.
UniProtKB/Swiss-Prot Summary for ORAI3 Gene
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1. ( ORAI3_HUMAN,Q9BRQ5 )
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STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.
Additional gene information for ORAI3 Gene
- HGNC (28185)
- NCBI Gene (93129)
- Ensembl (ENSG00000175938)
- OMIM® (610930)
- UniProtKB/Swiss-Prot (Q9BRQ5)
- Open Targets Platform(ENSG00000175938)
- Alliance of Genome Resources
- Search for ORAI3 at DataMed
- Search for ORAI3 at HumanCyc