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Aliases for ORAI3 Gene

Aliases for ORAI3 Gene

  • ORAI Calcium Release-Activated Calcium Modulator 3 2 3
  • Transmembrane Protein 142C 2 3 4
  • TMEM142C 3 4 6
  • Protein Orai-3 3

External Ids for ORAI3 Gene

Previous HGNC Symbols for ORAI3 Gene

  • TMEM142C

Previous GeneCards Identifiers for ORAI3 Gene

  • GC16P030869
  • GC16P030870
  • GC16P028524

Summaries for ORAI3 Gene

GeneCards Summary for ORAI3 Gene

ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway. An important paralog of this gene is ORAI2.

UniProtKB/Swiss-Prot for ORAI3 Gene

  • Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.

Tocris Summary for ORAI3 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the emptying of intracellular Ca2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and STIM2, serve as ER Ca2+ sensors. They contain N'-terminal Ca2+-sensing EF-hand domains and are localized to the tubular ER. Following Ca2+ store depletion, STIMs rapidly cluster and relocalize to the plasma membrane-adjacent ER regions, where they oligomerize and form 'puncta'. Orai proteins, Orai1, Orai2 and Orai3, are STIM binding partners that form the pore of the channel. Orai proteins are uniformly distributed in the plasma membrane and exist as dimers in the resting state. STIM activation induces tetramerization of Orai proteins and subsequent STIM-Orai colocalization, which forms the active store-operated calcium channel.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAI3 Gene

Genomics for ORAI3 Gene

Regulatory Elements for ORAI3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ORAI3 Gene

30,949,066 bp from pter
30,956,461 bp from pter
7,396 bases
Plus strand

Genomic View for ORAI3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAI3 Gene

Proteins for ORAI3 Gene

  • Protein details for ORAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein orai-3
    Protein Accession:
    Secondary Accessions:
    • Q96BI8

    Protein attributes for ORAI3 Gene

    295 amino acids
    Molecular mass:
    31499 Da
    Quaternary structure:
    • Interacts with CRACR2A/EFCAB4B.

neXtProt entry for ORAI3 Gene

Proteomics data for ORAI3 Gene at MOPED

Post-translational modifications for ORAI3 Gene

  • Glycosylation at Ser213, Ser214, Ser216, and Ser220
  • Modification sites at PhosphoSitePlus

Other Protein References for ORAI3 Gene

Antibody Products

No data available for DME Specific Peptides for ORAI3 Gene

Domains for ORAI3 Gene

Protein Domains for ORAI3 Gene

Suggested Antigen Peptide Sequences for ORAI3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Orai family.
  • Belongs to the Orai family.
genes like me logo Genes that share domains with ORAI3: view

Function for ORAI3 Gene

Molecular function for ORAI3 Gene

UniProtKB/Swiss-Prot Function:
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.

Gene Ontology (GO) - Molecular Function for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20418871
GO:0015279 store-operated calcium channel activity IBA --
genes like me logo Genes that share ontologies with ORAI3: view

Animal Model Products

miRNA for ORAI3 Gene

miRTarBase miRNAs that target ORAI3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ORAI3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAI3 Gene

Localization for ORAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORAI3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ORAI3 Gene COMPARTMENTS Subcellular localization image for ORAI3 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ORAI3: view

Pathways for ORAI3 Gene

SuperPathways for ORAI3 Gene

Superpath Contained pathways
1 Calcium signaling pathway
genes like me logo Genes that share pathways with ORAI3: view

Pathways by source for ORAI3 Gene

1 KEGG pathway for ORAI3 Gene

Interacting Proteins for ORAI3 Gene

Gene Ontology (GO) - Biological Process for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002115 store-operated calcium entry IBA --
GO:0070588 calcium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with ORAI3: view

Drugs for ORAI3 Gene

(1) Tocris Compounds for ORAI3 Gene

Compound Action Cas Number
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry [130495-35-1]
genes like me logo Genes that share compounds with ORAI3: view

Transcripts for ORAI3 Gene

mRNA/cDNA for ORAI3 Gene

Unigene Clusters for ORAI3 Gene

ORAI calcium release-activated calcium modulator 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ORAI3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ORAI3 Gene

No ASD Table

Relevant External Links for ORAI3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ORAI3 Gene

mRNA expression in normal human tissues for ORAI3 Gene

SOURCE GeneReport for Unigene cluster for ORAI3 Gene Hs.745104

genes like me logo Genes that share expressions with ORAI3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for ORAI3 Gene

Orthologs for ORAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ORAI3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ORAI3 35
  • 89.97 (n)
  • 92.39 (a)
ORAI3 36
  • 85 (a)
(Canis familiaris)
Mammalia ORAI3 35
  • 90.9 (n)
  • 92.83 (a)
ORAI3 36
  • 76 (a)
(Mus musculus)
Mammalia Orai3 35
  • 86.04 (n)
  • 89.27 (a)
Orai3 16
Orai3 36
  • 84 (a)
(Pan troglodytes)
Mammalia ORAI3 35
  • 98.98 (n)
  • 99.32 (a)
ORAI3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Orai3 35
  • 85.81 (n)
  • 90.66 (a)
(Monodelphis domestica)
Mammalia ORAI3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ORAI3 36
  • 74 (a)
(Anolis carolinensis)
Reptilia ORAI3 36
  • 61 (a)
(Danio rerio)
Actinopterygii orai1b 36
  • 68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005071 35
  • 57.21 (n)
  • 50.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta olf186-F 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea orai-1 36
  • 28 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15111 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8521 36
  • 35 (a)
Species with no ortholog for ORAI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ORAI3 Gene

Gene Tree for ORAI3 (if available)
Gene Tree for ORAI3 (if available)

Paralogs for ORAI3 Gene

Paralogs for ORAI3 Gene

(2) SIMAP similar genes for ORAI3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ORAI3: view

Variants for ORAI3 Gene

Sequence variations from dbSNP and Humsavar for ORAI3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs528228161 -- 30,954,410(+) ACGGG(C/G)TTTCG utr-variant-3-prime
rs527760462 -- 30,950,289(+) AGATC(A/G)TGGAG intron-variant
rs527700213 -- 30,949,620(+) TAAAG(A/G)GGGCT intron-variant
rs377453585 -- 30,953,718(+) GTACC(C/T)GTGGG reference, synonymous-codon
rs377253597 -- 30,949,481(+) GCTTC(C/T)AGCCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ORAI3 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
nsv905733 CNV Loss 21882294
nsv833189 CNV Loss 17160897
dgv35n68 CNV Loss 17160897
dgv2670n71 CNV Loss 21882294
dgv2671n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv905738 CNV Loss 21882294
nsv482192 CNV Gain 20164927
nsv833193 CNV Gain+Loss 17160897

Relevant External Links for ORAI3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAI3 Gene

Disorders for ORAI3 Gene

No disorders were found for ORAI3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ORAI3 Gene

Publications for ORAI3 Gene

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PMID: 16582901) Feske S. … Rao A. (Nature 2006) 2 3 4
  2. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. (PMID: 20418871) Srikanth S. … Gwack Y. (Nat. Cell Biol. 2010) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Expression of Orai genes and I(CRAC) activation in the human retinal pigment epithelium. (PMID: 20607548) Cordeiro S. … Strauss O. (Graefes Arch. Clin. Exp. Ophthalmol. 2011) 3

Products for ORAI3 Gene

  • Addgene plasmids for ORAI3

Sources for ORAI3 Gene

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