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Aliases for ORAI3 Gene

Aliases for ORAI3 Gene

  • ORAI Calcium Release-Activated Calcium Modulator 3 2 3 5
  • Transmembrane Protein 142C 2 3 4
  • TMEM142C 3 4

External Ids for ORAI3 Gene

Previous HGNC Symbols for ORAI3 Gene

  • TMEM142C

Previous GeneCards Identifiers for ORAI3 Gene

  • GC16P030869
  • GC16P030870
  • GC16P030960
  • GC16P028524

Summaries for ORAI3 Gene

GeneCards Summary for ORAI3 Gene

ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway. GO annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI2.

UniProtKB/Swiss-Prot for ORAI3 Gene

  • Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.

Tocris Summary for ORAI3 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAI3 Gene

Genomics for ORAI3 Gene

Regulatory Elements for ORAI3 Gene

Enhancers for ORAI3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ORAI3 on UCSC Golden Path with GeneCards custom track

Promoters for ORAI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ORAI3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ORAI3 Gene

30,949,066 bp from pter
30,956,461 bp from pter
7,396 bases
Plus strand

Genomic View for ORAI3 Gene

Genes around ORAI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAI3 Gene

Proteins for ORAI3 Gene

  • Protein details for ORAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein orai-3
    Protein Accession:
    Secondary Accessions:
    • Q96BI8

    Protein attributes for ORAI3 Gene

    295 amino acids
    Molecular mass:
    31499 Da
    Quaternary structure:
    • Interacts with CRACR2A/EFCAB4B.

neXtProt entry for ORAI3 Gene

Proteomics data for ORAI3 Gene at MOPED

Post-translational modifications for ORAI3 Gene

  • Glycosylation at Ser 213, Ser 214, Ser 216, and Ser 220
  • Modification sites at PhosphoSitePlus

Other Protein References for ORAI3 Gene

No data available for DME Specific Peptides for ORAI3 Gene

Domains & Families for ORAI3 Gene

Gene Families for ORAI3 Gene

Protein Domains for ORAI3 Gene

Suggested Antigen Peptide Sequences for ORAI3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Orai family.
  • Belongs to the Orai family.
genes like me logo Genes that share domains with ORAI3: view

Function for ORAI3 Gene

Molecular function for ORAI3 Gene

UniProtKB/Swiss-Prot Function:
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.

Gene Ontology (GO) - Molecular Function for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015279 store-operated calcium channel activity IBA --
genes like me logo Genes that share ontologies with ORAI3: view
genes like me logo Genes that share phenotypes with ORAI3: view

Animal Model Products

miRNA for ORAI3 Gene

miRTarBase miRNAs that target ORAI3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAI3 Gene

Localization for ORAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORAI3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ORAI3 Gene COMPARTMENTS Subcellular localization image for ORAI3 gene
Compartment Confidence
plasma membrane 4
cytosol 3
endoplasmic reticulum 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA --
genes like me logo Genes that share ontologies with ORAI3: view

Pathways & Interactions for ORAI3 Gene

SuperPathways for ORAI3 Gene

Superpath Contained pathways
1 Calcium signaling pathway
genes like me logo Genes that share pathways with ORAI3: view

Pathways by source for ORAI3 Gene

1 KEGG pathway for ORAI3 Gene

Interacting Proteins for ORAI3 Gene

Gene Ontology (GO) - Biological Process for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070588 calcium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with ORAI3: view

No data available for SIGNOR curated interactions for ORAI3 Gene

Drugs & Compounds for ORAI3 Gene

(1) Drugs for ORAI3 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-APB Pharma Antagonist, Pore Blocker IP3 receptor antagonist. Also TRP channel modulator 0

(4) Additional Compounds for ORAI3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5J 4
ML 9 hydrochloride
SKF 96365 hydrochloride
YM 58483

(5) Tocris Compounds for ORAI3 Gene

Compound Action Cas Number
2-APB IP3 receptor antagonist. Also TRP channel modulator 524-95-8
5J 4 CRAC channel blocker; anti-inflammatory 827001-82-1
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry 130495-35-1
YM 58483 Inhibitor of SOCE in non-excitable cells 223499-30-7
genes like me logo Genes that share compounds with ORAI3: view

Transcripts for ORAI3 Gene

Unigene Clusters for ORAI3 Gene

ORAI calcium release-activated calcium modulator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORAI3 Gene

No ASD Table

Relevant External Links for ORAI3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ORAI3 Gene

mRNA expression in normal human tissues for ORAI3 Gene

SOURCE GeneReport for Unigene cluster for ORAI3 Gene Hs.745104

genes like me logo Genes that share expression patterns with ORAI3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ORAI3 Gene

Orthologs for ORAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ORAI3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ORAI3 35
  • 89.97 (n)
  • 92.39 (a)
ORAI3 36
  • 85 (a)
(Canis familiaris)
Mammalia ORAI3 35
  • 90.9 (n)
  • 92.83 (a)
ORAI3 36
  • 76 (a)
(Mus musculus)
Mammalia Orai3 35
  • 86.04 (n)
  • 89.27 (a)
Orai3 16
Orai3 36
  • 84 (a)
(Pan troglodytes)
Mammalia ORAI3 35
  • 98.98 (n)
  • 99.32 (a)
ORAI3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Orai3 35
  • 85.81 (n)
  • 90.66 (a)
(Monodelphis domestica)
Mammalia ORAI3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ORAI3 36
  • 74 (a)
(Anolis carolinensis)
Reptilia ORAI3 36
  • 61 (a)
(Danio rerio)
Actinopterygii orai1b 36
  • 68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005071 35
  • 57.21 (n)
  • 50.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta olf186-F 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea orai-1 36
  • 28 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15111 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8521 36
  • 35 (a)
Species with no ortholog for ORAI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ORAI3 Gene

Gene Tree for ORAI3 (if available)
Gene Tree for ORAI3 (if available)

Paralogs for ORAI3 Gene

Paralogs for ORAI3 Gene

(2) SIMAP similar genes for ORAI3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ORAI3: view

Variants for ORAI3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ORAI3 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
nsv905733 CNV Loss 21882294
nsv833189 CNV Loss 17160897
dgv35n68 CNV Loss 17160897
dgv2670n71 CNV Loss 21882294
dgv2671n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv905738 CNV Loss 21882294
nsv482192 CNV Gain 20164927
nsv833193 CNV Gain+Loss 17160897

Variation tolerance for ORAI3 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for ORAI3 Gene

Disorders for ORAI3 Gene

Relevant External Links for ORAI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ORAI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORAI3 Gene

Publications for ORAI3 Gene

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PMID: 16582901) Feske S. … Rao A. (Nature 2006) 2 3 4 67
  2. Facilitation of Orai3 targeting and store-operated function by Orai1. (PMID: 25791427) Alansary D. … Niemeyer B.A. (Biochim. Biophys. Acta 2015) 3
  3. Are Orai1 and Orai3 channels more important than calcium influx for cell proliferation? (PMID: 24321771) Borowiec A.S. … Capiod T. (Biochim. Biophys. Acta 2014) 3
  4. Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis. (PMID: 24603752) Dragoni S. … Moccia F. (PLoS ONE 2014) 3
  5. Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1. (PMID: 24909327) Kar P. … Parekh A.B. (Curr. Biol. 2014) 3

Products for ORAI3 Gene

Sources for ORAI3 Gene