Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ORAI3 Gene

protein-coding   GIFtS: 49
GCID: GC16P030960

ORAI Calcium Release-Activated Calcium Modulator 3

(Previous name: transmembrane protein 142C)
(Previous symbol: TMEM142C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ORAI Calcium Release-Activated Calcium Modulator 31 2
TMEM142C1 2 3 5
Transmembrane Protein 142C1 2 3
Protein Orai-32

External Ids:    HGNC: 281851   Entrez Gene: 931292   Ensembl: ENSG000001759387   OMIM: 6109305   UniProtKB: Q9BRQ53   

Export aliases for ORAI3 gene to outside databases

Previous GC identifers: GC16P030869 GC16P030870 GC16P028524


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ORAI3 Gene: 
ORAI3 (ORAI calcium release-activated calcium modulator 3) is a protein-coding gene. Diseases associated with ORAI3 include estrogen-receptor negative breast cancer, and breast cancer. GO annotations related to this gene include protein binding. An important paralog of this gene is ORAI2.

UniProtKB/Swiss-Prot: ORAI3_HUMAN, Q9BRQ5
Function: Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import
(By similarity)

summary for ORAI3 Gene:
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated
calcium entry (SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the
emptying of intracellular Ca2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and
STIM2, serve as ER Ca2+ sensors. They contain N'-terminal Ca2+-sensing EF-hand domains and are localized to
the tubular ER. Following Ca2+ store depletion, STIMs rapidly cluster and relocalize to the plasma
membrane-adjacent ER regions, where they oligomerize and form 'puncta'. Orai proteins, Orai1, Orai2 and
Orai3, are STIM binding partners that form the pore of the channel. Orai proteins are uniformly distributed
in the plasma membrane and exist as dimers in the resting state. STIM activation induces tetramerization of
Orai proteins and subsequent STIM-Orai colocalization, which forms the active store-operated calcium
channel.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ORAI3 gene promoter:
         NF-1/L   NF-1   HTF   LCR-F1   NF-AT   Arnt   MZF-1   AREB6   CREB   c-Rel   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidORAI3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ORAI3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORAI3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ORAI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORAI3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P030960:  view genomic region     (about GC identifiers)

Start:
30,960,387 bp from pter      End:
30,967,782 bp from pter
Size:
7,396 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ORAI3_HUMAN, Q9BRQ5 (See protein sequence)
Recommended Name: Protein orai-3  
Size: 295 amino acids; 31499 Da
Subunit: Interacts with EFCAB4B/CRACR2A
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q96BI8

Explore the universe of human proteins at neXtProt for ORAI3: NX_Q9BRQ5

Explore proteomics data for ORAI3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BRQ5

  • ORAI3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ORAI3 Protein Expression
    REFSEQ proteins: NP_689501.1  
    ENSEMBL proteins: 
     ENSP00000322249   ENSP00000457221   ENSP00000457388   ENSP00000457025  

    Human Recombinant Protein Products for ORAI3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ORAI3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ORAI3
    GenScript Custom Purified and Recombinant Proteins Services for ORAI3
    Novus Biologicals ORAI3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ORAI3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ORAI3 for ontologies           About GeneDecksing



    ORAI3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ORAI3
    OriGene Custom Antibody Services for ORAI3
    GenScript Custom Superior Antibodies Services for ORAI3
    Novus Biologicals ORAI3 Antibody
    Abcam antibodies for ORAI3
    Cloud-Clone Corp. Antibodies for ORAI3 
    ThermoFisher Antibodies for ORAI3
    LSBio Antibodies in human, mouse, rat for ORAI3 

    Assay Products for ORAI3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ORAI3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ORAI3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ORAI3 
    Cloud-Clone Corp. CLIAs for ORAI3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ORAI: ORAI calcium release-activated calcium modulators

    1 InterPro protein domain:
     IPR012446 CRAC_channel

    Graphical View of Domain Structure for InterPro Entry Q9BRQ5

    ProtoNet protein and cluster: Q9BRQ5

    1 Blocks protein domain: IPB012446 Protein of unknown function DUF1650

    UniProtKB/Swiss-Prot: ORAI3_HUMAN, Q9BRQ5
    Similarity: Belongs to the Orai family


    ORAI3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORAI3_HUMAN, Q9BRQ5
    Function: Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import
    (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    ORAI3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ORAI3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ORAI3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ORAI3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ORAI3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORAI3
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ORAI3 (see all 24):
    hsa-miR-34b* hsa-miR-1321 hsa-miR-624 hsa-miR-650 hsa-miR-449a hsa-miR-629* hsa-miR-613 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidORAI3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ORAI3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORAI3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ORAI3
    Sirion Biotech Customized adenovirus for overexpression of ORAI3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ORAI3 (see all 8)
    OriGene ORF clones in mouse, rat for ORAI3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ORAI3 (NM_152288)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORAI3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORAI3
    Sirion Biotech Customized lentivirus for stable overexpression of ORAI3 
                         Customized lentivirus expression plasmids for stable overexpression of ORAI3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ORAI3
    Search LifeMap BioReagents cell lines for ORAI3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORAI3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ORAI3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium signaling pathway
    Calcium signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for ORAI3):
        Calcium signaling pathway


    ORAI3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ORAI3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for ORAI3 (Q9BRQ53 ENSP000003222494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX6P261963I2D: score=3 
    ORAI1ENSP000003282164STRING: ENSP00000328216
    STIM1ENSP000003007374STRING: ENSP00000300737
    EFCAB4BENSP000004093824STRING: ENSP00000409382
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ORAI3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SKF 96365 hydrochlorideTRPC channel blocker; also inhibits store-operated Ca2+ entry[130495-35-1]

    Search CenterWatch for drugs/clinical trials and news about ORAI3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ORAI3 gene: 
    NM_152288.2  

    Unigene Cluster for ORAI3:

    ORAI calcium release-activated calcium modulator 3
    Hs.745104  [show with all ESTs]
    Unigene Representative Sequence: BC015555
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318663(uc002eac.3) ENST00000563161 ENST00000566237 ENST00000562699

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ORAI3
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ORAI3 (see all 24):
    hsa-miR-34b* hsa-miR-1321 hsa-miR-624 hsa-miR-650 hsa-miR-449a hsa-miR-629* hsa-miR-613 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidORAI3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ORAI3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORAI3
    Clone
    Products:
         
    OriGene clones in human, mouse for ORAI3 (see all 8)
    OriGene ORF clones in mouse, rat for ORAI3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ORAI3 (NM_152288)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORAI3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORAI3
    Sirion Biotech Customized lentivirus for stable overexpression of ORAI3 
                         Customized lentivirus expression plasmids for stable overexpression of ORAI3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ORAI3
    OriGene qSTAR qPCR primer pairs in human, mouse for ORAI3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ORAI3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORAI3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORAI3

    Additional mRNA sequence: 

    AK298276.1 BC006126.1 BC015555.1 BC016150.1 BC022786.1 

    5 DOTS entries:

    DT.408811  DT.40249054  DT.100783943  DT.95105479  DT.120669094 

    24/186 AceView cDNA sequences (see all 186):

    AL137589 BM904282 BM556657 CK819710 C01878 BU185173 BC059173 BQ648716 
    CA412795 AW444819 AK098777 BU608652 BF002009 BM680919 AA423891 BG677581 
    AI280701 NM_019085 BX384015 AK127701 CK819711 AI216337 BQ574949 AI289104 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ORAI3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTAGATAG
    ORAI3 Expression
    About this image


    See ORAI3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ORAI3

    SOURCE GeneReport for Unigene cluster: Hs.745104
        SABiosciences Custom PCR Arrays for ORAI3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ORAI3
    OriGene qSTAR qPCR primer pairs in human, mouse for ORAI3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ORAI3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORAI3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORAI3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORAI3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ORAI3 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Orai31 , 5 ORAI calcium release-activated calcium modulator 31, 5 86.62(n)1
    90.31(a)1
      7 (69.73 cM)5
    2699991  NM_198424.31  NP_940816.11 
     1277698155 
    lizard
    (Anolis carolinensis)
    Reptilia ORAI36
    Uncharacterized protein
    62(a)
    1 ↔ 1
    GL343220.1(1845020-1858078)
    fruit fly
    (Drosophila melanogaster)
    Insecta olf186-F6
    olf186-F
    23(a)
    1 → many
    2R(13730950-13748075)
    worm
    (Caenorhabditis elegans)
    Secernentea orai-16
    Protein orai
    29(a)
    1 → many
    III(647126-654463)


    ENSEMBL Gene Tree for ORAI3 (if available)
    TreeFam Gene Tree for ORAI3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ORAI3 gene
    ORAI22  ORAI12  
    2 SIMAP similar genes for ORAI3 using alignment to 4 protein entries:     ORAI3_HUMAN (see all proteins):
    ORAI2    ORAI1

    ORAI3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/127 SNPs in ORAI3 are shown (see all 127)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs596732291,2
    C--30963464(+) TTTTT-/TTGAGAC 1 -- int11Minor allele frequency- TT:0.00NA 2
    rs617384911,2
    C,F--31959349(+) TGCCCG/AGCTGG 1 -- us2k12Minor allele frequency- A:0.01NS EU 411
    rs2008759081,2
    --31959364(+) TGCCGC/GGCCCC 1 -- us2k10--------
    rs1999499971,2
    C--31959468(+) CCTCCA/GGCTTC 1 -- us2k10--------
    rs1164233891,2
    C,F--31959548(+) GATTCC/GCACCC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs796486081,2
    F--31959697(+) GAGCCG/AAAGGG 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs727993541,2
    C--31959734(+) GTGTTA/GGGGGG 1 -- us2k10--------
    rs1854342261,2
    --31959999(+) AATACC/TCCCTT 1 -- us2k10--------
    rs1425159371,2
    C--31960254(+) GGAGCC/TGGGGT 1 -- us2k10--------
    rs1442870331,2
    --31960373(+) GGCACC/TCGCCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ORAI3 (30960387 - 30967782 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ORAI3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv35n68CNV Loss17160897
    nsv833189CNV Loss17160897
    nsv905738CNV Loss21882294
    nsv457483CNV Loss19166990
    dgv2671n71CNV Loss21882294
    nsv905729CNV Loss21882294
    nsv905733CNV Loss21882294
    dgv2670n71CNV Loss21882294
    nsv482192CNV Gain20164927
    nsv833193CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ORAI3
    DNA2.0 Custom Variant and Variant Library Synthesis for ORAI3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610930    OMIM disorders: --

    3 diseases for ORAI3:    About MalaCards
    estrogen-receptor negative breast cancer    breast cancer    retinitis


    ORAI3 for disorders           About GeneDecksing


    Export disorders for ORAI3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ORAI3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ORAI3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PubMed id 16582901)1, 2, 3 Feske S.... Rao A. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. ORAI3 silencing alters cell proliferation and cell cyc le progression via c-myc pathway in breast cancer cells. (PubMed id 23266555)1 Faouzi M....Ouadid-Ahidouch H. (2013)
    4. Orai3 is an estrogen receptor a-regulated Ca^^+ channe l that promotes tumorigenesis. (PubMed id 22993197)1 Motiani R.K....Trebak M. (2013)
    5. Expression of Orai genes and I(CRAC) activation in th e human retinal pigment epithelium. (PubMed id 20607548)1 Cordeiro S. and Strauss O. (2011)
    6. Down-regulation of Orai3 arrests cell-cycle progressi on and induces apoptosis in breast cancer cells but not in normal breast epithe lial cells. (PubMed id 20683915)1 Faouzi M....Ouadid-Ahidouch H. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Molecular determinants within N terminus of Orai3 pro tein that control channel activation and gating. (PubMed id 21724845)1 Bergsmann J....Romanin C. (2011)
    9. Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. (PubMed id 20354224)1 Bogeski I....Niemeyer B.A. (2010)
    10. A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-pos itive versus estrogen receptor-negative breast cancer cells. (PubMed id 20395295)1 Motiani R.K....Trebak M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93129 HGNC: 28185 AceView: FBXL19andMGC13024 Ensembl:ENSG00000175938 euGenes: HUgn93129
    ECgene: ORAI3 Kegg: 93129 H-InvDB: ORAI3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ORAI3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ORAI3 gene:
    Search GeneIP for patents involving ORAI3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ORAI3   OriGene RNAi products in human, mouse, rat for ORAI3  
     OriGene qPCR primer pairs and template standards for ORAI3   OriGene Protein Over-expression Lysate for ORAI3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ORAI3  
     OriGene qSTAR qPCR primer pairs in human, mouse for ORAI3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ORAI3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ORAI3   OriGene Custom Protein Services for ORAI3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ORAI3
     QIAGEN SeqTarget long-range PCR primers for resequencing ORAI3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORAI3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ORAI3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ORAI3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ORAI3
     GenScript Custom Purified and Recombinant Proteins Services for ORAI3 GenScript cDNA clones with any tag delivered in your preferred vector for ORAI3
     GenScript Custom Assay Services for ORAI3 GenScript Custom Superior Antibodies Services for ORAI3
     GenScript Custom overexpressing Cell Line Services for ORAI3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ORAI3 promoter
     Search Chromatin IP Primers for ORAI3
     RT2 qPCR Primer Assay in human, mouse, rat ORAI3
     Search GNC Networks for ORAI3
     SABiosciences Custom PCR Arrays for ORAI3
     Tocris compounds for ORAI3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ORAI3 antibodies
     ORAI3 lysates
     Antibodies for ORAI3
     See all of Abcam's Antibodies, Kits and Proteins for ORAI3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ORAI3
     Antibodies for ORAI3
     ELISAs for ORAI3
     CLIAs for ORAI3
     Search LifeMap BioReagents cell lines for ORAI3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORAI3
     SwitchGear 3'UTR luciferase reporter plasmids for ORAI3
     SwitchGear Promoter luciferase reporter plasmids for ORAI3
     ThermoFisher Antibodies for ORAI3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORAI3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ORAI3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ORAI3
    Customized:
     lentivirus for stable overexpression of ORAI3
     lentivirus expression plasmids for stable overexpression of ORAI3
     adenovirus for overexpression of ORAI3
     LSBio Antibodies in human, mouse, rat for ORAI3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ORAI3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4