Aliases for ORAI3 Gene
External Ids for ORAI3 Gene
Previous HGNC Symbols for ORAI3 Gene
Previous GeneCards Identifiers for ORAI3 Gene
GeneCards Summary for ORAI3 Gene
ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway. Gene Ontology (GO) annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI2.
UniProtKB/Swiss-Prot for ORAI3 Gene
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.