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Aliases for ORAI3 Gene

Aliases for ORAI3 Gene

  • ORAI Calcium Release-Activated Calcium Modulator 3 2 3 5
  • Transmembrane Protein 142C 2 3 4
  • TMEM142C 3 4
  • Protein Orai-3 3

External Ids for ORAI3 Gene

Previous HGNC Symbols for ORAI3 Gene

  • TMEM142C

Previous GeneCards Identifiers for ORAI3 Gene

  • GC16P030869
  • GC16P030870
  • GC16P030960
  • GC16P028524

Summaries for ORAI3 Gene

GeneCards Summary for ORAI3 Gene

ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway. GO annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is ORAI2.

UniProtKB/Swiss-Prot for ORAI3 Gene

  • Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.

Tocris Summary for ORAI3 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

Additional gene information for ORAI3 Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAI3 Gene

Genomics for ORAI3 Gene

Regulatory Elements for ORAI3 Gene

Enhancers for ORAI3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H031125 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.8 +182.1 182073 10.7 HDGF ARNT SIN3A ZNF766 ZNF207 ZNF548 SP3 MCM3 ZNF592 SREBF1 SRCAP SETD1A ENSG00000260267 SMG1P5 ZNF764 ENSG00000260304 KAT8 BCL7C TGFB1I1 ITGAX
GH16H030956 1.4 ENCODE dbSUPER 19.1 +8.8 8826 3.4 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC MEF2D SSRP1 ZNF610 SETD1A SRCAP INO80E ENSG00000260267 ZNF764 ZNF747 SMG1P5 ENSG00000260304 BCL7C KAT8
GH16H030598 1.4 Ensembl ENCODE 18.7 -350.8 -350765 0.6 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF302 ZNF143 SP3 SRCAP INO80E ENSG00000260267 FBRS SETD1A ZNF764 PRR14 RNF40 SMG1P5 ENSG00000260304
GH16H030052 1.4 ENCODE dbSUPER 18.7 -894.9 -894862 3.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZC3H11A SETD1A SRCAP INO80E NPIPB12 ZNF747 ZNF764 SMG1P5 SMG1P2 NPIPB13 BCL7C
GH16H030566 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -379.2 -379192 6 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H11A SETD1A SRCAP ENSG00000260267 ZNF747 NPIPB13 INO80E ZNF764 C16orf58 SMG1P5 SMG1P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ORAI3 on UCSC Golden Path with GeneCards custom track

Promoters for ORAI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ORAI3 Gene

Genomic Locations for ORAI3 Gene
7,396 bases
Plus strand

Genomic View for ORAI3 Gene

Genes around ORAI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ORAI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ORAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAI3 Gene

Proteins for ORAI3 Gene

  • Protein details for ORAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein orai-3
    Protein Accession:
    Secondary Accessions:
    • Q96BI8

    Protein attributes for ORAI3 Gene

    295 amino acids
    Molecular mass:
    31499 Da
    Quaternary structure:
    • Interacts with CRACR2A/EFCAB4B.

neXtProt entry for ORAI3 Gene

Post-translational modifications for ORAI3 Gene

  • Glycosylation at Ser213, posLast=214214, Ser216, and Ser220
  • Modification sites at PhosphoSitePlus

Other Protein References for ORAI3 Gene

No data available for DME Specific Peptides for ORAI3 Gene

Domains & Families for ORAI3 Gene

Gene Families for ORAI3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ORAI3 Gene

Suggested Antigen Peptide Sequences for ORAI3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Orai family.
  • Belongs to the Orai family.
genes like me logo Genes that share domains with ORAI3: view

Function for ORAI3 Gene

Molecular function for ORAI3 Gene

UniProtKB/Swiss-Prot Function:
Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import.

Phenotypes From GWAS Catalog for ORAI3 Gene

Gene Ontology (GO) - Molecular Function for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20418871
GO:0015279 store-operated calcium channel activity IBA --
genes like me logo Genes that share ontologies with ORAI3: view
genes like me logo Genes that share phenotypes with ORAI3: view

miRNA for ORAI3 Gene

miRTarBase miRNAs that target ORAI3

Clone Products

  • Addgene plasmids for ORAI3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAI3 Gene

Localization for ORAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORAI3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ORAI3 gene
Compartment Confidence
plasma membrane 4
cytosol 3
peroxisome 2
nucleus 2
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ORAI3: view

Pathways & Interactions for ORAI3 Gene

SuperPathways for ORAI3 Gene

SuperPathway Contained pathways
1 Calcium signaling pathway
genes like me logo Genes that share pathways with ORAI3: view

Pathways by source for ORAI3 Gene

1 KEGG pathway for ORAI3 Gene

Gene Ontology (GO) - Biological Process for ORAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002115 store-operated calcium entry IBA --
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ORAI3: view

No data available for SIGNOR curated interactions for ORAI3 Gene

Drugs & Compounds for ORAI3 Gene

(1) Drugs for ORAI3 Gene - From:

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Tocris Compounds for ORAI3 Gene

Compound Action Cas Number
2-APB IP3 receptor antagonist. Also TRP channel modulator 524-95-8
5J 4 CRAC channel blocker; anti-inflammatory 827001-82-1
ML 9 hydrochloride Myosin light chain kinase inhibitor 105637-50-1
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry 130495-35-1
YM 58483 Inhibitor of SOCE in non-excitable cells 223499-30-7
genes like me logo Genes that share compounds with ORAI3: view

Transcripts for ORAI3 Gene

Unigene Clusters for ORAI3 Gene

ORAI calcium release-activated calcium modulator 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for ORAI3

Alternative Splicing Database (ASD) splice patterns (SP) for ORAI3 Gene

No ASD Table

Relevant External Links for ORAI3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ORAI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ORAI3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ORAI3 Gene:


SOURCE GeneReport for Unigene cluster for ORAI3 Gene:


Evidence on tissue expression from TISSUES for ORAI3 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ORAI3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ORAI3 Gene

Orthologs for ORAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ORAI3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ORAI3 33 34
  • 98.98 (n)
(Canis familiaris)
Mammalia ORAI3 33 34
  • 90.9 (n)
(Bos Taurus)
Mammalia ORAI3 33 34
  • 89.97 (n)
(Mus musculus)
Mammalia Orai3 33 16 34
  • 86.04 (n)
(Rattus norvegicus)
Mammalia Orai3 33
  • 85.81 (n)
(Monodelphis domestica)
Mammalia ORAI3 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ORAI3 34
  • 74 (a)
(Anolis carolinensis)
Reptilia ORAI3 34
  • 61 (a)
(Danio rerio)
Actinopterygii orai1b 34
  • 68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005071 33
  • 57.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta olf186-F 34
  • 23 (a)
(Caenorhabditis elegans)
Secernentea orai-1 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8521 34
  • 35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15111 33
Species where no ortholog for ORAI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ORAI3 Gene

Gene Tree for ORAI3 (if available)
Gene Tree for ORAI3 (if available)

Paralogs for ORAI3 Gene

Paralogs for ORAI3 Gene

(2) SIMAP similar genes for ORAI3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ORAI3: view

Variants for ORAI3 Gene

Sequence variations from dbSNP and Humsavar for ORAI3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000252352 -- 30,955,321(+) TGTGC(C/T)GCCAC intron-variant, upstream-variant-2KB
rs1001689636 -- 30,949,687(+) GATGT(C/G)TGTGT intron-variant
rs1002436049 -- 30,951,783(+) GTTGC(C/T)ATGCA intron-variant
rs1002841141 -- 30,952,009(+) AAGAA(C/G)AGCAA intron-variant
rs1003043860 -- 30,949,560(+) GCAAG(G/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ORAI3 Gene

Variant ID Type Subtype PubMed ID
nsv953802 CNV deletion 24416366
nsv833193 CNV gain+loss 17160897
nsv833189 CNV loss 17160897
nsv571820 CNV loss 21841781
nsv482192 CNV gain 20164927
nsv457483 CNV loss 19166990
dgv35n68 CNV loss 17160897

Variation tolerance for ORAI3 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ORAI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAI3 Gene

Disorders for ORAI3 Gene

Relevant External Links for ORAI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ORAI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ORAI3 Gene

Publications for ORAI3 Gene

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PMID: 16582901) Feske S … Rao A (Nature 2006) 2 3 4 60
  2. Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle. (PMID: 26718630) Spinelli AM … Trebak M (American journal of physiology. Cell physiology 2016) 2 3 60
  3. A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels. (PMID: 26956485) Saul S … Bogeski I (Science signaling 2016) 2 3 60
  4. The neglected CRAC proteins: Orai2, Orai3, and STIM2. (PMID: 23890118) Hoth M … Niemeyer BA (Current topics in membranes 2013) 2 3 60
  5. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. (PMID: 20418871) Srikanth S … Gwack Y (Nature cell biology 2010) 3 4 60

Products for ORAI3 Gene

  • Addgene plasmids for ORAI3

Sources for ORAI3 Gene

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