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ORAI2 Gene

protein-coding   GIFtS: 54
GCID: GC07P102074

ORAI Calcium Release-Activated Calcium Modulator 2

(Previous names: chromosome 7 open reading frame 19, transmembrane protein...)
(Previous symbols: C7orf19, TMEM142B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ORAI Calcium Release-Activated Calcium Modulator 21 2     CAP-Binding Protein Complex-Interacting Protein 22 3
C7orf191 2 3 5     MEM142B2 5
Transmembrane Protein 142B1 2 3     Chromosome 7 Open Reading Frame 191
TMEM142B1 2 3     H_NH0514P08.82
CAP-Binding Protein Complex Interacting Protein 21 2     Protein Orai-22
CBCIP22 3     Putative Protein ORAI2-22

External Ids:    HGNC: 216671   Entrez Gene: 802282   Ensembl: ENSG000001609917   OMIM: 6109295   UniProtKB: Q96SN73   

Export aliases for ORAI2 gene to outside databases

Previous GC identifers: GC07P101862 GC07P096656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ORAI2 Gene:
ORAI2 (ORAI calcium release-activated calcium modulator 2) is a protein-coding gene. An important paralog of this gene is ORAI3.

UniProtKB/Swiss-Prot: ORAI2_HUMAN, Q96SN7
Function: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and
increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1

summary for ORAI2 Gene:
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated
calcium entry (SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the
emptying of intracellular Ca2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and
STIM2, serve as ER Ca2+ sensors. They contain N'-terminal Ca2+-sensing EF-hand domains and are localized to
the tubular ER. Following Ca2+ store depletion, STIMs rapidly cluster and relocalize to the plasma
membrane-adjacent ER regions, where they oligomerize and form 'puncta'. Orai proteins, Orai1, Orai2 and
Orai3, are STIM binding partners that form the pore of the channel. Orai proteins are uniformly distributed
in the plasma membrane and exist as dimers in the resting state. STIM activation induces tetramerization of
Orai proteins and subsequent STIM-Orai colocalization, which forms the active store-operated calcium
channel.

Gene Wiki entry for ORAI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ORAI2 gene promoter:
         COUP-TF1   GR   Bach2   HNF-4alpha1   AREB6   RORalpha1   PPAR-gamma1   COUP-TF   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ORAI2 promoter sequence
   Search Chromatin IP Primers for ORAI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ORAI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ORAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORAI2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P102074:  view genomic region     (about GC identifiers)

Start:
102,073,553 bp from pter      End:
102,097,268 bp from pter
Size:
23,716 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 101,434,297-101,457,569     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ORAI2_HUMAN, Q96SN7 (See protein sequence)
Recommended Name: Protein orai-2  
Size: 254 amino acids; 28570 Da
Subunit: Interacts with EFCAB4B/CRACR2A
Sequence caution: Sequence=AAG23755.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAP22352.1;
Type=Erroneous gene model prediction; Sequence=CAG33568.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q6IA68 Q8WY94 Q9H9Y3

Explore the universe of human proteins at neXtProt for ORAI2: NX_Q96SN7

Explore proteomics data for ORAI2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ORAI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001119812.1  NP_001258747.1  NP_001258748.1  NP_116220.1  

    ENSEMBL proteins: 
     ENSP00000419416   ENSP00000420178   ENSP00000418140   ENSP00000417407   ENSP00000385489  
     ENSP00000418464   ENSP00000417928   ENSP00000348752  

    ORAI2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ORAI2
    OriGene Custom MassSpec
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    Novus Biologicals ORAI2 Proteins
    Novus Biologicals ORAI2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ORAI2

     
    Search eBioscience for Proteins for ORAI2 

     
    antibodies-online proteins for ORAI2 (2 products) 

     
    antibodies-online peptides for ORAI2

    ORAI2 Antibody Products:

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    antibodies-online antibodies for ORAI2 (30 products) 

    ORAI2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ORAI2
    Cloud-Clone Corp. CLIAs for ORAI2
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    antibodies-online kits for ORAI2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ORAI: ORAI calcium release-activated calcium modulators

    1 InterPro protein domain:
     IPR012446 CRAC_channel

    Graphical View of Domain Structure for InterPro Entry Q96SN7

    ProtoNet protein and cluster: Q96SN7

    1 Blocks protein domain: IPB012446 Protein of unknown function DUF1650

    UniProtKB/Swiss-Prot: ORAI2_HUMAN, Q96SN7
    Similarity: Belongs to the Orai family


    Find genes that share domains with ORAI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORAI2_HUMAN, Q96SN7
    Function: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and
    increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with ORAI2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ORAI2:
     Decreased number of cells in m 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ORAI2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ORAI2:
    hsa-let-7a-5p (MIRT052447), hsa-mir-10a-5p (MIRT047579), hsa-mir-320a (MIRT044701), hsa-mir-484 (MIRT042351), hsa-mir-16-5p (MIRT051095), hsa-mir-10b-5p (MIRT047449)

    Block miRNA regulation of human, mouse, rat ORAI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ORAI2 (see all 12):
    hsa-miR-3194-5p hsa-miR-133b hsa-miR-3157-5p hsa-miR-1205 hsa-miR-520a-5p hsa-miR-370 hsa-miR-9 hsa-miR-361-3p
    SwitchGear 3'UTR luciferase reporter plasmidORAI2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ORAI2
    Predesigned siRNA for gene silencing in human, mouse, rat ORAI2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ORAI2

    Clone
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    OriGene clones in human, mouse for ORAI2 (see all 11)
    OriGene ORF clones in mouse, rat for ORAI2
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    GenScript: all cDNA clones in your preferred vector (see all 2): ORAI2 (NM_032831)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORAI2
    Addgene plasmids for ORAI2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ORAI2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ORAI2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORAI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ORAI2_HUMAN, Q96SN7: Membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0030426growth cone IEA--

    Find genes that share ontologies with ORAI2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ORAI2 About    
    See pathways by source

    SuperPathContained pathways About
    1Calcium signaling pathway
    Calcium signaling pathway


    Find genes that share SuperPaths with ORAI2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for ORAI2):
        Calcium signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ORAI2
    Interactions:

        Search GeneGlobe Interaction Network for ORAI2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for ORAI2 (Q96SN73 ENSP000003487524) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N13I2D: score=5 
    GDF9O603833I2D: score=5 
    MED31Q9Y3C73I2D: score=5 
    SETDB1Q150473I2D: score=5 
    UNC119Q134323I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ORAI2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SKF 96365 hydrochlorideTRPC channel blocker; also inhibits store-operated Ca2+ entry[130495-35-1]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ORAI2 gene (4 alternative transcripts): 
    NM_001126340.2  NM_001271818.1  NM_001271819.1  NM_032831.3  

    Unigene Cluster for ORAI2:

    ORAI calcium release-activated calcium modulator 2
    Hs.363308  [show with all ESTs]
    Unigene Representative Sequence: NM_001271819
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482237 ENST00000495936 ENST00000488996 ENST00000478730 ENST00000468241
    ENST00000403646 ENST00000498661 ENST00000473939 ENST00000356387(uc010lhz.1 uc003uzj.2 uc003uzk.2 uc011kks.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ORAI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ORAI2 (see all 12):
    hsa-miR-3194-5p hsa-miR-133b hsa-miR-3157-5p hsa-miR-1205 hsa-miR-520a-5p hsa-miR-370 hsa-miR-9 hsa-miR-361-3p
    SwitchGear 3'UTR luciferase reporter plasmidORAI2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ORAI2
    Predesigned siRNA for gene silencing in human, mouse, rat ORAI2
    Clone
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    OriGene clones in human, mouse for ORAI2 (see all 11)
    OriGene ORF clones in mouse, rat for ORAI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ORAI2 (NM_032831)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ORAI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ORAI2
    Addgene plasmids for ORAI2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ORAI2
    OriGene qSTAR qPCR primer pairs in human, mouse for ORAI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ORAI2
      QuantiTect SYBR Green Assays in human, mouse, rat ORAI2
      QuantiFast Probe-based Assays in human, mouse, rat ORAI2

    Additional mRNA sequence: 

    AF258552.1 AK022536.1 AK128753.1 AK300574.1 AL834292.1 BC009183.2 BC016797.1 CR457287.1 

    20 DOTS entries:

    DT.100735284  DT.121040063  DT.100740577  DT.101969520  DT.100888922  DT.102840191  DT.109323  DT.121040282 
    DT.436608  DT.95163030  DT.121040362  DT.121040398  DT.121040140  DT.100740575  DT.121040162  DT.100740574 
    DT.121040227  DT.422481  DT.91863151  DT.95276867 

    Selected AceView cDNA sequences (see all 170):

    AW576484 AI760535 AA766538 AI066649 BM480375 AI758348 AI554664 BE207007 
    AW044192 AI675155 BX475379 Z41515 AA375649 AI569823 BG756954 BQ672263 
    BE674677 AI038477 AI494558 CA951030 BC009183 BC016797 AW592376 BG166308 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ORAI2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:              -                                 
    SP2:              -     -                           
    SP3:                                                


    ECgene alternative splicing isoforms for ORAI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ORAI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ORAI2 Expression
    About this image

    ORAI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ORAI2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.363308
        Custom PCR Arrays for ORAI2
    Primer
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    OriGene qPCR primer pairs and template standards for ORAI2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ORAI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ORAI2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Orai21 , 5 ORAI calcium release-activated calcium modulator 21, 5 89.73(n)1
    96.8(a)1
      5 (75.84 cM)5
    2697171  NM_178751.31  NP_848866.21 
     1361474645 
    chicken
    (Gallus gallus)
    Aves ORAI21 ORAI calcium release-activated calcium modulator 2 82.68(n)
    89.76(a)
      417509  NM_001030710.1  NP_001025881.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia orai11 ORAI calcium release-activated calcium modulator 1 71.26(n)
    82.68(a)
      100125061  NM_001102978.1  NP_001096448.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.140762 Transcribed sequence with moderate similarity to protein refNP_116220.1 (H.sapiens) CAP-binding protein complex interacting protein 2 [Homo sapiens] less 85.12(n)    BI844783.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta olf186-F6
    olf186-F
    23(a)
    1 → many
    2R(13730950-13748075)
    worm
    (Caenorhabditis elegans)
    Secernentea orai-16
    Protein ORAI-1, isoform b (orai-1) mRNA, complete ...
    28(a)
    1 → many
    III(647126-654463) WBGene00015648


    ENSEMBL Gene Tree for ORAI2 (if available)
    TreeFam Gene Tree for ORAI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ORAI2 gene
    ORAI32  ORAI12  
    2 SIMAP similar genes for ORAI2 using alignment to 5 protein entries:     ORAI2_HUMAN (see all proteins):
    ORAI1    ORAI3

    Find genes that share paralogs with ORAI2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ORAI2 (see all 582)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124442631,2
    C--96657664(+) CCGACA/-AAAAA 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs766273391,2
    --96657665(+) CCCGAA/CAAAAA 4 -- int10--------
    rs3728353361,2
    C--96657665(+) CCGAC-/AAAAAA 4 -- int10--------
    rs114429311,2
    C--96657666(+) AAAAA-/ACCACC 4 -- int10--------
    rs1512379511,2
    --96657703(+) GTAATA/GTCCCT 4 -- int10--------
    rs1863620181,2
    --96657791(+) CACAAG/TAATTC 4 -- int10--------
    rs1404490851,2
    --96657849(+) AAGGCC/TGAGGC 4 -- int10--------
    rs1458743171,2
    --96657864(+) GGATCA/GCTTGA 4 -- int10--------
    rs1905805741,2
    --96657936(+) AAAATC/TATCTG 4 -- int10--------
    rs734043101,2
    C,F--96658069(+) ACACAG/ATGAGA 4 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for ORAI2 (102073553 - 102097268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ORAI2 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672060CNV Deletion23128226
    esv2656867CNV Deletion23128226
    nsv888832CNV Loss21882294
    nsv831083CNV Loss17160897
    nsv5879CNV Loss18451855
    nsv464665CNV Loss19166990
    dgv7412n71CNV Loss21882294
    nsv464664CNV Gain19166990
    nsv428182CNV Gain18775914
    nsv824248CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610929    OMIM disorders: --


    Find genes that share disorders with ORAI2           About GenesLikeMe


    Export disorders for ORAI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ORAI2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ORAI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PubMed id 16582901)1, 2, 3 Feske S.... Rao A. (Nature 2006)
    2. Calcium inhibition and calcium potentiation of orai1, orai2, and orai3 calcium release-activated calcium channels. (PubMed id 17452328)1, 2 Dehaven W.I.... Putney J.W. Jr. (J. Biol. Chem. 2007)
    3. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. (PubMed id 16807233)1, 2 Mercer J.C.... Putney J.W. Jr. (J. Biol. Chem. 2006)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Capacitative and non-capacitative signaling complexes in human platelets. (PubMed id 22640869)1 Berna-Erro A....Rosado J.A. (Biochim. Biophys. Acta 2012)
    9. Expression of Orai genes and I(CRAC) activation in the human retinal pigment epithelium. (PubMed id 20607548)1 Cordeiro S. and Strauss O. (Graefes Arch. Clin. Exp. Ophthalmol. 2011)
    10. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. (PubMed id 20418871)2 Srikanth S.... Gwack Y. (Nat. Cell Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80228 HGNC: 21667 AceView: C7orf19 Ensembl:ENSG00000160991 euGenes: HUgn80228
    ECgene: ORAI2 Kegg: 80228 H-InvDB: ORAI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ORAI2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ORAI2 gene:
    Search GeneIP for patents involving ORAI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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