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Aliases for ORAI2 Gene

Aliases for ORAI2 Gene

  • ORAI Calcium Release-Activated Calcium Modulator 2 2 3
  • Transmembrane Protein 142B 2 3 4
  • C7orf19 3 4 6
  • CAP-Binding Protein Complex Interacting Protein 2 2 3
  • CAP-Binding Protein Complex-Interacting Protein 2 3 4
  • TMEM142B 3 4
  • MEM142B 3 6
  • CBCIP2 3 4
  • Chromosome 7 Open Reading Frame 19 2
  • Putative Protein ORAI2-2 3
  • Protein Orai-2 3
  • H_NH0514P08.8 3

External Ids for ORAI2 Gene

Previous HGNC Symbols for ORAI2 Gene

  • C7orf19
  • TMEM142B

Previous GeneCards Identifiers for ORAI2 Gene

  • GC07P101862
  • GC07P102074
  • GC07P096656

Summaries for ORAI2 Gene

GeneCards Summary for ORAI2 Gene

ORAI2 (ORAI Calcium Release-Activated Calcium Modulator 2) is a Protein Coding gene. Among its related pathways are Calcium signaling pathway. An important paralog of this gene is ORAI3.

UniProtKB/Swiss-Prot for ORAI2 Gene

  • Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Tocris Summary for ORAI2 Gene

  • STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the emptying of intracellular Ca2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and STIM2, serve as ER Ca2+ sensors. They contain N'-terminal Ca2+-sensing EF-hand domains and are localized to the tubular ER. Following Ca2+ store depletion, STIMs rapidly cluster and relocalize to the plasma membrane-adjacent ER regions, where they oligomerize and form 'puncta'. Orai proteins, Orai1, Orai2 and Orai3, are STIM binding partners that form the pore of the channel. Orai proteins are uniformly distributed in the plasma membrane and exist as dimers in the resting state. STIM activation induces tetramerization of Orai proteins and subsequent STIM-Orai colocalization, which forms the active store-operated calcium channel.

Gene Wiki entry for ORAI2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORAI2 Gene

Genomics for ORAI2 Gene

Regulatory Elements for ORAI2 Gene

Genomic Location for ORAI2 Gene

102,433,106 bp from pter
102,456,821 bp from pter
23,716 bases
Plus strand

Genomic View for ORAI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORAI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORAI2 Gene

Proteins for ORAI2 Gene

  • Protein details for ORAI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein orai-2
    Protein Accession:
    Secondary Accessions:
    • Q6IA68
    • Q8WY94
    • Q9H9Y3

    Protein attributes for ORAI2 Gene

    254 amino acids
    Molecular mass:
    28570 Da
    Quaternary structure:
    • Interacts with CRACR2A/EFCAB4B.
    • Sequence=AAG23755.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAP22352.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAG33568.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for ORAI2 Gene

Proteomics data for ORAI2 Gene at MOPED

Post-translational modifications for ORAI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ORAI2 Gene

Domains for ORAI2 Gene

Protein Domains for ORAI2 Gene

Suggested Antigen Peptide Sequences for ORAI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Orai family.
  • Belongs to the Orai family.
genes like me logo Genes that share domains with ORAI2: view

Function for ORAI2 Gene

Molecular function for ORAI2 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.

Gene Ontology (GO) - Molecular Function for ORAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20418871
GO:0015279 store-operated calcium channel activity IBA --
genes like me logo Genes that share ontologies with ORAI2: view

Phenotypes for ORAI2 Gene

genes like me logo Genes that share phenotypes with ORAI2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ORAI2 Gene

Localization for ORAI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORAI2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ORAI2 Gene COMPARTMENTS Subcellular localization image for ORAI2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ORAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with ORAI2: view

Pathways for ORAI2 Gene

SuperPathways for ORAI2 Gene

Superpath Contained pathways
1 Calcium signaling pathway
genes like me logo Genes that share pathways with ORAI2: view

Pathways by source for ORAI2 Gene

1 KEGG pathway for ORAI2 Gene

Interacting Proteins for ORAI2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000348752 Q96SN7-ORAI2_HUMAN for ORAI2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ORAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002115 store-operated calcium entry IBA --
GO:0070588 calcium ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with ORAI2: view

Drugs for ORAI2 Gene

(1) Tocris Compounds for ORAI2 Gene

Compound Action Cas Number
SKF 96365 hydrochloride TRPC channel blocker; also inhibits store-operated Ca2+ entry [130495-35-1]
genes like me logo Genes that share compounds with ORAI2: view

Transcripts for ORAI2 Gene

Unigene Clusters for ORAI2 Gene

ORAI calcium release-activated calcium modulator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORAI2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -

Relevant External Links for ORAI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ORAI2 Gene

mRNA expression in normal human tissues for ORAI2 Gene

mRNA differential expression in normal tissues according to GTEx for ORAI2 Gene

This gene is overexpressed in Whole Blood (10.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORAI2 Gene

SOURCE GeneReport for Unigene cluster for ORAI2 Gene Hs.363308

genes like me logo Genes that share expressions with ORAI2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for ORAI2 Gene

Orthologs for ORAI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ORAI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ORAI2 35
  • 92.91 (n)
  • 97.64 (a)
ORAI2 36
  • 98 (a)
(Canis familiaris)
Mammalia ORAI2 35
  • 91.34 (n)
  • 98.03 (a)
ORAI2 36
  • 96 (a)
(Mus musculus)
Mammalia Orai2 35
  • 89.73 (n)
  • 96.8 (a)
Orai2 16
Orai2 36
  • 96 (a)
(Pan troglodytes)
Mammalia ORAI2 35
  • 99.08 (n)
  • 100 (a)
ORAI2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Orai2 35
  • 89.2 (n)
  • 96.8 (a)
(Monodelphis domestica)
Mammalia ORAI2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia ORAI2 36
  • 56 (a)
(Gallus gallus)
Aves ORAI2 35
  • 82.68 (n)
  • 89.76 (a)
ORAI2 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia orai1 35
  • 71.26 (n)
  • 82.68 (a)
(Danio rerio)
Actinopterygii Dr.14076 35
orai2 35
  • 78.74 (n)
  • 83.86 (a)
orai2 36
  • 79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8808 35
fruit fly
(Drosophila melanogaster)
Insecta olf186-F 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea orai-1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8521 36
  • 36 (a)
Species with no ortholog for ORAI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ORAI2 Gene

Gene Tree for ORAI2 (if available)
Gene Tree for ORAI2 (if available)

Paralogs for ORAI2 Gene

Paralogs for ORAI2 Gene

(2) SIMAP similar genes for ORAI2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ORAI2: view

Variants for ORAI2 Gene

Sequence variations from dbSNP and Humsavar for ORAI2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs188421596 -- 102,453,568(+) CCTCA(A/G)TACCG utr-variant-3-prime
rs188600257 -- 102,455,699(+) GATGC(A/G)CAGTG utr-variant-3-prime
rs188720460 -- 102,436,094(+) GTCAT(C/G)AGACC intron-variant
rs188861919 -- 102,435,877(+) TGATC(A/C)GCCCA intron-variant
rs188930086 -- 102,440,589(+) GAGGG(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ORAI2 Gene

Variant ID Type Subtype PubMed ID
nsv428182 CNV Gain 18775914
nsv831083 CNV Loss 17160897
nsv464664 CNV Gain 19166990
nsv464665 CNV Loss 19166990
esv2656867 CNV Deletion 23128226
esv2672060 CNV Deletion 23128226
dgv7412n71 CNV Loss 21882294
esv259612 OTHER Complex 20981092
esv260065 OTHER Complex 20981092
nsv888832 CNV Loss 21882294
nsv5879 CNV Loss 18451855
nsv8192 CNV Gain 18304495
nsv824248 CNV Gain 20364138

Relevant External Links for ORAI2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ORAI2 Gene

Disorders for ORAI2 Gene

No disorders were found for ORAI2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ORAI2 Gene

Publications for ORAI2 Gene

  1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PMID: 16582901) Feske S. … Rao A. (Nature 2006) 2 3 4
  2. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. (PMID: 16807233) Mercer J.C. … Putney J.W. Jr. (J. Biol. Chem. 2006) 3 4
  3. Calcium inhibition and calcium potentiation of orai1, orai2, and orai3 calcium release-activated calcium channels. (PMID: 17452328) Dehaven W.I. … Putney J.W. Jr. (J. Biol. Chem. 2007) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ORAI2 Gene

  • Addgene plasmids for ORAI2

Sources for ORAI2 Gene

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