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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ORAI2 Gene

protein-coding   GIFtS: 54
GCID: GC07P102074

ORAI Calcium Release-Activated Calcium Modulator 2

(Previous names: chromosome 7 open reading frame 19, transmembrane protein...)
(Previous symbols: C7orf19, TMEM142B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ORAI Calcium Release-Activated Calcium Modulator 21 2     CAP-Binding Protein Complex-Interacting Protein 22 3
C7orf191 2 3 5     MEM142B2 5
Transmembrane Protein 142B1 2 3     Chromosome 7 Open Reading Frame 191
TMEM142B1 2 3     H_NH0514P08.82
CAP-Binding Protein Complex Interacting Protein 21 2     Protein Orai-22
CBCIP22 3     Putative Protein ORAI2-22

External Ids:    HGNC: 216671   Entrez Gene: 802282   Ensembl: ENSG000001609917   OMIM: 6109295   UniProtKB: Q96SN73   

Export aliases for ORAI2 gene to outside databases

Previous GC identifers: GC07P101862 GC07P096656


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ORAI2 Gene: 
ORAI2 (ORAI calcium release-activated calcium modulator 2) is a protein-coding gene. Diseases associated with ORAI2 include estrogen-receptor negative breast cancer, and retinitis. GO annotations related to this gene include protein binding. An important paralog of this gene is ORAI3.

UniProtKB/Swiss-Prot: ORAI2_HUMAN, Q96SN7
Function: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and
increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1

summary for ORAI2 Gene:
STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated
calcium entry (SOCE). SOCE allows rapid Ca2+ efflux from the endoplasmic reticulum (ER), following the
emptying of intracellular Ca2+ stores. STIM (sensors stromal interaction molecule) proteins, STIM1 and
STIM2, serve as ER Ca2+ sensors. They contain N'-terminal Ca2+-sensing EF-hand domains and are localized to
the tubular ER. Following Ca2+ store depletion, STIMs rapidly cluster and relocalize to the plasma
membrane-adjacent ER regions, where they oligomerize and form 'puncta'. Orai proteins, Orai1, Orai2 and
Orai3, are STIM binding partners that form the pore of the channel. Orai proteins are uniformly distributed
in the plasma membrane and exist as dimers in the resting state. STIM activation induces tetramerization of
Orai proteins and subsequent STIM-Orai colocalization, which forms the active store-operated calcium
channel.

Gene Wiki entry for ORAI2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ORAI2 gene promoter:
         COUP-TF1   GR   Bach2   HNF-4alpha1   AREB6   RORalpha1   PPAR-gamma1   COUP-TF   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): ORAI2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ORAI2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ORAI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

ORAI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ORAI2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P102074:  view genomic region     (about GC identifiers)

Start:
102,073,553 bp from pter      End:
102,097,268 bp from pter
Size:
23,716 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 101,434,297-101,457,569     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ORAI2_HUMAN, Q96SN7 (See protein sequence)
Recommended Name: Protein orai-2  
Size: 254 amino acids; 28570 Da
Subunit: Interacts with EFCAB4B/CRACR2A
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAG23755.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAP22352.1;
Type=Erroneous gene model prediction; Sequence=CAG33568.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q6IA68 Q8WY94 Q9H9Y3

Explore the universe of human proteins at neXtProt for ORAI2: NX_Q96SN7

Explore proteomics data for ORAI2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96SN7

  • ORAI2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ORAI2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001119812.1  NP_001258747.1  NP_001258748.1  NP_116220.1  

    ENSEMBL proteins: 
     ENSP00000419416   ENSP00000420178   ENSP00000418140   ENSP00000417407   ENSP00000385489  
     ENSP00000418464   ENSP00000417928   ENSP00000348752  

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    Novus Biologicals ORAI2 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ORAI2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    ORAI2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ORAI: ORAI calcium release-activated calcium modulators

    1 InterPro protein domain:
     IPR012446 CRAC_channel

    Graphical View of Domain Structure for InterPro Entry Q96SN7

    ProtoNet protein and cluster: Q96SN7

    1 Blocks protein domain: IPB012446 Protein of unknown function DUF1650

    UniProtKB/Swiss-Prot: ORAI2_HUMAN, Q96SN7
    Similarity: Belongs to the Orai family


    ORAI2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ORAI2_HUMAN, Q96SN7
    Function: Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and
    increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    ORAI2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ORAI2:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ORAI2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ORAI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ORAI2 
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    hsa-miR-3194-5p hsa-miR-133b hsa-miR-3157-5p hsa-miR-1205 hsa-miR-520a-5p hsa-miR-370 hsa-miR-9 hsa-miR-361-3p
    SwitchGear 3'UTR luciferase reporter plasmidORAI2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ORAI2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium signaling pathway
    Calcium signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for ORAI2):
        Calcium signaling pathway


    ORAI2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ORAI2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/7 Interacting proteins for ORAI2 (Q96SN73 ENSP000003487524) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS6Q7L5N13I2D: score=5 
    GDF9O603833I2D: score=5 
    MED31Q9Y3C73I2D: score=5 
    SETDB1Q150473I2D: score=5 
    UNC119Q134323I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ORAI2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SKF 96365 hydrochlorideTRPC channel blocker; also inhibits store-operated Ca2+ entry[130495-35-1]

    Search CenterWatch for drugs/clinical trials and news about ORAI2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ORAI2 gene (4 alternative transcripts): 
    NM_001126340.2  NM_001271818.1  NM_001271819.1  NM_032831.3  

    Unigene Clusters for ORAI2:

    ORAI calcium release-activated calcium modulator 2
    Hs.363308  [show with all ESTs], Hs.736659  [show with all ESTs]
    Unigene Representative Sequences: NM_001271819, NM_001271818
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482237 ENST00000495936 ENST00000488996 ENST00000478730 ENST00000468241
    ENST00000403646 ENST00000498661 ENST00000473939 ENST00000356387(uc010lhz.1 uc003uzj.2 uc003uzk.2 uc011kks.1)

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ORAI2 (see all 12):
    hsa-miR-3194-5p hsa-miR-133b hsa-miR-3157-5p hsa-miR-1205 hsa-miR-520a-5p hsa-miR-370 hsa-miR-9 hsa-miR-361-3p
    SwitchGear 3'UTR luciferase reporter plasmidORAI2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK027639.1 AK056497.1 BC069270.1 

    23 DOTS entries:

    DT.100735284  DT.101969520  DT.100888922  DT.121040063  DT.100740577  DT.109323  DT.100888927  DT.102840191 
    DT.121040282  DT.436608  DT.95163030  DT.121040362  DT.121040398  DT.97869174  DT.121040140  DT.121040227 
    DT.100740575  DT.121040162  DT.95276867  DT.100740574  DT.121040545  DT.422481  DT.91863151 

    24/170 AceView cDNA sequences (see all 170):

    AI760535 BM480375 AW576484 AI038477 AI554664 BQ672263 BE207007 AA375649 
    BX475379 AI758348 BG756954 AW044192 Z41515 AI569823 BE674677 AI675155 
    BC016797 AA766538 AI494558 BC009183 CA951030 AI066649 AW592376 BM975436 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ORAI2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:              -                                 
    SP2:              -     -                           
    SP3:                                                


    ECgene alternative splicing isoforms for ORAI2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ORAI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ORAI2 Expression
    About this image


    See ORAI2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ORAI2

    SOURCE GeneReport for Unigene clusters: Hs.363308 Hs.736659
        SABiosciences Custom PCR Arrays for ORAI2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ORAI2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Orai21 , 5 ORAI calcium release-activated calcium modulator 21, 5 89.73(n)1
    96.8(a)1
      5 (75.84 cM)5
    2697171  NM_178751.31  NP_848866.21 
     1361474645 
    chicken
    (Gallus gallus)
    Aves ORAI21 ORAI calcium release-activated calcium modulator 2 82.68(n)
    89.76(a)
      417509  NM_001030710.1  NP_001025881.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.140762 Transcribed sequence with moderate similarity to protein more 85.12(n)    BI844783.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta olf186-F6
    olf186-F
    23(a)
    1 → many
    2R(13730950-13748075)
    worm
    (Caenorhabditis elegans)
    Secernentea orai-16
    Protein orai
    28(a)
    1 → many
    III(647126-654463)


    ENSEMBL Gene Tree for ORAI2 (if available)
    TreeFam Gene Tree for ORAI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ORAI2 gene
    ORAI32  ORAI12  
    2 SIMAP similar genes for ORAI2 using alignment to 5 protein entries:     ORAI2_HUMAN (see all proteins):
    ORAI1    ORAI3

    ORAI2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/582 SNPs in ORAI2 are shown (see all 582)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1124442631,2
    C--96657664(+) CCGACA/-AAAAA 4 -- int11Minor allele frequency- -:0.00CSA 2
    rs766273391,2
    --96657665(+) CCCGAA/CAAAAA 4 -- int10--------
    rs3728353361,2
    C--96657665(+) CCGAC-/AAAAAA 4 -- int10--------
    rs114429311,2
    C--96657666(+) AAAAA-/ACCACC 4 -- int10--------
    rs1512379511,2
    --96657703(+) GTAATA/GTCCCT 4 -- int10--------
    rs1863620181,2
    --96657791(+) CACAAG/TAATTC 4 -- int10--------
    rs1404490851,2
    --96657849(+) AAGGCC/TGAGGC 4 -- int10--------
    rs1458743171,2
    --96657864(+) GGATCA/GCTTGA 4 -- int10--------
    rs1905805741,2
    --96657936(+) AAAATC/TATCTG 4 -- int10--------
    rs734043101,2
    C,F--96658069(+) ACACAG/ATGAGA 4 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for ORAI2 (102073553 - 102097268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for ORAI2 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672060CNV Deletion23128226
    esv2656867CNV Deletion23128226
    nsv888832CNV Loss21882294
    nsv831083CNV Loss17160897
    nsv5879CNV Loss18451855
    nsv464665CNV Loss19166990
    dgv7412n71CNV Loss21882294
    nsv464664CNV Gain19166990
    nsv428182CNV Gain18775914
    nsv824248CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610929    OMIM disorders: --

    3 diseases for ORAI2:    About MalaCards
    estrogen-receptor negative breast cancer    retinitis    breast cancer


    ORAI2 for disorders           About GeneDecksing


    Export disorders for ORAI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ORAI2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ORAI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. (PubMed id 16582901)1, 2, 3 Feske S.... Rao A. (2006)
    2. Calcium inhibition and calcium potentiation of orai1, orai2, and orai3 calcium release-activated calcium channels. (PubMed id 17452328)1, 2 Dehaven W.I.... Putney J.W. Jr. (2007)
    3. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. (PubMed id 16807233)1, 2 Mercer J.C.... Putney J.W. Jr. (2006)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. Capacitative and non-capacitative signaling complexes in human platelets. (PubMed id 22640869)1 Berna-Erro A....Rosado J.A. (2012)
    9. Expression of Orai genes and I(CRAC) activation in th e human retinal pigment epithelium. (PubMed id 20607548)1 Cordeiro S. and Strauss O. (2011)
    10. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. (PubMed id 20418871)2 Srikanth S....Gwack Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80228 HGNC: 21667 AceView: C7orf19 Ensembl:ENSG00000160991 euGenes: HUgn80228
    ECgene: ORAI2 Kegg: 80228 H-InvDB: ORAI2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ORAI2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ORAI2 gene:
    Search GeneIP for patents involving ORAI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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