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OR9Q2 Gene

protein-coding   GIFtS: 45
GCID: GC11P057957

Olfactory Receptor, Family 9, Subfamily Q, Member 2


(Previous symbol: OR9Q2P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 9, Subfamily Q, Member 21 2
OR9Q2P1 2 3
Olfactory Receptor 9Q22
Olfactory Receptor, Family 9, Subfamily Q, Member 2 Pseudogene2

External Ids:    HGNC: 153281   Entrez Gene: 2199572   Ensembl: ENSG000001865137   UniProtKB: Q8NGE93   

Export aliases for OR9Q2 gene to outside databases

Previous GC identifers: GC11P057735 GC11P057714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR9Q2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR9Q2 Gene:
OR9Q2 (olfactory receptor, family 9, subfamily Q, member 2) is a protein-coding gene. Diseases associated with OR9Q2 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5AK2.

UniProtKB/Swiss-Prot: OR9Q2_HUMAN, Q8NGE9
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR9Q2 gene promoter:
         Sox5   AP-1   ATF-2   IRF-1   AP-4   YY1   Pax-4a   Ik-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR9Q2 promoter sequence
   Search Chromatin IP Primers for OR9Q2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR9Q2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

OR9Q2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR9Q2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P057957:  view genomic region     (about GC identifiers)

Start:
57,957,963 bp from pter      End:
57,958,904 bp from pter
Size:
942 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR9Q2_HUMAN, Q8NGE9 (See protein sequence)
Recommended Name: Olfactory receptor 9Q2  
Size: 314 amino acids; 35363 Da

Explore the universe of human proteins at neXtProt for OR9Q2: NX_Q8NGE9

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR9Q2
    REFSEQ proteins: NP_001005283.1  
    ENSEMBL proteins: 
     ENSP00000308714  
    Reactome Protein details: Q8NGE9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR9: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGE9

    ProtoNet protein and cluster: Q8NGE9

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR9Q2_HUMAN, Q8NGE9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR9Q2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR9Q2_HUMAN, Q8NGE9
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR9Q2 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR9Q2_HUMAN, Q8NGE9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR9Q2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR9Q2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR9Q2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR9Q2):
        Olfactory transduction


    OR9Q2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR9Q2
    Interactions:

        Search GeneGlobe Interaction Network for OR9Q2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR9Q2 (ENSP000003087144) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A4ENSP000003691574STRING: ENSP00000369157
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR9Q2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR9Q2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR9Q2 gene: 
    NM_001005283.2  

    Unigene Cluster for OR9Q2:

    Olfactory receptor, family 9, subfamily Q, member 2
    Hs.553643
    Unigene Representative Sequence: NM_001005283
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000311591(uc010rka.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR9Q2

    Additional mRNA sequence: BC140718.1 
    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR9Q2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTGCGAG
    OR9Q2 Expression
    About this image

    OR9Q2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.553643
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR9Q2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr14971 , 5 olfactory receptor 14971, 5 82.48(n)1
    85.67(a)1
      19 (8.88 cM)5
    2587361  NM_146741.11  NP_666952.11 
     137946655 


    ENSEMBL Gene Tree for OR9Q2 (if available)
    TreeFam Gene Tree for OR9Q2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR9Q2 gene
    OR5AK22  OR5B122  OR5AU12  OR9Q12  OR5AP22  OR8H32  OR8H12  OR5B32  
    OR5F12  OR9I12  OR5B212  OR8I22  OR5B22  OR5B172  OR8H22  
    Selected SIMAP similar genes for OR9Q2 using alignment to 2 protein entries:     OR9Q2_HUMAN (see all proteins) (see all similar genes):
    OR9Q1    OR9I1    OR5T1    OR5A2    OR5AR1    OR5B21
    OR5E1P    OR5T3    OR8U9    OR5AP2    OR5B2    OR5I1
    OR5T2    OR8B2    OR8D1    OR5A1    OR5AK3P    OR5AS1

    OR9Q2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR9Q2
    PGOHUM00000242741


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR9Q2 (see all 93)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39112321,2
    C,F,A,H--57955909(+) GTGGGA/GCACTG 1 -- us2k114Minor allele frequency- G:0.20NS EA NA WA CSA 777
    rs1180815001,2
    F--57956172(+) CAAAAG/ACTTAT 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1831655121,2
    --57956205(+) GGATCA/GGTTCA 1 -- us2k10--------
    rs1461527641,2
    --57956315(+) AAGAAC/TGCAAG 1 -- us2k10--------
    rs772066921,2
    F--57956430(+) CATATG/AAAGAT 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1141331391,2
    F--57956447(+) CCTTCC/TCCTGG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1146967091,2
    C,F--57956476(+) AATTAG/AGGTGT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs342288991,2
    C,F--57956565(+) CCCTAG/ATCTTG 1 -- us2k14Minor allele frequency- A:0.06NA 126
    rs1379065481,2
    --57956623(+) GGATAC/TATTGT 1 -- us2k10--------
    rs1494595771,2
    C--57956770(+) GGCAAA/GGTAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR9Q2 ( 57957963 - 57958904 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR9Q2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832165CNV Gain17160897
    nsv897589CNV Gain21882294
    nsv832166CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR9Q2:    
    About MalaCards
    neuronitis


    OR9Q2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR9Q2

    Export disorders for OR9Q2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR9Q2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR9Q2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219957 HGNC: 15328 Ensembl:ENSG00000186513 euGenes: HUgn219957 ECgene: OR9Q2 Kegg: 219957
    H-InvDB: OR9Q2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR9Q2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR9Q2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR9Q2 gene:
    Search GeneIP for patents involving OR9Q2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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