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OR9G4 Gene

protein-coding   GIFtS: 45
GCID: GC11M056510

Olfactory Receptor, Family 9, Subfamily G, Member 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 9, Subfamily G, Member 41 2
Olfactory Receptor OR11-2162 3
OR11-2162
Olfactory Receptor 9G42

External Ids:    HGNC: 153221   Entrez Gene: 2831892   Ensembl: ENSG000001724577   UniProtKB: Q8NGQ13   

Export aliases for OR9G4 gene to outside databases

Previous GC identifers: GC11U990392 GC11M056286 GC11M056266


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR9G4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR9G4 Gene:
OR9G4 (olfactory receptor, family 9, subfamily G, member 4) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR9G1.

UniProtKB/Swiss-Prot: OR9G4_HUMAN, Q8NGQ1
Function: Odorant receptor (Potential)

Gene Wiki entry for OR9G4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR9G4 gene promoter:
         HOXA3   AML1a   Pbx1a   COMP1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR9G4 promoter sequence
   Search Chromatin IP Primers for OR9G4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR9G4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11

OR9G4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR9G4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M056510:  view genomic region     (about GC identifiers)

Start:
56,510,307 bp from pter      End:
56,511,242 bp from pter
Size:
936 bases      Orientation:
minus strand

1 alternative location:
Chr11-,NW_003571044 572,256-573,239     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR9G4_HUMAN, Q8NGQ1 (See protein sequence)
Recommended Name: Olfactory receptor 9G4  
Size: 327 amino acids; 36344 Da
Caution: It is uncertain whether Met-1 or Met-16 is the initiator
Sequence caution: Sequence=BAC05959.1; Type=Erroneous initiation;
Secondary accessions: Q6IF62 Q96RA9

Explore the universe of human proteins at neXtProt for OR9G4: NX_Q8NGQ1

Explore proteomics data for OR9G4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn20
  • HORDE protein sequence for OR9G4

    See OR9G4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005284.1  
    ENSEMBL proteins: 
     ENSP00000307515  
    Reactome Protein details: Q8NGQ1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR9: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGQ1

    ProtoNet protein and cluster: Q8NGQ1

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR9G4_HUMAN, Q8NGQ1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR9G4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR9G4_HUMAN, Q8NGQ1
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR9G4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR9G4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR9G4_HUMAN, Q8NGQ1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR9G4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR9G4 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR9G4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR9G4
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR9G4):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR9G4
    Interactions:

        Search GeneGlobe Interaction Network for OR9G4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR9G4 (ENSP000003075154) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J3ENSP000003317894STRING: ENSP00000331789
    OR10Q1ENSP000003143244STRING: ENSP00000314324
    OR1B1ENSP000003031514STRING: ENSP00000303151
    OR1N1ENSP000003069744STRING: ENSP00000306974
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR9G4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR9G4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR9G4 gene: 
    NM_001005284.1  

    Unigene Cluster for OR9G4:

    Olfactory receptor, family 9, subfamily G, member 4
    Hs.554521
    Unigene Representative Sequence: NM_001005284
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302957(uc010rjo.2)
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      QuantiFast Probe-based Assays in human, mouse, rat OR9G4

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR9G4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTCTATG
    OR9G4 Expression
    About this image

    OR9G4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR9G4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.554521
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR9G4 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr10061 , 5 olfactory receptor 10061, 5 84.94(n)1
    87.18(a)1
      2 (49.68 cM)5
    2585631  NM_146570.21  NP_666781.21 
     856742115 


    ENSEMBL Gene Tree for OR9G4 (if available)
    TreeFam Gene Tree for OR9G4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR9G4 gene
    OR9G12  
    Selected SIMAP similar genes for OR9G4 using alignment to 1 protein entry:     OR9G4_HUMAN(see all similar genes):
    OR5AR1    OR5B2    OR5B21    OR8U9    OR5A2    OR5AP2
    OR5B12    OR5B17    OR5B3    OR5M1    OR5M10    OR5M3
    OR8D1    OR8U1    OR8U8    OR5A1    OR5I1    OR5T1

    Find genes that share paralogs with OR9G4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR9G4
    PGOHUM00000241154


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR9G4 (see all 137)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832546211,2
    --56509846(+) GAGCTC/TTCTGA 1 -- ds50010--------
    rs1878710491,2
    --56509958(+) GATTGC/TTTACC 1 -- ds50010--------
    rs1175401861,2
    C,F--56509971(+) ACTTCA/CAAGTC 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1922608471,2
    --56510011(+) TTTTGC/TTCCCC 1 -- ds50010--------
    rs6741881,2
    C,F,H--56510066(+) TTAATA/GCTGCC 1 -- ds500117Minor allele frequency- G:0.01NS EA NA WA CSA 789
    rs1844631921,2
    --56510167(+) TAACAA/GGGAGT 1 -- ds50010--------
    rs112287611,2
    C,F,H--56510220(+) CTTAAT/CTGAAC 1 -- ds500115Minor allele frequency- C:0.03NS EA NA WA 1636
    rs112287621,2
    C,F,H--56510243(+) AATGAA/GCACAT 1 -- ds500124Minor allele frequency- G:0.39NS EA NA WA CSA EU 2943
    rs1997438331,2
    --56510381(+) GATGAA/GAGGGT 2 L F mis10--------
    rs1421193831,2
    C,F--56510405(+) GATCAC/TGGTGT 2 M V mis12Minor allele frequency- T:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for OR9G4 ( 56510307 - 56511242 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR9G4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468577CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR9G4           About GenesLikeMe

    Genetic Association Database (GAD): OR9G4

    Export disorders for OR9G4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR9G4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR9G4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1, 4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283189 HGNC: 15322 Ensembl:ENSG00000172457 euGenes: HUgn283189 ECgene: OR9G4 Kegg: 283189
    H-InvDB: OR9G4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR9G4 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR9G4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR9G4 gene:
    Search GeneIP for patents involving OR9G4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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