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Aliases for OR8U8 Gene

Aliases for OR8U8 Gene

  • Olfactory Receptor Family 8 Subfamily U Member 8 2 3
  • Olfactory Receptor, Family 8, Subfamily U, Member 8 2

External Ids for OR8U8 Gene

Previous GeneCards Identifiers for OR8U8 Gene

  • GC11P001823
  • GC11P001827
  • GC11P055899
  • GC11P056144
  • GC11P052472
  • GC11U901838
  • GC11P9H0186

Summaries for OR8U8 Gene

Entrez Gene Summary for OR8U8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8U8 Gene

OR8U8 (Olfactory Receptor Family 8 Subfamily U Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR8U8 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8U8 Gene

Genomics for OR8U8 Gene

Genomic Location for OR8U8 Gene

Chromosome:
11
Start:
186,374 bp from pter
End:
187,333 bp from pter
Size:
960 bases
Orientation:
Plus strand

Genomic View for OR8U8 Gene

Genes around OR8U8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for OR8U8 Gene

Proteins for OR8U8 Gene

  • Protein details for OR8U8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7N1-OR8U8_HUMAN
    Recommended name:
    Olfactory receptor 8U8
    Protein Accession:
    P0C7N1

    Protein attributes for OR8U8 Gene

    Size:
    319 amino acids
    Molecular mass:
    36334 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8U8 Gene

Post-translational modifications for OR8U8 Gene

Other Protein References for OR8U8 Gene

REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8U8 Gene

Domains & Families for OR8U8 Gene

Gene Families for OR8U8 Gene

Protein Domains for OR8U8 Gene

Suggested Antigen Peptide Sequences for OR8U8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7N1

UniProtKB/Swiss-Prot:

OR8U8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8U8: view

Function for OR8U8 Gene

Molecular function for OR8U8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8U8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8U8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8U8 Gene

Localization for OR8U8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8U8 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR8U8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8U8: view

No data available for Subcellular locations from COMPARTMENTS for OR8U8 Gene

Pathways & Interactions for OR8U8 Gene

genes like me logo Genes that share pathways with OR8U8: view

Pathways by source for OR8U8 Gene

Interacting Proteins for OR8U8 Gene

Gene Ontology (GO) - Biological Process for OR8U8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8U8: view

No data available for SIGNOR curated interactions for OR8U8 Gene

Transcripts for OR8U8 Gene

mRNA/cDNA for OR8U8 Gene

(1) REFSEQ mRNAs :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8U8 Gene

No ASD Table

Relevant External Links for OR8U8 Gene

GeneLoc Exon Structure for
OR8U8
ECgene alternative splicing isoforms for
OR8U8

Expression for OR8U8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8U8 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8U8 Gene:

OR8U8
genes like me logo Genes that share expression patterns with OR8U8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR8U8 Gene

Orthologs for OR8U8 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OR8U8 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Or8u8 55 Olfr52
  • chr2:86,181,153-86,182,109
Species where no ortholog for OR8U8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for OR8U8 Gene

Paralogs for OR8U8 Gene

(458) SIMAP similar genes for OR8U8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR8U8: view

No data available for Paralogs for OR8U8 Gene

Variants for OR8U8 Gene

Sequence variations from dbSNP and Humsavar for OR8U8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10791961 -- 56,375,958(+) AGAAT(C/G)CTTGC reference, missense
rs10791964 -- 56,376,052(+) ATTCA(A/G)CTTGT reference, synonymous-codon
rs10896302 -- 56,374,120(+) AAATC(A/C)AGGAA upstream-variant-2KB
rs10896309 -- 56,376,240(+) TATCA(C/T)GTTCA reference, missense
rs10896310 -- 56,376,241(+) ATCAT(A/G)TTCAT reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for OR8U8 Gene

Variant ID Type Subtype PubMed ID
dgv1948n54 CNV loss 21841781
esv3579724 CNV loss 25503493
nsv1138034 CNV deletion 24896259
nsv324 CNV insertion 18451855
nsv499490 CNV gain 21111241
nsv511006 OTHER complex 20534489
nsv832161 CNV gain 17160897

Relevant External Links for OR8U8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8U8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for OR8U8 Gene

Disorders for OR8U8 Gene

Relevant External Links for OR8U8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR8U8

No disorders were found for OR8U8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8U8 Gene

Publications for OR8U8 Gene

  1. Finishing the euchromatic sequence of the human genome. (PMID: 15496913) (Nature 2004) 3 64
  2. Initial sequencing and analysis of the human genome. (PMID: 11237011) Lander E.S. … Szustakowki J. (Nature 2001) 3 64

Products for OR8U8 Gene

Sources for OR8U8 Gene

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