Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR8U1 Gene

Aliases for OR8U1 Gene

  • Olfactory Receptor, Family 8, Subfamily U, Member 1 2 3

External Ids for OR8U1 Gene

Previous GeneCards Identifiers for OR8U1 Gene

  • GC00U903073
  • GC11P055919
  • GC11P055885
  • GC11P056145
  • GC11P056146

Summaries for OR8U1 Gene

Entrez Gene Summary for OR8U1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8U1 Gene

OR8U1 (Olfactory Receptor, Family 8, Subfamily U, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5M11.

UniProtKB/Swiss-Prot for OR8U1 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8U1 Gene

Genomics for OR8U1 Gene

Regulatory Elements for OR8U1 Gene

Genomic Location for OR8U1 Gene

Start:
56,375,624 bp from pter
End:
56,376,553 bp from pter
Size:
930 bases
Orientation:
Plus strand

Genomic View for OR8U1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8U1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8U1 Gene

Proteins for OR8U1 Gene

  • Protein details for OR8U1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH10-OR8U1_HUMAN
    Recommended name:
    Olfactory receptor 8U1
    Protein Accession:
    Q8NH10
    Secondary Accessions:

    Protein attributes for OR8U1 Gene

    Size:
    309 amino acids
    Molecular mass:
    35088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8U1 Gene

Proteomics data for OR8U1 Gene at MOPED

Post-translational modifications for OR8U1 Gene

Other Protein References for OR8U1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8U1 Gene

Domains for OR8U1 Gene

Gene Families for OR8U1 Gene

HGNC:
  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8U1 Gene

Suggested Antigen Peptide Sequences for OR8U1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH10

UniProtKB/Swiss-Prot:

OR8U1_HUMAN :
  • Q8NH10
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8U1: view

Function for OR8U1 Gene

Molecular function for OR8U1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8U1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8U1: view

Animal Model Products

CRISPR Products

miRNA for OR8U1 Gene

miRTarBase miRNAs that target OR8U1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8U1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR8U1 Gene

Localization for OR8U1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8U1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8U1 Gene COMPARTMENTS Subcellular localization image for OR8U1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8U1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR8U1: view

Pathways for OR8U1 Gene

genes like me logo Genes that share pathways with OR8U1: view

Pathways by source for OR8U1 Gene

Interacting Proteins for OR8U1 Gene

Gene Ontology (GO) - Biological Process for OR8U1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8U1: view

Transcripts for OR8U1 Gene

mRNA/cDNA for OR8U1 Gene

(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8U1 Gene

Olfactory receptor, family 8, subfamily U, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8U1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8U1 Gene

No ASD Table

Relevant External Links for OR8U1 Gene

GeneLoc Exon Structure for
OR8U1
ECgene alternative splicing isoforms for
OR8U1

Expression for OR8U1 Gene

mRNA expression in normal human tissues for OR8U1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR8U1 Gene

SOURCE GeneReport for Unigene cluster for OR8U1 Gene Hs.553618

genes like me logo Genes that share expressions with OR8U1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for OR8U1 Gene

Orthologs for OR8U1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8U1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR8U1 35
  • 84.36 (n)
  • 83.82 (a)
OR8U1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR8U1 35
  • 87.38 (n)
  • 89 (a)
OR8U1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1044 35
  • 83.71 (n)
  • 86.41 (a)
Olfr1044 16
Olfr1044 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC466560 35
  • 93.1 (n)
  • 92.23 (a)
OR8U1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr482 35
  • 83.5 (n)
  • 84.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
ManyToMany
Species with no ortholog for OR8U1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8U1 Gene

ENSEMBL:
Gene Tree for OR8U1 (if available)
TreeFam:
Gene Tree for OR8U1 (if available)

Paralogs for OR8U1 Gene

Paralogs for OR8U1 Gene

Selected SIMAP similar genes for OR8U1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8U1 Gene

genes like me logo Genes that share paralogs with OR8U1: view

Variants for OR8U1 Gene

Sequence variations from dbSNP and Humsavar for OR8U1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4990121 -- 56,376,223(+) ATCTT(G/T)GCCTG missense, reference
rs4990122 -- 56,376,220(+) TGGAT(C/T)TTTGC reference, synonymous-codon
rs4990123 -- 56,376,214(+) CAGCT(A/C)TGGAT synonymous-codon, reference
rs10896309 - 56,376,240(+) TATCA(C/T)GTTCA missense, reference
rs10896310 - 56,376,241(+) ATCAT(A/G)TTCAT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OR8U1 Gene

Variant ID Type Subtype PubMed ID
nsv832161 CNV Gain 17160897
nsv324 CNV Insertion 18451855
nsv511006 CNV Complex 20534489
nsv478256 CNV Insertion 20440878
nsv499490 CNV Gain 21111241

Relevant External Links for OR8U1 Gene

HapMap Linkage Disequilibrium report
OR8U1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8U1 Gene

Disorders for OR8U1 Gene

No disorders were found for OR8U1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR8U1 Gene

Publications for OR8U1 Gene

  1. The diploid genome sequence of an individual human. (PMID: 17803354) Levy S. … Venter J.C. (PLoS Biol. 2007) 3

Products for OR8U1 Gene

Sources for OR8U1 Gene

Back to Top

Content