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Aliases for OR8S1 Gene

Aliases for OR8S1 Gene

  • Olfactory Receptor, Family 8, Subfamily S, Member 1 2 3

External Ids for OR8S1 Gene

Previous GeneCards Identifiers for OR8S1 Gene

  • GC00U903088
  • GC12P047206
  • GC12P047208
  • GC12P048919

Summaries for OR8S1 Gene

Entrez Gene Summary for OR8S1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8S1 Gene

OR8S1 (Olfactory Receptor, Family 8, Subfamily S, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR8S1 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8S1 Gene

Genomics for OR8S1 Gene

Regulatory Elements for OR8S1 Gene

Genomic Location for OR8S1 Gene

Start:
48,507,354 bp from pter
End:
48,529,897 bp from pter
Size:
22,544 bases
Orientation:
Plus strand

Genomic View for OR8S1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8S1 Gene

Proteins for OR8S1 Gene

  • Protein details for OR8S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH09-OR8S1_HUMAN
    Recommended name:
    Olfactory receptor 8S1
    Protein Accession:
    Q8NH09
    Secondary Accessions:

    Protein attributes for OR8S1 Gene

    Size:
    359 amino acids
    Molecular mass:
    39645 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8S1 Gene

Proteomics data for OR8S1 Gene at MOPED

Post-translational modifications for OR8S1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8S1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

No data available for DME Specific Peptides for OR8S1 Gene

Domains for OR8S1 Gene

Gene Families for OR8S1 Gene

HGNC:
  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8S1 Gene

Suggested Antigen Peptide Sequences for OR8S1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH09

UniProtKB/Swiss-Prot:

OR8S1_HUMAN :
  • Q8NH09
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8S1: view

Function for OR8S1 Gene

Molecular function for OR8S1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR8S1: view

Phenotypes for OR8S1 Gene

genes like me logo Genes that share phenotypes with OR8S1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8S1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR8S1 Gene

Localization for OR8S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8S1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8S1 Gene COMPARTMENTS Subcellular localization image for OR8S1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8S1: view

Pathways for OR8S1 Gene

genes like me logo Genes that share pathways with OR8S1: view

Pathways by source for OR8S1 Gene

Interacting Proteins for OR8S1 Gene

Gene Ontology (GO) - Biological Process for OR8S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8S1: view

Transcripts for OR8S1 Gene

mRNA/cDNA for OR8S1 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8S1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8S1 Gene

No ASD Table

Relevant External Links for OR8S1 Gene

GeneLoc Exon Structure for
OR8S1
ECgene alternative splicing isoforms for
OR8S1

Expression for OR8S1 Gene

mRNA expression in normal human tissues for OR8S1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8S1 Gene

This gene is overexpressed in Testis (5.3) and Ovary (4.7).

SOURCE GeneReport for Unigene cluster for OR8S1 Gene Hs.524373

genes like me logo Genes that share expressions with OR8S1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR8S1 Gene

Orthologs for OR8S1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR8S1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR8S1 35
  • 86.82 (n)
  • 85.81 (a)
OR8S1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR8S1 35
  • 86.2 (n)
  • 84.51 (a)
OR8S1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr282 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OR8S1 36
  • 37 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OR8S1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
Species with no ortholog for OR8S1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8S1 Gene

ENSEMBL:
Gene Tree for OR8S1 (if available)
TreeFam:
Gene Tree for OR8S1 (if available)

Paralogs for OR8S1 Gene

Selected SIMAP similar genes for OR8S1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8S1 Gene

genes like me logo Genes that share paralogs with OR8S1: view

No data available for Paralogs for OR8S1 Gene

Variants for OR8S1 Gene

Sequence variations from dbSNP and Humsavar for OR8S1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2705143 -- 48,526,010(-) GCGGC(A/G)GATGG missense, reference
rs2731072 -- 48,523,642(+) TAGAT(A/T)AAGAT upstream-variant-2KB
rs2731073 - 48,525,773(+) TGCTC(A/G)TGATC reference, missense
rs4075258 - 48,525,876(-) TCTCC(A/G)GCATC missense, reference
rs4075259 -- 48,525,995(-) ATGGC(A/G)GTCAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR8S1 Gene

Variant ID Type Subtype PubMed ID
nsv697 CNV Insertion 18451855

Relevant External Links for OR8S1 Gene

HapMap Linkage Disequilibrium report
OR8S1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8S1 Gene

Disorders for OR8S1 Gene

Relevant External Links for OR8S1

Genetic Association Database (GAD)
OR8S1
Human Genome Epidemiology (HuGE) Navigator
OR8S1

No disorders were found for OR8S1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OR8S1 Gene

Publications for OR8S1 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48
  2. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. (PMID: 24105470) Wu Y. … Tai E.S. (Hum. Mol. Genet. 2014) 3
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for OR8S1 Gene

Sources for OR8S1 Gene

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