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Aliases for OR8S1 Gene

Aliases for OR8S1 Gene

  • Olfactory Receptor Family 8 Subfamily S Member 1 2 3 5
  • Olfactory Receptor, Family 8, Subfamily S, Member 1 2

External Ids for OR8S1 Gene

Previous GeneCards Identifiers for OR8S1 Gene

  • GC00U903088
  • GC12P047206
  • GC12P047208
  • GC12P048919

Summaries for OR8S1 Gene

Entrez Gene Summary for OR8S1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8S1 Gene

OR8S1 (Olfactory Receptor Family 8 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR8S1 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8S1 Gene

Genomics for OR8S1 Gene

Regulatory Elements for OR8S1 Gene

Enhancers for OR8S1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F047887 1.3 FANTOM5 Ensembl ENCODE 4.2 -618.6 -618556 2.1 CTCF DPF2 ZBTB40 GABPA FOSL1 CTBP1 GATA3 GATA2 POLR2A ZNF610 VDR TMEM106C HDAC7 RAPGEF3 SLC48A1 ENSG00000257433 OR8S1 ZNF641 ASB8 ENSG00000205537
GH12F048023 0.7 ENCODE 4.3 -483.9 -483882 1.5 SOX13 RAD21 TCF7L2 GATAD2A ZNF687 TEAD1 FOXA3 HMG20A ZSCAN16 CEBPA ZNF641 LOC102725258 OR8S1 COL2A1 LOC105369750
GH12F048186 0.6 FANTOM5 3.3 -321.0 -320976 0.4 CTCF PKNOX1 PBX2 IKZF1 FOS EBF1 ZNF641 LOC102725258 OR10AD1 RPL32P27 OR8S1 CCDC184 ENSG00000279875
GH12F048881 1.5 FANTOM5 Ensembl ENCODE 1.3 +375.8 375830 2.8 ELF3 PKNOX1 SIN3A ZNF48 RARA YY1 FOS DEK HMG20B SP3 FKBP11 ARF3 ENSG00000255863 WNT10B CCDC65 RND1 OR8S1 GC12M048893 RNU6-600P
GH12F048556 0.5 ENCODE 0.2 +49.5 49469 0.0 ATF1 PKNOX1 PBX2 OR5BS1P OR8S1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR8S1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR8S1 Gene

48,507,354 bp from pter
48,529,897 bp from pter
22,544 bases
Plus strand

Genomic View for OR8S1 Gene

Genes around OR8S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8S1 Gene

Proteins for OR8S1 Gene

  • Protein details for OR8S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8S1
    Protein Accession:

    Protein attributes for OR8S1 Gene

    359 amino acids
    Molecular mass:
    39645 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8S1 Gene

Post-translational modifications for OR8S1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8S1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8S1 Gene

Domains & Families for OR8S1 Gene

Gene Families for OR8S1 Gene

Protein Domains for OR8S1 Gene

Suggested Antigen Peptide Sequences for OR8S1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8S1: view

Function for OR8S1 Gene

Molecular function for OR8S1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR8S1: view
genes like me logo Genes that share phenotypes with OR8S1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8S1 Gene

Localization for OR8S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8S1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8S1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR8S1: view

Pathways & Interactions for OR8S1 Gene

genes like me logo Genes that share pathways with OR8S1: view

Pathways by source for OR8S1 Gene

Interacting Proteins for OR8S1 Gene

Gene Ontology (GO) - Biological Process for OR8S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR8S1: view

No data available for SIGNOR curated interactions for OR8S1 Gene

Transcripts for OR8S1 Gene

mRNA/cDNA for OR8S1 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8S1 Gene

No ASD Table

Relevant External Links for OR8S1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8S1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8S1 Gene

This gene is overexpressed in Testis (x5.3) and Ovary (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of OR8S1 Gene:


SOURCE GeneReport for Unigene cluster for OR8S1 Gene:

genes like me logo Genes that share expression patterns with OR8S1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR8S1 Gene

Orthologs for OR8S1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR8S1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR8S1 35
  • 98 (a)
(Bos Taurus)
Mammalia OR8S1 34 35
  • 86.82 (n)
(Canis familiaris)
Mammalia OR8S1 34 35
  • 86.2 (n)
(Mus musculus)
Mammalia Or8s10 55 Olfr282 35
  • 67 (a)
Or8s8 55 Olfr281
  • chr15:98,456,258-98,457,244
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
-- 35
  • 48 (a)
-- 35
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia OR8S1 35
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
-- 35
  • 45 (a)
Species where no ortholog for OR8S1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8S1 Gene

Gene Tree for OR8S1 (if available)
Gene Tree for OR8S1 (if available)

Paralogs for OR8S1 Gene

(408) SIMAP similar genes for OR8S1 Gene using alignment to 1 proteins: Pseudogenes for OR8S1 Gene

genes like me logo Genes that share paralogs with OR8S1: view

No data available for Paralogs for OR8S1 Gene

Variants for OR8S1 Gene

Sequence variations from dbSNP and Humsavar for OR8S1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10875826 -- 48,527,377(+) AAATT(C/T)CCAAG intron-variant
rs111309347 -- 48,528,033(+) CATTC(C/T)GGTCA reference, missense
rs111573391 -- 48,525,837(+) TTTTG(C/T)TGATC reference, missense
rs11168616 -- 48,524,835(+) gtagt(C/T)tgaca upstream-variant-2KB
rs11319044 -- 48,524,393(+) CTCTT(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8S1 Gene

Variant ID Type Subtype PubMed ID
nsv697 CNV insertion 18451855

Variation tolerance for OR8S1 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.12; 95.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8S1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8S1 Gene

Disorders for OR8S1 Gene

Relevant External Links for OR8S1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR8S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8S1 Gene

Publications for OR8S1 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  2. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. (PMID: 24105470) Wu Y. … Tai E.S. (Hum. Mol. Genet. 2014) 3 64
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64

Products for OR8S1 Gene

Sources for OR8S1 Gene

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