Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR8K5 Gene

Aliases for OR8K5 Gene

  • Olfactory Receptor, Family 8, Subfamily K, Member 5 2 3
  • Olfactory Receptor OR11-174 3 4
  • Olfactory Receptor 8K5 3
  • OR11-174 3

External Ids for OR8K5 Gene

Summaries for OR8K5 Gene

Entrez Gene Summary for OR8K5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8K5 Gene

OR8K5 (Olfactory Receptor, Family 8, Subfamily K, Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5M11.

UniProtKB/Swiss-Prot for OR8K5 Gene

  • Odorant receptor.

Gene Wiki entry for OR8K5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8K5 Gene

Genomics for OR8K5 Gene

Genomic Location for OR8K5 Gene

Start:
56,159,394 bp from pter
End:
56,160,317 bp from pter
Size:
924 bases
Orientation:
Minus strand

Genomic View for OR8K5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8K5 Gene

Regulatory Elements for OR8K5 Gene

Proteins for OR8K5 Gene

  • Protein details for OR8K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH50-OR8K5_HUMAN
    Recommended name:
    Olfactory receptor 8K5
    Protein Accession:
    Q8NH50
    Secondary Accessions:
    • Q6IFB5

    Protein attributes for OR8K5 Gene

    Size:
    307 amino acids
    Molecular mass:
    35190 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8K5 Gene

Proteomics data for OR8K5 Gene at MOPED

Post-translational modifications for OR8K5 Gene

Other Protein References for OR8K5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR8K5 Gene

Domains for OR8K5 Gene

Gene Families for OR8K5 Gene

HGNC:
  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8K5 Gene

Suggested Antigen Peptide Sequences for OR8K5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH50

UniProtKB/Swiss-Prot:

OR8K5_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NH50
genes like me logo Genes that share domains with OR8K5: view

Function for OR8K5 Gene

Molecular function for OR8K5 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8K5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR8K5 Gene

Localization for OR8K5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8K5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8K5 Gene COMPARTMENTS Subcellular localization image for OR8K5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR8K5: view

Pathways for OR8K5 Gene

genes like me logo Genes that share pathways with OR8K5: view

Pathways by source for OR8K5 Gene

Interacting Proteins for OR8K5 Gene

Gene Ontology (GO) - Biological Process for OR8K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8K5: view

Transcripts for OR8K5 Gene

mRNA/cDNA for OR8K5 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR8K5 Gene

No ASD Table

Relevant External Links for OR8K5 Gene

GeneLoc Exon Structure for
OR8K5
ECgene alternative splicing isoforms for
OR8K5

Expression for OR8K5 Gene

mRNA expression in normal human tissues for OR8K5 Gene

SOURCE GeneReport for Unigene cluster for OR8K5 Gene Hs.553626

genes like me logo Genes that share expressions with OR8K5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR8K5 Gene

Orthologs for OR8K5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8K5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466549 35
  • 99.11 (n)
  • 98.48 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
LOC790274 35
  • 84.58 (n)
  • 82.74 (a)
dog
(Canis familiaris)
Mammalia LOC100684477 35
  • 82.84 (n)
  • 81.43 (a)
mouse
(Mus musculus)
Mammalia Olfr1008 16
Olfr1008 36
  • 74 (a)
OneToMany
Olfr1048 36
  • 72 (a)
OneToMany
Olfr1049 36
  • 75 (a)
OneToMany
Olfr1051 36
  • 75 (a)
OneToMany
Olfr1053 35
  • 79.15 (n)
  • 75.57 (a)
Olfr1053 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr490 35
  • 79.37 (n)
  • 77.2 (a)
Species with no ortholog for OR8K5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8K5 Gene

ENSEMBL:
Gene Tree for OR8K5 (if available)
TreeFam:
Gene Tree for OR8K5 (if available)

Paralogs for OR8K5 Gene

Paralogs for OR8K5 Gene

Selected SIMAP similar genes for OR8K5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8K5 Gene

genes like me logo Genes that share paralogs with OR8K5: view

Variants for OR8K5 Gene

Sequence variations from dbSNP and Humsavar for OR8K5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2512774 -- 56,159,320(+) AATTA(C/T)CAAGT downstream-variant-500B
rs2512938 - 56,160,115(+) CAACA(A/G)AAGCC missense, reference
rs7480694 -- 56,162,317(+) TCTTA(C/T)GGAAA upstream-variant-2KB
rs7928039 -- 56,161,518(+) AAACT(A/G)TTTCA upstream-variant-2KB
rs11227400 -- 56,161,705(+) AGTAA(C/T)GGAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8K5 Gene

Variant ID Type Subtype PubMed ID
nsv521440 CNV Loss 19592680
nsv468575 CNV Loss 19166990

Relevant External Links for OR8K5 Gene

HapMap Linkage Disequilibrium report
OR8K5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8K5 Gene

Disorders for OR8K5 Gene

No disorders were found for OR8K5 Gene.

No data available for UniProtKB/Swiss-Prot for OR8K5 Gene

Publications for OR8K5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility. (PMID: 25015289) Renaudin X. … Rosselli F. (J. Cell. Sci. 2014) 3

Products for OR8K5 Gene

Sources for OR8K5 Gene

Back to Top

Content