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OR8K5 Gene

protein-coding   GIFtS: 42
GCID: GC11M055926

Olfactory Receptor, Family 8, Subfamily K, Member 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 8, Subfamily K, Member 51 2
Olfactory Receptor OR11-1742 3
OR11-1742
Olfactory Receptor 8K52

External Ids:    HGNC: 153151   Entrez Gene: 2194532   Ensembl: ENSG000001817527   UniProtKB: Q8NH503   

Export aliases for OR8K5 gene to outside databases

Previous GC identifers: GC11U990399 GC11M055683


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR8K5 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR8K5 Gene:
OR8K5 (olfactory receptor, family 8, subfamily K, member 5) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8U1.

UniProtKB/Swiss-Prot: OR8K5_HUMAN, Q8NH50
Function: Odorant receptor (Potential)

Gene Wiki entry for OR8K5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR8K5 gene promoter:
         GR   TBP   HOXA3   Pbx1a   GR-beta   POU3F2   TFIID   Cart-1   POU2F1c   GR-alpha   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR8K5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11

OR8K5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR8K5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M055926:  view genomic region     (about GC identifiers)

Start:
55,926,873 bp from pter      End:
55,927,793 bp from pter
Size:
921 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR8K5_HUMAN, Q8NH50 (See protein sequence)
Recommended Name: Olfactory receptor 8K5  
Size: 307 amino acids; 35190 Da
Secondary accessions: Q6IFB5

Explore the universe of human proteins at neXtProt for OR8K5: NX_Q8NH50

Explore proteomics data for OR8K5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn263
  • HORDE protein sequence for OR8K5

    See OR8K5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004058.2  
    ENSEMBL proteins: 
     ENSP00000323853  
    Reactome Protein details: Q8NH50

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR8: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NH50

    ProtoNet protein and cluster: Q8NH50

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR8K5_HUMAN, Q8NH50
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR8K5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR8K5_HUMAN, Q8NH50
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR8K5           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR8K5_HUMAN, Q8NH50: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR8K5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR8K5 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR8K5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR8K5
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR8K5):
        Olfactory transduction

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    Interactions:

        Search GeneGlobe Interaction Network for OR8K5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR8K5 (ENSP000003238534) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR4E2ENSP000003861954STRING: ENSP00000386195
    OR4F6ENSP000003275254STRING: ENSP00000327525
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR8K5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for OR8K5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR8K5 gene: 
    NM_001004058.2  

    Unigene Cluster for OR8K5:

    Olfactory receptor, family 8, subfamily K, member 5
    Hs.553626
    Unigene Representative Sequence: NM_001004058
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313447(uc010rja.2)
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    1 AceView cDNA sequence:

    NM_001004058 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR8K5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAACCCTT
    OR8K5 Expression
    About this image

    OR8K5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR8K5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553626
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR8K5 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr10085
    Olfr10531
    olfactory receptor 10085
    olfactory receptor 10531
    79.15(n)1
    75.57(a)1
      2 (49.68 cM)5
    2579741  NM_001177857.11  NP_001171328.11 
     856894315 
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ250757.12   -- 73.15(n)    AJ250757.1 


    ENSEMBL Gene Tree for OR8K5 (if available)
    TreeFam Gene Tree for OR8K5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR8K5 gene
    OR8U12  OR8K12  OR5M112  OR5R12  OR5M82  OR8J32  OR5M102  OR8K32  
    OR5M32  OR5M92  OR8J12  OR5M12  
    Selected SIMAP similar genes for OR8K5 using alignment to 1 protein entry:     OR8K5_HUMAN(see all similar genes):
    OR8K3    OR8J2    OR8J3    OR8K1    OR8J1    OR5R1
    OR8U1    OR8U8    OR5AR1    OR8U9    OR5AS1    OR5AL1
    OR5B21    OR5D18    OR9I1    OR5E1P    OR5F1    OR5A1

    Find genes that share paralogs with OR8K5           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for OR8K5
    PGOHUM00000242268 PGOHUM00000242269 PGOHUM00000242724 PGOHUM00000262552


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR8K5 (see all 118)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385937581,2
    Cuntested155926882(+) TCAAAA/G/TAGCTT 2 L syn10--------
    rs1918025131,2
    --55926500(+) AACCAA/GATATC 1 -- ds50010--------
    rs1836464691,2
    --55926517(+) TCTCAC/TTTATA 1 -- ds50010--------
    rs347970611,2
    C--55926576(+) TATTTT/GGGGGA 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs802249701,2
    F--55926689(+) CCAATG/TAACTT 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs25127741,2
    C,F,A,H--55926796(+) AATTAT/CCAAGT 1 -- ds50017Minor allele frequency- C:0.02NS EA NA WA 544
    rs758662371,2
    C,F--55926805(+) GTGACA/TTTAAT 1 -- ds50012Minor allele frequency- T:0.03WA 120
    rs798778491,2
    C,F--55926840(+) ATATTA/TCAAAT 1 -- ds50013Minor allele frequency- T:0.12WA NA EA 358
    rs3770624621,2
    C--55926859(+) AAACAC/TAAAGT 1 -- ds50010--------
    rs1471157331,2
    C--55926912(+) TCTTCG/ATTTCT 2 /N syn11Minor allele frequency- A:0.00NA 4480

    HapMap Linkage Disequilibrium report for OR8K5 ( 55926873 - 55927793 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR8K5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521440CNV Loss19592680
    nsv468575CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR8K5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR8K5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219453 HGNC: 15315 AceView: OR8K5 Ensembl:ENSG00000181752 euGenes: HUgn219453
    ECgene: OR8K5 Kegg: 219453 H-InvDB: OR8K5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR8K5 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR8K5 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR8K5 gene:
    Search GeneIP for patents involving OR8K5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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