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Aliases for OR8K3 Gene

Aliases for OR8K3 Gene

  • Olfactory Receptor Family 8 Subfamily K Member 3 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-181 3 4
  • Olfactory Receptor, Family 8, Subfamily K, Member 3 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 8, Subfamily K, Member 3 3
  • OR11-181 3

External Ids for OR8K3 Gene

Previous GeneCards Identifiers for OR8K3 Gene

  • GC11U990401
  • GC11P055862
  • GC11P055842
  • GC11P056085

Summaries for OR8K3 Gene

Entrez Gene Summary for OR8K3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR8K3 Gene

OR8K3 (Olfactory Receptor Family 8 Subfamily K Member 3 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is ENSG00000279961.

UniProtKB/Swiss-Prot for OR8K3 Gene

  • Odorant receptor.

Gene Wiki entry for OR8K3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8K3 Gene

Genomics for OR8K3 Gene

Regulatory Elements for OR8K3 Gene

Genomic Location for OR8K3 Gene

Chromosome:
11
Start:
56,318,307 bp from pter
End:
56,319,245 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR8K3 Gene

Genes around OR8K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for OR8K3 Gene

Proteins for OR8K3 Gene

  • Protein details for OR8K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH51-OR8K3_HUMAN
    Recommended name:
    Olfactory receptor 8K3
    Protein Accession:
    Q8NH51
    Secondary Accessions:
    • Q6IFC4

    Protein attributes for OR8K3 Gene

    Size:
    312 amino acids
    Molecular mass:
    35463 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8K3 Gene

Proteomics data for OR8K3 Gene at MOPED

Post-translational modifications for OR8K3 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8K3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8K3 Gene

Domains & Families for OR8K3 Gene

Gene Families for OR8K3 Gene

Protein Domains for OR8K3 Gene

Suggested Antigen Peptide Sequences for OR8K3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH51

UniProtKB/Swiss-Prot:

OR8K3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8K3: view

Function for OR8K3 Gene

Molecular function for OR8K3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8K3: view

Phenotypes for OR8K3 Gene

GenomeRNAi human phenotypes for OR8K3:
genes like me logo Genes that share phenotypes with OR8K3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8K3 Gene

Localization for OR8K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8K3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8K3 Gene COMPARTMENTS Subcellular localization image for OR8K3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for OR8K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8K3: view

Pathways & Interactions for OR8K3 Gene

genes like me logo Genes that share pathways with OR8K3: view

Pathways by source for OR8K3 Gene

Interacting Proteins for OR8K3 Gene

Gene Ontology (GO) - Biological Process for OR8K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8K3: view

No data available for SIGNOR curated interactions for OR8K3 Gene

Drugs & Compounds for OR8K3 Gene

No Compound Related Data Available

Transcripts for OR8K3 Gene

mRNA/cDNA for OR8K3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR8K3 Gene

No ASD Table

Relevant External Links for OR8K3 Gene

GeneLoc Exon Structure for
OR8K3
ECgene alternative splicing isoforms for
OR8K3

Expression for OR8K3 Gene

mRNA expression in normal human tissues for OR8K3 Gene

SOURCE GeneReport for Unigene cluster for OR8K3 Gene Hs.553629

genes like me logo Genes that share expression patterns with OR8K3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR8K3 Gene

Orthologs for OR8K3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8K3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC514057 35
  • 83.17 (n)
  • 79.74 (a)
dog
(Canis familiaris)
Mammalia LOC100688585 35
  • 83.88 (n)
  • 81.37 (a)
mouse
(Mus musculus)
Mammalia Olfr1054 35
  • 80.43 (n)
  • 77.42 (a)
Olfr1054 16
chimpanzee
(Pan troglodytes)
Mammalia LOC466557 35
  • 99.57 (n)
  • 99.68 (a)
Species with no ortholog for OR8K3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8K3 Gene

ENSEMBL:
Gene Tree for OR8K3 (if available)
TreeFam:
Gene Tree for OR8K3 (if available)

Paralogs for OR8K3 Gene

Paralogs for OR8K3 Gene

(446) SIMAP similar genes for OR8K3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR8K3: view

Variants for OR8K3 Gene

Sequence variations from dbSNP and Humsavar for OR8K3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_024123 -
VAR_034273 -
VAR_034274 -

Structural Variations from Database of Genomic Variants (DGV) for OR8K3 Gene

Variant ID Type Subtype PubMed ID
nsv832161 CNV Gain 17160897

Variation tolerance for OR8K3 Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8K3 Gene

HapMap Linkage Disequilibrium report
OR8K3
Human Gene Mutation Database (HGMD)
OR8K3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8K3 Gene

Disorders for OR8K3 Gene

Relevant External Links for OR8K3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR8K3

No disorders were found for OR8K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8K3 Gene

Publications for OR8K3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3

Products for OR8K3 Gene

Sources for OR8K3 Gene

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