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Aliases for OR8K1 Gene

Aliases for OR8K1 Gene

  • Olfactory Receptor Family 8 Subfamily K Member 1 2 3 5
  • Olfactory Receptor OR11-182 3 4
  • Olfactory Receptor, Family 8, Subfamily N, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 8, Subfamily K, Member 1 2
  • Olfactory Receptor 8K1 3
  • OR11-182 3
  • OR8N1P 3

External Ids for OR8K1 Gene

Previous GeneCards Identifiers for OR8K1 Gene

  • GC11U990350
  • GC11P055889
  • GC11P055870
  • GC11P056113

Summaries for OR8K1 Gene

Entrez Gene Summary for OR8K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8K1 Gene

OR8K1 (Olfactory Receptor Family 8 Subfamily K Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8K3.

UniProtKB/Swiss-Prot for OR8K1 Gene

  • Odorant receptor.

Gene Wiki entry for OR8K1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8K1 Gene

Genomics for OR8K1 Gene

Regulatory Elements for OR8K1 Gene

Genomic Location for OR8K1 Gene

56,346,039 bp from pter
56,346,998 bp from pter
960 bases
Plus strand

Genomic View for OR8K1 Gene

Genes around OR8K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8K1 Gene

Proteins for OR8K1 Gene

  • Protein details for OR8K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8K1
    Protein Accession:
    Secondary Accessions:
    • B9EJB1
    • Q6IFC3
    • Q96RC1

    Protein attributes for OR8K1 Gene

    319 amino acids
    Molecular mass:
    36581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8K1 Gene

Post-translational modifications for OR8K1 Gene

Other Protein References for OR8K1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8K1 Gene

Domains & Families for OR8K1 Gene

Gene Families for OR8K1 Gene

Protein Domains for OR8K1 Gene

Suggested Antigen Peptide Sequences for OR8K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8K1: view

Function for OR8K1 Gene

Molecular function for OR8K1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8K1: view

Phenotypes for OR8K1 Gene

GenomeRNAi human phenotypes for OR8K1:
genes like me logo Genes that share phenotypes with OR8K1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8K1 Gene

Localization for OR8K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8K1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8K1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8K1: view

Pathways & Interactions for OR8K1 Gene

genes like me logo Genes that share pathways with OR8K1: view

Pathways by source for OR8K1 Gene

Interacting Proteins for OR8K1 Gene

Gene Ontology (GO) - Biological Process for OR8K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8K1: view

No data available for SIGNOR curated interactions for OR8K1 Gene

Drugs & Compounds for OR8K1 Gene

No Compound Related Data Available

Transcripts for OR8K1 Gene

mRNA/cDNA for OR8K1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8K1 Gene

No ASD Table

Relevant External Links for OR8K1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR8K1 Gene

Protein differential expression in normal tissues from HIPED for OR8K1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR8K1 Gene

Protein tissue co-expression partners for OR8K1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8K1 Gene:


SOURCE GeneReport for Unigene cluster for OR8K1 Gene:

genes like me logo Genes that share expression patterns with OR8K1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8K1 Gene

Orthologs for OR8K1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8K1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC747630 34
  • 98.62 (n)
OR8K1 35
  • 97 (a)
(Canis familiaris)
Mammalia LOC100684411 34
  • 86.21 (n)
OR08B10 35
  • 85 (a)
(Bos Taurus)
Mammalia LOC513114 34
  • 85.74 (n)
-- 35
  • 85 (a)
-- 35
  • 85 (a)
(Mus musculus)
Mammalia Or8k1 55 Olfr1046 34 16 35
  • 80.02 (n)
Or8k19-ps 55 Olfr1050-ps1
  • chr2:86,267,882-86,268,825
(Rattus norvegicus)
Mammalia Olr485 34
  • 79.66 (n)
Species where no ortholog for OR8K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8K1 Gene

Gene Tree for OR8K1 (if available)
Gene Tree for OR8K1 (if available)

Paralogs for OR8K1 Gene

Paralogs for OR8K1 Gene

(448) SIMAP similar genes for OR8K1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR8K1: view

Variants for OR8K1 Gene

Sequence variations from dbSNP and Humsavar for OR8K1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10896271 --
rs10896272 --
rs17614327 --

Structural Variations from Database of Genomic Variants (DGV) for OR8K1 Gene

Variant ID Type Subtype PubMed ID
dgv1948n54 CNV loss 21841781
esv3579724 CNV loss 25503493
esv3892014 CNV loss 25118596
nsv832161 CNV gain 17160897

Variation tolerance for OR8K1 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.67; 95.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8K1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8K1 Gene

Disorders for OR8K1 Gene

Relevant External Links for OR8K1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR8K1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8K1 Gene

Publications for OR8K1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR8K1 Gene

Sources for OR8K1 Gene

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