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OR8K1 Gene

protein-coding   GIFtS: 44
GCID: GC11P056113

Olfactory Receptor, Family 8, Subfamily K, Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 8, Subfamily K, Member 11 2
Olfactory Receptor OR11-1822 3
OR11-1822
OR8N1P2
Olfactory Receptor 8K12
Olfactory Receptor, Family 8, Subfamily N, Member 1 Pseudogene2

External Ids:    HGNC: 148311   Entrez Gene: 3901572   Ensembl: ENSG000001502617   UniProtKB: Q8NGG53   

Export aliases for OR8K1 gene to outside databases

Previous GC identifers: GC11U990350 GC11P055889 GC11P055870


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR8K1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR8K1 Gene:
OR8K1 (olfactory receptor, family 8, subfamily K, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8U1.

UniProtKB/Swiss-Prot: OR8K1_HUMAN, Q8NGG5
Function: Odorant receptor (Potential)

Gene Wiki entry for OR8K1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR8K1 gene promoter:
         AML1a   POU6F1 (c2)   FOXL1   NF-AT   NF-AT4   NF-AT2   NF-AT3   Msx-1   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR8K1 promoter sequence
   Search Chromatin IP Primers for OR8K1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR8K1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11

OR8K1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR8K1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P056113:  view genomic region     (about GC identifiers)

Start:
56,113,515 bp from pter      End:
56,114,471 bp from pter
Size:
957 bases      Orientation:
plus strand

1 alternative location:
Chr11+,NW_003571044 156,788-157,747     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR8K1_HUMAN, Q8NGG5 (See protein sequence)
Recommended Name: Olfactory receptor 8K1  
Size: 319 amino acids; 36581 Da
Secondary accessions: B9EJB1 Q6IFC3 Q96RC1

Explore the universe of human proteins at neXtProt for OR8K1: NX_Q8NGG5

Explore proteomics data for OR8K1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8
  • HORDE protein sequence for OR8K1

    See OR8K1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001002907.1  
    ENSEMBL proteins: 
     ENSP00000279783  
    Reactome Protein details: Q8NGG5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR8: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGG5

    ProtoNet protein and cluster: Q8NGG5

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR8K1_HUMAN, Q8NGG5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR8K1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR8K1_HUMAN, Q8NGG5
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR8K1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OR8K1:
     Decreased Hepatitis C virus re 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR8K1_HUMAN, Q8NGG5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR8K1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR8K1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR8K1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR8K1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR8K1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR8K1
    Interactions:

        Search GeneGlobe Interaction Network for OR8K1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR8K1 (ENSP000002797834) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A4ENSP000003691574STRING: ENSP00000369157
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR8K1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for OR8K1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR8K1 gene: 
    NM_001002907.1  

    Unigene Cluster for OR8K1:

    Olfactory receptor, family 8, subfamily K, member 1
    Hs.553748
    Unigene Representative Sequence: BC146844
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000279783(uc010rjg.2)
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      QuantiFast Probe-based Assays in human, mouse, rat OR8K1

    Additional mRNA sequence: BC146844.1 
    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    OR8K1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR8K1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553748
        Custom PCR Arrays for OR8K1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR8K1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr10461 , 5 olfactory receptor 10461, 5 80.02(n)1
    81.73(a)1
      2 (49.75 cM)5
    2585751  NM_146582.21  NP_666793.21 
     862167585 


    ENSEMBL Gene Tree for OR8K1 (if available)
    TreeFam Gene Tree for OR8K1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR8K1 gene
    OR8U12  OR8K52  OR5M112  OR5R12  OR5M82  OR8J32  OR5M102  OR8K32  
    OR5M32  OR5M92  OR8J12  OR5M12  
    Selected SIMAP similar genes for OR8K1 using alignment to 1 protein entry:     OR8K1_HUMAN(see all similar genes):
    OR8K3    OR8K5    OR5R1    OR8J1    OR8J2    OR8J3
    OR5B12    OR8U1    OR8U8    OR5AR1    OR5AP2    OR5B17
    OR5B2    OR5G3    OR8U9    OR9I1    OR5AS1    OR5B21

    Find genes that share paralogs with OR8K1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR8K1 (see all 125)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107919521,2
    C,F,A,H--56111515(+) TATTTT/AAAAAA 1 -- us2k1 tfbs312Minor allele frequency- A:0.23EA NS NA WA 660
    rs1866375011,2
    --56111516(+) ATTTAA/TAAAAA 1 -- us2k10--------
    rs1485170921,2
    --56111546(+) AAAAAA/GCTAAA 1 -- us2k10--------
    rs122959871,2
    C,H--56111612(+) aatttC/Gtgaaa 1 -- us2k1 tfbs34Minor allele frequency- G:0.00NS EA 414
    rs1910543651,2
    --56111638(+) AAATTC/GTTAAA 1 -- us2k10--------
    rs1835687991,2
    --56111841(+) ATTATA/GTAACT 1 -- us2k10--------
    rs788981981,2
    F--56111912(+) TTTGCA/CTGCAA 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1878669581,2
    --56111984(+) TTAGAC/TAAAGG 1 -- us2k10--------
    rs171503301,2
    C,F,H--56112025(+) ACATTC/TGGAGA 1 -- us2k1 tfbs319Minor allele frequency- T:0.09NA NS EA WA 1874
    rs734763271,2
    C--56112055(+) GGCACT/GTTCCC 1 -- us2k12Minor allele frequency- G:0.02WA 120

    HapMap Linkage Disequilibrium report for OR8K1 ( 56113515 - 56114471 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR8K1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832161CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR8K1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR8K1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR8K1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR8K1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390157 HGNC: 14831 Ensembl:ENSG00000150261 euGenes: HUgn390157 ECgene: OR8K1 Kegg: 390157
    H-InvDB: OR8K1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR8K1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR8K1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR8K1 gene:
    Search GeneIP for patents involving OR8K1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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