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Aliases for OR8J3 Gene

Aliases for OR8J3 Gene

  • Olfactory Receptor Family 8 Subfamily J Member 3 2 3 5
  • Olfactory Receptor OR11-173 3 4
  • Olfactory Receptor, Family 8, Subfamily J, Member 3 2
  • Olfactory Receptor 8J3 3
  • OR11-173 3

External Ids for OR8J3 Gene

Previous GeneCards Identifiers for OR8J3 Gene

  • GC11U990402
  • GC11M055681
  • GC11M055660
  • GC11M055904

Summaries for OR8J3 Gene

GeneCards Summary for OR8J3 Gene

OR8J3 (Olfactory Receptor Family 8 Subfamily J Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8J1.

UniProtKB/Swiss-Prot for OR8J3 Gene

  • Odorant receptor.

Gene Wiki entry for OR8J3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8J3 Gene

Genomics for OR8J3 Gene

Regulatory Elements for OR8J3 Gene


Genomic Location for OR8J3 Gene

Chromosome:
11
Start:
56,136,771 bp from pter
End:
56,137,718 bp from pter
Size:
948 bases
Orientation:
Minus strand

Genomic View for OR8J3 Gene

Genes around OR8J3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8J3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8J3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8J3 Gene

Proteins for OR8J3 Gene

  • Protein details for OR8J3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGG0-OR8J3_HUMAN
    Recommended name:
    Olfactory receptor 8J3
    Protein Accession:
    Q8NGG0
    Secondary Accessions:
    • Q6IFB6
    • Q96RC2

    Protein attributes for OR8J3 Gene

    Size:
    315 amino acids
    Molecular mass:
    35481 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8J3 Gene

Post-translational modifications for OR8J3 Gene

  • Glycosylation at Asn 5 and Asn 265
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8J3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8J3 Gene

Domains & Families for OR8J3 Gene

Gene Families for OR8J3 Gene

Protein Domains for OR8J3 Gene

Suggested Antigen Peptide Sequences for OR8J3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGG0

UniProtKB/Swiss-Prot:

OR8J3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8J3: view

Function for OR8J3 Gene

Molecular function for OR8J3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8J3: view

Phenotypes for OR8J3 Gene

genes like me logo Genes that share phenotypes with OR8J3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8J3 Gene

Localization for OR8J3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8J3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR8J3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8J3: view

Pathways & Interactions for OR8J3 Gene

genes like me logo Genes that share pathways with OR8J3: view

Pathways by source for OR8J3 Gene

Gene Ontology (GO) - Biological Process for OR8J3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8J3: view

No data available for SIGNOR curated interactions for OR8J3 Gene

Transcripts for OR8J3 Gene

mRNA/cDNA for OR8J3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8J3 Gene

No ASD Table

Relevant External Links for OR8J3 Gene

GeneLoc Exon Structure for
OR8J3
ECgene alternative splicing isoforms for
OR8J3

Expression for OR8J3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8J3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8J3 Gene:

OR8J3

SOURCE GeneReport for Unigene cluster for OR8J3 Gene:

Hs.554523
genes like me logo Genes that share expression patterns with OR8J3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR8J3 Gene

Orthologs for OR8J3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8J3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100609139 34
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia LOC100300446 34
  • 83.17 (n)
-- 35
  • 83 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 79 (a)
ManyToMany
-- 35
  • 78 (a)
ManyToMany
-- 35
  • 78 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Or8j3 55 Olfr1045 34 16 35
  • 82.01 (n)
Or8j3b 55 Olfr1057
  • chr2:86,374,466-86,375,410
Or8j3c 55 Olfr1062
  • chr2:86,422,730-86,423,674
rat
(Rattus norvegicus)
Mammalia LOC100912463 34
  • 82.01 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR10G10 35
  • 57 (a)
ManyToMany
Species where no ortholog for OR8J3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8J3 Gene

ENSEMBL:
Gene Tree for OR8J3 (if available)
TreeFam:
Gene Tree for OR8J3 (if available)

Paralogs for OR8J3 Gene

Paralogs for OR8J3 Gene

(441) SIMAP similar genes for OR8J3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR8J3: view

Variants for OR8J3 Gene

Sequence variations from dbSNP and Humsavar for OR8J3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10791829 -- 56,138,680(+) CAGAG(A/C)GAGAC upstream-variant-2KB
rs11227321 -- 56,137,352(+) CACAT(A/G)GCGGT reference, missense
rs112783093 -- 56,137,105(+) AATTT(G/T)TTGCT reference, missense
rs113645168 -- 56,136,909(+) TTATC(A/G)GTATC reference, synonymous-codon
rs114758947 -- 56,136,946(+) AATAC(A/G)TAAAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR8J3 Gene

Variant ID Type Subtype PubMed ID
nsv972029 CNV duplication 23825009
nsv832160 CNV gain 17160897
nsv555095 CNV loss 21841781
nsv521440 CNV loss 19592680
nsv468575 CNV loss 19166990
nsv1036290 CNV loss 25217958
esv3892014 CNV loss 25118596
esv3626473 CNV gain 21293372
esv3579805 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3579715 CNV loss 25503493
dgv200e214 CNV gain 21293372
dgv1205n100 CNV gain 25217958

Variation tolerance for OR8J3 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.76; 86.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8J3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8J3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8J3 Gene

Disorders for OR8J3 Gene

Relevant External Links for OR8J3

Genetic Association Database (GAD)
OR8J3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR8J3

No disorders were found for OR8J3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8J3 Gene

Publications for OR8J3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl G.R. … MunafA^ M.R. (Pharmacogenomics 2010) 46 64

Products for OR8J3 Gene

Sources for OR8J3 Gene

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