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OR8J3 Gene

protein-coding   GIFtS: 44
GCID: GC11M055904

Olfactory Receptor, Family 8, Subfamily J, Member 3

  Search for OR8J3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 8, Subfamily J, Member 31 2
Olfactory Receptor OR11-1732 3
OR11-1732
Olfactory Receptor 8J32

External Ids:    HGNC: 153121   Entrez Gene: 811682   Ensembl: ENSG000001678227   UniProtKB: Q8NGG03   

Export aliases for OR8J3 gene to outside databases

Previous GC identifers: GC11U990402 GC11M055681 GC11M055660


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OR8J3 Gene:
OR8J3 (olfactory receptor, family 8, subfamily J, member 3) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8U1.

UniProtKB/Swiss-Prot: OR8J3_HUMAN, Q8NGG0
Function: Odorant receptor (Potential)

Gene Wiki entry for OR8J3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR8J3 gene promoter:
         Meis-1b   POU2F1   CBF-A   CBF-B   POU2F1a   CP1A   Meis-1a   NF-Y   Meis-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR8J3 promoter sequence
   Search Chromatin IP Primers for OR8J3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR8J3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.2

OR8J3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR8J3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M055904:  view genomic region     (about GC identifiers)

Start:
55,904,250 bp from pter      End:
55,905,194 bp from pter
Size:
945 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR8J3_HUMAN, Q8NGG0 (See protein sequence)
Recommended Name: Olfactory receptor 8J3  
Size: 315 amino acids; 35481 Da
Secondary accessions: Q6IFB6 Q96RC2

Explore the universe of human proteins at neXtProt for OR8J3: NX_Q8NGG0

Explore proteomics data for OR8J3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn265
  • HORDE protein sequence for OR8J3

    See OR8J3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004064.1  
    ENSEMBL proteins: 
     ENSP00000301529  
    Reactome Protein details: Q8NGG0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR8: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGG0

    ProtoNet protein and cluster: Q8NGG0

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR8J3_HUMAN, Q8NGG0
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR8J3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR8J3_HUMAN, Q8NGG0
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR8J3 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR8J3_HUMAN, Q8NGG0: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR8J3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR8J3 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR8J3
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR8J3):
        Olfactory transduction


    OR8J3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR8J3
    Interactions:

        Search GeneGlobe Interaction Network for OR8J3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR8J3 (ENSP000003015294) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10R2ENSP000003571344STRING: ENSP00000357134
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR8J3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR8J3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR8J3 gene: 
    NM_001004064.1  

    Unigene Cluster for OR8J3:

    Olfactory receptor, family 8, subfamily J, member 3
    Hs.554523
    Unigene Representative Sequence: NM_001004064
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301529(uc010riz.2)
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR8J3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTCCTTT
    OR8J3 Expression
    About this image

    OR8J3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR8J3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.554523
        Custom PCR Arrays for OR8J3
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR8J3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr10451 olfactory receptor 1045 82.01(n)
    84.13(a)
      259019  NM_147017.2  NP_667228.2 


    ENSEMBL Gene Tree for OR8J3 (if available)
    TreeFam Gene Tree for OR8J3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR8J3 gene
    OR8U12  OR8K12  OR8K52  OR5M112  OR5R12  OR5M82  OR5M102  OR8K32  
    OR5M32  OR5M92  OR8J12  OR5M12  
    Selected SIMAP similar genes for OR8J3 using alignment to 1 protein entry:     OR8J3_HUMAN(see all similar genes):
    OR8J1    OR8J2    OR8K5    OR8B8    OR8K1    OR8K3
    OR5B12    OR5R1    OR8B2    OR8B3    OR5AR1    OR5E1P
    OR8B12    OR8D1    OR8U1    OR8U8    OR8U9    PJCG1

    OR8J3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for OR8J3
    PGOHUM00000242271 PGOHUM00000262549


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR8J3 (see all 116)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1847890231,2
    --55903764(+) ACAATA/GTTAAG 1 -- ds50010--------
    rs25129391,2
    C,F,O,A,H--55903814(+) ATTTGC/TTAACT 1 -- ds500117Minor allele frequency- T:0.23NA NS EA WA CSA 926
    rs1388035261,2
    C--55903833(+) AAAATA/GATTTT 1 -- ds50010--------
    rs1501149641,2
    C,F--55904252(+) TTACAT/CTGATT 2 /M /V mis12Minor allele frequency- C:0.00NA EU 4803
    rs1873021521,2
    C--55904345(+) CAGCAC/TAGGAA 2 M V mis10--------
    rs2003044131,2
    --55904366(+) GTAAAA/GCACAG 2 L F mis10--------
    rs171501021,2,,4
    C,F,H--55904382(+) ATCTTA/CTCAGT 2 E D mis116Minor allele frequency- C:0.09NA NS EA CSA WA EU 6927
    rs1421894901,2
    C,F--55904389(+) CAGTAT/CCCAGT 2 /D /G mis11Minor allele frequency- C:0.00NA 4550
    rs1433657331,2
    C,F--55904404(+) GGTTGG/ATTTGG 2 /T /I mis12Minor allele frequency- A:0.00NA EU 5873
    rs1147589471,2
    C,F--55904422(+) AATACA/GTAAAT 2 T M mis13Minor allele frequency- G:0.02WA NA EU 5991

    HapMap Linkage Disequilibrium report for OR8J3 ( 55904250 - 55905194 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR8J3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521440CNV Loss19592680
    nsv468575CNV Loss19166990
    nsv832160CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OR8J3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR8J3

    Export disorders for OR8J3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR8J3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR8J3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    4. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81168 HGNC: 15312 Ensembl:ENSG00000167822 euGenes: HUgn81168 ECgene: OR8J3 Kegg: 81168
    H-InvDB: OR8J3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR8J3 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR8J3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR8J3 gene:
    Search GeneIP for patents involving OR8J3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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