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Aliases for OR8I2 Gene

Aliases for OR8I2 Gene

  • Olfactory Receptor Family 8 Subfamily I Member 2 2 3 5
  • Olfactory Receptor OR11-170 3 4
  • Olfactory Receptor, Family 8, Subfamily I, Member 2 2
  • Olfactory Receptor 8I2 3
  • OR11-170 3

External Ids for OR8I2 Gene

Previous GeneCards Identifiers for OR8I2 Gene

  • GC11U990404
  • GC11P055617
  • GC11P055860

Summaries for OR8I2 Gene

Entrez Gene Summary for OR8I2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8I2 Gene

OR8I2 (Olfactory Receptor Family 8 Subfamily I Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8H3.

UniProtKB/Swiss-Prot for OR8I2 Gene

  • Odorant receptor.

Gene Wiki entry for OR8I2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8I2 Gene

Genomics for OR8I2 Gene

Regulatory Elements for OR8I2 Gene

Enhancers for OR8I2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F056057 0.9 ENCODE 11.5 -35.5 -35499 0.2 OR5BN2P OR8H3 OR8I2 OR8I4P OR8H2 GC11P056055 OR5J1P
GH11F056058 0.2 ENCODE 11.5 -35.0 -34999 0.7 OR5BN2P OR8H3 OR8I2 OR8I4P OR8H2 LOC100507561 FAM8A2P GC11P056055 OR5J1P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR8I2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR8I2 Gene

Chromosome:
11
Start:
56,093,308 bp from pter
End:
56,094,240 bp from pter
Size:
933 bases
Orientation:
Plus strand

Genomic View for OR8I2 Gene

Genes around OR8I2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8I2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8I2 Gene

Proteins for OR8I2 Gene

  • Protein details for OR8I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y5-OR8I2_HUMAN
    Recommended name:
    Olfactory receptor 8I2
    Protein Accession:
    Q8N0Y5
    Secondary Accessions:
    • B2RNN4
    • Q6IFC0
    • Q96RC5

    Protein attributes for OR8I2 Gene

    Size:
    310 amino acids
    Molecular mass:
    34661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8I2 Gene

Post-translational modifications for OR8I2 Gene

Other Protein References for OR8I2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8I2 Gene

Domains & Families for OR8I2 Gene

Gene Families for OR8I2 Gene

Protein Domains for OR8I2 Gene

Suggested Antigen Peptide Sequences for OR8I2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Y5

UniProtKB/Swiss-Prot:

OR8I2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8I2: view

Function for OR8I2 Gene

Molecular function for OR8I2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8I2: view

Phenotypes for OR8I2 Gene

GenomeRNAi human phenotypes for OR8I2:
genes like me logo Genes that share phenotypes with OR8I2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8I2 Gene

Localization for OR8I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8I2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8I2 Gene COMPARTMENTS Subcellular localization image for OR8I2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8I2: view

Pathways & Interactions for OR8I2 Gene

genes like me logo Genes that share pathways with OR8I2: view

Pathways by source for OR8I2 Gene

Interacting Proteins for OR8I2 Gene

Gene Ontology (GO) - Biological Process for OR8I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8I2: view

No data available for SIGNOR curated interactions for OR8I2 Gene

Transcripts for OR8I2 Gene

mRNA/cDNA for OR8I2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8I2 Gene

No ASD Table

Relevant External Links for OR8I2 Gene

GeneLoc Exon Structure for
OR8I2
ECgene alternative splicing isoforms for
OR8I2

Expression for OR8I2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8I2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8I2 Gene:

OR8I2

SOURCE GeneReport for Unigene cluster for OR8I2 Gene:

Hs.554524
genes like me logo Genes that share expression patterns with OR8I2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR8I2 Gene

Orthologs for OR8I2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8I2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466545 34
  • 98.82 (n)
OR8I2 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100300545 34
  • 83.93 (n)
OR8I2 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or8i2 55 Olfr1104 34 16 35
  • 83.6 (n)
rat
(Rattus norvegicus)
Mammalia Olr536 34
  • 82.85 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
Species where no ortholog for OR8I2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8I2 Gene

ENSEMBL:
Gene Tree for OR8I2 (if available)
TreeFam:
Gene Tree for OR8I2 (if available)

Paralogs for OR8I2 Gene

Paralogs for OR8I2 Gene

(452) SIMAP similar genes for OR8I2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8I2 Gene

genes like me logo Genes that share paralogs with OR8I2: view

Variants for OR8I2 Gene

Sequence variations from dbSNP and Humsavar for OR8I2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10537071 -- 56,092,622(+) TTAAC(-/ATTT)ATTTA upstream-variant-2KB
rs10895998 -- 56,094,687(+) CACCA(A/T)CATAA downstream-variant-500B
rs111785740 -- 56,093,539(+) CTGTA(A/G)CACCT reference, missense
rs112181516 -- 56,093,832(+) AATCA(-/T)TTTTT reference, frameshift-variant
rs11227184 -- 56,091,582(+) ATAGA(A/C)CCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8I2 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1905n54 CNV gain 21841781
dgv200e214 CNV gain 21293372
dgv389e212 CNV gain 25503493
esv2751030 CNV gain 17911159
esv3579715 CNV loss 25503493
esv3579782 CNV gain 25503493
esv3579805 CNV gain 25503493
esv3626466 CNV loss 21293372
esv3626467 CNV gain 21293372
esv3626473 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv1036290 CNV loss 25217958
nsv1044174 CNV loss 25217958
nsv468575 CNV loss 19166990
nsv521440 CNV loss 19592680
nsv555095 CNV loss 21841781
nsv832160 CNV gain 17160897

Variation tolerance for OR8I2 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.62; 78.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8I2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8I2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8I2 Gene

Disorders for OR8I2 Gene

Relevant External Links for OR8I2

Genetic Association Database (GAD)
OR8I2
Human Genome Epidemiology (HuGE) Navigator
OR8I2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR8I2

No disorders were found for OR8I2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8I2 Gene

Publications for OR8I2 Gene

  1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  5. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl G.R. … MunafA^ M.R. (Pharmacogenomics 2010) 46 64

Products for OR8I2 Gene

Sources for OR8I2 Gene

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