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Aliases for OR8I2 Gene

Aliases for OR8I2 Gene

  • Olfactory Receptor, Family 8, Subfamily I, Member 2 2 3
  • Olfactory Receptor OR11-170 3 4
  • Olfactory Receptor 8I2 3
  • OR11-170 3

External Ids for OR8I2 Gene

Previous GeneCards Identifiers for OR8I2 Gene

  • GC11U990404
  • GC11P055617
  • GC11P055860

Summaries for OR8I2 Gene

Entrez Gene Summary for OR8I2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8I2 Gene

OR8I2 (Olfactory Receptor, Family 8, Subfamily I, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8H2.

UniProtKB/Swiss-Prot for OR8I2 Gene

  • Odorant receptor.

Gene Wiki entry for OR8I2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8I2 Gene

Genomics for OR8I2 Gene

Regulatory Elements for OR8I2 Gene

Genomic Location for OR8I2 Gene

Start:
56,093,308 bp from pter
End:
56,094,240 bp from pter
Size:
933 bases
Orientation:
Plus strand

Genomic View for OR8I2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8I2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8I2 Gene

Proteins for OR8I2 Gene

  • Protein details for OR8I2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0Y5-OR8I2_HUMAN
    Recommended name:
    Olfactory receptor 8I2
    Protein Accession:
    Q8N0Y5
    Secondary Accessions:
    • B2RNN4
    • Q6IFC0
    • Q96RC5

    Protein attributes for OR8I2 Gene

    Size:
    310 amino acids
    Molecular mass:
    34661 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8I2 Gene

Proteomics data for OR8I2 Gene at MOPED

Post-translational modifications for OR8I2 Gene

Other Protein References for OR8I2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8I2 Gene

Domains for OR8I2 Gene

Gene Families for OR8I2 Gene

HGNC:
  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8I2 Gene

Suggested Antigen Peptide Sequences for OR8I2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0Y5

UniProtKB/Swiss-Prot:

OR8I2_HUMAN :
  • Q8N0Y5
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8I2: view

Function for OR8I2 Gene

Molecular function for OR8I2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8I2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8I2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR8I2 Gene

Localization for OR8I2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8I2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8I2 Gene COMPARTMENTS Subcellular localization image for OR8I2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR8I2: view

Pathways for OR8I2 Gene

genes like me logo Genes that share pathways with OR8I2: view

Pathways by source for OR8I2 Gene

Interacting Proteins for OR8I2 Gene

Gene Ontology (GO) - Biological Process for OR8I2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8I2: view

Transcripts for OR8I2 Gene

mRNA/cDNA for OR8I2 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8I2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR8I2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8I2 Gene

No ASD Table

Relevant External Links for OR8I2 Gene

GeneLoc Exon Structure for
OR8I2
ECgene alternative splicing isoforms for
OR8I2

Expression for OR8I2 Gene

mRNA expression in normal human tissues for OR8I2 Gene

SOURCE GeneReport for Unigene cluster for OR8I2 Gene Hs.554524

genes like me logo Genes that share expressions with OR8I2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR8I2 Gene

Orthologs for OR8I2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8I2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466545 35
  • 98.82 (n)
  • 97.1 (a)
OR8I2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100300545 35
  • 83.93 (n)
  • 85.76 (a)
OR8I2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1104 35
  • 83.6 (n)
  • 85.99 (a)
Olfr1104 16
Olfr1104 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr536 35
  • 82.85 (n)
  • 86.08 (a)
Species with no ortholog for OR8I2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8I2 Gene

ENSEMBL:
Gene Tree for OR8I2 (if available)
TreeFam:
Gene Tree for OR8I2 (if available)

Paralogs for OR8I2 Gene

Selected SIMAP similar genes for OR8I2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8I2 Gene

genes like me logo Genes that share paralogs with OR8I2: view

Variants for OR8I2 Gene

Sequence variations from dbSNP and Humsavar for OR8I2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1384098 -- 56,093,074(+) CAATC(A/G)TGAAT upstream-variant-2KB
rs1842700 -- 56,093,304(+) TTGAT(A/G)TAAAT upstream-variant-2KB
rs2449154 -- 56,094,337(+) AAAGC(A/G)TAACA downstream-variant-500B
rs2945816 -- 56,094,615(-) caaca(A/G)tctaa downstream-variant-500B
rs4938821 -- 56,091,364(+) CCTAA(C/T)ATCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8I2 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv521440 CNV Loss 19592680
nsv832160 CNV Gain 17160897
nsv468575 CNV Loss 19166990

Relevant External Links for OR8I2 Gene

HapMap Linkage Disequilibrium report
OR8I2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8I2 Gene

Disorders for OR8I2 Gene

Relevant External Links for OR8I2

Genetic Association Database (GAD)
OR8I2
Human Genome Epidemiology (HuGE) Navigator
OR8I2
genes like me logo Genes that share disorders with OR8I2: view

No data available for UniProtKB/Swiss-Prot for OR8I2 Gene

Publications for OR8I2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 48
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR8I2 Gene

Sources for OR8I2 Gene

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