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Aliases for OR8H3 Gene

Aliases for OR8H3 Gene

  • Olfactory Receptor, Family 8, Subfamily H, Member 3 2 3
  • Olfactory Receptor OR11-172 3 4
  • Olfactory Receptor 8H3 3
  • OR11-172 3

External Ids for OR8H3 Gene

Previous GeneCards Identifiers for OR8H3 Gene

  • GC11U990405
  • GC11P055666
  • GC11P055646
  • GC11P055890

Summaries for OR8H3 Gene

Entrez Gene Summary for OR8H3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8H3 Gene

OR8H3 (Olfactory Receptor, Family 8, Subfamily H, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8H2.

UniProtKB/Swiss-Prot for OR8H3 Gene

  • Odorant receptor.

Gene Wiki entry for OR8H3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8H3 Gene

Genomics for OR8H3 Gene

Regulatory Elements for OR8H3 Gene

Genomic Location for OR8H3 Gene

Start:
56,122,373 bp from pter
End:
56,123,311 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR8H3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8H3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8H3 Gene

Proteins for OR8H3 Gene

  • Protein details for OR8H3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N146-OR8H3_HUMAN
    Recommended name:
    Olfactory receptor 8H3
    Protein Accession:
    Q8N146
    Secondary Accessions:
    • Q6IFB7

    Protein attributes for OR8H3 Gene

    Size:
    312 amino acids
    Molecular mass:
    35219 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8H3 Gene

Proteomics data for OR8H3 Gene at MOPED

Post-translational modifications for OR8H3 Gene

Other Protein References for OR8H3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8H3 Gene

Domains for OR8H3 Gene

Gene Families for OR8H3 Gene

HGNC:
  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8H3 Gene

Suggested Antigen Peptide Sequences for OR8H3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N146

UniProtKB/Swiss-Prot:

OR8H3_HUMAN :
  • Q8N146
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8H3: view

Function for OR8H3 Gene

Molecular function for OR8H3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8H3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8H3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR8H3 Gene

Localization for OR8H3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8H3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8H3 Gene COMPARTMENTS Subcellular localization image for OR8H3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR8H3: view

Pathways for OR8H3 Gene

genes like me logo Genes that share pathways with OR8H3: view

Pathways by source for OR8H3 Gene

Interacting Proteins for OR8H3 Gene

Gene Ontology (GO) - Biological Process for OR8H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8H3: view

Transcripts for OR8H3 Gene

mRNA/cDNA for OR8H3 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8H3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8H3 Gene

No ASD Table

Relevant External Links for OR8H3 Gene

GeneLoc Exon Structure for
OR8H3
ECgene alternative splicing isoforms for
OR8H3

Expression for OR8H3 Gene

mRNA expression in normal human tissues for OR8H3 Gene

SOURCE GeneReport for Unigene cluster for OR8H3 Gene Hs.553745

genes like me logo Genes that share expressions with OR8H3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR8H3 Gene

Orthologs for OR8H3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8H3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466547 35
  • 98.82 (n)
  • 97.44 (a)
OR8H3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr527 35
  • 75.46 (n)
  • 71.38 (a)
mouse
(Mus musculus)
Mammalia Olfr1100 16
Olfr1097 36
  • 69 (a)
ManyToMany
Olfr1098 36
  • 68 (a)
ManyToMany
Olfr1099 36
  • 71 (a)
ManyToMany
Olfr1100 36
  • 69 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 76 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
Species with no ortholog for OR8H3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8H3 Gene

ENSEMBL:
Gene Tree for OR8H3 (if available)
TreeFam:
Gene Tree for OR8H3 (if available)

Paralogs for OR8H3 Gene

Selected SIMAP similar genes for OR8H3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8H3 Gene

genes like me logo Genes that share paralogs with OR8H3: view

Variants for OR8H3 Gene

Sequence variations from dbSNP and Humsavar for OR8H3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1531759 -- 56,121,380(+) ATATT(A/C)ATGTA upstream-variant-2KB
rs1825158 -- 56,123,707(+) GTGGG(C/T)AGGAG downstream-variant-500B
rs1842691 - 56,122,781(+) TTATG(C/T)CCAAA reference, missense
rs1842692 -- 56,123,606(+) TTCAA(C/T)TGTAG downstream-variant-500B
rs2035407 -- 56,122,092(+) TTAGC(A/G)ATTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8H3 Gene

Variant ID Type Subtype PubMed ID
nsv521440 CNV Loss 19592680
nsv832160 CNV Gain 17160897
nsv468575 CNV Loss 19166990

Relevant External Links for OR8H3 Gene

HapMap Linkage Disequilibrium report
OR8H3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8H3 Gene

Disorders for OR8H3 Gene

Relevant External Links for OR8H3

Genetic Association Database (GAD)
OR8H3

No disorders were found for OR8H3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OR8H3 Gene

Publications for OR8H3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl G.R. … MunafA^ M.R. (Pharmacogenomics 2010) 48

Products for OR8H3 Gene

Sources for OR8H3 Gene

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