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Aliases for OR8G5 Gene

Aliases for OR8G5 Gene

  • Olfactory Receptor, Family 8, Subfamily G, Member 5 2 3
  • Olfactory Receptor OR11-298 3 4
  • Olfactory Receptor 8G6 3 4
  • OR8G5P 3 4
  • OR8G6 3 4
  • Olfactory Receptor, Family 8, Subfamily G, Member 5 Pseudogene 3
  • Olfactory Receptor, Family 8, Subfamily G, Member 6 3
  • Olfactory Receptor 8G5 3
  • OR11-298 3

External Ids for OR8G5 Gene

Previous HGNC Symbols for OR8G5 Gene

  • OR8G5P
  • OR8G6

Previous GeneCards Identifiers for OR8G5 Gene

  • GC11P123673
  • GC11P123640
  • GC11P124120
  • GC11P124134

Summaries for OR8G5 Gene

Entrez Gene Summary for OR8G5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8G5 Gene

OR8G5 (Olfactory Receptor, Family 8, Subfamily G, Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8B8.

UniProtKB/Swiss-Prot for OR8G5 Gene

  • Odorant receptor.

Gene Wiki entry for OR8G5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8G5 Gene

Genomics for OR8G5 Gene

Regulatory Elements for OR8G5 Gene

Genomic Location for OR8G5 Gene

Start:
124,264,827 bp from pter
End:
124,265,867 bp from pter
Size:
1,041 bases
Orientation:
Plus strand

Genomic View for OR8G5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8G5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8G5 Gene

Proteins for OR8G5 Gene

  • Protein details for OR8G5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG78-OR8G5_HUMAN
    Recommended name:
    Olfactory receptor 8G5
    Protein Accession:
    Q8NG78
    Secondary Accessions:
    • B2RND3
    • Q6IEU6

    Protein attributes for OR8G5 Gene

    Size:
    346 amino acids
    Molecular mass:
    38798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06171.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR8G5 Gene

Proteomics data for OR8G5 Gene at MOPED

Post-translational modifications for OR8G5 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8G5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8G5 Gene

Domains for OR8G5 Gene

Gene Families for OR8G5 Gene

HGNC:
  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8G5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NG78

UniProtKB/Swiss-Prot:

OR8G5_HUMAN :
  • Q8NG78
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8G5: view

Function for OR8G5 Gene

Molecular function for OR8G5 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR8G5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8G5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR8G5 Gene

Localization for OR8G5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8G5 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR8G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8G5: view

No data available for Subcellular locations from COMPARTMENTS for OR8G5 Gene

Pathways for OR8G5 Gene

genes like me logo Genes that share pathways with OR8G5: view

Pathways by source for OR8G5 Gene

Interacting Proteins for OR8G5 Gene

Gene Ontology (GO) - Biological Process for OR8G5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8G5: view

Transcripts for OR8G5 Gene

mRNA/cDNA for OR8G5 Gene

(7) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8G5 Gene

Olfactory receptor, family 8, subfamily G, member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8G5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR8G5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8G5 Gene

No ASD Table

Relevant External Links for OR8G5 Gene

GeneLoc Exon Structure for
OR8G5
ECgene alternative splicing isoforms for
OR8G5

Expression for OR8G5 Gene

SOURCE GeneReport for Unigene cluster for OR8G5 Gene Hs.722725

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR8G5 Gene

Orthologs for OR8G5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR8G5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466826 35
  • 98.55 (n)
  • 97.69 (a)
OR8G5 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 80 (a)
ManyToMany
-- 36
  • 79 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TPCR79 36
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr146 36
  • 74 (a)
ManyToMany
Olfr1537 36
  • 68 (a)
ManyToMany
Olfr27 36
  • 68 (a)
ManyToMany
Olfr44 16
Olfr44 36
  • 76 (a)
ManyToMany
Olfr935 35
  • 79.65 (n)
  • 77.6 (a)
Olfr935 36
  • 78 (a)
ManyToMany
Olfr936 36
  • 76 (a)
ManyToMany
Olfr937 36
  • 76 (a)
ManyToMany
Olfr943 36
  • 69 (a)
ManyToMany
Olfr944 36
  • 65 (a)
ManyToMany
Olfr945 36
  • 68 (a)
ManyToMany
Olfr948 36
  • 65 (a)
ManyToMany
Olfr951 36
  • 69 (a)
ManyToMany
Olfr954 36
  • 69 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
OPOR128 36
  • 70 (a)
ManyToMany
OPOR88 36
  • 69 (a)
ManyToMany
OPOR89 36
  • 72 (a)
ManyToMany
OPOR89 36
  • 72 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100910409 35
  • 77.74 (n)
  • 76.45 (a)
zebrafish
(Danio rerio)
Actinopterygii or115-7 35
  • 48.23 (n)
  • 34.77 (a)
Species with no ortholog for OR8G5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR8G5 Gene

ENSEMBL:
Gene Tree for OR8G5 (if available)
TreeFam:
Gene Tree for OR8G5 (if available)

Paralogs for OR8G5 Gene

Paralogs for OR8G5 Gene

Selected SIMAP similar genes for OR8G5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OR8G5: view

Variants for OR8G5 Gene

Sequence variations from dbSNP and Humsavar for OR8G5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2466635 -- 124,264,454(+) AATCT(A/G)GATTT upstream-variant-2KB
rs2466636 -- 124,264,656(+) AAATA(C/T)TGACT upstream-variant-2KB
rs2466637 -- 124,264,847(+) CAAGG(A/G)ATCAC synonymous-codon, reference
rs2466666 -- 124,263,595(-) AACAC(C/T)GCATG upstream-variant-2KB
rs2466667 -- 124,263,474(-) GGAGA(A/T)ATACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8G5 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV Gain 19592680
nsv898435 CNV Gain 21882294
esv2745180 CNV Deletion 23290073
esv2745184 CNV Deletion 23290073

Relevant External Links for OR8G5 Gene

HapMap Linkage Disequilibrium report
OR8G5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8G5 Gene

Disorders for OR8G5 Gene

No disorders were found for OR8G5 Gene.

No data available for UniProtKB/Swiss-Prot for OR8G5 Gene

Publications for OR8G5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR8G5 Gene

Sources for OR8G5 Gene

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