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Aliases for OR8G1 Gene

Aliases for OR8G1 Gene

  • Olfactory Receptor, Family 8, Subfamily G, Member 1 (Gene/Pseudogene) 2 3
  • Olfactory Receptor, Family 8, Subfamily G, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR11-281 3 4
  • Olfactory Receptor TPCR25 3 4
  • OR8G1P 3 4
  • Olfactory Receptor 8G1 3
  • HSTPCR25 3
  • TPCR25 3

External Ids for OR8G1 Gene

Previous HGNC Symbols for OR8G1 Gene

  • OR8G1P

Previous GeneCards Identifiers for OR8G1 Gene

  • GC11P126121
  • GC11P125634
  • GC11P124154
  • GC11P123672
  • GC11P123627
  • GC11P124121
  • GC11P124122

Summaries for OR8G1 Gene

Entrez Gene Summary for OR8G1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3' end deletion. [provided by RefSeq, Feb 2014]

GeneCards Summary for OR8G1 Gene

OR8G1 (Olfactory Receptor, Family 8, Subfamily G, Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8B8.

UniProtKB/Swiss-Prot for OR8G1 Gene

  • Odorant receptor.

Gene Wiki entry for OR8G1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8G1 Gene

Genomics for OR8G1 Gene

Regulatory Elements for OR8G1 Gene

Genomic Location for OR8G1 Gene

Start:
124,249,676 bp from pter
End:
124,250,611 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR8G1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8G1 Gene

Proteins for OR8G1 Gene

  • Protein details for OR8G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15617-OR8G1_HUMAN
    Recommended name:
    Olfactory receptor 8G1
    Protein Accession:
    Q15617
    Secondary Accessions:
    • Q8NG88

    Protein attributes for OR8G1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34904 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8G1 Gene

Proteomics data for OR8G1 Gene at MOPED

Post-translational modifications for OR8G1 Gene

  • Glycosylation at Asn5 and Asn6
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8G1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8G1 Gene

Domains for OR8G1 Gene

Gene Families for OR8G1 Gene

HGNC:
  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8G1 Gene

Suggested Antigen Peptide Sequences for OR8G1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15617

UniProtKB/Swiss-Prot:

OR8G1_HUMAN :
  • Q15617
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8G1: view

Function for OR8G1 Gene

Molecular function for OR8G1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR8G1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8G1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR8G1 Gene

Localization for OR8G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8G1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8G1 Gene COMPARTMENTS Subcellular localization image for OR8G1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR8G1: view

Pathways for OR8G1 Gene

genes like me logo Genes that share pathways with OR8G1: view

Pathways by source for OR8G1 Gene

1 BioSystems pathway for OR8G1 Gene
1 KEGG pathway for OR8G1 Gene

Interacting Proteins for OR8G1 Gene

Gene Ontology (GO) - Biological Process for OR8G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 9119360
genes like me logo Genes that share ontologies with OR8G1: view

Transcripts for OR8G1 Gene

mRNA/cDNA for OR8G1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8G1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR8G1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8G1 Gene

No ASD Table

Relevant External Links for OR8G1 Gene

GeneLoc Exon Structure for
OR8G1
ECgene alternative splicing isoforms for
OR8G1

Expression for OR8G1 Gene

mRNA expression in normal human tissues for OR8G1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8G1 Gene

This gene is overexpressed in Testis (53.0).

SOURCE GeneReport for Unigene cluster for OR8G1 Gene Hs.448172

genes like me logo Genes that share expressions with OR8G1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR8G1 Gene

Orthologs for OR8G1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8G1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
ManyToMany
LOC526276 35
  • 84.78 (n)
  • 82.32 (a)
dog
(Canis familiaris)
Mammalia LOC102151657 35
  • 79.65 (n)
  • 77.92 (a)
TPCR79 36
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr146 36
  • 72 (a)
ManyToMany
Olfr935 36
  • 74 (a)
ManyToMany
Olfr936 36
  • 72 (a)
ManyToMany
Olfr967 35
  • 77.63 (n)
  • 75.9 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
OPOR128 36
  • 72 (a)
ManyToMany
OPOR88 36
  • 70 (a)
ManyToMany
OPOR89 36
  • 75 (a)
ManyToMany
OPOR89 36
  • 74 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1321 35
  • 76.98 (n)
  • 73.29 (a)
Species with no ortholog for OR8G1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8G1 Gene

ENSEMBL:
Gene Tree for OR8G1 (if available)
TreeFam:
Gene Tree for OR8G1 (if available)

Paralogs for OR8G1 Gene

Paralogs for OR8G1 Gene

Selected SIMAP similar genes for OR8G1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR8G1: view

Variants for OR8G1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR8G1 Gene

Q15617-OR8G1_HUMAN
A stop codon in the gene coding for this protein at position Tyr-259 is responsible for functional diversity thus producing thus a pseudogene

Sequence variations from dbSNP and Humsavar for OR8G1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2466645 -- 124,247,880(+) tcttg(A/G)gtaag upstream-variant-2KB
rs2466702 -- 124,249,016(+) TTTAA(A/G)GCCTG upstream-variant-2KB
rs2466703 -- 124,249,167(+) AATAA(C/T)ATTTT upstream-variant-2KB
rs2466704 -- 124,249,308(+) AGGCA(A/G)GGTTT upstream-variant-2KB
rs2512237 -- 124,249,326(+) CCAAG(G/T)TTTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8G1 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV Gain 19592680
nsv898435 CNV Gain 21882294
esv2745180 CNV Deletion 23290073
esv24586 CNV Gain 19812545
esv2745184 CNV Deletion 23290073
esv1452743 CNV Insertion 17803354

Relevant External Links for OR8G1 Gene

HapMap Linkage Disequilibrium report
OR8G1

Disorders for OR8G1 Gene

No disorders were found for OR8G1 Gene.

No data available for UniProtKB/Swiss-Prot for OR8G1 Gene

Publications for OR8G1 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P. … Parmentier M. (Genomics 1997) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Extensive copy-number variation of the human olfactory receptor gene family. (PMID: 18674749) Young J.M. … Trask B.J. (Am. J. Hum. Genet. 2008) 3
  5. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I. … Lancet D. (PLoS Biol. 2007) 4

Products for OR8G1 Gene

Sources for OR8G1 Gene

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