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Aliases for OR8G1 Gene

Aliases for OR8G1 Gene

  • Olfactory Receptor Family 8 Subfamily G Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 8, Subfamily G, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR11-281 3 4
  • Olfactory Receptor TPCR25 3 4
  • OR8G1P 3 4
  • Olfactory Receptor, Family 8, Subfamily G, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor 8G1 3
  • HSTPCR25 3
  • TPCR25 3

External Ids for OR8G1 Gene

Previous HGNC Symbols for OR8G1 Gene

  • OR8G1P

Previous GeneCards Identifiers for OR8G1 Gene

  • GC11P126121
  • GC11P125634
  • GC11P124154
  • GC11P123672
  • GC11P123627
  • GC11P124121
  • GC11P124122

Summaries for OR8G1 Gene

Entrez Gene Summary for OR8G1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This family member represents a polymorphic pseudogene, whereby some individuals have a functional allele that encodes a full-length protein, while others have a non-functional allele due to the presence of an early stop codon and a 3' end deletion. [provided by RefSeq, Feb 2014]

GeneCards Summary for OR8G1 Gene

OR8G1 (Olfactory Receptor Family 8 Subfamily G Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8G5.

UniProtKB/Swiss-Prot for OR8G1 Gene

  • Odorant receptor.

Gene Wiki entry for OR8G1 Gene

Additional gene information for OR8G1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8G1 Gene

Genomics for OR8G1 Gene

Regulatory Elements for OR8G1 Gene

Enhancers for OR8G1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H124206 1 ENCODE 13.9 -33.6 -33616 1 PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 ATF7 CAVIN1 VWA5A OR8G1 OR8F1P OR8G3P
GH11H124588 0.3 FANTOM5 12 +348.0 347972 0.4 OR8A1 OR8G1 OR8D1 OR8D2 OR8G2P OR8B12 OR8B8 SPA17 OR8Q1P
GH11H124008 0.3 FANTOM5 11.4 -232.4 -232421 0.4 OR8D1 OR4D5 OR10G9 OR8D4 OR10G4 OR6M1 OR8G1 OR10S1 OR8D2 OR6X1
GH11H124521 0.3 FANTOM5 7.9 +280.4 280401 0.3 OR8A1 OR8B8 OR10G7 OR8G2P OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P
GH11H124642 1.5 FANTOM5 Ensembl ENCODE 1.5 +403.0 402961 2.5 PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 ZNF143 FOS ATF7 ZNF202 MSANTD2 TMEM218 STT3A ENSG00000254509 SPA17 OR8A1 OR8B4 OR8D1 OR8G1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR8G1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR8G1 Gene

Genomic Locations for OR8G1 Gene
13,270 bases
Plus strand

Genomic View for OR8G1 Gene

Genes around OR8G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8G1 Gene

Proteins for OR8G1 Gene

  • Protein details for OR8G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8G1
    Protein Accession:
    Secondary Accessions:
    • Q8NG88

    Protein attributes for OR8G1 Gene

    311 amino acids
    Molecular mass:
    34904 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8G1 Gene

Post-translational modifications for OR8G1 Gene

  • Glycosylation at posLast=55 and posLast=66
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8G1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8G1 Gene

Domains & Families for OR8G1 Gene

Gene Families for OR8G1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR8G1 Gene

Suggested Antigen Peptide Sequences for OR8G1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8G1: view

Function for OR8G1 Gene

Molecular function for OR8G1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8G1: view

Phenotypes for OR8G1 Gene

GenomeRNAi human phenotypes for OR8G1:
genes like me logo Genes that share phenotypes with OR8G1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8G1 Gene

Localization for OR8G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8G1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR8G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR8G1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR8G1 Gene

Pathways & Interactions for OR8G1 Gene

genes like me logo Genes that share pathways with OR8G1: view

Pathways by source for OR8G1 Gene

1 BioSystems pathway for OR8G1 Gene
1 KEGG pathway for OR8G1 Gene

Interacting Proteins for OR8G1 Gene

Gene Ontology (GO) - Biological Process for OR8G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8G1: view

No data available for SIGNOR curated interactions for OR8G1 Gene

Drugs & Compounds for OR8G1 Gene

No Compound Related Data Available

Transcripts for OR8G1 Gene

mRNA/cDNA for OR8G1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8G1 Gene

No ASD Table

Relevant External Links for OR8G1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR8G1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8G1 Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of OR8G1 Gene:


SOURCE GeneReport for Unigene cluster for OR8G1 Gene:

genes like me logo Genes that share expression patterns with OR8G1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR8G1 Gene

Orthologs for OR8G1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8G1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC526276 33
  • 84.78 (n)
-- 34
  • 75 (a)
(Canis familiaris)
Mammalia LOC102151657 33
  • 79.65 (n)
TPCR79 34
  • 79 (a)
(Mus musculus)
Mammalia Olfr967 33 16
  • 77.63 (n)
Olfr935 34
  • 74 (a)
Olfr146 34
  • 72 (a)
Olfr936 34
  • 72 (a)
Or8ab1-ps 52 Olfr940-ps1
  • chr9:39,092,688-39,093,169
Or8ab1-ps 52 Olfr950-ps1
  • chr9:39,383,330-39,384,276
Or8ab2-ps 52 Olfr953-ps1
  • chr9:39,452,325-39,453,313
Or8ac1-ps 52 Olfr942-ps1
  • chr9:39,158,924-39,159,919
Or8g26 52 Olfr943
  • chr9:39,184,042-39,185,121
Or8g28 52 Olfr945
  • chr9:39,257,723-39,258,679
Or8o1-ps 52 Olfr1556-ps1
  • chr10:106,502,737-106,503,295
(Rattus norvegicus)
Mammalia Olr1321 33
  • 76.98 (n)
(Monodelphis domestica)
Mammalia OPOR89 34 34
  • 75 (a)
-- 34
  • 74 (a)
-- 34
  • 74 (a)
-- 34
  • 72 (a)
-- 34
  • 72 (a)
OPOR128 34
  • 72 (a)
-- 34
  • 71 (a)
-- 34
  • 70 (a)
-- 34
  • 70 (a)
OPOR88 34
  • 70 (a)
-- 34
  • 69 (a)
-- 34
  • 69 (a)
-- 34
  • 67 (a)
Species where no ortholog for OR8G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8G1 Gene

Gene Tree for OR8G1 (if available)
Gene Tree for OR8G1 (if available)

Paralogs for OR8G1 Gene

Paralogs for OR8G1 Gene

(456) SIMAP similar genes for OR8G1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR8G1: view

Variants for OR8G1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR8G1 Gene

A stop codon in the gene coding for this protein at position Tyr-259 is responsible for functional diversity thus producing thus a pseudogene.

Sequence variations from dbSNP and Humsavar for OR8G1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001953828 -- 124,247,712(+) GAGGA(-/AGAGAGAGAGGG)AGAGA intron-variant, upstream-variant-2KB
rs1003160880 -- 124,248,725(+) TTCAC(A/G)AAAGT intron-variant, upstream-variant-2KB
rs1004912387 -- 124,249,679(+) AGATG(C/T)CAGGA intron-variant, nc-transcript-variant, reference, missense
rs1005827106 -- 124,248,749(+) AAAAA(A/T)TGGAG intron-variant, upstream-variant-2KB
rs1006127071 -- 124,248,594(+) TAAGC(C/T)ATTTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8G1 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680
esv24586 CNV gain 19812545
esv2745180 CNV deletion 23290073
esv2745184 CNV deletion 23290073
nsv975992 CNV duplication 23825009

Relevant External Links for OR8G1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Variation tolerance for OR8G1 Gene

Disorders for OR8G1 Gene

Relevant External Links for OR8G1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR8G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8G1 Gene

Publications for OR8G1 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 2 3 4 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  4. Extensive copy-number variation of the human olfactory receptor gene family. (PMID: 18674749) Young JM … Trask BJ (American journal of human genetics 2008) 3 60
  5. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I … Lancet D (PLoS biology 2007) 4 60

Products for OR8G1 Gene

Sources for OR8G1 Gene

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