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Aliases for OR8D4 Gene

Aliases for OR8D4 Gene

  • Olfactory Receptor Family 8 Subfamily D Member 4 2 3 5
  • Olfactory Receptor OR11-275 3 4
  • Olfactory Receptor, Family 8, Subfamily D, Member 4 2
  • Olfactory Receptor 8D4 3
  • OR11-275 3

External Ids for OR8D4 Gene

Previous GeneCards Identifiers for OR8D4 Gene

  • GC11U990345
  • GC11P123315
  • GC11P123282
  • GC11P123777

Summaries for OR8D4 Gene

Entrez Gene Summary for OR8D4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8D4 Gene

OR8D4 (Olfactory Receptor Family 8 Subfamily D Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8A1.

UniProtKB/Swiss-Prot for OR8D4 Gene

  • Odorant receptor.

Gene Wiki entry for OR8D4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8D4 Gene

Genomics for OR8D4 Gene

Regulatory Elements for OR8D4 Gene

Enhancers for OR8D4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F123695 0.4 FANTOM5 15.1 -210.8 -210813 0.4 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9
GH11F124008 0.3 FANTOM5 15 +102.5 102529 0.4 OR8D1 OR4D5 OR10G9 OR8D4 OR10G4 OR6M1 OR8G1 OR10S1 OR8D2 OR6X1
GH11F123773 0.2 ENCODE 9.6 -129.9 -129927 4.6 ETS1 JUND ZNF316 POLR2A BCL11A SMARCA4 POU5F1 MAFK EMSY ZNF558 ZNF202 OR6X1 OR6M1 TMEM225 OR8D4 RNU1-21P LOC105369544
GH11F123774 0.6 ENCODE 9.6 -132.9 -132879 0.2 OR6M1 ZNF202 TMEM225 OR8D4 RNU1-21P LOC105369544
GH11F123477 0.9 FANTOM5 Ensembl ENCODE 7.5 -426.2 -426173 4.0 HDGF PKNOX1 WRNIP1 RAD21 EGR1 ELK1 ETV6 CREM ZNF654 CBFB GRAMD1B ENSG00000254710 CLMP OR8D4 OR6M1 GC11M123460 GC11P123564
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR8D4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR8D4 Gene

123,906,146 bp from pter
123,907,476 bp from pter
1,331 bases
Plus strand

Genomic View for OR8D4 Gene

Genes around OR8D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8D4 Gene

Proteins for OR8D4 Gene

  • Protein details for OR8D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8D4
    Protein Accession:
    Secondary Accessions:
    • Q6IFE9

    Protein attributes for OR8D4 Gene

    314 amino acids
    Molecular mass:
    35019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8D4 Gene

Post-translational modifications for OR8D4 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8D4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8D4 Gene

Domains & Families for OR8D4 Gene

Gene Families for OR8D4 Gene

Protein Domains for OR8D4 Gene

Suggested Antigen Peptide Sequences for OR8D4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8D4: view

Function for OR8D4 Gene

Molecular function for OR8D4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8D4: view

Phenotypes for OR8D4 Gene

GenomeRNAi human phenotypes for OR8D4:
genes like me logo Genes that share phenotypes with OR8D4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OR8D4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8D4 Gene

Localization for OR8D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8D4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR8D4 Gene COMPARTMENTS Subcellular localization image for OR8D4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8D4: view

Pathways & Interactions for OR8D4 Gene

genes like me logo Genes that share pathways with OR8D4: view

Pathways by source for OR8D4 Gene

Gene Ontology (GO) - Biological Process for OR8D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8D4: view

No data available for SIGNOR curated interactions for OR8D4 Gene

Transcripts for OR8D4 Gene

mRNA/cDNA for OR8D4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8D4 Gene

Olfactory receptor, family 8, subfamily D, member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8D4 Gene

No ASD Table

Relevant External Links for OR8D4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8D4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8D4 Gene:


SOURCE GeneReport for Unigene cluster for OR8D4 Gene:

genes like me logo Genes that share expression patterns with OR8D4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR8D4 Gene

Orthologs for OR8D4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR8D4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466815 34
  • 98.62 (n)
OR8D4 35
  • 97 (a)
(Bos Taurus)
Mammalia OR8D4 34 35
  • 87.74 (n)
(Canis familiaris)
Mammalia LOC100688741 34
  • 85.74 (n)
OR8D4 35
  • 83 (a)
(Mus musculus)
Mammalia Or8d4 55 Olfr985 34 16 35
  • 83.87 (n)
(Rattus norvegicus)
Mammalia Olr1340 34
  • 83.44 (n)
(Monodelphis domestica)
Mammalia OR8D4 35
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
(Gallus gallus)
Aves OR8D4 34
  • 59.74 (n)
Species where no ortholog for OR8D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8D4 Gene

Gene Tree for OR8D4 (if available)
Gene Tree for OR8D4 (if available)

Paralogs for OR8D4 Gene

Paralogs for OR8D4 Gene

(453) SIMAP similar genes for OR8D4 Gene using alignment to 1 proteins: Pseudogenes for OR8D4 Gene

genes like me logo Genes that share paralogs with OR8D4: view

Variants for OR8D4 Gene

Sequence variations from dbSNP and Humsavar for OR8D4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10559521 -- 123,907,768(+) GTCTC(-/AA)AAAAA downstream-variant-500B
rs10750249 -- 123,906,342(+) ATAGA(G/T)AGAAA upstream-variant-2KB
rs10750250 -- 123,906,790(+) GGCCT(A/G)CGATC reference, missense
rs10790608 -- 123,904,606(+) TGATC(C/T)TCCAT upstream-variant-2KB
rs10790609 -- 123,904,627(+) TAGGA(C/T)GAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8D4 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680

Variation tolerance for OR8D4 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.73; 98.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8D4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8D4 Gene

Disorders for OR8D4 Gene

Relevant External Links for OR8D4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR8D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8D4 Gene

Publications for OR8D4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR8D4 Gene

Sources for OR8D4 Gene

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