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Aliases for OR8D1 Gene

Aliases for OR8D1 Gene

  • Olfactory Receptor Family 8 Subfamily D Member 1 2 3 5
  • Olfactory Receptor, Family 8, Subfamily D, Member 1 2 3
  • Olfactory Receptor-Like Protein JCG9 3 4
  • Olfactory Receptor OR11-301 3 4
  • Olfactory Receptor 8D3 3 4
  • OST004 3 4
  • OR8D3 3 4
  • Olfactory Receptor, Family 8, Subfamily D, Member 3 3
  • Olfactory-Like Receptor JCG9 3
  • PDJ9J14 3
  • JCG9 3

External Ids for OR8D1 Gene

Previous HGNC Symbols for OR8D1 Gene

  • OR8D3

Previous GeneCards Identifiers for OR8D1 Gene

  • GC11U990224
  • GC11M123718
  • GC11M123684
  • GC11M124179

Summaries for OR8D1 Gene

Entrez Gene Summary for OR8D1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8D1 Gene

OR8D1 (Olfactory Receptor Family 8 Subfamily D Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8B4.

UniProtKB/Swiss-Prot for OR8D1 Gene

  • Odorant receptor (Potential). May be involved in taste perception.

Gene Wiki entry for OR8D1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8D1 Gene

Genomics for OR8D1 Gene

Regulatory Elements for OR8D1 Gene

Genomic Location for OR8D1 Gene

Chromosome:
11
Start:
124,309,812 bp from pter
End:
124,310,837 bp from pter
Size:
1,026 bases
Orientation:
Minus strand

Genomic View for OR8D1 Gene

Genes around OR8D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8D1 Gene

Proteins for OR8D1 Gene

  • Protein details for OR8D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ84-OR8D1_HUMAN
    Recommended name:
    Olfactory receptor 8D1
    Protein Accession:
    Q8WZ84
    Secondary Accessions:
    • B2RNL4
    • Q6IEW1
    • Q8NGH0

    Protein attributes for OR8D1 Gene

    Size:
    308 amino acids
    Molecular mass:
    34445 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8D1 Gene

Proteomics data for OR8D1 Gene at MOPED

Post-translational modifications for OR8D1 Gene

  • Glycosylation at Asn 5 and Asn 186
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8D1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8D1 Gene

Domains & Families for OR8D1 Gene

Gene Families for OR8D1 Gene

Protein Domains for OR8D1 Gene

Suggested Antigen Peptide Sequences for OR8D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ84

UniProtKB/Swiss-Prot:

OR8D1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8D1: view

Function for OR8D1 Gene

Molecular function for OR8D1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.

Gene Ontology (GO) - Molecular Function for OR8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8D1: view

Phenotypes for OR8D1 Gene

genes like me logo Genes that share phenotypes with OR8D1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8D1 Gene

Localization for OR8D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8D1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8D1 Gene COMPARTMENTS Subcellular localization image for OR8D1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8D1: view

Pathways & Interactions for OR8D1 Gene

genes like me logo Genes that share pathways with OR8D1: view

Pathways by source for OR8D1 Gene

Interacting Proteins for OR8D1 Gene

Gene Ontology (GO) - Biological Process for OR8D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8D1: view

No data available for SIGNOR curated interactions for OR8D1 Gene

Drugs & Compounds for OR8D1 Gene

No Compound Related Data Available

Transcripts for OR8D1 Gene

mRNA/cDNA for OR8D1 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR8D1 Gene

No ASD Table

Relevant External Links for OR8D1 Gene

GeneLoc Exon Structure for
OR8D1
ECgene alternative splicing isoforms for
OR8D1

Expression for OR8D1 Gene

mRNA expression in normal human tissues for OR8D1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8D1 Gene

This gene is overexpressed in Testis (x42.5) and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for OR8D1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR8D1 Gene



SOURCE GeneReport for Unigene cluster for OR8D1 Gene Hs.504211

mRNA Expression by UniProt/SwissProt for OR8D1 Gene

Q8WZ84-OR8D1_HUMAN
Tissue specificity: Expressed in the tongue.
genes like me logo Genes that share expression patterns with OR8D1: view

Protein tissue co-expression partners for OR8D1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OR8D1 Gene

Orthologs for OR8D1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466828 35
  • 99.24 (n)
  • 99.03 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia OR8D1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr26 36
  • 85 (a)
OneToMany
Olfr930 36
  • 79 (a)
OneToMany
Olfr933 36
  • 85 (a)
OneToMany
Olfr933 16
Olfr26 35
  • 84.2 (n)
  • 84.74 (a)
oppossum
(Monodelphis domestica)
Mammalia OR8D1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
Species with no ortholog for OR8D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8D1 Gene

ENSEMBL:
Gene Tree for OR8D1 (if available)
TreeFam:
Gene Tree for OR8D1 (if available)

Paralogs for OR8D1 Gene

(453) SIMAP similar genes for OR8D1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR8D1: view

Variants for OR8D1 Gene

Sequence variations from dbSNP and Humsavar for OR8D1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_024116 -
VAR_053242 -
VAR_053243 -

Structural Variations from Database of Genomic Variants (DGV) for OR8D1 Gene

Variant ID Type Subtype PubMed ID
nsv898435 CNV Gain 21882294
nsv826113 CNV Loss 20364138

Variation tolerance for OR8D1 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.33; 97.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8D1 Gene

HapMap Linkage Disequilibrium report
OR8D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8D1 Gene

Disorders for OR8D1 Gene

Relevant External Links for OR8D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR8D1

No disorders were found for OR8D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8D1 Gene

Publications for OR8D1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Olfactory-like receptor cDNAs are present in human lingual cDNA libraries. (PMID: 15950192) DurzyA8ski L. … HaertlAc T. (Biochem. Biophys. Res. Commun. 2005) 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin J.-C. … Haertle T. (Chem. Senses 2001) 3

Products for OR8D1 Gene

Sources for OR8D1 Gene

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