Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR8B8 Gene

Aliases for OR8B8 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 8 2 3 5
  • Olfactory-Like Receptor JCG8 3 4
  • Olfactory Receptor TPCR85 3 4
  • Olfactory Receptor, Family 8, Subfamily B, Member 8 2
  • Olfactory Receptor OR11-316 3
  • Olfactory Receptor 8B8 3
  • TPCR85 3

External Ids for OR8B8 Gene

Previous GeneCards Identifiers for OR8B8 Gene

  • GC11M126311
  • GC11M125823
  • GC11M124343
  • GC11M123848
  • GC11M123163
  • GC11M123815

Summaries for OR8B8 Gene

Entrez Gene Summary for OR8B8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B8 Gene

OR8B8 (Olfactory Receptor Family 8 Subfamily B Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8B12.

UniProtKB/Swiss-Prot for OR8B8 Gene

  • Odorant receptor (Potential). May be involved in taste perception.

Gene Wiki entry for OR8B8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8B8 Gene

Genomics for OR8B8 Gene

Regulatory Elements for OR8B8 Gene

Enhancers for OR8B8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F124521 0.3 FANTOM5 20.1 -80.3 -80338 0.3 OR8A1 OR8B8 OR10G7 OR8G2 OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P
GH11F124482 0.4 ENCODE 10.4 -41.5 -41487 0.1 ZNF316 MAFG NFE2L1 NFE2 OR8B8 OR8B9P GC11M124487
GH11F124481 0.2 ENCODE 10.4 -40.6 -40596 0.9 ATF1 PKNOX1 ARNT ETV1 BACH1 UBTF ZNF316 POLR2A NCOR1 ZSCAN29 OR8B8 OR8B10P OR8B9P GC11M124467
GH11F124605 0.2 Ensembl 9.3 -164.8 -164843 0.4 ATF1 ATF3 ZKSCAN8 OR8B8 ROBO3 OR8Q1P PANX3
GH11F124588 0.4 FANTOM5 6.3 -147.9 -147909 0.4 OR8A1 OR8G1 OR8D1 OR8D2 OR8G2 OR8B12 OR8B8 SPA17 OR8Q1P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR8B8 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR8B8 Gene

Chromosome:
11
Start:
124,440,126 bp from pter
End:
124,441,158 bp from pter
Size:
1,033 bases
Orientation:
Minus strand

Genomic View for OR8B8 Gene

Genes around OR8B8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8B8 Gene

Proteins for OR8B8 Gene

  • Protein details for OR8B8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15620-OR8B8_HUMAN
    Recommended name:
    Olfactory receptor 8B8
    Protein Accession:
    Q15620
    Secondary Accessions:
    • A1L446
    • Q96RC8

    Protein attributes for OR8B8 Gene

    Size:
    311 amino acids
    Molecular mass:
    34482 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B8 Gene

Post-translational modifications for OR8B8 Gene

Other Protein References for OR8B8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B8 Gene

Domains & Families for OR8B8 Gene

Gene Families for OR8B8 Gene

Protein Domains for OR8B8 Gene

Suggested Antigen Peptide Sequences for OR8B8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15620

UniProtKB/Swiss-Prot:

OR8B8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B8: view

Function for OR8B8 Gene

Molecular function for OR8B8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.

Gene Ontology (GO) - Molecular Function for OR8B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8B8: view
genes like me logo Genes that share phenotypes with OR8B8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8B8 Gene

Localization for OR8B8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8B8 Gene COMPARTMENTS Subcellular localization image for OR8B8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR8B8: view

Pathways & Interactions for OR8B8 Gene

genes like me logo Genes that share pathways with OR8B8: view

Pathways by source for OR8B8 Gene

1 KEGG pathway for OR8B8 Gene

Gene Ontology (GO) - Biological Process for OR8B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B8: view

No data available for SIGNOR curated interactions for OR8B8 Gene

Transcripts for OR8B8 Gene

mRNA/cDNA for OR8B8 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B8 Gene

No ASD Table

Relevant External Links for OR8B8 Gene

GeneLoc Exon Structure for
OR8B8
ECgene alternative splicing isoforms for
OR8B8

Expression for OR8B8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8B8 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8B8 Gene:

OR8B8

SOURCE GeneReport for Unigene cluster for OR8B8 Gene:

Hs.351822

mRNA Expression by UniProt/SwissProt for OR8B8 Gene:

Q15620-OR8B8_HUMAN
Tissue specificity: Expressed in the tongue and testis.
genes like me logo Genes that share expression patterns with OR8B8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OR8B8 Gene

Orthologs for OR8B8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615359 34
  • 98.8 (n)
cow
(Bos Taurus)
Mammalia OR8B8 34 35
  • 88.17 (n)
dog
(Canis familiaris)
Mammalia LOC489317 34
  • 87.53 (n)
OR8B8 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1201 34
  • 85.59 (n)
mouse
(Mus musculus)
Mammalia Or8b8 55 Olfr145 34 16 35
  • 85.05 (n)
Or8c12-ps 55 Olfr879-ps1
  • chr9:37,941,457-37,942,093
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
-- 35
  • 73 (a)
ManyToMany
Species where no ortholog for OR8B8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8B8 Gene

ENSEMBL:
Gene Tree for OR8B8 (if available)
TreeFam:
Gene Tree for OR8B8 (if available)

Paralogs for OR8B8 Gene

Paralogs for OR8B8 Gene

(448) SIMAP similar genes for OR8B8 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8B8 Gene

genes like me logo Genes that share paralogs with OR8B8: view

Variants for OR8B8 Gene

Sequence variations from dbSNP and Humsavar for OR8B8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10555793 -- 124,441,129(+) TATTT(-/AG)AGAGA upstream-variant-2KB
rs10893221 -- 124,440,070(+) AAAAT(C/T)ATATT downstream-variant-500B
rs11219659 -- 124,439,918(+) GGGGA(A/G)GGTAC downstream-variant-500B
rs112614649 -- 124,443,048(+) TTTCA(-/C)CCTAT upstream-variant-2KB
rs113216016 -- 124,440,267(+) GAAGA(C/T)ACCTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR8B8 Gene

Variant ID Type Subtype PubMed ID
esv3892105 CNV gain 25118596

Variation tolerance for OR8B8 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8B8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR8B8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8B8 Gene

Disorders for OR8B8 Gene

Relevant External Links for OR8B8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR8B8

No disorders were found for OR8B8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8B8 Gene

Publications for OR8B8 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P. … Parmentier M. (Genomics 1997) 2 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin J.-C. … Haertle T. (Chem. Senses 2001) 3 4 64
  4. Olfactory-like receptor cDNAs are present in human lingual cDNA libraries. (PMID: 15950192) DurzyA8ski L. … HaertlAc T. (Biochem. Biophys. Res. Commun. 2005) 22 64
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 64

Products for OR8B8 Gene

Sources for OR8B8 Gene

Content
Loading form....