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Aliases for OR8B3 Gene

Aliases for OR8B3 Gene

  • Olfactory Receptor, Family 8, Subfamily B, Member 3 2 3
  • Olfactory Receptor OR11-311 3 4
  • Olfactory Receptor 8B3 3
  • OR11-311 3

External Ids for OR8B3 Gene

Previous GeneCards Identifiers for OR8B3 Gene

  • GC11U990229
  • GC11M123771
  • GC11M124266

Summaries for OR8B3 Gene

Entrez Gene Summary for OR8B3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B3 Gene

OR8B3 (Olfactory Receptor, Family 8, Subfamily B, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8B8.

UniProtKB/Swiss-Prot for OR8B3 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8B3 Gene

Genomics for OR8B3 Gene

Regulatory Elements for OR8B3 Gene

Genomic Location for OR8B3 Gene

Start:
124,396,382 bp from pter
End:
124,397,368 bp from pter
Size:
987 bases
Orientation:
Minus strand

Genomic View for OR8B3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8B3 Gene

Proteins for OR8B3 Gene

  • Protein details for OR8B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGG8-OR8B3_HUMAN
    Recommended name:
    Olfactory receptor 8B3
    Protein Accession:
    Q8NGG8
    Secondary Accessions:
    • Q6IFQ8
    • Q8NGH1

    Protein attributes for OR8B3 Gene

    Size:
    313 amino acids
    Molecular mass:
    35305 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B3 Gene

Proteomics data for OR8B3 Gene at MOPED

Post-translational modifications for OR8B3 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8B3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B3 Gene

Domains for OR8B3 Gene

Gene Families for OR8B3 Gene

HGNC:
  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8B3 Gene

Suggested Antigen Peptide Sequences for OR8B3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGG8

UniProtKB/Swiss-Prot:

OR8B3_HUMAN :
  • Q8NGG8
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B3: view

Function for OR8B3 Gene

Molecular function for OR8B3 Gene

GENATLAS Biochemistry: olfactory receptor,family 8,subfamily B,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8B3: view

Animal Model Products

CRISPR Products

miRNA for OR8B3 Gene

miRTarBase miRNAs that target OR8B3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR8B3 Gene

Localization for OR8B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8B3 Gene COMPARTMENTS Subcellular localization image for OR8B3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR8B3: view

Pathways for OR8B3 Gene

genes like me logo Genes that share pathways with OR8B3: view

Pathways by source for OR8B3 Gene

Interacting Proteins for OR8B3 Gene

Gene Ontology (GO) - Biological Process for OR8B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B3: view

Transcripts for OR8B3 Gene

mRNA/cDNA for OR8B3 Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8B3 Gene

Olfactory receptor, family 8, subfamily B, member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8B3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR8B3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B3 Gene

No ASD Table

Relevant External Links for OR8B3 Gene

GeneLoc Exon Structure for
OR8B3
ECgene alternative splicing isoforms for
OR8B3

Expression for OR8B3 Gene

mRNA expression in normal human tissues for OR8B3 Gene

mRNA differential expression in normal tissues according to GTEx for OR8B3 Gene

This gene is overexpressed in Testis (44.3).

SOURCE GeneReport for Unigene cluster for OR8B3 Gene Hs.690456

genes like me logo Genes that share expressions with OR8B3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR8B3 Gene

Orthologs for OR8B3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466832 35
  • 97.98 (n)
  • 95.53 (a)
OR8B3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
LOC511657 35
  • 87.33 (n)
  • 87.22 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 89 (a)
OneToMany
LOC100687027 35
  • 88.35 (n)
  • 90.38 (a)
mouse
(Mus musculus)
Mammalia Olfr147 35
  • 82.22 (n)
  • 83.39 (a)
Olfr147 16
Olfr147 36
  • 82 (a)
ManyToMany
Olfr918 36
  • 78 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1235 35
  • 84.09 (n)
  • 84.52 (a)
Species with no ortholog for OR8B3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8B3 Gene

ENSEMBL:
Gene Tree for OR8B3 (if available)
TreeFam:
Gene Tree for OR8B3 (if available)

Paralogs for OR8B3 Gene

Paralogs for OR8B3 Gene

Selected SIMAP similar genes for OR8B3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8B3 Gene

genes like me logo Genes that share paralogs with OR8B3: view

Variants for OR8B3 Gene

Sequence variations from dbSNP and Humsavar for OR8B3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_047145 -
VAR_047146 -

Structural Variations from Database of Genomic Variants (DGV) for OR8B3 Gene

Variant ID Type Subtype PubMed ID
nsv898435 CNV Gain 21882294
esv2658517 CNV Deletion 23128226
esv2745185 CNV Deletion 23290073
nsv436130 CNV Deletion 17901297
esv2424130 CNV Deletion 19546169

Relevant External Links for OR8B3 Gene

HapMap Linkage Disequilibrium report
OR8B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8B3 Gene

Disorders for OR8B3 Gene

No disorders were found for OR8B3 Gene.

No data available for UniProtKB/Swiss-Prot for OR8B3 Gene

Publications for OR8B3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for OR8B3 Gene

Sources for OR8B3 Gene

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