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Aliases for OR8B2 Gene

Aliases for OR8B2 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 2 2 3 5
  • Olfactory Receptor, Family 8, Subfamily B, Member 2 2 3
  • Olfactory Receptor OR11-309 3 4
  • Olfactory Receptor OR11-310 3
  • OR11-309 3
  • OR11-310 3

External Ids for OR8B2 Gene

Previous GeneCards Identifiers for OR8B2 Gene

  • GC11U990230
  • GC11M123757
  • GC11M124252

Summaries for OR8B2 Gene

Entrez Gene Summary for OR8B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B2 Gene

OR8B2 (Olfactory Receptor Family 8 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8B4.

UniProtKB/Swiss-Prot for OR8B2 Gene

  • Odorant receptor.

Gene Wiki entry for OR8B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8B2 Gene

Genomics for OR8B2 Gene

Regulatory Elements for OR8B2 Gene

Genomic Location for OR8B2 Gene

Chromosome:
11
Start:
124,382,395 bp from pter
End:
124,383,362 bp from pter
Size:
968 bases
Orientation:
Minus strand

Genomic View for OR8B2 Gene

Genes around OR8B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8B2 Gene

Proteins for OR8B2 Gene

  • Protein details for OR8B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD0-OR8B2_HUMAN
    Recommended name:
    Olfactory receptor 8B2
    Protein Accession:
    Q96RD0
    Secondary Accessions:
    • Q8NGH2

    Protein attributes for OR8B2 Gene

    Size:
    313 amino acids
    Molecular mass:
    35272 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B2 Gene

Proteomics data for OR8B2 Gene at MOPED

Post-translational modifications for OR8B2 Gene

Other Protein References for OR8B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B2 Gene

Domains & Families for OR8B2 Gene

Gene Families for OR8B2 Gene

Protein Domains for OR8B2 Gene

Suggested Antigen Peptide Sequences for OR8B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RD0

UniProtKB/Swiss-Prot:

OR8B2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B2: view

Function for OR8B2 Gene

Molecular function for OR8B2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 8,subfamily B,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8B2: view

Animal Model Products

CRISPR Products

miRNA for OR8B2 Gene

miRTarBase miRNAs that target OR8B2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR8B2 Gene

Localization for OR8B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8B2 Gene COMPARTMENTS Subcellular localization image for OR8B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8B2: view

Pathways & Interactions for OR8B2 Gene

genes like me logo Genes that share pathways with OR8B2: view

Pathways by source for OR8B2 Gene

Interacting Proteins for OR8B2 Gene

Gene Ontology (GO) - Biological Process for OR8B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B2: view

No data available for SIGNOR curated interactions for OR8B2 Gene

Drugs & Compounds for OR8B2 Gene

No Compound Related Data Available

Transcripts for OR8B2 Gene

mRNA/cDNA for OR8B2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B2 Gene

No ASD Table

Relevant External Links for OR8B2 Gene

GeneLoc Exon Structure for
OR8B2
ECgene alternative splicing isoforms for
OR8B2

Expression for OR8B2 Gene

mRNA expression in normal human tissues for OR8B2 Gene

mRNA differential expression in normal tissues according to GTEx for OR8B2 Gene

This gene is overexpressed in Testis (x45.7).

Protein differential expression in normal tissues from HIPED for OR8B2 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR8B2 Gene



SOURCE GeneReport for Unigene cluster for OR8B2 Gene Hs.576944

genes like me logo Genes that share expression patterns with OR8B2: view

Protein tissue co-expression partners for OR8B2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR8B2 Gene

Orthologs for OR8B2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC511657 35
  • 86.9 (n)
  • 86.26 (a)
-- 36
  • 85 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC100687027 35
  • 87.93 (n)
  • 89.42 (a)
-- 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr147 35
  • 81.47 (n)
  • 82.43 (a)
Olfr147 36
  • 81 (a)
ManyToMany
Olfr918 36
  • 77 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC466832 35
  • 98.4 (n)
  • 97.12 (a)
OR8B2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1235 35
  • 83.33 (n)
  • 83.87 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
Species with no ortholog for OR8B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8B2 Gene

ENSEMBL:
Gene Tree for OR8B2 (if available)
TreeFam:
Gene Tree for OR8B2 (if available)

Paralogs for OR8B2 Gene

(442) SIMAP similar genes for OR8B2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR8B2: view

Variants for OR8B2 Gene

Sequence variations from dbSNP and Humsavar for OR8B2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs530740 - 124,383,265(+) AAAGA(A/G)GGGTT reference, missense
rs886202 - 124,382,854(+) TCTAA(A/G)CATGC reference, missense
rs28373946 - 124,383,285(+) CTGGA(C/G/T)GATCT reference, missense
rs503220 - 124,382,526(+) CAGAA(A/G)AAACT reference, missense
rs480634 -- 124,385,230(+) CATTT(C/T)AAGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8B2 Gene

Variant ID Type Subtype PubMed ID
nsv898435 CNV Gain 21882294
esv2658517 CNV Deletion 23128226
esv2745185 CNV Deletion 23290073

Variation tolerance for OR8B2 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.00; 89.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8B2 Gene

HapMap Linkage Disequilibrium report
OR8B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8B2 Gene

Disorders for OR8B2 Gene

Relevant External Links for OR8B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR8B2

No disorders were found for OR8B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8B2 Gene

Publications for OR8B2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR8B2 Gene

Sources for OR8B2 Gene

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