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Aliases for OR8B12 Gene

Aliases for OR8B12 Gene

  • Olfactory Receptor, Family 8, Subfamily B, Member 12 2 3
  • Olfactory Receptor OR11-317 3 4
  • Olfactory Receptor 8B12 3
  • OR11-317 3

External Ids for OR8B12 Gene

Previous GeneCards Identifiers for OR8B12 Gene

  • GC11U990407
  • GC11M123951
  • GC11M123917
  • GC11M124412

Summaries for OR8B12 Gene

Entrez Gene Summary for OR8B12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B12 Gene

OR8B12 (Olfactory Receptor, Family 8, Subfamily B, Member 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8B8.

UniProtKB/Swiss-Prot for OR8B12 Gene

  • Odorant receptor.

Gene Wiki entry for OR8B12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8B12 Gene

Genomics for OR8B12 Gene

Regulatory Elements for OR8B12 Gene

Genomic Location for OR8B12 Gene

Start:
124,542,682 bp from pter
End:
124,543,679 bp from pter
Size:
998 bases
Orientation:
Minus strand

Genomic View for OR8B12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8B12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8B12 Gene

Proteins for OR8B12 Gene

  • Protein details for OR8B12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGG6-OR8BC_HUMAN
    Recommended name:
    Olfactory receptor 8B12
    Protein Accession:
    Q8NGG6
    Secondary Accessions:
    • B2RNF6
    • Q6IEW8
    • Q96RC7

    Protein attributes for OR8B12 Gene

    Size:
    310 amino acids
    Molecular mass:
    34372 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B12 Gene

Proteomics data for OR8B12 Gene at MOPED

Post-translational modifications for OR8B12 Gene

  • Glycosylation at Asn5, Asn164, and Asn189
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8B12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B12 Gene

Domains for OR8B12 Gene

Gene Families for OR8B12 Gene

HGNC:
  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8B12 Gene

Suggested Antigen Peptide Sequences for OR8B12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGG6

UniProtKB/Swiss-Prot:

OR8BC_HUMAN :
  • Q8NGG6
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B12: view

Function for OR8B12 Gene

Molecular function for OR8B12 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8B12: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8B12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR8B12 Gene

Localization for OR8B12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR8B12 Gene COMPARTMENTS Subcellular localization image for OR8B12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR8B12: view

Pathways for OR8B12 Gene

genes like me logo Genes that share pathways with OR8B12: view

Pathways by source for OR8B12 Gene

Interacting Proteins for OR8B12 Gene

Gene Ontology (GO) - Biological Process for OR8B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B12: view

Transcripts for OR8B12 Gene

mRNA/cDNA for OR8B12 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8B12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B12 Gene

No ASD Table

Relevant External Links for OR8B12 Gene

GeneLoc Exon Structure for
OR8B12
ECgene alternative splicing isoforms for
OR8B12

Expression for OR8B12 Gene

mRNA expression in normal human tissues for OR8B12 Gene

mRNA differential expression in normal tissues according to GTEx for OR8B12 Gene

This gene is overexpressed in Testis (47.3).

SOURCE GeneReport for Unigene cluster for OR8B12 Gene Hs.553634

genes like me logo Genes that share expressions with OR8B12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR8B12 Gene

Orthologs for OR8B12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC513334 35
  • 85.08 (n)
  • 82.35 (a)
-- 36
  • 79 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC489314 35
  • 83.6 (n)
  • 83.82 (a)
OR8B12 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr874 35
  • 82.15 (n)
  • 85.16 (a)
Olfr874 16
Olfr874 36
  • 85 (a)
OneToMany
Olfr875 36
  • 84 (a)
OneToMany
Olfr876 36
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1196 35
  • 82.9 (n)
  • 85.81 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
Species with no ortholog for OR8B12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8B12 Gene

ENSEMBL:
Gene Tree for OR8B12 (if available)
TreeFam:
Gene Tree for OR8B12 (if available)

Paralogs for OR8B12 Gene

Paralogs for OR8B12 Gene

Selected SIMAP similar genes for OR8B12 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR8B12 Gene

genes like me logo Genes that share paralogs with OR8B12: view

Variants for OR8B12 Gene

Sequence variations from dbSNP and Humsavar for OR8B12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10893251 -- 124,544,850(+) TGATT(A/G)TCATT upstream-variant-2KB
rs11219693 -- 124,544,347(+) TCACC(A/G)TGTTA upstream-variant-2KB
rs12800266 -- 124,542,255(+) ATAGA(A/T)TTAGG downstream-variant-500B
rs12800821 -- 124,542,307(+) CAAGG(C/G)CAGCA downstream-variant-500B
rs12801868 -- 124,542,261(+) TTAGG(G/T)TTTAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR8B12 Gene

Variant ID Type Subtype PubMed ID
nsv518199 CNV Gain 19592680

Relevant External Links for OR8B12 Gene

HapMap Linkage Disequilibrium report
OR8B12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8B12 Gene

Disorders for OR8B12 Gene

No disorders were found for OR8B12 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR8B12 Gene

Publications for OR8B12 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR8B12 Gene

Sources for OR8B12 Gene

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