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Aliases for OR8B12 Gene

Aliases for OR8B12 Gene

  • Olfactory Receptor Family 8 Subfamily B Member 12 2 3 5
  • Olfactory Receptor, Family 8, Subfamily B, Member 12 2 3
  • Olfactory Receptor OR11-317 3 4
  • OR11-317 3

External Ids for OR8B12 Gene

Previous GeneCards Identifiers for OR8B12 Gene

  • GC11U990407
  • GC11M123951
  • GC11M123917
  • GC11M124412

Summaries for OR8B12 Gene

Entrez Gene Summary for OR8B12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8B12 Gene

OR8B12 (Olfactory Receptor Family 8 Subfamily B Member 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8B4.

UniProtKB/Swiss-Prot for OR8B12 Gene

  • Odorant receptor.

Gene Wiki entry for OR8B12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8B12 Gene

Genomics for OR8B12 Gene

Regulatory Elements for OR8B12 Gene

Enhancers for OR8B12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR8B12 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR8B12 Gene

124,542,682 bp from pter
124,543,679 bp from pter
998 bases
Minus strand

Genomic View for OR8B12 Gene

Genes around OR8B12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8B12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8B12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8B12 Gene

Proteins for OR8B12 Gene

  • Protein details for OR8B12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8B12
    Protein Accession:
    Secondary Accessions:
    • B2RNF6
    • Q6IEW8
    • Q96RC7

    Protein attributes for OR8B12 Gene

    310 amino acids
    Molecular mass:
    34372 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR8B12 Gene

Proteomics data for OR8B12 Gene at MOPED

Post-translational modifications for OR8B12 Gene

  • Glycosylation at Asn 5, Asn 164, and Asn 189
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8B12 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8B12 Gene

Domains & Families for OR8B12 Gene

Gene Families for OR8B12 Gene

Protein Domains for OR8B12 Gene

Suggested Antigen Peptide Sequences for OR8B12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8B12: view

Function for OR8B12 Gene

Molecular function for OR8B12 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8B12: view

Phenotypes for OR8B12 Gene

genes like me logo Genes that share phenotypes with OR8B12: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR8B12 Gene

Localization for OR8B12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8B12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR8B12 Gene COMPARTMENTS Subcellular localization image for OR8B12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8B12: view

Pathways & Interactions for OR8B12 Gene

genes like me logo Genes that share pathways with OR8B12: view

Pathways by source for OR8B12 Gene

Interacting Proteins for OR8B12 Gene

Gene Ontology (GO) - Biological Process for OR8B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8B12: view

No data available for SIGNOR curated interactions for OR8B12 Gene

Drugs & Compounds for OR8B12 Gene

No Compound Related Data Available

Transcripts for OR8B12 Gene

mRNA/cDNA for OR8B12 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR8B12 Gene

No ASD Table

Relevant External Links for OR8B12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8B12 Gene

mRNA expression in normal human tissues for OR8B12 Gene

mRNA differential expression in normal tissues according to GTEx for OR8B12 Gene

This gene is overexpressed in Testis (x47.3).

SOURCE GeneReport for Unigene cluster for OR8B12 Gene Hs.553634

genes like me logo Genes that share expression patterns with OR8B12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR8B12 Gene

Orthologs for OR8B12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8B12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC513334 35
  • 85.08 (n)
  • 82.35 (a)
-- 36
  • 79 (a)
-- 36
  • 82 (a)
(Canis familiaris)
Mammalia LOC489314 35
  • 83.6 (n)
  • 83.82 (a)
OR8B12 36
  • 84 (a)
(Mus musculus)
Mammalia Olfr874 35
  • 82.15 (n)
  • 85.16 (a)
Olfr874 16
Olfr874 36
  • 85 (a)
Olfr875 36
  • 84 (a)
Olfr876 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Olr1196 35
  • 82.9 (n)
  • 85.81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
-- 36
  • 72 (a)
-- 36
  • 72 (a)
Species with no ortholog for OR8B12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8B12 Gene

Gene Tree for OR8B12 (if available)
Gene Tree for OR8B12 (if available)

Paralogs for OR8B12 Gene

(449) SIMAP similar genes for OR8B12 Gene using alignment to 1 proteins: Pseudogenes for OR8B12 Gene

genes like me logo Genes that share paralogs with OR8B12: view

Variants for OR8B12 Gene

Sequence variations from dbSNP and Humsavar for OR8B12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs61743599 -- 124,543,352(+) AAGAA(A/G)AAGAG reference, synonymous-codon
rs61743861 -- 124,543,365(+) GAGTC(A/T)TACAC reference, missense
rs61745404 -- 124,542,851(+) CCTTG(C/T)TCGAG reference, synonymous-codon
rs61745407 -- 124,542,834(+) ACAGG(A/G)AGGAC reference, missense
rs61746453 -- 124,543,595(+) AGTCC(C/T)GGCTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR8B12 Gene

Variant ID Type Subtype PubMed ID
nsv518199 CNV Gain 19592680

Variation tolerance for OR8B12 Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR8B12 Gene

Disorders for OR8B12 Gene

Relevant External Links for OR8B12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR8B12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8B12 Gene

Publications for OR8B12 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR8B12 Gene

Sources for OR8B12 Gene