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OR8A1 Gene

protein-coding   GIFtS: 46
GCID: GC11P124439

Olfactory Receptor, Family 8, Subfamily A, Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 8, Subfamily A, Member 11 2
Olfactory Receptor OR11-3182 3
OST0252 3
OR11-3182
Olfactory Receptor 8A12

External Ids:    HGNC: 84691   Entrez Gene: 3902752   Ensembl: ENSG000001961197   UniProtKB: Q8NGG73   

Export aliases for OR8A1 gene to outside databases

Previous GC identifers: GC00U990586 GC11P123978 GC11P123945


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR8A1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR8A1 Gene:
OR8A1 (olfactory receptor, family 8, subfamily A, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8B8.

UniProtKB/Swiss-Prot: OR8A1_HUMAN, Q8NGG7
Function: Odorant receptor (Potential)

Gene Wiki entry for OR8A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR8A1 gene promoter:
         Bach1   NRSF form 1   Nkx2-2   NRSF form 2   E47   Egr-4   PPAR-gamma1   PPAR-gamma2   Pax-4a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR8A1 promoter sequence
   Search Chromatin IP Primers for OR8A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR8A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

OR8A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR8A1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P124439:  view genomic region     (about GC identifiers)

Start:
124,440,016 bp from pter      End:
124,440,942 bp from pter
Size:
927 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR8A1_HUMAN, Q8NGG7 (See protein sequence)
Recommended Name: Olfactory receptor 8A1  
Size: 326 amino acids; 36388 Da
Sequence caution: Sequence=BAC06052.1; Type=Erroneous initiation;
Secondary accessions: Q6IEW7 Q96RC6

Explore the universe of human proteins at neXtProt for OR8A1: NX_Q8NGG7

Explore proteomics data for OR8A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn22
  • HORDE protein sequence for OR8A1

    See OR8A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005194.1  
    ENSEMBL proteins: 
     ENSP00000284287  
    Reactome Protein details: Q8NGG7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR8: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGG7

    ProtoNet protein and cluster: Q8NGG7

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR8A1_HUMAN, Q8NGG7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR8A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR8A1_HUMAN, Q8NGG7
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR8A1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Olfr160):
     cellular  craniofacial  nervous system  no phenotypic analysis  normal 
     respiratory system  taste/olfaction 

    Find genes that share phenotypes with OR8A1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR8A1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR8A1_HUMAN, Q8NGG7: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR8A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR8A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR8A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR8A1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR8A1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR8A1
    Interactions:

        Search GeneGlobe Interaction Network for OR8A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR8A1 (ENSP000002842874) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    GNALENSP000003340514STRING: ENSP00000334051
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR11G2ENSP000003499304STRING: ENSP00000349930
    OR2B6ENSP000002446234STRING: ENSP00000244623
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007411axon guidance IEA--

    Find genes that share ontologies with OR8A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR8A1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR8A1 gene: 
    NM_001005194.1  

    Unigene Cluster for OR8A1:

    Olfactory receptor, family 8, subfamily A, member 1
    Hs.632104  [show with all ESTs]
    Unigene Representative Sequence: BC137197
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000284287(uc010san.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR8A1
      QuantiFast Probe-based Assays in human, mouse, rat OR8A1

    Additional mRNA sequence: 

    AY726592.1 BC137194.1 BC137197.1 

    1 DOTS entry:

    DT.86843226 

    3 AceView cDNA sequences:

    NM_001005194 BI093413 AW573021 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR8A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR8A1 Expression
    About this image

    OR8A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR8A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632104
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR8A1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr1605
    Olfr1511
    olfactory receptor 1605
    olfactory receptor 1511
    83.06(n)1
    85.44(a)1
      9 (20.80 cM)5
    4061761  NM_207664.21  NP_997547.11 
     377113485 


    ENSEMBL Gene Tree for OR8A1 (if available)
    TreeFam Gene Tree for OR8A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR8A1 gene
    OR8B82  OR8B42  OR8B122  OR8D22  OR8D42  OR8G52  OR8B22  OR8D12  
    OR8B32  OR8G12  
    Selected SIMAP similar genes for OR8A1 using alignment to 1 protein entry:     OR8A1_HUMAN(see all similar genes):
    OR8B3    OR8G2    OR8G1    OR8B2    OR8D2    OR8G5
    OR8B12    OR8B8    OR8D1    OR8D4    OR5A2    OR8B4
    OR9I1    OR5AU1    OR8U8    OR5F1    OR5B12    OR5G3

    Find genes that share paralogs with OR8A1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for OR8A1
    PGOHUM00000242922 PGOHUM00000242923 PGOHUM00000242924


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR8A1 (see all 115)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1849441341,2
    --124438238(+) TAGCAA/GTAGAT 1 -- us2k10--------
    rs1897915631,2
    --124438253(+) CCTCTA/GTCTTC 1 -- us2k10--------
    rs112197121,2
    C,F,A,H--124438314(+) AGATAC/TGCTAA 1 -- us2k1 tfbs320Minor allele frequency- T:0.05NS EA NA 2048
    rs1809917371,2
    --124438315(+) GATACA/GCTAAA 1 -- us2k10--------
    rs1143497701,2
    F--124438508(+) TATCAA/GGCTTA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs736206541,2
    C,F--124438509(+) ATCAAG/CCTTAA 1 -- us2k13Minor allele frequency- C:0.07WA CSA 122
    rs1843551651,2
    --124438571(+) GCTGCA/GCATGT 1 -- us2k10--------
    rs108932681,2
    C,F,A,H--124438612(+) AGAGCC/TGAGGT 1 -- us2k127Minor allele frequency- T:0.48NS EA NA WA CSA 2774
    rs19426591,2
    C,F,A,H--124438746(+) TTTCCC/GAAAAC 1 -- us2k137Minor allele frequency- G:0.14NA EA NS WA CSA 3270
    rs556508831,2
    C,F--124438771(+) AGATCG/AACCTT 1 -- us2k12Minor allele frequency- A:0.09WA 120

    HapMap Linkage Disequilibrium report for OR8A1 ( 124440016 - 124440942 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR8A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518199CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR8A1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR8A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390275 HGNC: 8469 AceView: OR8A1 Ensembl:ENSG00000196119 euGenes: HUgn390275
    ECgene: OR8A1 Kegg: 390275 H-InvDB: OR8A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR8A1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR8A1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR8A1 gene:
    Search GeneIP for patents involving OR8A1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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