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Aliases for OR8A1 Gene

Aliases for OR8A1 Gene

  • Olfactory Receptor, Family 8, Subfamily A, Member 1 2 3
  • Olfactory Receptor OR11-318 3 4
  • OST025 3 4
  • Olfactory Receptor 8A1 3
  • OR11-318 3

External Ids for OR8A1 Gene

Previous GeneCards Identifiers for OR8A1 Gene

  • GC00U990586
  • GC11P123978
  • GC11P123945
  • GC11P124439

Summaries for OR8A1 Gene

Entrez Gene Summary for OR8A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8A1 Gene

OR8A1 (Olfactory Receptor, Family 8, Subfamily A, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8B8.

UniProtKB/Swiss-Prot for OR8A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR8A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8A1 Gene

Genomics for OR8A1 Gene

Regulatory Elements for OR8A1 Gene

Genomic Location for OR8A1 Gene

124,569,997 bp from pter
124,571,142 bp from pter
1,146 bases
Plus strand

Genomic View for OR8A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR8A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8A1 Gene

Proteins for OR8A1 Gene

  • Protein details for OR8A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8A1
    Protein Accession:
    Secondary Accessions:
    • Q6IEW7
    • Q96RC6

    Protein attributes for OR8A1 Gene

    326 amino acids
    Molecular mass:
    36388 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC06052.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR8A1 Gene

Proteomics data for OR8A1 Gene at MOPED

Post-translational modifications for OR8A1 Gene

  • Glycosylation at Asn22
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8A1 Gene

Domains for OR8A1 Gene

Gene Families for OR8A1 Gene

  • OR8 :GPCR / Class A : Olfactory receptors

Protein Domains for OR8A1 Gene

Suggested Antigen Peptide Sequences for OR8A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8NGG7
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8A1: view

Function for OR8A1 Gene

Molecular function for OR8A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8A1: view
genes like me logo Genes that share phenotypes with OR8A1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR8A1 Gene

Localization for OR8A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR8A1 Gene COMPARTMENTS Subcellular localization image for OR8A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR8A1: view

Pathways for OR8A1 Gene

genes like me logo Genes that share pathways with OR8A1: view

Pathways by source for OR8A1 Gene

Interacting Proteins for OR8A1 Gene

Gene Ontology (GO) - Biological Process for OR8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007411 axon guidance IEA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8A1: view

Transcripts for OR8A1 Gene

mRNA/cDNA for OR8A1 Gene

(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8A1 Gene

Olfactory receptor, family 8, subfamily A, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR8A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8A1 Gene

No ASD Table

Relevant External Links for OR8A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8A1 Gene

mRNA expression in normal human tissues for OR8A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8A1 Gene

This gene is overexpressed in Testis (37.8) and Brain - Hypothalamus (4.1).

Protein differential expression in normal tissues for OR8A1 Gene

This gene is overexpressed in Saliva (51.6) and Islet of Langerhans (15.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR8A1 Gene

SOURCE GeneReport for Unigene cluster for OR8A1 Gene Hs.632104

genes like me logo Genes that share expressions with OR8A1: view

Expression partners for OR8A1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR8A1 Gene

Orthologs for OR8A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC783205 35
  • 87.59 (n)
  • 89.32 (a)
-- 36
  • 80 (a)
-- 36
  • 82 (a)
-- 36
  • 85 (a)
-- 36
  • 82 (a)
-- 36
  • 83 (a)
-- 36
  • 88 (a)
-- 36
  • 84 (a)
(Canis familiaris)
Mammalia OR8A1 35
  • 87.27 (n)
  • 89.32 (a)
OR8A1 36
  • 88 (a)
(Mus musculus)
Mammalia Olfr151 35
  • 83.06 (n)
  • 85.44 (a)
Olfr160 16
Olfr160 36
  • 85 (a)
(Pan troglodytes)
Mammalia LOC451635 35
  • 99.18 (n)
  • 98.77 (a)
OR8A1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Olr1194 35
  • 84.47 (n)
  • 87.38 (a)
(Monodelphis domestica)
Mammalia OR8A1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
Species with no ortholog for OR8A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8A1 Gene

Gene Tree for OR8A1 (if available)
Gene Tree for OR8A1 (if available)

Paralogs for OR8A1 Gene

Paralogs for OR8A1 Gene

Selected SIMAP similar genes for OR8A1 Gene using alignment to 1 proteins: Pseudogenes for OR8A1 Gene

genes like me logo Genes that share paralogs with OR8A1: view

Variants for OR8A1 Gene

Sequence variations from dbSNP and Humsavar for OR8A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1942659 -- 124,568,850(+) TTTCC(C/G)AAAAC upstream-variant-2KB
rs1942660 -- 124,569,987(+) AGGGC(A/G)GGGAG upstream-variant-2KB
rs2226753 -- 124,569,840(+) AGAAA(C/T)ACTGC upstream-variant-2KB
rs7103533 -- 124,569,521(+) CACTG(A/C)GTAAA upstream-variant-2KB
rs7103653 -- 124,569,618(+) CCATC(C/T)CCAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR8A1 Gene

Variant ID Type Subtype PubMed ID
nsv518199 CNV Gain 19592680

Relevant External Links for OR8A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8A1 Gene

Disorders for OR8A1 Gene

No disorders were found for OR8A1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR8A1 Gene

Publications for OR8A1 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR8A1 Gene

Sources for OR8A1 Gene

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