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Aliases for OR8A1 Gene

Aliases for OR8A1 Gene

  • Olfactory Receptor Family 8 Subfamily A Member 1 2 3 5
  • Olfactory Receptor OR11-318 3 4
  • OST025 3 4
  • Olfactory Receptor, Family 8, Subfamily A, Member 1 2
  • Olfactory Receptor 8A1 3
  • OR11-318 3

External Ids for OR8A1 Gene

Previous GeneCards Identifiers for OR8A1 Gene

  • GC00U990586
  • GC11P123978
  • GC11P123945
  • GC11P124439

Summaries for OR8A1 Gene

Entrez Gene Summary for OR8A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR8A1 Gene

OR8A1 (Olfactory Receptor Family 8 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR8G5.

UniProtKB/Swiss-Prot for OR8A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR8A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR8A1 Gene

Genomics for OR8A1 Gene

Regulatory Elements for OR8A1 Gene

Enhancers for OR8A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F124521 0.3 FANTOM5 43.8 -48.5 -48502 0.3 OR8A1 OR8B8 OR10G7 OR8G2 OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P
GH11F124588 0.4 FANTOM5 16.7 +19.1 19070 0.4 OR8A1 OR8G1 OR8D1 OR8D2 OR8G2 OR8B12 OR8B8 SPA17 OR8Q1P
GH11F124191 0.8 FANTOM5 4.3 -377.9 -377908 0.3 DDX20 MAFG VWA5A OR8A1 OR6X1 OR10G7 OR8G2 OR8B12 OR4D5 OR10G4 OR6M1 OR8G1
GH11F124642 1.3 FANTOM5 Ensembl ENCODE 3.1 +74.1 74059 2.5 ATF1 ARNT WRNIP1 YY1 GATA2 ZNF143 FOS REST KAT8 HMBOX1 SPA17 OR8A1 OR8B4 OR8D1 OR8G1 OR8D2 OR8B12 OR8B8 RNA5SP352
GH11F124078 0.6 FANTOM5 ENCODE 1.2 -489.9 -489947 3.3 PKNOX1 ATF1 ARNT ELK1 GATA2 JUNB NCOA1 MBD2 MEF2D SMARCA4 VWA5A MSANTD2 SPA17 OR8G2 OR8B12 OR8D1 OR8A1 LOC105369545 GC11M124060
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR8A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR8A1 Gene

124,569,997 bp from pter
124,602,563 bp from pter
32,567 bases
Plus strand

Genomic View for OR8A1 Gene

Genes around OR8A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR8A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR8A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR8A1 Gene

Proteins for OR8A1 Gene

  • Protein details for OR8A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 8A1
    Protein Accession:
    Secondary Accessions:
    • Q6IEW7
    • Q96RC6

    Protein attributes for OR8A1 Gene

    326 amino acids
    Molecular mass:
    36388 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC06052.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR8A1 Gene

Post-translational modifications for OR8A1 Gene

  • Glycosylation at Asn 22
  • Modification sites at PhosphoSitePlus

Other Protein References for OR8A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR8A1 Gene

Domains & Families for OR8A1 Gene

Gene Families for OR8A1 Gene

Protein Domains for OR8A1 Gene

Suggested Antigen Peptide Sequences for OR8A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR8A1: view

Function for OR8A1 Gene

Molecular function for OR8A1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR8A1: view
genes like me logo Genes that share phenotypes with OR8A1: view

Animal Models for OR8A1 Gene

MGI Knock Outs for OR8A1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OR8A1 Gene

Localization for OR8A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR8A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR8A1 Gene COMPARTMENTS Subcellular localization image for OR8A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR8A1: view

Pathways & Interactions for OR8A1 Gene

genes like me logo Genes that share pathways with OR8A1: view

Pathways by source for OR8A1 Gene

Interacting Proteins for OR8A1 Gene

Gene Ontology (GO) - Biological Process for OR8A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR8A1: view

No data available for SIGNOR curated interactions for OR8A1 Gene

Transcripts for OR8A1 Gene

mRNA/cDNA for OR8A1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR8A1 Gene

Olfactory receptor, family 8, subfamily A, member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR8A1 Gene

No ASD Table

Relevant External Links for OR8A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR8A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR8A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR8A1 Gene

This gene is overexpressed in Testis (x37.8) and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for OR8A1 Gene

This gene is overexpressed in Saliva (51.6) and Islet of Langerhans (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR8A1 Gene

Protein tissue co-expression partners for OR8A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR8A1 Gene:


SOURCE GeneReport for Unigene cluster for OR8A1 Gene:

genes like me logo Genes that share expression patterns with OR8A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR8A1 Gene

Orthologs for OR8A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR8A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC451635 34
  • 99.18 (n)
OR8A1 35
  • 99 (a)
(Bos Taurus)
Mammalia -- 35
  • 88 (a)
LOC783205 34
  • 87.59 (n)
-- 35
  • 85 (a)
-- 35
  • 84 (a)
-- 35
  • 83 (a)
-- 35
  • 82 (a)
-- 35
  • 82 (a)
-- 35
  • 80 (a)
(Canis familiaris)
Mammalia OR8A1 34 35
  • 87.27 (n)
(Mus musculus)
Mammalia Or8a1b 55 Olfr160 16 35
  • 85 (a)
Olfr151 34
  • 83.06 (n)
Or8a1-ps 55 Olfr151-ps1
  • chr9:37,730,056-37,730,981
Or8d6 55 Olfr974
  • chr9:39,942,262-39,943,191
(Rattus norvegicus)
Mammalia Olr1194 34
  • 84.47 (n)
(Monodelphis domestica)
Mammalia OR8A1 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
Species where no ortholog for OR8A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR8A1 Gene

Gene Tree for OR8A1 (if available)
Gene Tree for OR8A1 (if available)

Paralogs for OR8A1 Gene

Paralogs for OR8A1 Gene

(454) SIMAP similar genes for OR8A1 Gene using alignment to 1 proteins: Pseudogenes for OR8A1 Gene

genes like me logo Genes that share paralogs with OR8A1: view

Variants for OR8A1 Gene

Sequence variations from dbSNP and Humsavar for OR8A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10893268 -- 124,568,716(+) AGAGC(C/T)GAGGT upstream-variant-2KB
rs111755132 -- 124,570,154(+) AGAGT(C/T)CATTC reference, missense
rs111805939 -- 124,570,944(+) TCTGT(A/G)TTCTA reference, synonymous-codon
rs11219712 -- 124,568,418(+) AGATA(C/T)GCTAA upstream-variant-2KB
rs113509811 -- 124,571,176(+) GGGCA(G/T)TTTTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR8A1 Gene

Variant ID Type Subtype PubMed ID
nsv1045156 CNV loss 25217958
nsv518199 CNV gain 19592680

Variation tolerance for OR8A1 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.97; 92.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR8A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR8A1 Gene

Disorders for OR8A1 Gene

Relevant External Links for OR8A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR8A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR8A1 Gene

Publications for OR8A1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. (PMID: 25390645) Otowa T. … Hettema J.M. (PLoS ONE 2014) 3 64
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for OR8A1 Gene

Sources for OR8A1 Gene

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