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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR7E24 Gene

protein-coding   GIFtS: 45
GCID: GC19P009361

Olfactory Receptor, Family 7, Subfamily E, Member 24

(Previous names: olfactory receptor, family 7, subfamily E, member 24 pseudogene)
(Previous symbol: OR7E24P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 7, Subfamily E, Member 241 2     HSHT22
OR7E24P1 2 3     OR19-82
Olfactory Receptor OR19-142 3     OR7E24Q2
Olfactory Receptor, Family 7, Subfamily E, Member 24 Pseudogene1     Olfactory Receptor 7E242

External Ids:    HGNC: 83961   Entrez Gene: 266482   Ensembl: ENSG000002375217   UniProtKB: Q6IFN53   

Export aliases for OR7E24 gene to outside databases

Previous GC identifers: GC19P009221 GC19P009210 GC19P009213 GC19P009223


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR7E24 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR7E24 Gene: 
OR7E24 (olfactory receptor, family 7, subfamily E, member 24) is a protein-coding gene. Diseases associated with OR7E24 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot: O7E24_HUMAN, Q6IFN5
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR7E24 gene promoter:
         TBP   LHX3b/Lhx3b   AML1a   SREBP-1c   POU6F1 (c2)   SREBP-1b   SREBP-1a   TFIID   LHX3a/Lhx3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR7E24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

OR7E24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR7E24 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P009361:  view genomic region     (about GC identifiers)

Start:
9,361,720 bp from pter      End:
9,362,736 bp from pter
Size:
1,017 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O7E24_HUMAN, Q6IFN5 (See protein sequence)
Recommended Name: Olfactory receptor 7E24  
Size: 339 amino acids; 38279 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAD03353.1; Type=Erroneous gene model prediction;
Secondary accessions: B9EJD9 Q9UPJ1

Explore the universe of human proteins at neXtProt for OR7E24: NX_Q6IFN5

Explore proteomics data for OR7E24 at MOPED 

HORDE protein sequence for OR7E24
OR7E24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR7E24 Protein Expression

REFSEQ proteins: NP_001073404.1  
ENSEMBL proteins: 
 ENSP00000387523  
Reactome Protein details: Q6IFN5
Human Recombinant Protein Products for OR7E24: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR7E24 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR7: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q6IFN5

ProtoNet protein and cluster: Q6IFN5

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O7E24_HUMAN, Q6IFN5
Similarity: Belongs to the G-protein coupled receptor 1 family


OR7E24 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: O7E24_HUMAN, Q6IFN5
Function: Odorant receptor (Potential)

     Genatlas biochemistry entry for OR7E24:
olfactory receptor,family 7,subfamily E,member 24,G protein coupled receptor superfamily

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR7E24 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR7E24 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3GPCRs, Other
GPCRs, Other

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for OR7E24
    GPCRs, Other

4        Reactome Pathways for OR7E24
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR7E24):
    Olfactory transduction


OR7E24 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR7E24

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/273 Interacting proteins for OR7E24 (ENSP000003875234) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR10AD1ENSP000003086894STRING: ENSP00000308689
OR10H2ENSP000003060954STRING: ENSP00000306095
OR10J1ENSP000003990784STRING: ENSP00000399078
OR10P1ENSP000003080824STRING: ENSP00000308082
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR7E24 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR7E24 (O7E24)

Search CenterWatch for drugs/clinical trials and news about OR7E24 / O7E24

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR7E24 gene: 
NM_001079935.1  

Unigene Cluster for OR7E24:

Olfactory receptor, family 7, subfamily E, member 24
Hs.129832  [show with all ESTs]
Unigene Representative Sequence: BC146920
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000456448(uc002mlb.1)
miRNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR7E24

Additional mRNA sequence: 

BC146920.1 Y10529.1 

1 DOTS entry:

DT.202923 

5 AceView cDNA sequences:

BX279722 Y10529 BF062364 BE501015 AA758739 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR7E24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAGAATCAT
OR7E24 Expression
About this image


See OR7E24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR7E24

SOURCE GeneReport for Unigene cluster: Hs.129832
    SABiosciences Custom PCR Arrays for OR7E24
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OR7E24 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr181 , 5 olfactory receptor 181, 5 79.11(n)1
75.97(a)1
  9 (7.52 cM)5
183151  NM_146563.11  NP_666774.11 
 203138925 


ENSEMBL Gene Tree for OR7E24 (if available)
TreeFam Gene Tree for OR7E24 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR7E24 gene
18/455 SIMAP similar genes for OR7E24 using alignment to 1 protein entry:     O7E24_HUMAN(see all similar genes):
LOC441453    tpcr110    OR7E86P    OR7E5P    OR7A2P    OR7C2
OR7E85P    OR7G2    OR7G3    OR7A10    OR7A17    PJCG2
OR7D4    OR7E18P    OR7E35P    OR7G1    OR7A5    OR7C1

OR7E24 for paralogs           About GeneDecksing


5/80 Pseudogenes.org Pseudogenes for OR7E24 (see all 80)
PGOHUM00000258459 PGOHUM00000238360 PGOHUM00000238361 PGOHUM00000242117 PGOHUM00000250354


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/105 SNPs in OR7E24 are shown (see all 105)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1134931921,2
C,F--9359821(+) TATCCA/GGGAAC 1 -- us2k12Minor allele frequency- G:0.03WA 120
rs7588681,2
C,F,H--9359823(+) TCCAGG/CAACCT 1 -- us2k112Minor allele frequency- C:0.03MN NS EA NA WA 864
rs739207201,2
C,F--9359897(+) AGGATT/CGTGAG 1 -- us2k16Minor allele frequency- C:0.13NA WA EA 364
rs1875079821,2
--9360017(+) CTTAGG/TTCACA 1 -- us2k10--------
rs1458878081,2
C--9360158(+) CATAAC/TAATAG 1 -- us2k10--------
rs1385430721,2
--9360194(+) GACCAC/TGGCAG 1 -- us2k10--------
rs794415231,2
C,F--9360324(+) TAATGC/GCAAAG 1 -- us2k12Minor allele frequency- G:0.07WA NA 238
rs72494821,2
C,F--9360481(+) AAAATC/TAGCTG 1 -- us2k14Minor allele frequency- T:0.10NA WA 126
rs1910911101,2
--9360498(+) GTGGGA/GCGTGC 1 -- us2k10--------
rs1488178311,2
C--9360499(+) TGGGGC/TGTGCG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR7E24 ( 9361720 - 9362736 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OR7E24:    About this table     
Variant IDTypeSubtypePubMed ID
nsv911022CNV Loss21882294
nsv523472CNV Loss19592680
nsv911020CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR7E24:    About MalaCards
neuronitis    


OR7E24 for disorders           About GeneDecksing


Export disorders for OR7E24 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR7E24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR7E24)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
  3. Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. (PubMed id 9268701)1, 3 Vanderhaeghen P.... Parmentier M. (1997)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (2002)
  7. Expression of a testis-specific member of the olfactory receptor gene family in human primordial germ cells. (PubMed id 11385110)1 Goto T....Monk M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 26648 HGNC: 8396 AceView: OR7E24 Ensembl:ENSG00000237521 euGenes: HUgn26648
ECgene: OR7E24 Kegg: 26648 H-InvDB: OR7E24

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR7E24 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR7E24 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR7E24 gene:
Search GeneIP for patents involving OR7E24

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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