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Aliases for OR7D4 Gene

Aliases for OR7D4 Gene

  • Olfactory Receptor, Family 7, Subfamily D, Member 4 2 3
  • Olfactory Receptor OR19-7 3 4
  • OR7D4P 3 4
  • OR19-B 3 4
  • OR19B 3 6
  • Olfactory Receptor, Family 7, Subfamily D, Member 4 Pseudogene 3
  • Odorant Receptor Family 7 Subfamily D Member 4 RT 3
  • Odorant Receptor Family Subfamily D Member 4RT 4
  • Olfactory Receptor 7D4 3
  • OR19-7 3
  • Hg105 3

External Ids for OR7D4 Gene

Previous Symbols for OR7D4 Gene

  • OR7D4P

Summaries for OR7D4 Gene

Entrez Gene Summary for OR7D4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7D4 Gene

OR7D4 (Olfactory Receptor, Family 7, Subfamily D, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7G1.

UniProtKB/Swiss-Prot for OR7D4 Gene

  • Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone

Gene Wiki entry for OR7D4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7D4 Gene

Genomics for OR7D4 Gene

Genomic Location for OR7D4 Gene

Start:
9,213,850 bp from pter
End:
9,214,871 bp from pter
Size:
1,022 bases
Orientation:
Minus strand

Genomic View for OR7D4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR7D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7D4 Gene

Proteins for OR7D4 Gene

  • Protein details for OR7D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG98-OR7D4_HUMAN
    Recommended name:
    Olfactory receptor 7D4
    Protein Accession:
    Q8NG98
    Secondary Accessions:
    • A8CAH8
    • A8CAH9
    • A8CAI0
    • A8CAI1
    • B9EH79

    Protein attributes for OR7D4 Gene

    Size:
    312 amino acids
    Molecular mass:
    34448 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7D4 Gene

Proteomics data for OR7D4 Gene at MOPED

Post-translational modifications for OR7D4 Gene

Other Protein References for OR7D4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR7D4 Gene

Domains for OR7D4 Gene

Gene Families for OR7D4 Gene

HGNC:
  • OR7 :GPCR / Class A : Olfactory receptors

Protein Domains for OR7D4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NG98

UniProtKB/Swiss-Prot:

OR7D4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NG98
genes like me logo Genes that share domains with OR7D4: view

Function for OR7D4 Gene

Molecular function for OR7D4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone

Gene Ontology (GO) - Molecular Function for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR7D4: view
genes like me logo Genes that share phenotypes with OR7D4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR7D4 Gene

Localization for OR7D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7D4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR7D4 Gene COMPARTMENTS Subcellular localization image for OR7D4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR7D4: view

Pathways for OR7D4 Gene

genes like me logo Genes that share pathways with OR7D4: view

Pathways by source for OR7D4 Gene

Interacting Proteins for OR7D4 Gene

Gene Ontology (GO) - Biological Process for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR7D4: view

Transcripts for OR7D4 Gene

mRNA/cDNA for OR7D4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR7D4 Gene

Olfactory receptor, family 7, subfamily D, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR7D4 Gene

No ASD Table

Relevant External Links for OR7D4 Gene

GeneLoc Exon Structure for
OR7D4
ECgene alternative splicing isoforms for
OR7D4

Expression for OR7D4 Gene

mRNA expression in normal human tissues for OR7D4 Gene

mRNA differential expression in normal tissues according to GTEx for OR7D4 Gene

This gene is overexpressed in Testis (33.4), Brain - Hypothalamus (5.2), Brain - Cortex (4.9), Cervix - Ectocervix (4.8), and Cervix - Endocervix (4.6).

SOURCE GeneReport for Unigene cluster for OR7D4 Gene Hs.446910

mRNA Expression by UniProt/SwissProt for OR7D4 Gene

Q8NG98-OR7D4_HUMAN
Tissue specificity: Nasal olfactory epithelium.
genes like me logo Genes that share expressions with OR7D4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for OR7D4 Gene

Orthologs for OR7D4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7D4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR7D4 35
  • 98.93 (n)
  • 98.4 (a)
OR7D4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 70 (a)
ManyToMany
LOC785624 35
  • 71.1 (n)
  • 62.01 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
OneToMany
LOC484973 35
  • 85.04 (n)
  • 82.05 (a)
OR10A07 36
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr39 35
  • 78.46 (n)
  • 78.14 (a)
Olfr39 36
  • 76 (a)
OneToMany
Olfr77 16
Olfr77 36
  • 70 (a)
OneToMany
Olfr867 36
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
OPOR13 36
  • 60 (a)
ManyToMany
OPOR142 36
  • 61 (a)
ManyToMany
OPOR17 36
  • 65 (a)
ManyToMany
OPOR20 36
  • 64 (a)
ManyToMany
OPOR21 36
  • 62 (a)
ManyToMany
OPOR24 36
  • 61 (a)
ManyToMany
OPOR9 36
  • 64 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1186 35
  • 77.81 (n)
  • 76.53 (a)
Species with no ortholog for OR7D4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7D4 Gene

ENSEMBL:
Gene Tree for OR7D4 (if available)
TreeFam:
Gene Tree for OR7D4 (if available)

Paralogs for OR7D4 Gene

Paralogs for OR7D4 Gene

Selected SIMAP similar genes for OR7D4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for OR7D4 Gene

genes like me logo Genes that share paralogs with OR7D4: view

Variants for OR7D4 Gene

Sequence variations from dbSNP and Humsavar for OR7D4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1235784 -- 9,215,268(+) AACCC(A/G)GGAGG upstream-variant-2KB
rs2195952 -- 9,213,880(-) CAGAA(A/C)TAAGA utr-variant-3-prime
rs2878329 -- 9,215,066(+) TTGGC(C/T)GGGCA upstream-variant-2KB
rs4564704 - 9,213,964(+) CCTCA(G/T)GCTGT missense, reference
rs5020277 - 9,214,430(+) GGGTT(C/T)ATGAT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OR7D4 Gene

Variant ID Type Subtype PubMed ID
nsv911020 CNV Gain 21882294
nsv911021 CNV Loss 21882294
nsv523472 CNV Loss 19592680
nsv911022 CNV Loss 21882294

Relevant External Links for OR7D4 Gene

HapMap Linkage Disequilibrium report
OR7D4
Human Gene Mutation Database (HGMD)
OR7D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7D4 Gene

Disorders for OR7D4 Gene

Relevant External Links for OR7D4

Human Genome Epidemiology (HuGE) Navigator
OR7D4
genes like me logo Genes that share disorders with OR7D4: view

No data available for UniProtKB/Swiss-Prot for OR7D4 Gene

Publications for OR7D4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Genetic variation in a human odorant receptor alters odour perception. (PMID: 17873857) Keller A. … Matsunami H. (Nature 2007) 3 4
  3. Odor perception between heterosexual partners: its association with depression, anxiety, and genetic variation in odorant receptor OR7D4. (PMID: 21093532) Sookoian S. … Pirola C.J. (Biol Psychol 2011) 3
  4. Association between olfactory receptor genes, eating behavior traits and adiposity: results from the Quebec Family Study. (PMID: 22044667) Choquette A.C. … PAcrusse L. (Physiol. Behav. 2012) 3
  5. Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone. (PMID: 22567099) Lunde K. … Matsunami H. (PLoS ONE 2012) 3

Products for OR7D4 Gene

Sources for OR7D4 Gene

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