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Aliases for OR7D4 Gene

Aliases for OR7D4 Gene

  • Olfactory Receptor Family 7 Subfamily D Member 4 2 3 5
  • Olfactory Receptor OR19-7 3 4
  • OR7D4P 3 4
  • OR19-B 3 4
  • Olfactory Receptor, Family 7, Subfamily D, Member 4 Pseudogene 3
  • Olfactory Receptor, Family 7, Subfamily D, Member 4 2
  • Odorant Receptor Family 7 Subfamily D Member 4 RT 3
  • Odorant Receptor Family Subfamily D Member 4RT 4
  • Olfactory Receptor 7D4 3
  • OR19-7 3
  • OR19B 3
  • Hg105 3

External Ids for OR7D4 Gene

Previous HGNC Symbols for OR7D4 Gene

  • OR7D4P

Previous GeneCards Identifiers for OR7D4 Gene

  • GC19M009186
  • GC19M009187
  • GC19M009324

Summaries for OR7D4 Gene

Entrez Gene Summary for OR7D4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7D4 Gene

OR7D4 (Olfactory Receptor Family 7 Subfamily D Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7D2.

UniProtKB/Swiss-Prot for OR7D4 Gene

  • Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

Gene Wiki entry for OR7D4 Gene

Additional gene information for OR7D4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7D4 Gene

Genomics for OR7D4 Gene

Regulatory Elements for OR7D4 Gene

Enhancers for OR7D4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H009638 0.3 FANTOM5 14.8 -418.8 -418763 0 ZNF561 OR7D4 ZNF846 ZNF177 OR7E24 OLFM2 ZNF559 ZNF562 ZNF426 ZNF559-ZNF177
GH19H009666 0.4 FANTOM5 1.5 -446.6 -446625 0 ZNF846 ZNF559 ZNF559-ZNF177 OR7D4 ZNF121 ZNF426 OLFM2 ZNF177 PIR46077 ZNF562
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR7D4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR7D4 Gene

Chromosome:
19
Start:
9,210,276 bp from pter
End:
9,219,589 bp from pter
Size:
9,314 bases
Orientation:
Minus strand

Genomic View for OR7D4 Gene

Genes around OR7D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7D4 Gene

Proteins for OR7D4 Gene

  • Protein details for OR7D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG98-OR7D4_HUMAN
    Recommended name:
    Olfactory receptor 7D4
    Protein Accession:
    Q8NG98
    Secondary Accessions:
    • A8CAH8
    • A8CAH9
    • A8CAI0
    • A8CAI1
    • B9EH79

    Protein attributes for OR7D4 Gene

    Size:
    312 amino acids
    Molecular mass:
    34448 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7D4 Gene

Post-translational modifications for OR7D4 Gene

Other Protein References for OR7D4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7D4 Gene

Domains & Families for OR7D4 Gene

Gene Families for OR7D4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7D4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NG98

UniProtKB/Swiss-Prot:

OR7D4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7D4: view

Function for OR7D4 Gene

Molecular function for OR7D4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.

Gene Ontology (GO) - Molecular Function for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR7D4: view
genes like me logo Genes that share phenotypes with OR7D4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR7D4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7D4 Gene

Localization for OR7D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7D4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7D4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR7D4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7D4 Gene

Pathways & Interactions for OR7D4 Gene

genes like me logo Genes that share pathways with OR7D4: view

Pathways by source for OR7D4 Gene

Interacting Proteins for OR7D4 Gene

Gene Ontology (GO) - Biological Process for OR7D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR7D4: view

No data available for SIGNOR curated interactions for OR7D4 Gene

Drugs & Compounds for OR7D4 Gene

No Compound Related Data Available

Transcripts for OR7D4 Gene

mRNA/cDNA for OR7D4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR7D4 Gene

Olfactory receptor, family 7, subfamily D, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR7D4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR7D4 Gene

No ASD Table

Relevant External Links for OR7D4 Gene

GeneLoc Exon Structure for
OR7D4
ECgene alternative splicing isoforms for
OR7D4

Expression for OR7D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR7D4 Gene

mRNA differential expression in normal tissues according to GTEx for OR7D4 Gene

This gene is overexpressed in Testis (x33.4), Brain - Hypothalamus (x5.2), Brain - Cortex (x4.9), Cervix - Ectocervix (x4.8), and Cervix - Endocervix (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of OR7D4 Gene:

OR7D4

SOURCE GeneReport for Unigene cluster for OR7D4 Gene:

Hs.446910

mRNA Expression by UniProt/SwissProt for OR7D4 Gene:

Q8NG98-OR7D4_HUMAN
Tissue specificity: Nasal olfactory epithelium.
genes like me logo Genes that share expression patterns with OR7D4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7D4 Gene

Orthologs for OR7D4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7D4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR7D4 33 34
  • 98.93 (n)
dog
(Canis familiaris)
Mammalia LOC484973 33
  • 85.04 (n)
-- 34
  • 82 (a)
OneToMany
OR10A07 34
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or7d41 52 Olfr39 33 16 34
  • 78.46 (n)
Or7d42 52 Olfr77 34
  • 70 (a)
OneToMany
Or7d43 52 Olfr867 34
  • 68 (a)
OneToMany
Or7d45-ps 52 Olfr861-ps1
  • chr9:19,875,907-19,876,577
rat
(Rattus norvegicus)
Mammalia Olr1186 33
  • 77.81 (n)
cow
(Bos Taurus)
Mammalia LOC785624 33
  • 71.1 (n)
-- 34
  • 70 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
OPOR17 34
  • 65 (a)
ManyToMany
-- 34
  • 64 (a)
ManyToMany
OPOR20 34
  • 64 (a)
ManyToMany
OPOR9 34
  • 64 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
-- 34
  • 62 (a)
ManyToMany
OPOR21 34
  • 62 (a)
ManyToMany
OPOR142 34
  • 61 (a)
ManyToMany
OPOR24 34
  • 61 (a)
ManyToMany
-- 34
  • 60 (a)
ManyToMany
OPOR13 34
  • 60 (a)
ManyToMany
-- 34
  • 59 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
ManyToMany
-- 34
  • 58 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
Species where no ortholog for OR7D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7D4 Gene

ENSEMBL:
Gene Tree for OR7D4 (if available)
TreeFam:
Gene Tree for OR7D4 (if available)

Paralogs for OR7D4 Gene

Paralogs for OR7D4 Gene

(459) SIMAP similar genes for OR7D4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for OR7D4 Gene

genes like me logo Genes that share paralogs with OR7D4: view

Variants for OR7D4 Gene

Sequence variations from dbSNP and Humsavar for OR7D4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000162779 -- 9,215,690(+) AGGAA(C/T)ATCAA upstream-variant-2KB
rs1001047207 -- 9,215,164(+) ATGGT(A/G/T)AAACC upstream-variant-2KB
rs1001076415 -- 9,215,012(+) TTCTA(C/T)TTGTG upstream-variant-2KB
rs1001388855 -- 9,216,418(+) ACCAT(A/T)GAGAA upstream-variant-2KB
rs1001568538 -- 9,215,029(+) TATCC(A/G)GCCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR7D4 Gene

Variant ID Type Subtype PubMed ID
nsv523472 CNV loss 19592680
nsv963001 CNV duplication 23825009

Variation tolerance for OR7D4 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.58; 82.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR7D4 Gene

Human Gene Mutation Database (HGMD)
OR7D4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7D4 Gene

Disorders for OR7D4 Gene

Relevant External Links for OR7D4

Human Genome Epidemiology (HuGE) Navigator
OR7D4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR7D4

No disorders were found for OR7D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7D4 Gene

Publications for OR7D4 Gene

  1. Genetic variation in a human odorant receptor alters odour perception. (PMID: 17873857) Keller A … Matsunami H (Nature 2007) 3 4 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  3. Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution. (PMID: 26072518) Hoover KC … Matsunami H (Chemical senses 2015) 3 60
  4. Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone. (PMID: 22567099) Lunde K … Matsunami H (PloS one 2012) 3 60
  5. Association between olfactory receptor genes, eating behavior traits and adiposity: results from the Quebec Family Study. (PMID: 22044667) Choquette AC … Pérusse L (Physiology & behavior 2012) 3 60

Products for OR7D4 Gene

Sources for OR7D4 Gene

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