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Aliases for OR7D2 Gene

Aliases for OR7D2 Gene

  • Olfactory Receptor Family 7 Subfamily D Member 2 2 3 5
  • Olfactory Receptor, Family 7, Subfamily D, Member 2 2 3
  • Olfactory Receptor OR19-10 3 4
  • Olfactory Receptor 19-4 3 4
  • HTPCRH03 3 4
  • OR19-4 3 4
  • OR19-10 3

External Ids for OR7D2 Gene

Previous GeneCards Identifiers for OR7D2 Gene

  • GC19U990187
  • GC19P009298

Summaries for OR7D2 Gene

Entrez Gene Summary for OR7D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7D2 Gene

OR7D2 (Olfactory Receptor Family 7 Subfamily D Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A17.

UniProtKB/Swiss-Prot for OR7D2 Gene

  • Odorant receptor.

Gene Wiki entry for OR7D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7D2 Gene

Genomics for OR7D2 Gene

Regulatory Elements for OR7D2 Gene

Genomic Location for OR7D2 Gene

Chromosome:
19
Start:
9,185,594 bp from pter
End:
9,188,817 bp from pter
Size:
3,224 bases
Orientation:
Plus strand

Genomic View for OR7D2 Gene

Genes around OR7D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7D2 Gene

Proteins for OR7D2 Gene

  • Protein details for OR7D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RA2-OR7D2_HUMAN
    Recommended name:
    Olfactory receptor 7D2
    Protein Accession:
    Q96RA2
    Secondary Accessions:
    • Q6IFJ7
    • Q8N133

    Protein attributes for OR7D2 Gene

    Size:
    312 amino acids
    Molecular mass:
    34747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7D2 Gene

Proteomics data for OR7D2 Gene at MOPED

Post-translational modifications for OR7D2 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR7D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7D2 Gene

Domains & Families for OR7D2 Gene

Gene Families for OR7D2 Gene

Protein Domains for OR7D2 Gene

Suggested Antigen Peptide Sequences for OR7D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RA2

UniProtKB/Swiss-Prot:

OR7D2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7D2: view

Function for OR7D2 Gene

Molecular function for OR7D2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily D,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Animal Model Products

CRISPR Products

miRNA for OR7D2 Gene

miRTarBase miRNAs that target OR7D2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR7D2 Gene

Localization for OR7D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7D2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR7D2 Gene COMPARTMENTS Subcellular localization image for OR7D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR7D2: view

Pathways & Interactions for OR7D2 Gene

genes like me logo Genes that share pathways with OR7D2: view

Pathways by source for OR7D2 Gene

Interacting Proteins for OR7D2 Gene

Gene Ontology (GO) - Biological Process for OR7D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR7D2: view

No data available for SIGNOR curated interactions for OR7D2 Gene

Drugs & Compounds for OR7D2 Gene

No Compound Related Data Available

Transcripts for OR7D2 Gene

mRNA/cDNA for OR7D2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR7D2 Gene

Olfactory receptor, family 7, subfamily D, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR7D2 Gene

No ASD Table

Relevant External Links for OR7D2 Gene

GeneLoc Exon Structure for
OR7D2
ECgene alternative splicing isoforms for
OR7D2

Expression for OR7D2 Gene

mRNA expression in normal human tissues for OR7D2 Gene

mRNA differential expression in normal tissues according to GTEx for OR7D2 Gene

This gene is overexpressed in Testis (x7.7).

SOURCE GeneReport for Unigene cluster for OR7D2 Gene Hs.531755

genes like me logo Genes that share expression patterns with OR7D2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR7D2 Gene

Orthologs for OR7D2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR7D2 35
  • 87.39 (n)
  • 86.86 (a)
OR7D2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC611376 35
  • 87.29 (n)
  • 88.78 (a)
-- 36
  • 63 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC468710 35
  • 99.04 (n)
  • 98.4 (a)
OR7D2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1193 35
  • 68.42 (n)
  • 64.8 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
OPOR13 36
  • 59 (a)
ManyToMany
OPOR142 36
  • 60 (a)
ManyToMany
OPOR17 36
  • 64 (a)
ManyToMany
OPOR20 36
  • 63 (a)
ManyToMany
OPOR21 36
  • 61 (a)
ManyToMany
OPOR24 36
  • 61 (a)
ManyToMany
OPOR9 36
  • 63 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr871 36
  • 62 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
Species with no ortholog for OR7D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7D2 Gene

ENSEMBL:
Gene Tree for OR7D2 (if available)
TreeFam:
Gene Tree for OR7D2 (if available)

Paralogs for OR7D2 Gene

Paralogs for OR7D2 Gene

(456) SIMAP similar genes for OR7D2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR7D2 Gene

genes like me logo Genes that share paralogs with OR7D2: view

Variants for OR7D2 Gene

Sequence variations from dbSNP and Humsavar for OR7D2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs13345452 - 9,186,371(+) CAGCA(C/T)GTTGA reference, missense
rs7246654 -- 9,187,198(+) CGCCC(A/G)GCCAA utr-variant-3-prime
rs6511918 -- 9,187,688(+) catat(C/T)ccttt utr-variant-3-prime
rs7247330 -- 9,187,847(+) agttg(A/C)tacaa utr-variant-3-prime
rs8109554 -- 9,183,798(+) taaaa(A/G)tacaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR7D2 Gene

Variant ID Type Subtype PubMed ID
nsv509720 CNV Insertion 20534489
nsv911020 CNV Gain 21882294
nsv2411 CNV Loss 18451855
nsv911021 CNV Loss 21882294
nsv516657 CNV Gain 19592680
nsv523472 CNV Loss 19592680
nsv911022 CNV Loss 21882294

Variation tolerance for OR7D2 Gene

Residual Variation Intolerance Score: 74.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR7D2 Gene

HapMap Linkage Disequilibrium report
OR7D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7D2 Gene

Disorders for OR7D2 Gene

Relevant External Links for OR7D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR7D2

No disorders were found for OR7D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7D2 Gene

Publications for OR7D2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. (PMID: 12175488) Wilanowski T. … Jane S.M. (Mech. Dev. 2002) 3
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  5. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 3

Products for OR7D2 Gene

Sources for OR7D2 Gene

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