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OR7C2 Gene

protein-coding   GIFtS: 50
GCID: GC19P015052

Olfactory Receptor, Family 7, Subfamily C, Member 2


(Previous symbol: OR7C3)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 7, Subfamily C, Member 21 2     OR19-182 3
OR7C31 2 3     CIT-HSP-87M172
Olfactory Receptor 19-182 3     Olfactory Receptor 7C22
Olfactory Receptor 7C32 3     Olfactory Receptor, Family 7, Subfamily C, Member 32
Olfactory Receptor OR19-222 3     

External Ids:    HGNC: 83741   Entrez Gene: 266582   Ensembl: ENSG000001275297   UniProtKB: O604123   

Export aliases for OR7C2 gene to outside databases

Previous GC identifers: GC19P015431 GC19P014853 GC19P014913 GC19P014869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR7C2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR7C2 Gene:
OR7C2 (olfactory receptor, family 7, subfamily C, member 2) is a protein-coding gene. Diseases associated with OR7C2 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A10.

UniProtKB/Swiss-Prot: OR7C2_HUMAN, O60412
Function: Odorant receptor (Potential)

Gene Wiki entry for OR7C2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR7C2 gene promoter:
         GR   AML1a   GR-beta   CUTL1   RelA   NF-kappaB   E47   HNF-4alpha1   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR7C2 promoter sequence
   Search Chromatin IP Primers for OR7C2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR7C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

OR7C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR7C2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015052:  view genomic region     (about GC identifiers)

Start:
15,052,301 bp from pter      End:
15,053,257 bp from pter
Size:
957 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR7C2_HUMAN, O60412 (See protein sequence)
Recommended Name: Olfactory receptor 7C2  
Size: 319 amino acids; 35323 Da
Sequence caution: Sequence=DAA04611.1; Type=Erroneous initiation;
Secondary accessions: O43881 Q6IFP9

Explore the universe of human proteins at neXtProt for OR7C2: NX_O60412

Explore proteomics data for OR7C2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR7C2

    See OR7C2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036509.1  
    ENSEMBL proteins: 
     ENSP00000248072  
    Reactome Protein details: O60412

    OR7C2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR7: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O60412

    ProtoNet protein and cluster: O60412

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR7C2_HUMAN, O60412
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR7C2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR7C2_HUMAN, O60412
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR7C2:
    olfactory receptor,family 7,subfamily C,member 2,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR7C2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR7C2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR7C2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR7C2_HUMAN, O60412: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR7C2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR7C2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR7C2
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR7C2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR7C2):
        Olfactory transduction


    OR7C2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR7C2
    Interactions:

        Search GeneGlobe Interaction Network for OR7C2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR7C2 (ENSP000002480724) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10P1ENSP000003080824STRING: ENSP00000308082
    OR1B1ENSP000003031514STRING: ENSP00000303151
    OR1D2ENSP000003275854STRING: ENSP00000327585
    OR4F15ENSP000003331844STRING: ENSP00000333184
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR7C2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR7C2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR7C2 gene: 
    NM_012377.1  

    Unigene Cluster for OR7C2:

    Olfactory receptor, family 7, subfamily C, member 2
    Hs.589620
    Unigene Representative Sequence: BC110063
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248072(uc010xoc.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR7C2

    Additional mRNA sequence: BC110063.1 

    1 DOTS entry:

    DT.99958183 

    1 AceView cDNA sequence:

    NM_012377 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR7C2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGGTCAC
    OR7C2 Expression
    About this image

    OR7C2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR7C2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.589620
        Custom PCR Arrays for OR7C2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR7C2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr13561 , 5 olfactory receptor 13561, 5 78.62(n)1
    72.01(a)1
      10 (39.72 cM)5
    2583051  NM_146308.21  NP_666420.21 
     788469515 


    ENSEMBL Gene Tree for OR7C2 (if available)
    TreeFam Gene Tree for OR7C2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR7C2 gene
    OR7A102  OR7A52  OR7G12  OR7G32  OR7A172  OR7D42  OR7C12  OR7D22  
    OR7G22  
    Selected SIMAP similar genes for OR7C2 using alignment to 1 protein entry:     OR7C2_HUMAN(see all similar genes):
    OR7C1    OR7A2P    OR7A5    OR7A10    OR7A17    OR7D4
    OR7D2    OR7E24    OR7G1    OR7G3    OR7E86P    OR7G2
    tpcr110    OR1D2    OR1E1    OR1G1    OR17-130    OR1F2P

    OR7C2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR7C2 (see all 177)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72469261,2
    C,F,A,H--14618121(+) TAAGAG/CTGTGA 1 -- us2k18Minor allele frequency- C:0.30NA WA EA 368
    rs1501166871,2
    C--14618149(+) TGTTT-/TTGTTGTT 1 -- us2k10--------
    rs777204831,2
    C--14618164(+) TGTTGG/TTGTTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs787506011,2
    C--14618167(+) TGTTGG/TTGTTT 1 -- us2k10--------
    rs2012357171,2
    --14618167(+) TGTTG-/TTGTTT 1 -- us2k10--------
    rs1499426141,2
    C--15050384(+) CACCAC/TGCCCA 1 -- us2k10--------
    rs621161861,2
    C--15050484(+) GCCTCG/CGAAAG 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs81052271,2
    C,F,A--15050515(+) gccacT/Cgcgcc 1 -- us2k14Minor allele frequency- C:0.43NA WA CSA 7
    rs1173423221,2
    C,F--15050526(+) CGGCCG/AGAAAT 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs352587151,2
    C--15050552(+) AAAAA-/CAACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR7C2 ( 15052301 - 15053257 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OR7C2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510756CNV Loss20534489
    nsv2424CNV Loss18451855
    nsv911129CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR7C2:    About MalaCards
    neuronitis


    OR7C2 for disorders           About GeneDecksing


    Export disorders for OR7C2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR7C2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR7C2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    4. Distribution of olfactory receptor genes in the human genome. (PubMed id 9500546)1, 2 Rouquier S.... Giorgi D. (Nat. Genet. 1998)
    5. Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. (PubMed id 22552337)1 Kim R.N....Park H.S. (J. Genet. 2012)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26658 HGNC: 8374 AceView: OR7C2 Ensembl:ENSG00000127529 euGenes: HUgn26658
    ECgene: OR7C2 Kegg: 26658 H-InvDB: OR7C2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR7C2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR7C2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR7C2 gene:
    Search GeneIP for patents involving OR7C2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for OR7C2   OriGene RNAi products in human, mouse, rat for OR7C2  
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     OriGene Custom Mass Spec   OriGene clones in human, mouse for OR7C2  
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     OriGene Custom Antibody Services for OR7C2   OriGene Custom Protein Services for OR7C2  

     
     
     Block miRNA regulation of human, mouse, rat OR7C2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR7C2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR7C2 Predesigned siRNA for gene silencing in human, mouse, rat OR7C2
     QuantiFast Probe-based Assays in human, mouse, rat OR7C2 QuantiTect SYBR Green Assays in human, mouse, rat OR7C2
     Custom PCR Arrays for OR7C2 Search Chromatin IP Primers for OR7C2
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     Search Tocris compounds for OR7C2
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR7C2
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for OR7C2
     SwitchGear Promoter luciferase reporter plasmids for OR7C2
     Search ThermoFisher Antibodies for OR7C2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR7C2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR7C2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OR7C2
     LSBio Antibodies in human, mouse, rat for OR7C2
    Customized transgenic rodents for:
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