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Aliases for OR7C2 Gene

Aliases for OR7C2 Gene

  • Olfactory Receptor, Family 7, Subfamily C, Member 2 2 3
  • Olfactory Receptor OR19-22 3 4
  • Olfactory Receptor 19-18 3 4
  • Olfactory Receptor 7C3 3 4
  • OR19-18 3 4
  • OR7C3 3 4
  • Olfactory Receptor, Family 7, Subfamily C, Member 3 3
  • Olfactory Receptor 7C2 3
  • CIT-HSP-87M17 3

External Ids for OR7C2 Gene

Previous Symbols for OR7C2 Gene

  • OR7C3

Summaries for OR7C2 Gene

Entrez Gene Summary for OR7C2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7C2 Gene

OR7C2 (Olfactory Receptor, Family 7, Subfamily C, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7G1.

UniProtKB/Swiss-Prot for OR7C2 Gene

  • Odorant receptor.

Gene Wiki entry for OR7C2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7C2 Gene

Genomics for OR7C2 Gene

Genomic Location for OR7C2 Gene

Start:
14,941,489 bp from pter
End:
14,942,448 bp from pter
Size:
960 bases
Orientation:
Plus strand

Genomic View for OR7C2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR7C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7C2 Gene

Regulatory Elements for OR7C2 Gene

Proteins for OR7C2 Gene

  • Protein details for OR7C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60412-OR7C2_HUMAN
    Recommended name:
    Olfactory receptor 7C2
    Protein Accession:
    O60412
    Secondary Accessions:
    • O43881
    • Q6IFP9

    Protein attributes for OR7C2 Gene

    Size:
    319 amino acids
    Molecular mass:
    35323 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04611.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR7C2 Gene

Proteomics data for OR7C2 Gene at MOPED

Post-translational modifications for OR7C2 Gene

Other Protein References for OR7C2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR7C2 Gene

Domains for OR7C2 Gene

Gene Families for OR7C2 Gene

HGNC:
  • OR7 :GPCR / Class A : Olfactory receptors

Protein Domains for OR7C2 Gene

UniProtKB/Swiss-Prot:

OR7C2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • O60412
genes like me logo Genes that share domains with OR7C2: view

Function for OR7C2 Gene

Molecular function for OR7C2 Gene

GENATLAS Biochemistry: olfactory receptor,family 7,subfamily C,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR7C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR7C2: view

Phenotypes for OR7C2 Gene

GenomeRNAi human phenotypes for OR7C2:
genes like me logo Genes that share phenotypes with OR7C2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR7C2 Gene

Localization for OR7C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7C2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR7C2 Gene COMPARTMENTS Subcellular localization image for OR7C2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR7C2: view

Pathways for OR7C2 Gene

genes like me logo Genes that share pathways with OR7C2: view

Pathways by source for OR7C2 Gene

1 KEGG pathway for OR7C2 Gene

Interacting Proteins for OR7C2 Gene

Gene Ontology (GO) - Biological Process for OR7C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR7C2: view

Transcripts for OR7C2 Gene

mRNA/cDNA for OR7C2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR7C2 Gene

No ASD Table

Relevant External Links for OR7C2 Gene

GeneLoc Exon Structure for
OR7C2
ECgene alternative splicing isoforms for
OR7C2

Expression for OR7C2 Gene

mRNA expression in normal human tissues for OR7C2 Gene

SOURCE GeneReport for Unigene cluster for OR7C2 Gene Hs.589620

genes like me logo Genes that share expressions with OR7C2: view

Orthologs for OR7C2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468751 36
  • 99.16 (n)
  • 98.12 (a)
OR7C2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR7C2 36
  • 82.65 (n)
  • 75.86 (a)
OR7C2 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR08B08 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1356 36
  • 78.62 (n)
  • 72.01 (a)
Olfr1356 16
Olfr1356 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 65 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 61 (a)
ManyToMany
-- 37
  • 61 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 64 (a)
ManyToMany
OPOR13 37
  • 60 (a)
ManyToMany
OPOR142 37
  • 59 (a)
ManyToMany
OPOR17 37
  • 65 (a)
ManyToMany
OPOR20 37
  • 66 (a)
ManyToMany
OPOR21 37
  • 61 (a)
ManyToMany
OPOR24 37
  • 63 (a)
ManyToMany
OPOR9 37
  • 63 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 59 (a)
ManyToMany
-- 37
  • 58 (a)
ManyToMany
-- 37
  • 56 (a)
ManyToMany
-- 37
  • 61 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1086 36
  • 78.27 (n)
  • 72.78 (a)
Species with no ortholog for OR7C2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7C2 Gene

ENSEMBL:
Gene Tree for OR7C2 (if available)
TreeFam:
Gene Tree for OR7C2 (if available)

Paralogs for OR7C2 Gene

Paralogs for OR7C2 Gene

Selected SIMAP similar genes for OR7C2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR7C2: view

Variants for OR7C2 Gene

Sequence variations from dbSNP and Humsavar for OR7C2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3044711 -- 14,942,171(-) CAGAT(-/AT/GAT)ACTCT reference, frameshift-variant, cds-indel
rs7254663 -- 14,940,744(+) catga(A/G)aattg upstream-variant-2KB
rs7256098 -- 14,941,099(+) caaga(C/T)tctgc upstream-variant-2KB
rs7256099 -- 14,941,101(+) agact(C/G)tgcca upstream-variant-2KB
rs7256506 -- 14,941,078(+) gaggc(A/G)gaggt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR7C2 Gene

Variant ID Type Subtype PubMed ID
nsv911129 CNV Loss 21882294
nsv510756 CNV Loss 20534489
nsv2424 CNV Loss 18451855

Relevant External Links for OR7C2 Gene

HapMap Linkage Disequilibrium report
OR7C2

Disorders for OR7C2 Gene

No disorders were found for OR7C2 Gene.

No data available for UniProtKB/Swiss-Prot for OR7C2 Gene

Publications for OR7C2 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  5. Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. (PMID: 22552337) Kim R.N. … Park H.S. (J. Genet. 2012) 3

Products for OR7C2 Gene

Sources for OR7C2 Gene

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