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Aliases for OR7C1 Gene

Aliases for OR7C1 Gene

  • Olfactory Receptor Family 7 Subfamily C Member 1 2 3 5
  • Olfactory Receptor OR19-16 3 4
  • Olfactory Receptor TPCR86 3 4
  • Olfactory Receptor 7C4 3 4
  • OR7C4 3 4
  • Olfactory Receptor, Family 7, Subfamily C, Member 1 2
  • Olfactory Receptor, Family 7, Subfamily C, Member 4 3
  • Olfactory Receptor 7C1 3
  • CIT-HSP-146E8 3
  • HSTPCR86P 3
  • OR19-5 3
  • TPCR86 3

External Ids for OR7C1 Gene

Previous HGNC Symbols for OR7C1 Gene

  • OR7C4

Previous GeneCards Identifiers for OR7C1 Gene

  • GC19M015278
  • GC19M015330
  • GC19M014782
  • GC19M014770
  • GC19M014909
  • GC19M014801
  • GC19M014797

Summaries for OR7C1 Gene

Entrez Gene Summary for OR7C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7C1 Gene

OR7C1 (Olfactory Receptor Family 7 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7C2.

UniProtKB/Swiss-Prot for OR7C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR7C1 Gene

Additional gene information for OR7C1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7C1 Gene

Genomics for OR7C1 Gene

Regulatory Elements for OR7C1 Gene

Enhancers for OR7C1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H014671 1.4 FANTOM5 Ensembl ENCODE 9.8 +161.2 161229 4.9 TAL1 MAX EBF1 CEBPG TCF12 CTBP1 POLR2A NFE2 SOX6 HLF ADGRE3 ZNF333 OR7C1 ADGRE5 OR7A5 PKN1 ENSG00000275432
GH19H015123 1.4 ENCODE dbSUPER 9.8 -289.9 -289876 3.7 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 AKAP8 BRD4 ZNF333 TPM4 AKAP8L OR10H2 OR1AB1P LINC01855 OR10H5 LINC00905
GH19H015245 1.4 Ensembl ENCODE dbSUPER 9.5 -414.8 -414783 8.6 PKNOX1 ZFP64 ARID4B KLF17 RAD21 SCRT2 FOS EGR2 SMARCC1 ZNF680 AKAP8L AKAP8 RNU6-782P OR7C1 PIR55370 GC19P015251 GC19M015250
GH19H014888 1.1 Ensembl ENCODE 11.1 -53.5 -53494 1.3 CTCF PKNOX1 ATF1 JUN MAX EBF1 ZNF2 RAD21 FOSL1 DIDO1 OR7C1 RNU6-782P OR7A5 OR7A18P OR7A1P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR7C1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR7C1 Gene

Genomic Locations for OR7C1 Gene
46,117 bases
Minus strand

Genomic View for OR7C1 Gene

Genes around OR7C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7C1 Gene

Proteins for OR7C1 Gene

  • Protein details for OR7C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 7C1
    Protein Accession:
    Secondary Accessions:
    • Q15621
    • Q6IFP2
    • Q96R94

    Protein attributes for OR7C1 Gene

    320 amino acids
    Molecular mass:
    35519 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7C1 Gene

Post-translational modifications for OR7C1 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR7C1 Gene

No data available for DME Specific Peptides for OR7C1 Gene

Domains & Families for OR7C1 Gene

Gene Families for OR7C1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7C1 Gene

Suggested Antigen Peptide Sequences for OR7C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7C1: view

Function for OR7C1 Gene

Molecular function for OR7C1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily C,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR7C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS,IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR7C1: view

Phenotypes for OR7C1 Gene

genes like me logo Genes that share phenotypes with OR7C1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7C1 Gene

Localization for OR7C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR7C1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7C1 Gene

Pathways & Interactions for OR7C1 Gene

genes like me logo Genes that share pathways with OR7C1: view

Pathways by source for OR7C1 Gene

1 KEGG pathway for OR7C1 Gene

Interacting Proteins for OR7C1 Gene

Gene Ontology (GO) - Biological Process for OR7C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007283 spermatogenesis TAS 9268701
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR7C1: view

No data available for SIGNOR curated interactions for OR7C1 Gene

Drugs & Compounds for OR7C1 Gene

No Compound Related Data Available

Transcripts for OR7C1 Gene

mRNA/cDNA for OR7C1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR7C1 Gene

Olfactory receptor, family 7, subfamily C, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR7C1 Gene

No ASD Table

Relevant External Links for OR7C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR7C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR7C1 Gene

mRNA differential expression in normal tissues according to GTEx for OR7C1 Gene

This gene is overexpressed in Pituitary (x9.3), Testis (x9.2), Skin - Sun Exposed (Lower leg) (x4.4), and Adrenal Gland (x4.1).

Protein differential expression in normal tissues from HIPED for OR7C1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR7C1 Gene

Protein tissue co-expression partners for OR7C1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR7C1 Gene:


SOURCE GeneReport for Unigene cluster for OR7C1 Gene:

genes like me logo Genes that share expression patterns with OR7C1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7C1 Gene

Orthologs for OR7C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC748178 33
  • 98.12 (n)
OR7C1 34
  • 97 (a)
(Canis familiaris)
Mammalia -- 34
  • 79 (a)
OR10D01 34
  • 78 (a)
LOC102151861 33
  • 74.63 (n)
(Bos Taurus)
Mammalia OR7A10 33
  • 74.11 (n)
-- 34
  • 68 (a)
(Rattus norvegicus)
Mammalia Olr1077 33
  • 69.18 (n)
(Mus musculus)
Mammalia Or7c19 52 Olfr371 34
  • 69 (a)
Olfr1352 33 16
  • 67.98 (n)
Or7b1-ps 52 Olfr1327-ps1
  • chrX:74,762,037-74,762,879
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
-- 34
  • 67 (a)
-- 34
  • 67 (a)
OPOR20 34
  • 67 (a)
-- 34
  • 66 (a)
-- 34
  • 65 (a)
OPOR17 34
  • 65 (a)
OPOR9 34
  • 65 (a)
OPOR24 34
  • 64 (a)
-- 34
  • 63 (a)
-- 34
  • 63 (a)
OPOR142 34
  • 63 (a)
OPOR21 34
  • 63 (a)
-- 34
  • 62 (a)
-- 34
  • 62 (a)
OPOR13 34
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
-- 34
  • 60 (a)
-- 34
  • 59 (a)
-- 34
  • 55 (a)
Species where no ortholog for OR7C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7C1 Gene

Gene Tree for OR7C1 (if available)
Gene Tree for OR7C1 (if available)

Paralogs for OR7C1 Gene

Paralogs for OR7C1 Gene

(455) SIMAP similar genes for OR7C1 Gene using alignment to 1 proteins: Pseudogenes for OR7C1 Gene

genes like me logo Genes that share paralogs with OR7C1: view

Variants for OR7C1 Gene

Sequence variations from dbSNP and Humsavar for OR7C1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000049959 -- 14,820,201(+) GCCAC(C/T)GCGCC intron-variant
rs1000090018 -- 14,817,790(+) TGGGA(A/G)TGGAA intron-variant
rs1000244047 -- 14,835,080(+) AGGAG(A/G)GGATC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000455400 -- 14,797,725(+) GCCAA(A/T)AAAAT utr-variant-3-prime
rs1000554452 -- 14,825,888(+) AATAG(C/T)TTACT intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OR7C1 Gene

Variant ID Type Subtype PubMed ID
nsv963011 CNV duplication 23825009
nsv509722 CNV insertion 20534489
esv3893167 CNV gain 25118596
esv3643751 CNV loss 21293372

Variation tolerance for OR7C1 Gene

Residual Variation Intolerance Score: 88.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.68; 78.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR7C1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7C1 Gene

Disorders for OR7C1 Gene

Relevant External Links for OR7C1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR7C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7C1 Gene

Publications for OR7C1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  4. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for OR7C1 Gene

Sources for OR7C1 Gene

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