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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR7C1 Gene

protein-coding   GIFtS: 51
GCID: GC19M014909

Olfactory Receptor, Family 7, Subfamily C, Member 1


(Previous symbol: OR7C4)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 7, Subfamily C, Member 11 2     HSTPCR86P2
OR7C41 2 3     OR19-52
Olfactory Receptor 7C42 3     TPCR862
Olfactory Receptor OR19-162 3     Olfactory Receptor 7C12
Olfactory Receptor TPCR862 3     Olfactory Receptor, Family 7, Subfamily C, Member 42
CIT-HSP-146E82     

External Ids:    HGNC: 83731   Entrez Gene: 266642   Ensembl: ENSG000001275307   UniProtKB: O760993   

Export aliases for OR7C1 gene to outside databases

Previous GC identifers: GC19M015278 GC19M015330 GC19M014782 GC19M014770


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR7C1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR7C1 Gene: 
OR7C1 (olfactory receptor, family 7, subfamily C, member 1) is a protein-coding gene. Diseases associated with OR7C1 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A10.

UniProtKB/Swiss-Prot: OR7C1_HUMAN, O76099
Function: Odorant receptor (Potential)

Gene Wiki entry for OR7C1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR7C1 gene promoter:
         HOXA9   HOXA9B   Tal-1   POU3F1   E47   PPAR-alpha   FOXO1a   Meis-1a   Meis-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR7C1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR7C1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR7C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

OR7C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR7C1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014909:  view genomic region     (about GC identifiers)

Start:
14,909,989 bp from pter      End:
14,910,948 bp from pter
Size:
960 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR7C1_HUMAN, O76099 (See protein sequence)
Recommended Name: Olfactory receptor 7C1  
Size: 320 amino acids; 35519 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q15621 Q6IFP2 Q96R94

Explore the universe of human proteins at neXtProt for OR7C1: NX_O76099

Explore proteomics data for OR7C1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O76099

  • HORDE protein sequence for OR7C1
    OR7C1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR7C1 Protein Expression
    REFSEQ proteins: NP_945182.1  
    ENSEMBL proteins: 
     ENSP00000248073  
    Reactome Protein details: O76099
    Human Recombinant Protein Products for OR7C1: 
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    Novus Biologicals OR7C1 Protein
    Novus Biologicals OR7C1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OR7C1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR7C1 for ontologies           About GeneDecksing



    OR7C1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR7: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O76099

    ProtoNet protein and cluster: O76099

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR7C1_HUMAN, O76099
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR7C1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR7C1_HUMAN, O76099
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR7C1:
    olfactory receptor,family 7,subfamily C,member 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR7C1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR7C1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OR7C1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR7C1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCRs, Class A Rhodopsin-like0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR7C1
        GPCRs, Class A Rhodopsin-like


    4        Reactome Pathways for OR7C1
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR7C1):
        Olfactory transduction


    OR7C1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR7C1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR7C1 (ENSP000002480734) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR5P2ENSP000003318234STRING: ENSP00000331823
    OR6Q1ENSP000003077344STRING: ENSP00000307734
    OR7A5ENSP000003169554STRING: ENSP00000316955
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007283spermatogenesis TAS9268701

    OR7C1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR7C1

    Search CenterWatch for drugs/clinical trials and news about OR7C1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR7C1 gene: 
    NM_198944.1  

    Unigene Cluster for OR7C1:

    Olfactory receptor, family 7, subfamily C, member 1
    Hs.466053  [show with all ESTs]
    Unigene Representative Sequence: BC117212
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248073(uc010xnz.2)
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OR7C1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR7C1
    Clone
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    OriGene clones in human, mouse for OR7C1 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OR7C1 (NM_198944)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR7C1

    Additional mRNA sequence: 

    BC117212.1 X89676.1 

    1 DOTS entry:

    DT.91716488 

    2 AceView cDNA sequences:

    NM_198944 X89676 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR7C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGGGCCC
    OR7C1 Expression
    About this image


    See OR7C1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OR7C1

    SOURCE GeneReport for Unigene cluster: Hs.466053
        SABiosciences Custom PCR Arrays for OR7C1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR7C1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for OR7C1 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia LOC6105821 olfactory receptor 7C1-like 83.06(n)
    81.31(a)
      610582  XM_848116.2  XP_853209.2 


    ENSEMBL Gene Tree for OR7C1 (if available)
    TreeFam Gene Tree for OR7C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR7C1 gene
    OR7A102  OR7A52  OR7G12  OR7G32  OR7A172  OR7D42  OR7C22  OR7D22  
    OR7G22  
    18/455 SIMAP similar genes for OR7C1 using alignment to 1 protein entry:     OR7C1_HUMAN(see all similar genes):
    OR7A5    OR7C2    OR7A2P    OR7A17    OR7G3    OR7G1
    OR7A10    OR7D2    OR7D4    OR7G2    OR7E24    OR1D2
    OR1D5    OR7E85P    PJCG2    tpcr110    OR1D4    OR1F2P

    OR7C1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR7C1
    PGOHUM00000234141


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/124 SNPs in OR7C1 are shown (see all 124)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1170278511,2
    C,F--14909666(+) TGGTCC/TCCAGC 1 -- ds50012Minor allele frequency- T:0.04NA EA 240
    rs1117425871,2
    C,F--14909698(+) GCAGCC/TGGCAT 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1140733091,2
    F--14909767(+) TTCTTT/CGTTAG 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs739266821,2
    C,F--14909807(+) GTTAAC/TGGGGA 1 -- ds50012Minor allele frequency- T:0.04WA 120
    rs747053001,2
    C,F--14909815(+) GGAAAC/ACTTGC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1828474751,2
    --14909824(+) GCCAAA/GGACTC 1 -- ds50010--------
    rs1379332751,2
    C--14909948(+) AAGAAC/GCACCA 1 -- ds50010--------
    rs1424978831,2
    C--14909968(+) CCCAAT/CGGTCC 1 -- ds50011Minor allele frequency- C:0.00EU 1323
    rs1996686101,2
    --14910068(+) CCGTGC/TTCCTC 2 N S mis10--------
    rs2012163411,2
    C--14910199(+) TAGAAC/AAAGGT 2 /L /F mis11Minor allele frequency- A:0.00EU 1323

    HapMap Linkage Disequilibrium report for OR7C1 ( 14909989 - 14910948 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR7C1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509722CNV Insertion20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR7C1:    About MalaCards
    neuronitis    


    OR7C1 for disorders           About GeneDecksing


    Export disorders for OR7C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR7C1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR7C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
    4. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PubMed id 9119360)1, 2 Vanderhaeghen P....Parmentier M. (1997)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. (PubMed id 9268701)1 Vanderhaeghen P.... Parmentier M. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26664 HGNC: 8373 AceView: OR7C1 Ensembl:ENSG00000127530 euGenes: HUgn26664
    ECgene: OR7C1 Kegg: 26664 H-InvDB: OR7C1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR7C1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR7C1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR7C1 gene:
    Search GeneIP for patents involving OR7C1

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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