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OR7C1 Gene

protein-coding   GIFtS: 51
GCID: GC19M014909

Olfactory Receptor, Family 7, Subfamily C, Member 1


(Previous symbol: OR7C4)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 7, Subfamily C, Member 11 2     HSTPCR86P2
OR7C41 2 3     OR19-52
Olfactory Receptor 7C42 3     TPCR862
Olfactory Receptor OR19-162 3     Olfactory Receptor 7C12
Olfactory Receptor TPCR862 3     Olfactory Receptor, Family 7, Subfamily C, Member 42
CIT-HSP-146E82     

External Ids:    HGNC: 83731   Entrez Gene: 266642   Ensembl: ENSG000001275307   UniProtKB: O760993   

Export aliases for OR7C1 gene to outside databases

Previous GC identifers: GC19M015278 GC19M015330 GC19M014782 GC19M014770


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR7C1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR7C1 Gene:
OR7C1 (olfactory receptor, family 7, subfamily C, member 1) is a protein-coding gene. Diseases associated with OR7C1 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A10.

UniProtKB/Swiss-Prot: OR7C1_HUMAN, O76099
Function: Odorant receptor (Potential)

Gene Wiki entry for OR7C1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR7C1 gene promoter:
         HOXA9   HOXA9B   Tal-1   POU3F1   E47   PPAR-alpha   FOXO1a   Meis-1a   Meis-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR7C1 promoter sequence
   Search Chromatin IP Primers for OR7C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR7C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

OR7C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR7C1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014909:  view genomic region     (about GC identifiers)

Start:
14,909,989 bp from pter      End:
14,910,948 bp from pter
Size:
960 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR7C1_HUMAN, O76099 (See protein sequence)
Recommended Name: Olfactory receptor 7C1  
Size: 320 amino acids; 35519 Da
Secondary accessions: Q15621 Q6IFP2 Q96R94

Explore the universe of human proteins at neXtProt for OR7C1: NX_O76099

Explore proteomics data for OR7C1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR7C1

    See OR7C1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_945182.1  
    ENSEMBL proteins: 
     ENSP00000248073  
    Reactome Protein details: O76099

    OR7C1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR7: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O76099

    ProtoNet protein and cluster: O76099

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR7C1_HUMAN, O76099
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR7C1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR7C1_HUMAN, O76099
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR7C1:
    olfactory receptor,family 7,subfamily C,member 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR7C1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR7C1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR7C1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR7C1_HUMAN, O76099: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR7C1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR7C1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR7C1
        GPCRs, Class A Rhodopsin-like


    1 Reactome Pathway for OR7C1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR7C1):
        Olfactory transduction


    OR7C1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR7C1
    Interactions:

        Search GeneGlobe Interaction Network for OR7C1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR7C1 (ENSP000002480734) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR1B1ENSP000003031514STRING: ENSP00000303151
    OR2B6ENSP000002446234STRING: ENSP00000244623
    OR52D1ENSP000003262324STRING: ENSP00000326232
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007283spermatogenesis TAS9268701

    OR7C1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR7C1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR7C1 gene: 
    NM_198944.1  

    Unigene Cluster for OR7C1:

    Olfactory receptor, family 7, subfamily C, member 1
    Hs.466053  [show with all ESTs]
    Unigene Representative Sequence: BC117212
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000248073(uc010xnz.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR7C1

    Additional mRNA sequence: 

    BC117212.1 X89676.1 

    1 DOTS entry:

    DT.91716488 

    2 AceView cDNA sequences:

    NM_198944 X89676 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR7C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGGGCCC
    OR7C1 Expression
    About this image

    OR7C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR7C1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466053
        Custom PCR Arrays for OR7C1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR7C1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR7C1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr13521 olfactory receptor 1352 67.98(n)
    64.92(a)
      259074  NM_147071.2  NP_667282.1 


    ENSEMBL Gene Tree for OR7C1 (if available)
    TreeFam Gene Tree for OR7C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR7C1 gene
    OR7A102  OR7A52  OR7G12  OR7G32  OR7A172  OR7D42  OR7C22  OR7D22  
    OR7G22  
    Selected SIMAP similar genes for OR7C1 using alignment to 1 protein entry:     OR7C1_HUMAN(see all similar genes):
    OR7A5    OR7C2    OR7A2P    OR7A17    OR7G3    OR7G1
    OR7A10    OR7D2    OR7D4    OR7G2    OR7E24    OR1D2
    OR1D5    OR7E85P    PJCG2    tpcr110    OR1D4    OR1F2P

    OR7C1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR7C1
    PGOHUM00000234141


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR7C1 (see all 124)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1170278511,2
    C,F--14909666(+) TGGTCC/TCCAGC 1 -- ds50012Minor allele frequency- T:0.04NA EA 240
    rs1117425871,2
    C,F--14909698(+) GCAGCC/TGGCAT 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs1140733091,2
    F--14909767(+) TTCTTT/CGTTAG 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs739266821,2
    C,F--14909807(+) GTTAAC/TGGGGA 1 -- ds50012Minor allele frequency- T:0.04WA 120
    rs747053001,2
    C,F--14909815(+) GGAAAC/ACTTGC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1828474751,2
    --14909824(+) GCCAAA/GGACTC 1 -- ds50010--------
    rs1379332751,2
    C--14909948(+) AAGAAC/GCACCA 1 -- ds50010--------
    rs1424978831,2
    C--14909968(+) CCCAAT/CGGTCC 1 -- ds50011Minor allele frequency- C:0.00EU 1323
    rs1996686101,2
    --14910068(+) CCGTGC/TTCCTC 2 N S mis10--------
    rs2012163411,2
    C--14910199(+) TAGAAC/AAAGGT 2 /L /F mis11Minor allele frequency- A:0.00EU 1323

    HapMap Linkage Disequilibrium report for OR7C1 ( 14909989 - 14910948 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR7C1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509722CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR7C1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR7C1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR7C1:    About MalaCards
    neuronitis


    OR7C1 for disorders           About GeneDecksing


    Export disorders for OR7C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR7C1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR7C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    4. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PubMed id 9119360)1, 2 Vanderhaeghen P.... Parmentier M. (Genomics 1997)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. (PubMed id 9268701)1 Vanderhaeghen P.... Parmentier M. (Biochem. Biophys. Res. Commun. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26664 HGNC: 8373 AceView: OR7C1 Ensembl:ENSG00000127530 euGenes: HUgn26664
    ECgene: OR7C1 Kegg: 26664 H-InvDB: OR7C1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR7C1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR7C1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR7C1 gene:
    Search GeneIP for patents involving OR7C1

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for OR7C1   OriGene RNAi products in human, mouse, rat for OR7C1  
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     Block miRNA regulation of human, mouse, rat OR7C1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR7C1
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR7C1
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