OR7A5 Gene
protein-coding GIFtS: 50
GCID: GC19M014937
|
|
olfactory receptor, family 7, subfamily A, member 5(Previous names: olfactory receptor, family 7, subfamily A, member 5 pseudogene...)
| |
Aliases
for OR7A5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 7, Subfamily A, Member 51 2 | | HTPCR21 2 | | Olfactory Receptor, Family 7, Subfamily A, Member 5 Pseudogene1 2 | | Olfactory Receptor OR19-172 3 | | Olfactory Receptor TPCR922 3 | | Olfactory Receptor 7A52 |
Export aliases for OR7A5 gene to outside databasesPrevious GC identifers: GC19U990190 GC19M014798 |
Summaries
for OR7A5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR7A5:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR7A5_HUMAN, Q15622Function: Odorant receptor (Potential)
Gene Wiki entry for OR7A5
|
Genomic Views
for OR7A5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR7A5 gene promoter:
Sox5 POU3F1 NF-AT NF-AT4 PPAR-gamma1 NF-AT2 NF-AT3 PPAR-gamma2 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR7A5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR7A5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.1 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.1OR7A5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M014937: view genomic region
(about GC identifiers)
Start:
|
14,938,097 bp from pter |
End:
|
14,939,053 bp from pter |
Size:
|
957 bases |
Orientation:
|
minus strand |
|
Proteins
for OR7A5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR7A5_HUMAN, Q15622 (See
protein sequence)Recommended Name: Olfactory receptor 7A5 Size: 319 amino acids; 35579 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B2R682 Q6IFP1 Q96R96Explore the universe of human proteins at neXtProt for OR7A5: NX_Q15622
HORDE protein sequence for OR7A5
OR7A5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_059976.1
ENSEMBL proteins: ENSP00000316955 Reactome Protein details: Q15622
Human Recombinant Protein Products for OR7A5:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
OR7A5 for ontologies About GeneDecksing
OR7A5 Antibody Products:
Assay Products for OR7A5: |
Protein
Domains /
Families
for OR7A5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR7A5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15622ProtoNet protein and cluster: Q15622 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR7A5_HUMAN, Q15622Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR7A5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: OR7A5_HUMAN, Q15622Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR7A5:olfactory receptor,family 7,subfamily A,member 5,pseudogene,G protein coupled receptor superfamily
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
NAS | 9119360 |
OR7A5 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for OR7A5:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR7A5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR7A5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR7A5 (NM_017506) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR7A5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR7A5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR7A5 |
|
Pathways & Interactions
for OR7A5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for OR7A5
4 
Reactome Pathways for OR7A5
1 
Kegg Pathway (Kegg details for OR7A5):
OR7A5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR7A5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR7A5 (ENSP000003169554) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007608 | sensory perception of smell |
NAS | 9119360 | | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell |
NAS | 9119360 |
OR7A5 for ontologies About GeneDecksing
|
Drugs & Compounds
for OR7A5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR7A5
Search CenterWatch for drugs/clinical trials and news about OR7A5
|
Transcripts
for OR7A5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR7A5 gene: NM_017506.1 Unigene Cluster for OR7A5: Olfactory receptor, family 7, subfamily A, member 5 Hs.137573 Unigene Representative Sequence: NM_0175061 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000322301(uc010xoa.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR7A5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR7A5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR7A5 (NM_017506) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR7A5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR7A5 |
Additional cDNA sequence: BC104809.1 X64976.1 X89677.1 1 DOTS entry: DT.92010791 4 AceView cDNA sequences: NM_017506 X89677 BP370465 X64976
GeneLoc Exon Structure
|
Expression
for OR7A5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR7A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATCTCATC
About this image
See OR7A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR7A5
SOURCE GeneReport for Unigene cluster: Hs.137573
SABiosciences Custom PCR Arrays for OR7A5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR7A5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR7A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR7A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR7A5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR7A5 |
Orthologs
for OR7A5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR7A5 (if available)
TreeFam Gene Tree for OR7A5 (if available) |
Paralogs
for OR7A5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR7A5 gene
- OR7A102 OR7G32 OR7A2P2 OR7C22 OR7G12 OR7A172 OR7D42 OR7C12
- OR7D22 OR7G22
18/459 SIMAP similar genes for OR7A5 using alignment to 2 protein entries: OR7A5_HUMAN (see all proteins)
(see all similar genes):OR7C1 OR7A2P OR7A17 OR7C2 OR7A10 OR7D4
OR7D2 OR7G1 OR7G3 OR7G2 OR7E24 OR1D2
PJCG2 OR1G1 OR1M1 tpcr110 OR17-130 OR1F12
OR7A5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for OR7A5
PGOHUM00000234176
|
Genomic Variants
for OR7A5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR7A5 ( 14938097 - 14939053 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR7A5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR7A5 |
|
Disorders
/ Diseases
for OR7A5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR7A5 for disorders About GeneDecksing
1  disease for OR7A5: About MalaCardsneuronitis
Export disorders for OR7A5 gene to outside databases
|
Publications
for OR7A5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR7A5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR7A5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PubMed id 9119360)1, 2 Vanderhaeghen P....Parmentier M. (1997)
- Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. (PubMed id 9268701)1, 2 Vanderhaeghen P.... Parmentier M. (1997)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1 Parmentier M.... Vassart G. (1992)
|
External Searches for OR7A5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR7A5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR7A5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR7A5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR7A5 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR7A5 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR7A5 gene:
Search GeneIP for patents involving OR7A5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR7A5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR7A5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR7A5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR7A5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR7A5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR7A5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR7A5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR7A5 | | OriGene Custom Protein Services for OR7A5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR7A5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR7A5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR7A5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR7A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR7A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR7A5 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for OR7A5 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | OR7A5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR7A5 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for OR7A5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR7A5 |
| |  | |
|
|
|
