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Aliases for OR7A5 Gene

Aliases for OR7A5 Gene

  • Olfactory Receptor Family 7 Subfamily A Member 5 2 3 5
  • Olfactory Receptor, Family 7, Subfamily A, Member 5 Pseudogene 2 3
  • Olfactory Receptor OR19-17 3 4
  • Olfactory Receptor TPCR92 3 4
  • Olfactory Receptor, Family 7, Subfamily A, Member 5 2
  • Olfactory Receptor 7A5 3
  • HTPCR2 3

External Ids for OR7A5 Gene

Previous GeneCards Identifiers for OR7A5 Gene

  • GC19U990190
  • GC19M014798
  • GC19M014937
  • GC19M014903
  • GC19M014792

Summaries for OR7A5 Gene

Entrez Gene Summary for OR7A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR7A5 Gene

OR7A5 (Olfactory Receptor Family 7 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A10.

UniProtKB/Swiss-Prot for OR7A5 Gene

  • Odorant receptor.

Gene Wiki entry for OR7A5 Gene

Additional gene information for OR7A5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR7A5 Gene

Genomics for OR7A5 Gene

GeneHancer (GH) Regulatory Elements for OR7A5 Gene

Promoters and enhancers for OR7A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I014835 Enhancer 0.2 ENCODE 580.5 +0.1 61 0.2 OR7A5 OR7C1 GC19M014827
GH19I014671 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 6.7 +161.1 161137 4.9 TEAD4 TAL1 MAX EBF1 CEBPG TCF12 CTBP1 POLR2A NFE2 SOX6 ADGRE3 ZNF333 OR7C1 ADGRE5 OR7A5 PKN1 ENSG00000275432
GH19I014782 Enhancer 1.5 FANTOM5 Ensembl ENCODE 5.8 +50.4 50425 4 HDGF ATF1 PKNOX1 ARNT ZNF2 ZBTB7B TCF12 ZNF121 ZNF766 CBX5 DCAF15 DDX39A RFX1 ADGRE2 AKAP8 BRD4 OR7C1 ADGRE5 ZNF333 ADGRE3
GH19I014888 Enhancer 1 Ensembl ENCODE 6.1 -53.6 -53585 1.3 PKNOX1 ATF1 ZNF2 RAD21 SMARCC2 FOS ATF7 IKZF2 SMARCC1 ZNF654 OR7A18P OR7C1 RNU6-782P OR7A5 OR7A1P
GH19I014890 Enhancer 0.9 ENCODE 5.7 -55.6 -55559 0.2 HDAC1 ZBTB40 TCF12 ZNF766 GATA2 ATF7 ZBTB11 NCOA1 USF2 ZEB2 OR7C1 RNU6-782P OR7A5 OR7A18P OR7A1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR7A5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR7A5 gene promoter:

Genomic Locations for OR7A5 Gene

Genomic Locations for OR7A5 Gene
chr19:14,824,251-14,835,285
(GRCh38/hg38)
Size:
11,035 bases
Orientation:
Minus strand
chr19:14,903,302-14,946,188
(GRCh37/hg19)

Genomic View for OR7A5 Gene

Genes around OR7A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR7A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR7A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR7A5 Gene

Proteins for OR7A5 Gene

  • Protein details for OR7A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15622-OR7A5_HUMAN
    Recommended name:
    Olfactory receptor 7A5
    Protein Accession:
    Q15622
    Secondary Accessions:
    • B2R682
    • Q6IFP1
    • Q96R96

    Protein attributes for OR7A5 Gene

    Size:
    319 amino acids
    Molecular mass:
    35579 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR7A5 Gene

Post-translational modifications for OR7A5 Gene

Other Protein References for OR7A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR7A5 Gene

Domains & Families for OR7A5 Gene

Gene Families for OR7A5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR7A5 Gene

Suggested Antigen Peptide Sequences for OR7A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15622

UniProtKB/Swiss-Prot:

OR7A5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR7A5: view

Function for OR7A5 Gene

Molecular function for OR7A5 Gene

GENATLAS Biochemistry:
olfactory receptor,family 7,subfamily A,member 5,pseudogene,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR7A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR7A5: view
genes like me logo Genes that share phenotypes with OR7A5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR7A5 Gene

Localization for OR7A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR7A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR7A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR7A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,IBA 9119360
genes like me logo Genes that share ontologies with OR7A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR7A5 Gene

Pathways & Interactions for OR7A5 Gene

genes like me logo Genes that share pathways with OR7A5: view

Pathways by source for OR7A5 Gene

1 KEGG pathway for OR7A5 Gene

Interacting Proteins for OR7A5 Gene

Gene Ontology (GO) - Biological Process for OR7A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR7A5: view

No data available for SIGNOR curated interactions for OR7A5 Gene

Drugs & Compounds for OR7A5 Gene

No Compound Related Data Available

Transcripts for OR7A5 Gene

mRNA/cDNA for OR7A5 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR7A5 Gene

Olfactory receptor, family 7, subfamily A, member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR7A5 Gene

No ASD Table

Relevant External Links for OR7A5 Gene

GeneLoc Exon Structure for
OR7A5
ECgene alternative splicing isoforms for
OR7A5

Expression for OR7A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR7A5 Gene

mRNA differential expression in normal tissues according to GTEx for OR7A5 Gene

This gene is overexpressed in Brain - Substantia nigra (x9.6), Brain - Spinal cord (cervical c-1) (x6.4), and Pituitary (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of OR7A5 Gene:

OR7A5

SOURCE GeneReport for Unigene cluster for OR7A5 Gene:

Hs.137573

Evidence on tissue expression from TISSUES for OR7A5 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with OR7A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR7A5 Gene

Orthologs for OR7A5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR7A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC747786 33
  • 99.27 (n)
OR7A5 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC610545 33
  • 81.96 (n)
cow
(Bos Taurus)
Mammalia LOC783313 33
  • 80.13 (n)
mouse
(Mus musculus)
Mammalia Olfr57 33 16
  • 78.99 (n)
Olfr1355 34
  • 65 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1075 33
  • 78.23 (n)
Species where no ortholog for OR7A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR7A5 Gene

ENSEMBL:
Gene Tree for OR7A5 (if available)
TreeFam:
Gene Tree for OR7A5 (if available)

Paralogs for OR7A5 Gene

Paralogs for OR7A5 Gene

(459) SIMAP similar genes for OR7A5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR7A5 Gene

genes like me logo Genes that share paralogs with OR7A5: view

Variants for OR7A5 Gene

Sequence variations from dbSNP and Humsavar for OR7A5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000244047 -- 14,835,080(-) G/A coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant
rs1000554452 -- 14,825,888(-) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000751571 -- 14,828,985(-) C/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000895993 -- 14,832,715(-) G/A genic_upstream_transcript_variant, intron_variant
rs1001238942 -- 14,836,726(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR7A5 Gene

Variant ID Type Subtype PubMed ID
esv3893167 CNV gain 25118596
nsv978777 CNV duplication 23825009

Variation tolerance for OR7A5 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR7A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR7A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR7A5 Gene

Disorders for OR7A5 Gene

Additional Disease Information for OR7A5

No disorders were found for OR7A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR7A5 Gene

Publications for OR7A5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  5. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P … Parmentier M (Genomics 1997) 3 4 58

Products for OR7A5 Gene

Sources for OR7A5 Gene

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