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OR7A5 Gene

protein-coding   GIFtS: 50
GCID: GC19M014903

Olfactory Receptor, Family 7, Subfamily A, Member 5

(Previous names: olfactory receptor, family 7, subfamily A, member 5 pseudogene)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Olfactory Receptor, Family 7, Subfamily A, Member 51 2
Olfactory Receptor, Family 7, Subfamily A, Member 5 Pseudogene1 2
Olfactory Receptor OR19-172 3
Olfactory Receptor TPCR922 3
HTPCR22
Olfactory Receptor 7A52

External Ids:    HGNC: 83681   Entrez Gene: 266592   Ensembl: ENSG000001882697   UniProtKB: Q156223   
ORGUL members:         

Export aliases for OR7A5 gene to outside databases

Previous GC identifers: GC19U990190 GC19M014798 GC19M014937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR7A5 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR7A5 Gene:
OR7A5 (olfactory receptor, family 7, subfamily A, member 5) is a protein-coding gene. Diseases associated with OR7A5 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A10.

UniProtKB/Swiss-Prot: OR7A5_HUMAN, Q15622
Function: Odorant receptor (Potential)

Gene Wiki entry for OR7A5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR7A5 gene promoter:
         Sox5   POU3F1   NF-AT   NF-AT4   PPAR-gamma1   NF-AT2   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR7A5 promoter sequence
   Search Chromatin IP Primers for OR7A5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR7A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

OR7A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR7A5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014903:  view genomic region     (about GC identifiers)

Start:
14,938,097 bp from pter      End:
14,939,053 bp from pter
Size:
957 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR7A5_HUMAN, Q15622 (See protein sequence)
Recommended Name: Olfactory receptor 7A5  
Size: 319 amino acids; 35579 Da
Secondary accessions: B2R682 Q6IFP1 Q96R96

Explore the universe of human proteins at neXtProt for OR7A5: NX_Q15622

Explore proteomics data for OR7A5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR7A5

    See OR7A5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_059976.1  
    ENSEMBL proteins: 
     ENSP00000471977   ENSP00000316955  
    Reactome Protein details: Q15622

    OR7A5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR7: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q15622

    ProtoNet protein and cluster: Q15622

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR7A5_HUMAN, Q15622
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR7A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR7A5_HUMAN, Q15622
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR7A5:
    olfactory receptor,family 7,subfamily A,member 5,pseudogene,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS9119360
         
    OR7A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR7A5:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR7A5
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR7A5_HUMAN, Q15622: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS9119360

    OR7A5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR7A5 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR7A5
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR7A5
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR7A5):
        Olfactory transduction


    OR7A5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR7A5
    Interactions:

        Search GeneGlobe Interaction Network for OR7A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR7A5 (ENSP000003169554) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10J1ENSP000003990784STRING: ENSP00000399078
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS9119360
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS9119360

    OR7A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR7A5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR7A5 gene: 
    NM_017506.1  

    Unigene Cluster for OR7A5:

    Olfactory receptor, family 7, subfamily A, member 5
    Hs.137573
    Unigene Representative Sequence: NM_017506
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601611 ENST00000599549 ENST00000595922 ENST00000594432 ENST00000322301(uc010xoa.2)

    miRNA
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    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat OR7A5
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR7A5
      QuantiTect SYBR Green Assays in human, mouse, rat OR7A5
      QuantiFast Probe-based Assays in human, mouse, rat OR7A5

    Additional mRNA sequence: 

    BC104809.1 X64976.1 X89677.1 

    1 DOTS entry:

    DT.92010791 

    4 AceView cDNA sequences:

    X89677 NM_017506 BP370465 X64976 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR7A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATCTCATC
    OR7A5 Expression
    About this image

    OR7A5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR7A5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.137573
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR7A5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR7A5 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr195
    Olfr571
    olfactory receptor 195
    olfactory receptor 571
    78.99(n)1
    72.28(a)1
      16 (10.34 cM)5
    183571  NM_147041.21  NP_667252.11 
     166730505 


    ENSEMBL Gene Tree for OR7A5 (if available)
    TreeFam Gene Tree for OR7A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR7A5 gene
    OR7A102  OR7G12  OR7G32  OR7A172  OR7D42  OR7C12  OR7C22  OR7D22  
    OR7G22  
    Selected SIMAP similar genes for OR7A5 using alignment to 2 protein entries:     OR7A5_HUMAN (see all proteins) (see all similar genes):
    OR7C1    OR7A2P    OR7A17    OR7C2    OR7A10    OR7D4
    OR7D2    OR7G1    OR7G3    OR7G2    OR7E24    OR1D2
    PJCG2    OR1G1    OR1M1    tpcr110    OR17-130    OR1F12

    OR7A5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR7A5
    PGOHUM00000234176


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR7A5 (see all 157)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397857781,2
    --14936652(+) AAAAGC/TATCAT 1 -- ds50010--------
    rs1441990421,2
    --14936660(+) CATCTG/TAAACC 1 -- ds50010--------
    rs764385751,2
    C,F--14936758(+) GCTGCT/CTCTTA 1 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1149603231,2
    C,F--14936808(+) CCCTGG/AATACT 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1819212701,2
    --14936874(+) CTAGGC/TGATCT 1 -- ds50010--------
    rs1875014471,2
    --14936968(+) GGGATA/GAGTTA 1 -- ds50010--------
    rs1465583571,2
    --14937074(+) CTTTAA/GTCATG 1 -- ds50010--------
    rs1397570751,2
    --14937129(+) TGATAC/TATTGA 1 -- ds50010--------
    rs762032521,2
    C--14937167(+) GTTTAC/TGACAA 1 -- ut310--------
    rs1449812971,2
    C--14937307(+) CATCAC/GTCCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OR7A5 ( 14938097 - 14939053 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OR7A5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR7A5
    DNA2.0 Custom Variant and Variant Library Synthesis for OR7A5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR7A5:    
    About MalaCards
    neuronitis


    OR7A5 for disorders           About GeneDecksing


    Export disorders for OR7A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR7A5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR7A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    5. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PubMed id 9119360)1, 2 Vanderhaeghen P.... Parmentier M. (Genomics 1997)
    6. Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. (PubMed id 9268701)1, 2 Vanderhaeghen P.... Parmentier M. (Biochem. Biophys. Res. Commun. 1997)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1 Parmentier M.... Vassart G. (Nature 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26659 HGNC: 8368 AceView: OR7A5 Ensembl:ENSG00000188269 euGenes: HUgn26659
    ECgene: OR7A5 Kegg: 26659 H-InvDB: OR7A5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR7A5 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR7A5 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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