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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR7A17 Gene

protein-coding   GIFtS: 49
GCID: GC19M014991

Olfactory Receptor, Family 7, Subfamily A, Member 17

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 7, Subfamily A, Member 171 2
BC85395_42
HTPCRX192
Olfactory Receptor 7A172
Olfactory Receptor OR19-202

External Ids:    HGNC: 83631   Entrez Gene: 263332   Ensembl: ENSG000001853857   UniProtKB: O145813   

Export aliases for OR7A17 gene to outside databases

Previous GC identifers: GC19M015360 GC19M015384 GC19M014836 GC19M014852


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR7A17 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR7A17 Gene: 
OR7A17 (olfactory receptor, family 7, subfamily A, member 17) is a protein-coding gene. Diseases associated with OR7A17 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR7A10.

UniProtKB/Swiss-Prot: OR7AH_HUMAN, O14581
Function: Odorant receptor (Potential)

Gene Wiki entry for OR7A17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR7A17 gene promoter:
         Nkx3-1   RP58   Nkx3-1 v4   Nkx3-1 v1   NF-kappaB   Nkx3-1 v2   NF-AT4   NF-kappaB2   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR7A17 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR7A17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR7A17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

OR7A17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR7A17 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M014991:  view genomic region     (about GC identifiers)

Start:
14,991,241 bp from pter      End:
14,992,167 bp from pter
Size:
927 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR7AH_HUMAN, O14581 (See protein sequence)
Recommended Name: Olfactory receptor 7A17  
Size: 309 amino acids; 34013 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IFQ6 Q96R98

Explore the universe of human proteins at neXtProt for OR7A17: NX_O14581

Explore proteomics data for OR7A17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14581

  • HORDE protein sequence for OR7A17
    OR7A17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR7A17 Protein Expression
    REFSEQ proteins: NP_112163.1  
    ENSEMBL proteins: 
     ENSP00000328144  
    Reactome Protein details: O14581
    Human Recombinant Protein Products for OR7A17: 
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    Cloud-Clone Corp. Proteins for OR7A17 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR7A17 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR7: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O14581

    ProtoNet protein and cluster: O14581

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR7AH_HUMAN, O14581
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR7A17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR7AH_HUMAN, O14581
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR7A17 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR7A17 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCRs, Class A Rhodopsin-like0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR7A17
        GPCRs, Class A Rhodopsin-like


    4        Reactome Pathways for OR7A17
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR7A17):
        Olfactory transduction


    OR7A17 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR7A17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR7A17 (ENSP000003281444) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR1A1ENSP000003052074STRING: ENSP00000305207
    OR1A2ENSP000003713774STRING: ENSP00000371377
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR7A17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR7A17 (OR7AH)

    Search CenterWatch for drugs/clinical trials and news about OR7A17 / OR7AH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR7A17 gene: 
    NM_030901.1  

    Unigene Cluster for OR7A17:

    Olfactory receptor, family 7, subfamily A, member 17
    Hs.247717
    Unigene Representative Sequence: BC101587
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000327462(uc010xob.2)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR7A17

    Additional mRNA sequence: 

    BC101587.1 BC117357.1 X64993.1 

    1 DOTS entry:

    DT.99953981 

    3 AceView cDNA sequences:

    NM_030901 X64993 AI909504 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR7A17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAACCCCT
    OR7A17 Expression
    About this image


    See OR7A17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OR7A17

    SOURCE GeneReport for Unigene cluster: Hs.247717
        SABiosciences Custom PCR Arrays for OR7A17
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR7A17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR7A17 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr571 , 5 olfactory receptor 571, 5 80.09(n)1
    73.27(a)1
      10 (39.72 cM)5
    183571  NM_147041.21  NP_667252.11 
     790347235 


    ENSEMBL Gene Tree for OR7A17 (if available)
    TreeFam Gene Tree for OR7A17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR7A17 gene
    OR7A102  OR7A52  OR7G12  OR7G32  OR7D42  OR7C12  OR7C22  OR7D22  
    OR7G22  
    18/454 SIMAP similar genes for OR7A17 using alignment to 1 protein entry:     OR7AH_HUMAN(see all similar genes):
    OR7A10    OR7A2P    OR7A5    OR7C2    OR7D4    OR7G1
    OR7D2    OR7G2    OR7G3    OR7C1    OR7E24    OR7E86P
    OR1G1    OR1E1    OR1F1    OR1F12    OR1F2P    OR1M1

    OR7A17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/139 SNPs in OR7A17 are shown (see all 139)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104026171,2
    C,F,A,H--14990746(+) ATAAAT/CGCCAT 1 -- ds500121Minor allele frequency- C:0.19NS EA NA WA CSA 2287
    rs1116150981,2
    C,F--14990773(+) CACTCG/ATGTGG 1 -- ds50012Minor allele frequency- A:0.05CSA WA 120
    rs1178559701,2
    C,F--14990783(+) GGGTAA/TAGTTT 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1880211901,2
    --14990786(+) TAAAGC/TTTACA 1 -- ds50010--------
    rs1488416491,2
    --14990797(+) TGACCA/GGGAAG 1 -- ds50010--------
    rs104210241,2
    C,F,H--14990821(+) GTGGTG/AGAGAA 1 -- ds500123Minor allele frequency- A:0.13NS EA NA WA CSA 2761
    rs1145274771,2
    C,F--14990877(+) AAAATA/GAAATT 1 -- ds50011Minor allele frequency- G:0.09WA 118
    rs169800531,2
    C,F,H--14990959(+) AAAATA/GGGAAT 1 -- ds50019Minor allele frequency- G:0.05NA EA NS WA 762
    rs37521961,2
    C,F,H--14990973(+) CACCTT/AGTTTC 1 -- ds500111Minor allele frequency- A:0.26EA NS NA WA CSA 1519
    rs1163108301,2
    F--14990984(+) TGACCC/TTAGTT 1 -- ds50011Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for OR7A17 ( 14991241 - 14992167 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OR7A17:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718221CNV Deletion23290073
    esv2669817CNV Deletion23128226
    esv2718222CNV Deletion23290073
    nsv911129CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR7A17:    About MalaCards
    neuronitis    


    OR7A17 for disorders           About GeneDecksing


    Export disorders for OR7A17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR7A17 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR7A17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
    5. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 3 Parmentier M.... Vassart G. (1992)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26333 HGNC: 8363 AceView: OR7A17 Ensembl:ENSG00000185385 euGenes: HUgn26333
    ECgene: OR7A17 Kegg: 26333 H-InvDB: OR7A17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR7A17 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR7A17 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR7A17 gene:
    Search GeneIP for patents involving OR7A17

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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