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OR6Y1 Gene

protein-coding   GIFtS: 44
GCID: GC01M158516

Olfactory Receptor, Family 6, Subfamily Y, Member 1


(Previous symbol: OR6Y2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 6, Subfamily Y, Member 11 2
OR6Y21 2 3
Olfactory Receptor 6Y22 3
Olfactory Receptor OR1-112 3
OR1-112
Olfactory Receptor 6Y12

External Ids:    HGNC: 148231   Entrez Gene: 3911122   Ensembl: ENSG000001975327   UniProtKB: Q8NGX83   

Export aliases for OR6Y1 gene to outside databases

Previous GC identifers: GC01U990366 GC01M155734 GC01M155329 GC01M156783


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR6Y1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR6Y1 Gene:
OR6Y1 (olfactory receptor, family 6, subfamily Y, member 1) is a protein-coding gene. Diseases associated with OR6Y1 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6B1.

UniProtKB/Swiss-Prot: OR6Y1_HUMAN, Q8NGX8
Function: Odorant receptor (Potential)

Gene Wiki entry for OR6Y1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR6Y1 gene promoter:
         AML1a   NRSF form 1   Lmo2   NRSF form 2   LCR-F1   GATA-1   E47   FOXL1   FOXC1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR6Y1 promoter sequence
   Search Chromatin IP Primers for OR6Y1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR6Y1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

OR6Y1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6Y1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M158516:  view genomic region     (about GC identifiers)

Start:
158,516,921 bp from pter      End:
158,517,895 bp from pter
Size:
975 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR6Y1_HUMAN, Q8NGX8 (See protein sequence)
Recommended Name: Olfactory receptor 6Y1  
Size: 325 amino acids; 36636 Da
Secondary accessions: Q6IFS0

Explore the universe of human proteins at neXtProt for OR6Y1: NX_Q8NGX8

Explore proteomics data for OR6Y1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn191
  • HORDE protein sequence for OR6Y1

    See OR6Y1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005189.1  
    ENSEMBL proteins: 
     ENSP00000304807  
    Reactome Protein details: Q8NGX8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR6: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGX8

    ProtoNet protein and cluster: Q8NGX8

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR6Y1_HUMAN, Q8NGX8
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR6Y1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR6Y1_HUMAN, Q8NGX8
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR6Y1 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR6Y1_HUMAN, Q8NGX8: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR6Y1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR6Y1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR6Y1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR6Y1):
        Olfactory transduction


    OR6Y1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR6Y1
    Interactions:

        Search GeneGlobe Interaction Network for OR6Y1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR6Y1 (ENSP000003048074) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR10K1ENSP000002894514STRING: ENSP00000289451
    OR10R2ENSP000003571344STRING: ENSP00000357134
    OR2G3ENSP000003263014STRING: ENSP00000326301
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR6Y1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR6Y1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR6Y1 gene: 
    NM_001005189.1  

    Unigene Cluster for OR6Y1:

    Olfactory receptor, family 6, subfamily Y, member 1
    Hs.553780
    Unigene Representative Sequence: NM_001005189
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302617(uc010pil.2)
    miRNA
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    1 AceView cDNA sequence:

    NM_001005189 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR6Y1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTAAAGGC
    OR6Y1 Expression
    About this image

    OR6Y1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR6Y1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553780
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR6Y1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr2201 , 5 olfactory receptor 2201, 5 84.37(n)1
    87.19(a)1
      1 (81.01 cM)5
    5467471  NM_207694.11  NP_997577.11 
     1744486255 
    lizard
    (Anolis carolinensis)
    Reptilia OR6Y16
    olfactory receptor, family 6, subfamily Y, member ...
    65(a)
    1 ↔ 1
    GL343253.1(700359-701748)


    ENSEMBL Gene Tree for OR6Y1 (if available)
    TreeFam Gene Tree for OR6Y1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR6Y1 gene
    OR6B12  OR6Q12  OR2AT42  OR6B32  OR6B22  OR6A22  OR11L12  OR6P12  
    Selected SIMAP similar genes for OR6Y1 using alignment to 1 protein entry:     OR6Y1_HUMAN(see all similar genes):
    OR6P1    OR6A2    OR6B1    OR6B2    OR6B3    OR10R3P
    OR6M1    OR11A1    OR1L4    OR2T11    OR2V2    OR4M1
    OR5V1    OR8A1    OR1F12    OR10R2    OR11L1    OR1J2

    OR6Y1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR6Y1
    PGOHUM00000239467


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR6Y1 (see all 137)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498445051,2
    --158516421(+) TAGCTG/TGGACT 1 -- ds50010--------
    rs1130905011,2
    C,F--158516517(+) CTTTTC/TTAACC 1 -- ds50012Minor allele frequency- T:0.07WA 120
    rs1454759441,2
    --158516541(+) ACGATA/GGTTTT 1 -- ds50010--------
    rs1488198291,2
    --158516593(+) TGATAA/CGTTGT 1 -- ds50010--------
    rs1158090191,2
    C--158516630(+) TTCCTC/TCCTCC 1 -- ds50010--------
    rs730142071,2
    C,F--158516676(+) CTTCCT/CGATTT 1 -- ds50012Minor allele frequency- C:0.07WA 120
    rs1931456761,2
    --158516720(+) CTCAGC/TCTGAT 1 -- ds50010--------
    rs1464528791,2
    C--158516740(+) TACTTA/CTTGAG 1 -- ds50010--------
    rs1466963211,2
    C--158516775(+) TGTAT-/ACACACA 1 -- ds50010--------
    rs118056171,2
    C,F,H--158516835(+) GATTGG/AGGGAT 1 -- ds50011Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for OR6Y1 ( 158516921 - 158517895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for OR6Y1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422163CNV Deletion20811451
    esv2667471CNV Deletion23128226
    dgv15n17CNV Loss16327808
    dgv40n27CNV Loss19166990
    nsv470743CNV Loss18288195
    nsv515774CNV Loss19592680
    nsv442095CNV CNV18776908

    Human Gene Mutation Database (HGMD): OR6Y1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR6Y1:    
    About MalaCards
    neuronitis


    OR6Y1 for disorders           About GeneDecksing


    Export disorders for OR6Y1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR6Y1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR6Y1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. Seventy-five genetic loci influencing the human red blood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (Nature 2012)
    4. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 391112 HGNC: 14823 AceView: OR6Y1 Ensembl:ENSG00000197532 euGenes: HUgn391112
    ECgene: OR6Y1 Kegg: 391112 H-InvDB: OR6Y1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR6Y1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR6Y1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR6Y1 gene:
    Search GeneIP for patents involving OR6Y1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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