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Aliases for OR6X1 Gene

Aliases for OR6X1 Gene

  • Olfactory Receptor Family 6 Subfamily X Member 1 2 3 5
  • Olfactory Receptor OR11-270 3 4
  • Olfactory Receptor, Family 6, Subfamily X, Member 1 2
  • Olfactory Receptor 6X1 3
  • OR11-270 3

External Ids for OR6X1 Gene

Previous GeneCards Identifiers for OR6X1 Gene

  • GC11U990322
  • GC11M123162
  • GC11M123129
  • GC11M123624

Summaries for OR6X1 Gene

Entrez Gene Summary for OR6X1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6X1 Gene

OR6X1 (Olfactory Receptor Family 6 Subfamily X Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6F1.

UniProtKB/Swiss-Prot for OR6X1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6X1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6X1 Gene

Genomics for OR6X1 Gene

Regulatory Elements for OR6X1 Gene

Enhancers for OR6X1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G123740 1.4 FANTOM5 ENCODE 10.4 +12.5 12472 3.8 HNRNPUL1 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 ZNF202 OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P OR4D5 TMEM225 OR6T1 OR8D4
GH11G123583 0.9 FANTOM5 11.9 +170.7 170677 0.4 ATF1 SIN3A FEZF1 GATA2 ETV6 FOS IKZF2 ELF1 ZEB2 MAFF OR10G7 OR6X1 OR10G4 OR6T1 OR4D5 OR6M1 OR8D4 OR10S1 GC11M123576 GC11M123593
GH11G123773 0.9 ENCODE dbSUPER 11.1 -21.7 -21675 4.6 CHD7 ETS1 JUND ZNF316 POLR2A BCL11A SMARCA4 POU5F1 EMSY MAFK ZNF202 OR6X1 OR6M1 TMEM225 OR8D4 RNU1-21P LOC105369544
GH11G123695 0.4 FANTOM5 15.7 +59.2 59212 0.4 ATF2 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9
GH11G123797 0.3 FANTOM5 10.6 -41.7 -41703 0.2 OR6X1 OR6M1 OR6T1 LOC105369544 RNU1-21P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR6X1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6X1 Gene

Chromosome:
11
Start:
123,753,488 bp from pter
End:
123,754,545 bp from pter
Size:
1,058 bases
Orientation:
Minus strand

Genomic View for OR6X1 Gene

Genes around OR6X1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6X1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6X1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6X1 Gene

Proteins for OR6X1 Gene

  • Protein details for OR6X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH79-OR6X1_HUMAN
    Recommended name:
    Olfactory receptor 6X1
    Protein Accession:
    Q8NH79
    Secondary Accessions:
    • B9EGW9
    • Q6IFA0

    Protein attributes for OR6X1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34727 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6X1 Gene

Post-translational modifications for OR6X1 Gene

  • Glycosylation at posLast=33
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6X1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6X1 Gene

Domains & Families for OR6X1 Gene

Gene Families for OR6X1 Gene

Protein Domains for OR6X1 Gene

Suggested Antigen Peptide Sequences for OR6X1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH79

UniProtKB/Swiss-Prot:

OR6X1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6X1: view

Function for OR6X1 Gene

Molecular function for OR6X1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6X1: view
genes like me logo Genes that share phenotypes with OR6X1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6X1 Gene

Localization for OR6X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6X1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6X1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6X1: view

Pathways & Interactions for OR6X1 Gene

genes like me logo Genes that share pathways with OR6X1: view

Pathways by source for OR6X1 Gene

Interacting Proteins for OR6X1 Gene

Gene Ontology (GO) - Biological Process for OR6X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6X1: view

No data available for SIGNOR curated interactions for OR6X1 Gene

Drugs & Compounds for OR6X1 Gene

No Compound Related Data Available

Transcripts for OR6X1 Gene

mRNA/cDNA for OR6X1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6X1 Gene

No ASD Table

Relevant External Links for OR6X1 Gene

GeneLoc Exon Structure for
OR6X1
ECgene alternative splicing isoforms for
OR6X1

Expression for OR6X1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6X1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6X1 Gene:

OR6X1

SOURCE GeneReport for Unigene cluster for OR6X1 Gene:

Hs.553759
genes like me logo Genes that share expression patterns with OR6X1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6X1 Gene

Orthologs for OR6X1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6X1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466811 34
  • 98.5 (n)
OR6X1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR6X1 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or6x1 55 Olfr986 34 16 35
  • 84.29 (n)
rat
(Rattus norvegicus)
Mammalia Olr1341 34
  • 83.01 (n)
oppossum
(Monodelphis domestica)
Mammalia OR6X1 35
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia OR6X1 35
  • 46 (a)
OneToOne
Species where no ortholog for OR6X1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6X1 Gene

ENSEMBL:
Gene Tree for OR6X1 (if available)
TreeFam:
Gene Tree for OR6X1 (if available)

Paralogs for OR6X1 Gene

Paralogs for OR6X1 Gene

(450) SIMAP similar genes for OR6X1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6X1: view

Variants for OR6X1 Gene

Sequence variations from dbSNP and Humsavar for OR6X1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000044121 -- 123,756,114(+) TAGGT(A/G)GATAC upstream-variant-2KB
rs1001007413 -- 123,755,483(+) AAAAC(C/T)ACTTC upstream-variant-2KB
rs1001057625 -- 123,755,837(+) CGAAC(A/G)TGATC upstream-variant-2KB
rs1002073055 -- 123,753,262(+) TCTGA(A/C)CTTAG downstream-variant-500B
rs1002619291 -- 123,753,145(+) TTATG(-/T)TTTTG downstream-variant-500B

Variation tolerance for OR6X1 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.01; 68.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6X1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6X1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR6X1 Gene

Disorders for OR6X1 Gene

Relevant External Links for OR6X1

Genetic Association Database (GAD)
OR6X1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6X1

No disorders were found for OR6X1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6X1 Gene

Publications for OR6X1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. A genome-wide association study of total serum and mite-specific IgEs in asthma patients. (PMID: 23967269) Kim J.H. … Shin H.D. (PLoS ONE 2013) 3 64
  3. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR6X1 Gene

Sources for OR6X1 Gene

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