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Aliases for OR6X1 Gene

Aliases for OR6X1 Gene

  • Olfactory Receptor, Family 6, Subfamily X, Member 1 2 3
  • Olfactory Receptor OR11-270 3 4
  • Olfactory Receptor 6X1 3
  • OR11-270 3

External Ids for OR6X1 Gene

Previous GeneCards Identifiers for OR6X1 Gene

  • GC11U990322
  • GC11M123162
  • GC11M123129
  • GC11M123624

Summaries for OR6X1 Gene

Entrez Gene Summary for OR6X1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6X1 Gene

OR6X1 (Olfactory Receptor, Family 6, Subfamily X, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR9A4.

UniProtKB/Swiss-Prot for OR6X1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6X1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6X1 Gene

Genomics for OR6X1 Gene

Regulatory Elements for OR6X1 Gene

Genomic Location for OR6X1 Gene

Start:
123,753,488 bp from pter
End:
123,754,545 bp from pter
Size:
1,058 bases
Orientation:
Minus strand

Genomic View for OR6X1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6X1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6X1 Gene

Proteins for OR6X1 Gene

  • Protein details for OR6X1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH79-OR6X1_HUMAN
    Recommended name:
    Olfactory receptor 6X1
    Protein Accession:
    Q8NH79
    Secondary Accessions:
    • B9EGW9
    • Q6IFA0

    Protein attributes for OR6X1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34727 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6X1 Gene

Proteomics data for OR6X1 Gene at MOPED

Post-translational modifications for OR6X1 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6X1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6X1 Gene

Domains for OR6X1 Gene

Gene Families for OR6X1 Gene

HGNC:
  • OR6 :GPCR / Class A : Olfactory receptors

Protein Domains for OR6X1 Gene

Suggested Antigen Peptide Sequences for OR6X1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH79

UniProtKB/Swiss-Prot:

OR6X1_HUMAN :
  • Q8NH79
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6X1: view

Function for OR6X1 Gene

Molecular function for OR6X1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6X1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6X1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR6X1 Gene

Localization for OR6X1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6X1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6X1 Gene COMPARTMENTS Subcellular localization image for OR6X1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6X1: view

Pathways for OR6X1 Gene

genes like me logo Genes that share pathways with OR6X1: view

Pathways by source for OR6X1 Gene

Interacting Proteins for OR6X1 Gene

Gene Ontology (GO) - Biological Process for OR6X1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6X1: view

Transcripts for OR6X1 Gene

mRNA/cDNA for OR6X1 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6X1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6X1 Gene

No ASD Table

Relevant External Links for OR6X1 Gene

GeneLoc Exon Structure for
OR6X1
ECgene alternative splicing isoforms for
OR6X1

Expression for OR6X1 Gene

mRNA expression in normal human tissues for OR6X1 Gene

SOURCE GeneReport for Unigene cluster for OR6X1 Gene Hs.553759

genes like me logo Genes that share expressions with OR6X1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR6X1 Gene

Orthologs for OR6X1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6X1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Olfr986 35
  • 84.29 (n)
  • 85.26 (a)
Olfr986 16
Olfr986 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC466811 35
  • 98.5 (n)
  • 97.44 (a)
OR6X1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1341 35
  • 83.01 (n)
  • 83.97 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 48 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR6X1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR6X1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia OR6X1 36
  • 46 (a)
OneToOne
Species with no ortholog for OR6X1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6X1 Gene

ENSEMBL:
Gene Tree for OR6X1 (if available)
TreeFam:
Gene Tree for OR6X1 (if available)

Paralogs for OR6X1 Gene

Paralogs for OR6X1 Gene

Selected SIMAP similar genes for OR6X1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6X1: view

Variants for OR6X1 Gene

Sequence variations from dbSNP and Humsavar for OR6X1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4935844 -- 123,755,290(+) ACTAA(C/T)CTACA upstream-variant-2KB
rs10502268 -- 123,756,028(+) AAGAG(C/T)TTATC upstream-variant-2KB
rs10502269 -- 123,756,284(+) TCAAA(A/G)GGAAA upstream-variant-2KB
rs11219278 -- 123,756,054(+) TAGGT(A/G)GATAG upstream-variant-2KB
rs12364099 - 123,753,950(+) TGCTG(G/T)TGTCT missense, reference

Relevant External Links for OR6X1 Gene

HapMap Linkage Disequilibrium report
OR6X1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR6X1 Gene

Disorders for OR6X1 Gene

Relevant External Links for OR6X1

Genetic Association Database (GAD)
OR6X1

No disorders were found for OR6X1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OR6X1 Gene

Publications for OR6X1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. A genome-wide association study of total serum and mite-specific IgEs in asthma patients. (PMID: 23967269) Kim J.H. … Shin H.D. (PLoS ONE 2013) 3
  3. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  4. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for OR6X1 Gene

Sources for OR6X1 Gene

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