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Aliases for OR6V1 Gene

Aliases for OR6V1 Gene

  • Olfactory Receptor Family 6 Subfamily V Member 1 2 3 5
  • Olfactory Receptor OR7-3 3 4
  • Olfactory Receptor, Family 6, Subfamily V, Member 1 2
  • Olfactory Receptor 6V1 3
  • GPR138 3

External Ids for OR6V1 Gene

Previous GeneCards Identifiers for OR6V1 Gene

  • GC07U990314
  • GC07P142222
  • GC07P142266
  • GC07P142459
  • GC07P142749
  • GC07P143053
  • GC07P143113
  • GC07P143204

Summaries for OR6V1 Gene

Entrez Gene Summary for OR6V1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6V1 Gene

OR6V1 (Olfactory Receptor Family 6 Subfamily V Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6S1.

UniProtKB/Swiss-Prot for OR6V1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6V1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6V1 Gene

Genomics for OR6V1 Gene

Regulatory Elements for OR6V1 Gene

Enhancers for OR6V1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143098 0.3 FANTOM5 12.9 +46.6 46642 0.4 JUND POLR2A MLLT1 SETDB1 OR6V1 OR9P1P TAS2R39 PIP OR6W1P
GH07F143120 0.6 ENCODE 11.3 +68.5 68525 1.3 GATA3 JUND PKNOX1 JUNB NR3C1 OR6V1 TAS2R39 OR9P1P KEL C7orf34 TRPV5 TMEM139 TCAF2 GSTK1 PIP
GH07F143012 0.8 Ensembl ENCODE 11.2 -36.9 -36867 4.9 CTCF RAD21 YY1 FOSL1 ZNF316 SMC3 NFE2 MAFK NFE2L2 SRF OR9P1P OR6V1 TAS2R39 KEL TRBV11-2 OR9A2
GH07F143172 0.6 Ensembl 11 +120.2 120181 0.6 BCOR ZMYM3 CHD7 RAD21 YY1 ZNF664 ZNF692 ADNP OR6V1 OR9P1P GSTK1 TAS2R39 PIP
GH07F143008 0.2 Ensembl 10.1 -44.0 -44020 0.2 CTCF ATF1 CBX3 MAX RAD21 ZNF143 SMC3 CREM ZNF654 NFIA TAS2R40 OR9P1P OR6V1 OR9A2 KEL
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR6V1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6V1 Gene

143,052,320 bp from pter
143,053,347 bp from pter
1,028 bases
Plus strand

Genomic View for OR6V1 Gene

Genes around OR6V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6V1 Gene

Proteins for OR6V1 Gene

  • Protein details for OR6V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6V1
    Protein Accession:
    Secondary Accessions:
    • A4D2I0
    • B9EH48
    • Q6IF70

    Protein attributes for OR6V1 Gene

    313 amino acids
    Molecular mass:
    34902 Da
    Quaternary structure:
    No Data Available
    • Sequence=DAA04790.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6V1 Gene

Post-translational modifications for OR6V1 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6V1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6V1 Gene

Domains & Families for OR6V1 Gene

Gene Families for OR6V1 Gene

Protein Domains for OR6V1 Gene

Suggested Antigen Peptide Sequences for OR6V1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6V1: view

Function for OR6V1 Gene

Molecular function for OR6V1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6V1: view
genes like me logo Genes that share phenotypes with OR6V1: view

Animal Model Products

miRNA for OR6V1 Gene

miRTarBase miRNAs that target OR6V1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR6V1 Gene

Localization for OR6V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6V1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR6V1 Gene COMPARTMENTS Subcellular localization image for OR6V1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6V1: view

Pathways & Interactions for OR6V1 Gene

genes like me logo Genes that share pathways with OR6V1: view

Pathways by source for OR6V1 Gene

Interacting Proteins for OR6V1 Gene

Gene Ontology (GO) - Biological Process for OR6V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6V1: view

No data available for SIGNOR curated interactions for OR6V1 Gene

Transcripts for OR6V1 Gene

mRNA/cDNA for OR6V1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6V1 Gene

No ASD Table

Relevant External Links for OR6V1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6V1 Gene

mRNA expression in normal human tissues for OR6V1 Gene

Protein differential expression in normal tissues from HIPED for OR6V1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR6V1 Gene

Protein tissue co-expression partners for OR6V1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6V1 Gene:


SOURCE GeneReport for Unigene cluster for OR6V1 Gene:

genes like me logo Genes that share expression patterns with OR6V1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR6V1 Gene

Orthologs for OR6V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6V1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC472558 34
  • 98.94 (n)
OR6V1 35
  • 98 (a)
(Canis familiaris)
Mammalia OR6V1 34 35
  • 87.5 (n)
(Bos Taurus)
Mammalia OR6V1 34
  • 85.9 (n)
-- 35
  • 42 (a)
(Monodelphis domestica)
Mammalia OR6V1 35
  • 70 (a)
(Mus musculus)
Mammalia Olfr461 35
  • 43 (a)
(Danio rerio)
Actinopterygii or101-1 35
  • 38 (a)
Species where no ortholog for OR6V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR6V1 Gene

Gene Tree for OR6V1 (if available)
Gene Tree for OR6V1 (if available)

Paralogs for OR6V1 Gene

Paralogs for OR6V1 Gene

(447) SIMAP similar genes for OR6V1 Gene using alignment to 1 proteins: Pseudogenes for OR6V1 Gene

genes like me logo Genes that share paralogs with OR6V1: view

Variants for OR6V1 Gene

Sequence variations from dbSNP and Humsavar for OR6V1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10241687 -- 143,052,132(+) TCTCC(C/T)ATTCC upstream-variant-2KB
rs10245778 -- 143,053,050(+) TTTCT(C/T)CACTT reference, missense
rs10246397 -- 143,053,582(+) ATGAT(C/T)AAGAG downstream-variant-500B
rs10246520 -- 143,053,660(+) TGTTC(C/T)GGGTG downstream-variant-500B
rs10256054 -- 143,051,388(+) GGAAG(C/T)TAATT upstream-variant-2KB

Variation tolerance for OR6V1 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.32; 85.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR6V1 Gene

Disorders for OR6V1 Gene

Relevant External Links for OR6V1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR6V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6V1 Gene

Publications for OR6V1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Novel human G-protein-coupled receptors. (PMID: 12732197) Vanti W.B. … O'Dowd B.F. (Biochem. Biophys. Res. Commun. 2003) 2 3 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64

Products for OR6V1 Gene

Sources for OR6V1 Gene

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