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Aliases for OR6T1 Gene

Aliases for OR6T1 Gene

  • Olfactory Receptor Family 6 Subfamily T Member 1 2 3 5
  • Olfactory Receptor, Family 6, Subfamily T, Member 1 2 3
  • Olfactory Receptor OR11-277 3 4
  • OR11-277 3

External Ids for OR6T1 Gene

Previous GeneCards Identifiers for OR6T1 Gene

  • GC11U990337
  • GC11M123352
  • GC11M123318
  • GC11M123813

Summaries for OR6T1 Gene

Entrez Gene Summary for OR6T1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6T1 Gene

OR6T1 (Olfactory Receptor Family 6 Subfamily T Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR9A4.

UniProtKB/Swiss-Prot for OR6T1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6T1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6T1 Gene

Genomics for OR6T1 Gene

Regulatory Elements for OR6T1 Gene

Enhancers for OR6T1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR6T1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6T1 Gene

Chromosome:
11
Start:
123,942,432 bp from pter
End:
123,993,780 bp from pter
Size:
51,349 bases
Orientation:
Minus strand

Genomic View for OR6T1 Gene

Genes around OR6T1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6T1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6T1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6T1 Gene

Proteins for OR6T1 Gene

  • Protein details for OR6T1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGN1-OR6T1_HUMAN
    Recommended name:
    Olfactory receptor 6T1
    Protein Accession:
    Q8NGN1
    Secondary Accessions:
    • Q6IFE7

    Protein attributes for OR6T1 Gene

    Size:
    323 amino acids
    Molecular mass:
    36348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6T1 Gene

Proteomics data for OR6T1 Gene at MOPED

Post-translational modifications for OR6T1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6T1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OR6T1

No data available for DME Specific Peptides for OR6T1 Gene

Domains & Families for OR6T1 Gene

Gene Families for OR6T1 Gene

Protein Domains for OR6T1 Gene

Suggested Antigen Peptide Sequences for OR6T1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGN1

UniProtKB/Swiss-Prot:

OR6T1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6T1: view

Function for OR6T1 Gene

Molecular function for OR6T1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR6T1 Gene

GenomeRNAi human phenotypes for OR6T1:
genes like me logo Genes that share phenotypes with OR6T1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6T1 Gene

Localization for OR6T1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6T1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6T1 Gene COMPARTMENTS Subcellular localization image for OR6T1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6T1: view

Pathways & Interactions for OR6T1 Gene

genes like me logo Genes that share pathways with OR6T1: view

Pathways by source for OR6T1 Gene

Interacting Proteins for OR6T1 Gene

Gene Ontology (GO) - Biological Process for OR6T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6T1: view

No data available for SIGNOR curated interactions for OR6T1 Gene

Drugs & Compounds for OR6T1 Gene

No Compound Related Data Available

Transcripts for OR6T1 Gene

mRNA/cDNA for OR6T1 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR6T1 Gene

No ASD Table

Relevant External Links for OR6T1 Gene

GeneLoc Exon Structure for
OR6T1
ECgene alternative splicing isoforms for
OR6T1

Expression for OR6T1 Gene

mRNA expression in normal human tissues for OR6T1 Gene

mRNA differential expression in normal tissues according to GTEx for OR6T1 Gene

This gene is overexpressed in Pancreas (x24.4), Testis (x19.4), and Colon - Transverse (x5.8).

SOURCE GeneReport for Unigene cluster for OR6T1 Gene Hs.553638

genes like me logo Genes that share expression patterns with OR6T1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR6T1 Gene

Orthologs for OR6T1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6T1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 38 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 41 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr213 36
  • 43 (a)
ManyToMany
Species with no ortholog for OR6T1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6T1 Gene

ENSEMBL:
Gene Tree for OR6T1 (if available)
TreeFam:
Gene Tree for OR6T1 (if available)

Paralogs for OR6T1 Gene

Paralogs for OR6T1 Gene

(434) SIMAP similar genes for OR6T1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6T1: view

Variants for OR6T1 Gene

Sequence variations from dbSNP and Humsavar for OR6T1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs6590022 - 123,943,771(+) ACTGT(A/G)TGAGG intron-variant, reference, missense
rs6590021 - 123,943,649(+) ATTCC(A/G/T)CAGGA reference, missense
rs7937317 - 123,943,088(+) ATAGA(C/T)GATGA reference, missense
rs522954 -- 123,956,146(-) cttct(C/T)cctgt intron-variant
rs554061 -- 123,971,141(-) aatac(A/C)aaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR6T1 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV Gain 19592680

Variation tolerance for OR6T1 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6T1 Gene

HapMap Linkage Disequilibrium report
OR6T1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6T1 Gene

Disorders for OR6T1 Gene

Relevant External Links for OR6T1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6T1

No disorders were found for OR6T1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6T1 Gene

Publications for OR6T1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR6T1 Gene

Sources for OR6T1 Gene

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