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Aliases for OR6T1 Gene

Aliases for OR6T1 Gene

  • Olfactory Receptor Family 6 Subfamily T Member 1 2 3 5
  • Olfactory Receptor OR11-277 3 4
  • Olfactory Receptor, Family 6, Subfamily T, Member 1 2
  • Olfactory Receptor 6T1 3
  • OR11-277 3

External Ids for OR6T1 Gene

Previous GeneCards Identifiers for OR6T1 Gene

  • GC11U990337
  • GC11M123352
  • GC11M123318
  • GC11M123813

Summaries for OR6T1 Gene

Entrez Gene Summary for OR6T1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6T1 Gene

OR6T1 (Olfactory Receptor Family 6 Subfamily T Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6M1.

UniProtKB/Swiss-Prot for OR6T1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6T1 Gene

Additional gene information for OR6T1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6T1 Gene

Genomics for OR6T1 Gene

Regulatory Elements for OR6T1 Gene

Enhancers for OR6T1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H123740 1.4 FANTOM5 ENCODE 5.3 +251.7 251707 3 HNRNPUL1 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 ZNF202 CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P OR4D5 TMEM225 OR6T1
GH11H123583 0.3 FANTOM5 7.3 +409.9 409912 0 OR10G7 OR6X1 OR10G4 OR6T1 OR4D5 OR6M1 OR8D4 OR10S1 GC11M123576 GC11M123593
GH11H123695 0.3 FANTOM5 6.9 +298.4 298447 0 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9
GH11H124008 0.3 FANTOM5 3.9 -14.9 -14895 0 OR8D1 OR4D5 OR10G9 OR8D4 OR10G4 OR6M1 OR8G1 OR10S1 OR8D2 OR6X1
GH11H124191 0.5 FANTOM5 2 -198.3 -198310 0 FOSL1 MAFG VWA5A OR8A1 OR6X1 OR10G7 OR8G2P OR8B12 OR4D5 OR10G4 OR8G1 OR6M1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR6T1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6T1 Gene

Chromosome:
11
Start:
123,942,432 bp from pter
End:
123,993,780 bp from pter
Size:
51,349 bases
Orientation:
Minus strand

Genomic View for OR6T1 Gene

Genes around OR6T1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6T1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6T1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6T1 Gene

Proteins for OR6T1 Gene

  • Protein details for OR6T1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGN1-OR6T1_HUMAN
    Recommended name:
    Olfactory receptor 6T1
    Protein Accession:
    Q8NGN1
    Secondary Accessions:
    • Q6IFE7

    Protein attributes for OR6T1 Gene

    Size:
    323 amino acids
    Molecular mass:
    36348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6T1 Gene

Post-translational modifications for OR6T1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6T1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6T1 Gene

Domains & Families for OR6T1 Gene

Gene Families for OR6T1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6T1 Gene

Suggested Antigen Peptide Sequences for OR6T1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGN1

UniProtKB/Swiss-Prot:

OR6T1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6T1: view

Function for OR6T1 Gene

Molecular function for OR6T1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0030594 neurotransmitter receptor activity IBA --
genes like me logo Genes that share ontologies with OR6T1: view

Phenotypes for OR6T1 Gene

genes like me logo Genes that share phenotypes with OR6T1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR6T1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6T1 Gene

Localization for OR6T1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6T1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6T1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6T1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6T1 Gene

Pathways & Interactions for OR6T1 Gene

genes like me logo Genes that share pathways with OR6T1: view

Pathways by source for OR6T1 Gene

Interacting Proteins for OR6T1 Gene

Gene Ontology (GO) - Biological Process for OR6T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6T1: view

No data available for SIGNOR curated interactions for OR6T1 Gene

Drugs & Compounds for OR6T1 Gene

No Compound Related Data Available

Transcripts for OR6T1 Gene

mRNA/cDNA for OR6T1 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR6T1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR6T1 Gene

No ASD Table

Relevant External Links for OR6T1 Gene

GeneLoc Exon Structure for
OR6T1
ECgene alternative splicing isoforms for
OR6T1

Expression for OR6T1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6T1 Gene

mRNA differential expression in normal tissues according to GTEx for OR6T1 Gene

This gene is overexpressed in Pancreas (x24.4), Testis (x19.4), and Colon - Transverse (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of OR6T1 Gene:

OR6T1

SOURCE GeneReport for Unigene cluster for OR6T1 Gene:

Hs.553638
genes like me logo Genes that share expression patterns with OR6T1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6T1 Gene

Orthologs for OR6T1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6T1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
OneToMany
-- 34
  • 74 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr213 34
  • 43 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 41 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 38 (a)
ManyToMany
Species where no ortholog for OR6T1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6T1 Gene

ENSEMBL:
Gene Tree for OR6T1 (if available)
TreeFam:
Gene Tree for OR6T1 (if available)

Paralogs for OR6T1 Gene

Paralogs for OR6T1 Gene

(434) SIMAP similar genes for OR6T1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6T1: view

Variants for OR6T1 Gene

Sequence variations from dbSNP and Humsavar for OR6T1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001685465 -- 123,941,818(+) TCTAA(A/C)AAAAC utr-variant-3-prime
rs1003324950 -- 123,945,789(+) ATTAT(G/T)ATTGT upstream-variant-2KB
rs1003388788 -- 123,945,284(+) ACATA(A/T)TCATT upstream-variant-2KB
rs1003760422 -- 123,944,837(+) TTTTT(A/T)AAACA upstream-variant-2KB
rs1004271177 -- 123,942,690(+) AGGAG(G/T)CACAA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OR6T1 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680

Variation tolerance for OR6T1 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6T1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6T1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6T1 Gene

Disorders for OR6T1 Gene

Relevant External Links for OR6T1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6T1

No disorders were found for OR6T1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6T1 Gene

Publications for OR6T1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR6T1 Gene

Sources for OR6T1 Gene

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