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Aliases for OR6S1 Gene

Aliases for OR6S1 Gene

  • Olfactory Receptor Family 6 Subfamily S Member 1 2 3 5
  • Olfactory Receptor OR14-37 3 4
  • Olfactory Receptor, Family 6, Subfamily S, Member 1 2
  • Olfactory Receptor 6S1 3
  • OR14-37 3
  • OR6S1Q 3

External Ids for OR6S1 Gene

Previous GeneCards Identifiers for OR6S1 Gene

  • GC14U990430
  • GC14M019099
  • GC14M020151
  • GC14M021109

Summaries for OR6S1 Gene

Entrez Gene Summary for OR6S1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6S1 Gene

OR6S1 (Olfactory Receptor Family 6 Subfamily S Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6M1.

UniProtKB/Swiss-Prot for OR6S1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6S1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6S1 Gene

Genomics for OR6S1 Gene

Regulatory Elements for OR6S1 Gene

Enhancers for OR6S1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020591 0.4 FANTOM5 17.4 +49.8 49820 0.1 ZFHX2 IKZF1 EGR2 OR4K17 OR6S1 RNASE12 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
GH14F020662 1.3 Ensembl ENCODE 12.1 -22.0 -22010 1.8 ARID4B SIN3A ZNF2 ZNF143 ZNF207 ZNF263 SP3 REST KAT8 SSRP1 METTL3 SUPT16H TEP1 PARP2 CHD8 ENSG00000222489 OR6S1 TMEM55B APEX1 TOX4
GH14F020617 0.5 Ensembl 11.4 +23.6 23590 1.4 TBP PKNOX1 RAD21 ZBTB40 GATA2 SMAD5 CBFB JUNB PBX2 IKZF1 ANG OR6S1 RNA5SP382 TEP1 PNP TMEM55B RPS26P9 GC14P020627 PIR59363
GH14F020621 0.2 ENCODE 11.3 +20.4 20435 0.2 ELF3 SOX5 SAP130 TEAD1 PPARG ZNF7 TEAD3 POLR2A ETV4 TCF7 ANG OR6S1 GC14P020627 RPS26P9 PIR59363
GH14F020797 1.1 FANTOM5 ENCODE 1.3 -155.7 -155686 0.2 POLR2A CHD7 PNP TMEM55B ARHGEF40 OR6S1 OR5AU1 HNRNPC LOC105370397 RNASE1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR6S1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6S1 Gene

Chromosome:
14
Start:
20,640,696 bp from pter
End:
20,641,691 bp from pter
Size:
996 bases
Orientation:
Minus strand

Genomic View for OR6S1 Gene

Genes around OR6S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6S1 Gene

Proteins for OR6S1 Gene

  • Protein details for OR6S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH40-OR6S1_HUMAN
    Recommended name:
    Olfactory receptor 6S1
    Protein Accession:
    Q8NH40
    Secondary Accessions:
    • Q6IFJ9

    Protein attributes for OR6S1 Gene

    Size:
    331 amino acids
    Molecular mass:
    36127 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05799.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OR6S1 Gene

Post-translational modifications for OR6S1 Gene

Other Protein References for OR6S1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6S1 Gene

Domains & Families for OR6S1 Gene

Gene Families for OR6S1 Gene

Protein Domains for OR6S1 Gene

Suggested Antigen Peptide Sequences for OR6S1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH40

UniProtKB/Swiss-Prot:

OR6S1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6S1: view

Function for OR6S1 Gene

Molecular function for OR6S1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6S1: view

Phenotypes for OR6S1 Gene

GenomeRNAi human phenotypes for OR6S1:
genes like me logo Genes that share phenotypes with OR6S1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6S1 Gene

Localization for OR6S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6S1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6S1 Gene COMPARTMENTS Subcellular localization image for OR6S1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6S1: view

Pathways & Interactions for OR6S1 Gene

genes like me logo Genes that share pathways with OR6S1: view

Pathways by source for OR6S1 Gene

Gene Ontology (GO) - Biological Process for OR6S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6S1: view

No data available for SIGNOR curated interactions for OR6S1 Gene

Transcripts for OR6S1 Gene

mRNA/cDNA for OR6S1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6S1 Gene

No ASD Table

Relevant External Links for OR6S1 Gene

GeneLoc Exon Structure for
OR6S1
ECgene alternative splicing isoforms for
OR6S1

Expression for OR6S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6S1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6S1 Gene:

OR6S1

SOURCE GeneReport for Unigene cluster for OR6S1 Gene:

Hs.513132
genes like me logo Genes that share expression patterns with OR6S1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR6S1 Gene

Orthologs for OR6S1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6S1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473323 34
  • 98.29 (n)
OR6S1 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR6S1 34 35
  • 85.8 (n)
dog
(Canis familiaris)
Mammalia OR6S1 34 35
  • 85.2 (n)
mouse
(Mus musculus)
Mammalia Or6s1 55 Olfr750 34 16 35
  • 81.4 (n)
rat
(Rattus norvegicus)
Mammalia Olr1637 34
  • 80.56 (n)
oppossum
(Monodelphis domestica)
Mammalia OR6S1 35
  • 72 (a)
OneToOne
Species where no ortholog for OR6S1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6S1 Gene

ENSEMBL:
Gene Tree for OR6S1 (if available)
TreeFam:
Gene Tree for OR6S1 (if available)

Paralogs for OR6S1 Gene

Paralogs for OR6S1 Gene

(448) SIMAP similar genes for OR6S1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6S1: view

Variants for OR6S1 Gene

Sequence variations from dbSNP and Humsavar for OR6S1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10498271 -- 20,642,349(+) CAACT(C/G)TACAA upstream-variant-2KB
rs11156622 -- 20,641,700(+) CTTTT(C/T)CACCT upstream-variant-2KB
rs112088064 -- 20,642,326(+) TATCA(A/G)TTTGT upstream-variant-2KB
rs112522436 -- 20,641,536(+) TCAGC(C/T)CTTAC reference, synonymous-codon
rs114188068 -- 20,640,737(+) TAAAA(G/T)ATTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR6S1 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545

Variation tolerance for OR6S1 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.19; 96.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6S1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6S1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6S1 Gene

Disorders for OR6S1 Gene

Relevant External Links for OR6S1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6S1

No disorders were found for OR6S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6S1 Gene

Publications for OR6S1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 64

Products for OR6S1 Gene

Sources for OR6S1 Gene

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