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Aliases for OR6Q1 Gene

Aliases for OR6Q1 Gene

  • Olfactory Receptor Family 6 Subfamily Q Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-226 3 4
  • Olfactory Receptor, Family 6, Subfamily Q, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 6, Subfamily Q, Member 1 3
  • Olfactory Receptor 6Q1 3
  • OR11-226 3

External Ids for OR6Q1 Gene

Previous GeneCards Identifiers for OR6Q1 Gene

  • GC11U990412
  • GC11P057574
  • GC11P057555
  • GC11P057798

Summaries for OR6Q1 Gene

Entrez Gene Summary for OR6Q1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR6Q1 Gene

OR6Q1 (Olfactory Receptor Family 6 Subfamily Q Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR6B1.

UniProtKB/Swiss-Prot for OR6Q1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6Q1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6Q1 Gene

Genomics for OR6Q1 Gene

Regulatory Elements for OR6Q1 Gene

Enhancers for OR6Q1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G058033 0.3 FANTOM5 3.6 +3.0 3033 0.3 OR6Q1 OR1S1 OR5B12 OR9I1 ENSG00000255146
GH11G058027 0.8 Ensembl ENCODE 0.7 -2.3 -2336 3.1 GATA2 HLF FOS PPARG RAD21 NR2F2 TIMM10 MED19 CLP1 GLYATL1 CTNND1 GC11M058027 OR6Q1
GH11G057946 0.4 FANTOM5 1.4 -84.5 -84496 0.0 RFX1 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12 MED19 OR5B3 OR1S1 OR9I1
GH11G058057 1.1 Ensembl ENCODE 0.3 +29.0 28983 5.7 ELF3 PKNOX1 FOXA2 ATF1 RAD21 RARA GATA4 GATA2 MIXL1 PPARG TIMM10 MED19 CLP1 GLYATL1 CTNND1 ENSG00000255146 OR6Q1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR6Q1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the OR6Q1 gene promoter:

Genomic Location for OR6Q1 Gene

Chromosome:
11
Start:
58,030,930 bp from pter
End:
58,031,931 bp from pter
Size:
1,002 bases
Orientation:
Plus strand

Genomic View for OR6Q1 Gene

Genes around OR6Q1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6Q1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6Q1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6Q1 Gene

Proteins for OR6Q1 Gene

  • Protein details for OR6Q1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGQ2-OR6Q1_HUMAN
    Recommended name:
    Olfactory receptor 6Q1
    Protein Accession:
    Q8NGQ2
    Secondary Accessions:
    • B9EKW1
    • Q6IFH1
    • Q96R34

    Protein attributes for OR6Q1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35736 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6Q1 Gene

Post-translational modifications for OR6Q1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR6Q1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6Q1 Gene

Domains & Families for OR6Q1 Gene

Gene Families for OR6Q1 Gene

Protein Domains for OR6Q1 Gene

Suggested Antigen Peptide Sequences for OR6Q1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGQ2

UniProtKB/Swiss-Prot:

OR6Q1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6Q1: view

Function for OR6Q1 Gene

Molecular function for OR6Q1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR6Q1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6Q1 Gene

Localization for OR6Q1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6Q1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6Q1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6Q1: view

Pathways & Interactions for OR6Q1 Gene

genes like me logo Genes that share pathways with OR6Q1: view

Pathways by source for OR6Q1 Gene

Interacting Proteins for OR6Q1 Gene

Gene Ontology (GO) - Biological Process for OR6Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6Q1: view

No data available for SIGNOR curated interactions for OR6Q1 Gene

Drugs & Compounds for OR6Q1 Gene

No Compound Related Data Available

Transcripts for OR6Q1 Gene

mRNA/cDNA for OR6Q1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6Q1 Gene

No ASD Table

Relevant External Links for OR6Q1 Gene

GeneLoc Exon Structure for
OR6Q1
ECgene alternative splicing isoforms for
OR6Q1

Expression for OR6Q1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6Q1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6Q1 Gene:

OR6Q1

SOURCE GeneReport for Unigene cluster for OR6Q1 Gene:

Hs.690432
genes like me logo Genes that share expression patterns with OR6Q1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6Q1 Gene

Orthologs for OR6Q1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6Q1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466592 34
  • 98.84 (n)
dog
(Canis familiaris)
Mammalia LOC483486 34
  • 87.28 (n)
cow
(Bos Taurus)
Mammalia OR6Q1 34
  • 78.23 (n)
Species where no ortholog for OR6Q1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6Q1 Gene

ENSEMBL:
Gene Tree for OR6Q1 (if available)
TreeFam:
Gene Tree for OR6Q1 (if available)

Paralogs for OR6Q1 Gene

Paralogs for OR6Q1 Gene

(457) SIMAP similar genes for OR6Q1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR6Q1: view

Variants for OR6Q1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR6Q1 Gene

OR6Q1_HUMAN-Q8NGQ2
A single nucleotide deletion at position Leu-229 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The deletion is more frequent in African-Americans than in non-Africans.

Sequence variations from dbSNP and Humsavar for OR6Q1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000938634 -- 58,029,337(+) TTCCT(C/T)ACACT intron-variant, upstream-variant-2KB
rs1001473137 -- 58,028,974(+) TGACT(A/G)TAGCA intron-variant, upstream-variant-2KB
rs1002871400 -- 58,029,231(+) CATCC(A/G)GCTGG intron-variant, upstream-variant-2KB
rs1003373507 -- 58,029,425(+) ACTTC(A/C)CCCTT intron-variant, upstream-variant-2KB
rs1003612201 -- 58,030,661(+) TATAG(A/G)CAGTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR6Q1 Gene

Variant ID Type Subtype PubMed ID
esv2761678 CNV loss 21179565

Variation tolerance for OR6Q1 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.19; 99.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6Q1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6Q1

Disorders for OR6Q1 Gene

Relevant External Links for OR6Q1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6Q1

No disorders were found for OR6Q1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6Q1 Gene

Publications for OR6Q1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3 64
  4. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 4 64
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3 64

Products for OR6Q1 Gene

Sources for OR6Q1 Gene

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